This document provides steps to configure multipath I/O (MPIO) on an Open-E DSS V6 system with VMware ESXi 4.x and a Windows 2008 virtual machine. It requires two network cards in both systems connected to a switch. The steps include configuring the DSS V6 as an iSCSI target with two IP addresses, creating two vmkernel ports on the ESXi host connected to different network cards, adding the DSS as two iSCSI targets, enabling round robin path selection, and installing the Windows VM to test I/O performance using Iometer.