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OPPORTUNITY ASSESSMENT
    Providing comprehensive market understanding and insights to support investment and commercialization



                           DISEASE BACKGROUND                                                                   MARKET OVERVIEW


    • Etiology & pathophysiology        • Epidemiology                         • Treatment algorithm                  • Market trends
    • Patient segmentation              • Demand analysis                      • Treatment guidelines                 • Future outlook
                                                                               • Prescribing drivers/resistors        • Growth drivers & resistors
                                                                               • Current size



                                                                     4C ANALYSIS




    CUSTOMER ANALYSIS                   COMPETITOR ANALYSIS                    CONSUMER ANALYSIS                      CANDIDATE ANALYSIS
    • KOL, treating physician and 		    • Treatment algorithm                  • Market segmentation                  • TPP ideation and 		
    	 payer interviews                  • Treatment guidelines                 • Market sizing (number of 	           	validation
    • In-depth phone, face-to-face 		   • Prescribing drivers and       	      	 treatable patients; current          • Stakeholder evaluations
    	 interviews and online surveys       resistors                            	 and future)                          • Gap analysis of TPP, pipeline 	
    • Influence mapping                 • Current size                         • Current standard of care’s 	         	 and existing products to 	
    • Decision-making process           • Market trends                        	 strengths and weaknesses             	 unmet needs
    • Requirements and unmet needs      • Future outlook/growth drivers        • Unmet needs
    • Price point testing                  resistors




                                     VALUATION                                                     INSIGHTS AND RECOMMENDATIONS

    • Approach: patient and/or 	        • Ouputs:                              • Key findings                         • High-value market targeting
    	 demand-based forecast models      	 - Volume, sales                      • Drivers and resistors                • Optimized product proposition 		
    • Inputs:                           	 - Scenarios and assumptions          • Medical and commercial 		            	 and positioning
    	 - Best available data             • Results Audit:                       	implications                          • Strategic recommendations
    	 - Prices                          	 - Triangulation
    	 - Uptake curves                   	 - Statistical analyses
    	 - Market shares                   	 - Quality control




INFORMING YOUR CRITICAL DECISIONS

Knowledge Building                                                            Internal or External Valuations
Ensuring you have the right information on new markets and                    Providing robust financial information for your go/no-go,
indications to support your pipeline and newly-launched products              in-licensing, out-licensing and partnering decisions.
by leveraging our robust research and information sources.
                                                                              Portfolio Management
Setting Strategic Direction                                                   Working closely with you, we bring clarity when assessing
Building your product concepts and testing product profiles, we help          product(s) in the context of your overall portfolio, and fully evaluate
you to define and position your business against its future challenges.       the options available, potential scenarios and resulting impacts.




Our consultants operate globally; our head offices are located in:
UK 	     119 Farringdon Road, London EC1R 3DA | +44 (0)20 7675 7000
US 	     52 Vanderbilt Avenue, 7th Floor, New York, NY 10017 | +1 (212) 686 7400                                    info@datamonitorconsulting.com
Japan 	 7th Kotakudo GINZA Building, 5-14-5, Ginza, Chuo, Tokyo 104-0061 | +81 (0)3 5148 7910                       www.datamonitorconsulting.com
RESULTS IN PRACTICE: HOW WE’VE HELPED OTHERS


OUR EXPERTISE

Experience across the lifecycle
We bring you over ten years of pharma and biotech focussed consulting experience, from shaping ideal TPPs in the preclinical settings and
developing robust pre-launch analyses, right through to managing the final years of patent life. Our tailored approaches ensure you are armed with
the best analysis and valuation to inform your decisions.

Consensus and collaboration
Datamonitor Consulting’s approach and style is focused on ensuring that all major data points and assumptions are presented to key stakeholders
and pressure-tested at multiple points during a project.

Transparent and robust market models
Our models are robust and sophisticated, yet remain fully transparent and user-friendly.



IN-LICENSING CANDIDATES EVALUATION                                            INTERNAL PIPELINE PRODUCT ASSESSMENT

                     The Issue                                                                   The Issue
                     Our client, a Top Ten pharma company, needed                                Our client needed a current market assessment
                     robust independent assessments with fast                                    of potential opportunities and threats to their
                     turnaround to support their BDL valuation of                               Phase III product. They also requested an
                     three in-licensing targets.                                                 associated valuation.




                     Our Approach                                                                Our Approach
                     Our consultants structured a rapid-initiation,                              We sourced and analyzed the best available
                     rapid-turnaround framework to analyze and                                   data, designed and conducted research to
                     summarize multiple elements, including:                                     gather insights from key market stakeholders:
                                                                                                 payers, treating physicians, patients and
                     • Target population  treatment algorithm                                   opinion leaders.
                     • Competitive landscape  unmet stakeholder       	
                       needs                                                                     We developed a transparent and robust forecast
                     • Pricing  market access drivers                                           which leveraged the insights from this process.
                     • Response to the Target Product Profile, 	
                       including share allocations  risk-adjusted 	
                       patient-based forecasts




                     The Result                                                                  The Result
                     Our assessment was completed in five weeks                                  Our output identified high probability/high
                     and the results informed their final BDL                                   impact events. We then estimated the product’s
                     decisions regarding the targets.                                            potential and associated NPVs based on
                                                                                                 different scenarios.
                     The success of the project led to an on-going
                     partnership: Datamonitor supports external                                  Based upon this output, we offered actionable
                     assessments where the client is resource                                    recommendations to support future investment
                     constrained or is dealing with unfamiliar                                   and development planning.
                     therapy areas.




Our consultants operate globally; our head offices are located in:
UK 	     119 Farringdon Road, London EC1R 3DA | +44 (0)20 7675 7000
US 	     52 Vanderbilt Avenue, 7th Floor, New York, NY 10017 | +1 (212) 686 7400                               info@datamonitorconsulting.com
Japan 	 7th Kotakudo GINZA Building, 5-14-5, Ginza, Chuo, Tokyo 104-0061 | +81 (0)3 5148 7910                  www.datamonitorconsulting.com

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Datamonitor Consulting: Opportunity Assessment and Forecasting in the Pharmaceutical and Biotechnology Industry

  • 1. OPPORTUNITY ASSESSMENT Providing comprehensive market understanding and insights to support investment and commercialization DISEASE BACKGROUND MARKET OVERVIEW • Etiology & pathophysiology • Epidemiology • Treatment algorithm • Market trends • Patient segmentation • Demand analysis • Treatment guidelines • Future outlook • Prescribing drivers/resistors • Growth drivers & resistors • Current size 4C ANALYSIS CUSTOMER ANALYSIS COMPETITOR ANALYSIS CONSUMER ANALYSIS CANDIDATE ANALYSIS • KOL, treating physician and • Treatment algorithm • Market segmentation • TPP ideation and payer interviews • Treatment guidelines • Market sizing (number of validation • In-depth phone, face-to-face • Prescribing drivers and treatable patients; current • Stakeholder evaluations interviews and online surveys resistors and future) • Gap analysis of TPP, pipeline • Influence mapping • Current size • Current standard of care’s and existing products to • Decision-making process • Market trends strengths and weaknesses unmet needs • Requirements and unmet needs • Future outlook/growth drivers • Unmet needs • Price point testing resistors VALUATION INSIGHTS AND RECOMMENDATIONS • Approach: patient and/or • Ouputs: • Key findings • High-value market targeting demand-based forecast models - Volume, sales • Drivers and resistors • Optimized product proposition • Inputs: - Scenarios and assumptions • Medical and commercial and positioning - Best available data • Results Audit: implications • Strategic recommendations - Prices - Triangulation - Uptake curves - Statistical analyses - Market shares - Quality control INFORMING YOUR CRITICAL DECISIONS Knowledge Building Internal or External Valuations Ensuring you have the right information on new markets and Providing robust financial information for your go/no-go, indications to support your pipeline and newly-launched products in-licensing, out-licensing and partnering decisions. by leveraging our robust research and information sources. Portfolio Management Setting Strategic Direction Working closely with you, we bring clarity when assessing Building your product concepts and testing product profiles, we help product(s) in the context of your overall portfolio, and fully evaluate you to define and position your business against its future challenges. the options available, potential scenarios and resulting impacts. Our consultants operate globally; our head offices are located in: UK 119 Farringdon Road, London EC1R 3DA | +44 (0)20 7675 7000 US 52 Vanderbilt Avenue, 7th Floor, New York, NY 10017 | +1 (212) 686 7400 info@datamonitorconsulting.com Japan 7th Kotakudo GINZA Building, 5-14-5, Ginza, Chuo, Tokyo 104-0061 | +81 (0)3 5148 7910 www.datamonitorconsulting.com
  • 2. RESULTS IN PRACTICE: HOW WE’VE HELPED OTHERS OUR EXPERTISE Experience across the lifecycle We bring you over ten years of pharma and biotech focussed consulting experience, from shaping ideal TPPs in the preclinical settings and developing robust pre-launch analyses, right through to managing the final years of patent life. Our tailored approaches ensure you are armed with the best analysis and valuation to inform your decisions. Consensus and collaboration Datamonitor Consulting’s approach and style is focused on ensuring that all major data points and assumptions are presented to key stakeholders and pressure-tested at multiple points during a project. Transparent and robust market models Our models are robust and sophisticated, yet remain fully transparent and user-friendly. IN-LICENSING CANDIDATES EVALUATION INTERNAL PIPELINE PRODUCT ASSESSMENT The Issue The Issue Our client, a Top Ten pharma company, needed Our client needed a current market assessment robust independent assessments with fast of potential opportunities and threats to their turnaround to support their BDL valuation of Phase III product. They also requested an three in-licensing targets. associated valuation. Our Approach Our Approach Our consultants structured a rapid-initiation, We sourced and analyzed the best available rapid-turnaround framework to analyze and data, designed and conducted research to summarize multiple elements, including: gather insights from key market stakeholders: payers, treating physicians, patients and • Target population treatment algorithm opinion leaders. • Competitive landscape unmet stakeholder needs We developed a transparent and robust forecast • Pricing market access drivers which leveraged the insights from this process. • Response to the Target Product Profile, including share allocations risk-adjusted patient-based forecasts The Result The Result Our assessment was completed in five weeks Our output identified high probability/high and the results informed their final BDL impact events. We then estimated the product’s decisions regarding the targets. potential and associated NPVs based on different scenarios. The success of the project led to an on-going partnership: Datamonitor supports external Based upon this output, we offered actionable assessments where the client is resource recommendations to support future investment constrained or is dealing with unfamiliar and development planning. therapy areas. Our consultants operate globally; our head offices are located in: UK 119 Farringdon Road, London EC1R 3DA | +44 (0)20 7675 7000 US 52 Vanderbilt Avenue, 7th Floor, New York, NY 10017 | +1 (212) 686 7400 info@datamonitorconsulting.com Japan 7th Kotakudo GINZA Building, 5-14-5, Ginza, Chuo, Tokyo 104-0061 | +81 (0)3 5148 7910 www.datamonitorconsulting.com