“Open Research Data: Implications for Science and Society”, Warsaw, Poland, May 28–29, 2015. The conference was organized by the Open Science Platform — an initiative of the Interdisciplinary Centre for Mathematical and Computational Modelling at the University of Warsaw. pon.edu.pl @OpenSciPlatform #ORD2015
OpenAIRE-COAR conference 2014: Open Access in H2020, by Anni Hellman - Europe...OpenAIRE
Presentation at the OpenAIRE-COAR Conference: "Open Access Movement to Reality: Putting the Pieces Together", Athens - May 21-22, 2014.
Open Access in H2020, by Anni Hellman - European Commission.
OpenAIRE-COAR conference 2014: Open Access in H2020, by Anni Hellman - Europe...OpenAIRE
Presentation at the OpenAIRE-COAR Conference: "Open Access Movement to Reality: Putting the Pieces Together", Athens - May 21-22, 2014.
Open Access in H2020, by Anni Hellman - European Commission.
The European Commission's proposal for embedding open science in horizon europe. Particular emphasis on open access and research data management aspects. Also presenting the new publishing platform of the Commission, Open Research Europe
Horizon 2020 - EU Funding Opportunities, SME instrumentThe Pathway Group
Horizon 2020 - Find out about current EU funding opportunities.
Horizon 2020 is designed to be simpler than previous European Commission funding programmes with only two funding rates for direct costs and a single flat rate for indirect costs. The evaluation and negotiation processes have been speeded up to reduce the time between the Call deadline and projects starting.
OpenAIRE webinar on Open Access in H2020 (OAW2016)OpenAIRE
OpenAIRE Webinar for project coordinators and researchers on Open Access to publications in H2020 - By Eloy Rodrigues and Pedro Principe (University of Minho, OpenAIRE Helpdesk & Training managers). Open Access Week 2016 initiatives.
After an introduction to open science policy in Horizon Europe, the main focus of the presentation is open access to publications requirements in Horizon Europe and Open Research Europe for the Estonian Research Council in June 2021
The section provides an overview of the open science requirements and how to comply with them stipulated by selected funders and organizations: H2020 & ERC, FWO and Belspo by Emilie Hermans
Presentació a càrrec de Lluís Anglada, director de Ciència Oberta al CSUC, duta a terme a la Training Session on Open Science and Open Access al Centre de Recerca Matemàtica de la UAB l'11 de novembre de 2018
OpenAIRE webinar: Horizon 2020 Open Science Policies and beyond, with Emilie ...OpenAIRE
The global shift towards making research findings available free of charge and sharing and opening up the research process, so-called 'Open Science’, has been a core strategy in the European Commission to improve knowledge circulation and innovation.
It is illustrated in particular by the Open Science policies for the ECs framework programme.
In this webinar, I will talk about the OS policies for open access to scientific publications and the pilot for research data in Horizon 2020, followed by a preview of what to expect for Open Science in the new Horizon Europe programme.
---
The 2019 International Open Access Week will be held October 21-27, 2019. This year’s theme, “Open for Whom? Equity in Open Knowledge,” builds on the groundwork laid during last year’s focus of “Designing Equitable Foundations for Open Knowledge.”
As has become a tradition of sorts, OpenAIRE organises a series of webinars during this week, highlighting OpenAIRE activities, services and tools, and reach out to the wider community with relevant talks on many aspects of Open Science.
Presentation of open science requirements in Horizon Europe for the Research and Innovation Foundation in Cyprus. Analyzes requirements of model grant agreement (publications, research data, additional open science practices, open science and evaluation process, open research europe.
Strengthening the Sustainable Development Goals with Open Access and Open S...Leslie Chan
The SDGs represent challenges in advancing the broad access to information agenda because of the divergent goals and proliferating targets and indicators. At the same time, the broadness of many of the goals presents opportunities for the agenda, particularly in the form of open access and open science, to embed itself at the core, thus allowing concrete actions and policies to be formulated in order to achieve tangible development outcomes. I will focus in particular on Goal 9 (“Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation”) and argue that information and knowledge are essential infrastructure needed to build local research capacity which are in turn the foundation for sustainable development. The growing understanding of the importance of sharing methods and results throughout the research life cycle further demands the need for appropriate infrastructure. Examples of such infrastructure, such as data and publication repositories, already exist at some local level, but they are often fragmented and lack adequate resources. It is therefore important for FAO/IFLA/COAR to continue to advocate for the development of knowledge infrastructure and to ensure that policies are in place to support their long term sustainability.
The Impact of World University Rankings on Research and Curriculum Developmen...Leslie Chan
The talk identifies the impact of “world university rankings” on research and curriculum development, particularly for universities in the global South. It is argued that relevance of local research and community engagement are better indicators of ‘excellence’ in the university and we need to rethink assumptions behind "objective" indicators that are underlying most of the major world rankings. These rankings have the effect of rendering research from the developing world invisible and dictating curriculum development oriented towards market needs of the global North. Such rankings thus represent a form of social and cognitive exclusion and institution of higher education should strongly resist this agenda, and formulate other forms of "excellence" based on social inclusion and community engagement.
From Open Access to Open Science: An Overview of Current Landscape; De Acceso...Leslie Chan
Presentation at CIENCIA ABIERTA:Descubriendo herramientas colaborativas para la investigación y el desarrollo 13 y 14 de Octubre de 2015. Sala Magistral 2 Bloque Y
Universidad Tecnológica de Pereira
The European Commission's proposal for embedding open science in horizon europe. Particular emphasis on open access and research data management aspects. Also presenting the new publishing platform of the Commission, Open Research Europe
Horizon 2020 - EU Funding Opportunities, SME instrumentThe Pathway Group
Horizon 2020 - Find out about current EU funding opportunities.
Horizon 2020 is designed to be simpler than previous European Commission funding programmes with only two funding rates for direct costs and a single flat rate for indirect costs. The evaluation and negotiation processes have been speeded up to reduce the time between the Call deadline and projects starting.
OpenAIRE webinar on Open Access in H2020 (OAW2016)OpenAIRE
OpenAIRE Webinar for project coordinators and researchers on Open Access to publications in H2020 - By Eloy Rodrigues and Pedro Principe (University of Minho, OpenAIRE Helpdesk & Training managers). Open Access Week 2016 initiatives.
After an introduction to open science policy in Horizon Europe, the main focus of the presentation is open access to publications requirements in Horizon Europe and Open Research Europe for the Estonian Research Council in June 2021
The section provides an overview of the open science requirements and how to comply with them stipulated by selected funders and organizations: H2020 & ERC, FWO and Belspo by Emilie Hermans
Presentació a càrrec de Lluís Anglada, director de Ciència Oberta al CSUC, duta a terme a la Training Session on Open Science and Open Access al Centre de Recerca Matemàtica de la UAB l'11 de novembre de 2018
OpenAIRE webinar: Horizon 2020 Open Science Policies and beyond, with Emilie ...OpenAIRE
The global shift towards making research findings available free of charge and sharing and opening up the research process, so-called 'Open Science’, has been a core strategy in the European Commission to improve knowledge circulation and innovation.
It is illustrated in particular by the Open Science policies for the ECs framework programme.
In this webinar, I will talk about the OS policies for open access to scientific publications and the pilot for research data in Horizon 2020, followed by a preview of what to expect for Open Science in the new Horizon Europe programme.
---
The 2019 International Open Access Week will be held October 21-27, 2019. This year’s theme, “Open for Whom? Equity in Open Knowledge,” builds on the groundwork laid during last year’s focus of “Designing Equitable Foundations for Open Knowledge.”
As has become a tradition of sorts, OpenAIRE organises a series of webinars during this week, highlighting OpenAIRE activities, services and tools, and reach out to the wider community with relevant talks on many aspects of Open Science.
Presentation of open science requirements in Horizon Europe for the Research and Innovation Foundation in Cyprus. Analyzes requirements of model grant agreement (publications, research data, additional open science practices, open science and evaluation process, open research europe.
Strengthening the Sustainable Development Goals with Open Access and Open S...Leslie Chan
The SDGs represent challenges in advancing the broad access to information agenda because of the divergent goals and proliferating targets and indicators. At the same time, the broadness of many of the goals presents opportunities for the agenda, particularly in the form of open access and open science, to embed itself at the core, thus allowing concrete actions and policies to be formulated in order to achieve tangible development outcomes. I will focus in particular on Goal 9 (“Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation”) and argue that information and knowledge are essential infrastructure needed to build local research capacity which are in turn the foundation for sustainable development. The growing understanding of the importance of sharing methods and results throughout the research life cycle further demands the need for appropriate infrastructure. Examples of such infrastructure, such as data and publication repositories, already exist at some local level, but they are often fragmented and lack adequate resources. It is therefore important for FAO/IFLA/COAR to continue to advocate for the development of knowledge infrastructure and to ensure that policies are in place to support their long term sustainability.
The Impact of World University Rankings on Research and Curriculum Developmen...Leslie Chan
The talk identifies the impact of “world university rankings” on research and curriculum development, particularly for universities in the global South. It is argued that relevance of local research and community engagement are better indicators of ‘excellence’ in the university and we need to rethink assumptions behind "objective" indicators that are underlying most of the major world rankings. These rankings have the effect of rendering research from the developing world invisible and dictating curriculum development oriented towards market needs of the global North. Such rankings thus represent a form of social and cognitive exclusion and institution of higher education should strongly resist this agenda, and formulate other forms of "excellence" based on social inclusion and community engagement.
From Open Access to Open Science: An Overview of Current Landscape; De Acceso...Leslie Chan
Presentation at CIENCIA ABIERTA:Descubriendo herramientas colaborativas para la investigación y el desarrollo 13 y 14 de Octubre de 2015. Sala Magistral 2 Bloque Y
Universidad Tecnológica de Pereira
The Future of Open Science and How to Stop itLeslie Chan
Presentation at the Open Science panel at the launch of Steps Latina America. The talk attempts to situate the rational and objectives of the Open and Collaborative Science in Development Network within the broader landscape of discourse on "openness". While recognizing the potential benefits of openness, it is important to keep in mind the existing structural inequality in global scientific knowledge production and circulation and reflect on the needs to challenge this power asymmetry as a starting point for further understanding on how open science may contribute to development challenges.
Vortrag im Rahmen der EERA-Session: Open Science and Educational Research? Inclusion and Exclusion at the European Open Science Cloud; am 5. September 2018 in Bolzano (Italien).
European Commission
DG Research and Innovation
RTD.A2. Open Data Policy and Science Cloud
Katarzyna Szkuta
Topics covered at the workshop address basic questions related to Research Data Management for open data, which include preparing a Research Data Management (RDM) plan, licensing data and intellectual property, metadata and contextual description (documentation), ethical and legal aspects of sharing sensitive or confidential data, anonymizing research data for reuse, data archiving and long-term preservation, and data security and storage.
Event: http://conferences.nib.si/AS2015/default.htm
Related material: http://conferences.nib.si/AS2015/BookAS15.pdf
Open Source & Open Data Session report from imaGIne 2014 ConferenceGSDI Association
Session report from the imaGIne 2014 Conference held in Berlin, Germany, in October 2014. Session was chaired by Dr. Gabor Remetey-Fulopp, of HUNAGI, who were co-organisers for Session 8C1.
Similar to Open Research Data: Present and planned EC Policy, Jean-Claude Burgelman implications of open data (20)
Umowy dot. autorskich praw majątkowych w praktyce wydawców książek naukowychPlatforma Otwartej Nauki
Umowy dot. autorskich praw majątkowych w praktyce wydawców książek naukowych
dr Sybilla Stanisławska-Kloc (UJ)
Webinarium "Prawne aspekty publikowania otwartych monografii” organizowane przez Platformę Otwartej Nauki i Komisję ds. Wydawnictw Naukowych przy KRASP.
15 grudnia 2022
Prawne aspekty otwartego dostępu
Krzysztof Siewicz
Webinarium "Prawne aspekty publikowania otwartych monografii” organizowane przez Platformę Otwartej Nauki i Komisję ds. Wydawnictw Naukowych przy KRASP.
15 grudnia 2022
Monografie Naukowe - Uniwersytet Śląski
Beata Klyta (UŚ)
Webinarium "Techniczne aspekty publikowania otwartych monografii” organizowane przez Platformę Otwartej Nauki i Komisję ds. Wydawnictw Naukowych przy KRASP.
21 listopada 2022
DSpace - doświadczenia Repozytorium Uniwersytetu Łódzkiego
Aleksandra Brzozowska (UŁ)
Webinarium "Techniczne aspekty publikowania otwartych monografii” organizowane przez Platformę Otwartej Nauki i Komisję ds. Wydawnictw Naukowych przy KRASP.
21 listopada 2022
Platforma czasopism Wydawnictwa Uniwersytetu Łódzkiego
Katarzyna Smyczek (UŁ)
Webinarium "Techniczne aspekty publikowania otwartych monografii” organizowane przez Platformę Otwartej Nauki i Komisję ds. Wydawnictw Naukowych przy KRASP.
21 listopada 2022
Biblioteka Nauki - techniczne możliwości wymiany metadanych
Jak Ciarka (ICM UW)
Webinarium "Techniczne aspekty publikowania otwartych monografii” organizowane przez Platformę Otwartej Nauki i Komisję ds. Wydawnictw Naukowych przy KRASP.
21 listopada 2022
Monografie w Bibliotece Nauki
Ryszard Burek (ICM UW)
Webinarium "Techniczne aspekty publikowania otwartych monografii” organizowane przez Platformę Otwartej Nauki i Komisję ds. Wydawnictw Naukowych przy KRASP.
21 listopada 2022
Open Science Platform. Facilitating Open Science in Poland
Natalia Gruenpeter
Wystąpienie podczas EOSC Festival – the National Tripartite Event Poland
"Otwarta Nauka dla lepszej nauki// Open Science for Better Science"
26 października: EOSC i otwarta nauka w praktyce // EOSC and Open Science in Practice
OpenAIRE Services for Open Science
Natalia Gruenpeter
Wystąpienie podczas EOSC Festival – the National Tripartite Event Poland
"Otwarta Nauka dla lepszej nauki// Open Science for Better Science"
26 października: EOSC i otwarta nauka w praktyce // EOSC and Open Science in Practice
Publikacje Ośrodka Badawczego Facta Ficta w Bibliotece Nauki
Joanna Brońka (Ośrodek Badawczy Facta Ficta)
Prezentacja podczas webinarium z okazji udostępnienia w Bibliotece Nauki ponad 500 000 artykułów
15 listopada 2022
Platforma Otwartej Nauki
http://pon.edu.pl/aktualnosci/226-ponad-pol-miliona-artykulow-w-bibliotece-nauki
PRESSto Platfoma otwartych czasopism naukowych Uniwersytetu im. Adama Mickiewicza w Poznaniu
Aleksandra Szulc (Redakcja PRESSto, UAM)
Prezentacja podczas webinarium z okazji udostępnienia w Bibliotece Nauki ponad 500 000 artykułów
15 listopada 2022
Platforma Otwartej Nauki
http://pon.edu.pl/aktualnosci/226-ponad-pol-miliona-artykulow-w-bibliotece-nauki
Publikacje Instytutu Historii Ukrainy w Bibliotece Nauki
Stepan Vidnyanskyj (Instytut Historii Ukrainy, Narodowa Akademia Nauk Ukrainy
Prezentacja podczas webinarium z okazji udostępnienia w Bibliotece Nauki ponad 500 000 artykułów
15 listopada 2022
Platforma Otwartej Nauki
http://pon.edu.pl/aktualnosci/226-ponad-pol-miliona-artykulow-w-bibliotece-nauki
Polska Akademia Nauk a otwarta nauka
Monika Małecka-Krawczyk (Biuro Upowszechniania i Promocji Nauki, Polska Akademia Nauk)
Prezentacja podczas webinarium z okazji udostępnienia w Bibliotece Nauki ponad 500 000 artykułów
15 listopada 2022
Platforma Otwartej Nauki
http://pon.edu.pl/aktualnosci/226-ponad-pol-miliona-artykulow-w-bibliotece-nauki
Otwarty dostęp do publikacji naukowych GUS - doświadczenia i wyzwania
Xavery Stańczyk (GUS)
Prezentacja podczas webinarium z okazji udostępnienia w Bibliotece Nauki ponad 500 000 artykułów
15 listopada 2022
Platforma Otwartej Nauki
http://pon.edu.pl/aktualnosci/226-ponad-pol-miliona-artykulow-w-bibliotece-nauki
Making Open Access Book Funding Work Fairly
Opening the Future, CEU Press,
Emily Poznanski (Central European University Press)
4.10.2022 r - webinarium Platformy Otwartej Nauki organizowane we współpracy z Komisją ds. Wydawnictw Naukowych przy KRASP.
More information:
http://pon.edu.pl/aktualnosci/219-webinarium-na-temat-modeli-biznesowym-publikowania-otwartych-monografii
UCL Press. The UK's first fully open access university press
Lara Speicher (University College London Press)
4.10.2022 r - webinarium Platformy Otwartej Nauki organizowane we współpracy z Komisją ds. Wydawnictw Naukowych przy KRASP.
More information:
http://pon.edu.pl/aktualnosci/219-webinarium-na-temat-modeli-biznesowym-publikowania-otwartych-monografii
Funding open access books at Open Book Publishers: A practical overview
Lucy Barnes
4.10.2022 r - webinarium Platformy Otwartej Nauki organizowane we współpracy z Komisją ds. Wydawnictw Naukowych przy KRASP.
More information:
http://pon.edu.pl/aktualnosci/219-webinarium-na-temat-modeli-biznesowym-publikowania-otwartych-monografii
Arianna Becerril García – Redalyc: A platform to advance non-commercial Open ...Platforma Otwartej Nauki
Discussion panel during the conference celebrating the public launch of the new platform of the Library of Science (https://bibliotekanauki.pl), developed by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, in cooperation with publishers, journal editorial boards, and indexing databases.
The Library of Science is an Open Access collection of Polish scientific journals and books. All the resources are available as full texts with metadata.
Panelists presented their individual experiences from the development of local and regional infrastructures for Open Access to scientific journals.
Panelists:
Arianna Becerril García (Redalyc)
Miroslav Milinović (HRČAK)
Susan Murray (AJOL)
Ritsuko Nakajima (J-STAGE)
Abel L Packer (SciELO)
moderator: Krzysztof Siewicz (ICM UW)
Recording: https://youtu.be/q8bfstI5vpE
The new version of the platform was developed in the framework of the “Platform of Polish Scientific Publications” project, co-financed from the European Regional Development Fund, 2nd priority axis of the Operational Program Digital Poland 2014-2020, Measure 2.3 (total project value: PLN 5,164,777.78, co-financing from European Funds: PLN 4,370,951.43).
Discussion panel during the conference celebrating the public launch of the new platform of the Library of Science (https://bibliotekanauki.pl), developed by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, in cooperation with publishers, journal editorial boards, and indexing databases.
The Library of Science is an Open Access collection of Polish scientific journals and books. All the resources are available as full texts with metadata.
Panelists presented their individual experiences from the development of local and regional infrastructures for Open Access to scientific journals.
Panelists:
Arianna Becerril García (Redalyc)
Miroslav Milinović (HRČAK)
Susan Murray (AJOL)
Ritsuko Nakajima (J-STAGE)
Abel L Packer (SciELO)
moderator: Krzysztof Siewicz (ICM UW)
Recording: https://youtu.be/q8bfstI5vpE
The new version of the platform was developed in the framework of the “Platform of Polish Scientific Publications” project, co-financed from the European Regional Development Fund, 2nd priority axis of the Operational Program Digital Poland 2014-2020, Measure 2.3 (total project value: PLN 5,164,777.78, co-financing from European Funds: PLN 4,370,951.43).
Prezentacja: dr Laura Bandura-Morgan (Narodowe Centrum Nauki)
Krajowe Warsztaty Otwartego Dostępu OpenAIRE 2020, Polska
Polityki otwartości w Polsce
Cześć 2: dane badawcze
25 listopada 2020, online
OpenAIRE National Workshop in Poland (2020), organized as part of the OpenAIRE Advance project, was be devoted to the implementation of open access policies in Polish scientific institutions.
http://pon.edu.pl/politykiotwartosci/
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Open Research Data: Present and planned EC Policy, Jean-Claude Burgelman implications of open data
1. Open Research Data:
Present and planned EC
Policy
Jean-Claude Burgelman, S. Luber, R. Von Schomberg, D.
Spichtinger, W.Lusoli
Head of Unit
European Commission
DG RTD/A6
Keynote
ORD Conference Open Research Data: Implications for
Science and Society - Warsaw May 2015
2. A new Commission (2014-19)
Andrus Ansip, Vice-President, Digital Single Market
Carlos Moedas, Commissioner for
Research, Science and Innovation
Günther Oettinger, Commissioner
for Digital Economy and Society
3. Commissioner view
"Open Science, of which Open Access is an
important part, will be vital to ensuring
European progress and prosperity in the
future"
(Speech at NETHER, January 26, 2015)
4. Open Research Data
• ORD refers to making research data freely
available for reuse beyond the purpose for which
they were originally collected.
• Making Research data freely available aid further
discovery, make scientific process more cost
efficient and reliable.
• ORD is part of a broader change: data driven
science underpinning Open Science
5. • A systemic change in the modus operandi of
science and research
• Affecting the whole research cycle and its
stakeholders
Open Research Data - Open Science
8. Research and
Innovation
ORD and Data Driven Science: Big
Data in Open Science
• Traditional modus operandi for Science: scientific experiments
and observations generate data to test Scientific Hypotheses.
- many limitations (empirical blackholes)
• New opportunities due to “big data”:
- The digitisation of science (e.g. DNA sequencing)
- The internet of everything
• Data Driven Science is the application of Big Data in Science.
• Enormous opportunities:
- 4th paradigm in science (inductive, computional)
- “here are the data, where is the hypothesis?”
- Potential to reboot completely SSH (“social physics”)
• Serious policy issues
9. Research and
Innovation
Data Driven Science: Big Data in
Science
Most important policy issues for DDS to take off:
• TDM
• Open Access
• Copyright
• Data protection
• Cloud
10. The EC wants to optimise the impact of
public funded research
• At European level (FP7 & Horizon 2020)
• At Member State level
One way to get there: open access
• to peer-reviewed scientific publications
• to research data
Expected benefits:
• Better, more transparant & efficient science Open Science & RRI
• Faster uptake of research leading to faster & better innovation &
economic growth Innovation Union
11. The ORD policies of the European
Commission are threefold.
The EC as Policy maker
• It proposes EU legislation & legislates with other EU
institutions
• It invites Member States to act
The EC as Funding agency
• It sets its own access and dissemination rules for EC-funded
research
The EC Capacity builder
• It funds projects that support EC/EU policy
ORD Policy developed jointly in DG RTD and CNECT, with
input from the R&I family
12. EC as funder - Open access in
Horizon 2020
• Mandatory for publications
• Pilot for data
13. H2020: OA to publications
FP7
• Green open access pilot in 7
areas of FP7 with 'best effort'
stipulation
• Allowed embargoes: 6/12
months
• Gold open access costs
eligible for reimbursement as
part of the project budget
while the project runs
Horizon 2020
• Obligation to provide OA, either
through the Green or Gold way
in all areas
• Allowed embargoes: 6/12 months
• Gold open access costs eligible
for reimbursement as part of the
project budget while the project
runs & post-grant support
being piloted
• Authors encouraged to retain
copyright and grant licences
instead
14. H2020: Pilot on Open Research
Data
• Certain areas
• Voluntary
• Opt out of the pilot
• Opt in for other areas
• DMP provisions
15. H2020: Pilot on Open Research Data
Areas of the 2014-2015 Work Programme participating in the Open
Research Data Pilot are:
• Future and Emerging Technologies
• Research infrastructures – part e-Infrastructures
• Leadership in enabling and industrial technologies – ICT
• Societal Challenge: Secure, Clean and Efficient Energy – part Smart cities
and communities
• Societal Challenge: Climate Action, Environment, Resource Efficiency and
Raw materials – except raw materials
• Societal Challenge: Europe in a changing world – inclusive, innovative and
reflective Societies
• Science with and for Society
Projects in other areas can participate on a voluntary basis (already
new areas to be added for 2016-17 WP
16. Projects may opt out of the Pilot on ORD, if:
• The project will not generate / collect any data
• Conflict with obligation to protect results
• Conflict with confidentiality obligations
• Conflict with security obligations
• Conflict with rules on protection of personal data
• The achievement of the action’s main objective would be
jeopardised by making specific parts of the research data
openly accessible (to be explained in data management
plan)
H2020: Pilot on Open Research Data
17. H2020: Pilot on Open Research Data
Types of data concerned:
• Data needed to validate the results presented in scientific publications
("underlying data")
• Other data as specified in DMP (=up to projects)
Beneficiaries participating in the Pilot will:
• Deposit this data in a research data repository of their choice
• Take measures to make it possible to access, mine, exploit, reproduce
and disseminate free of charge
• Provide information about tools and instruments at the disposal of the
beneficiaries and necessary for validating the results (where possible,
provide the tools and instruments themselves)
18. H2020: Pilot on Open Research Data:
Data Management Plan
• DMPs are NOT part of the proposal evaluation: to be
delivered within the first six months of the project and
updated as needed
• DMP’s mandatory for all projects participating in the Pilot, optional
for others
• DMP questions:
•What data will be collected / generated?
•What standards will be used / how will metadata be generated?
•What data will be exploited? What data will be shared / made
open?
•How will data be curated and preserved?
19. H2020: Pilot on ORD: take-up in first calls
Basis: 3054 Horizon 2020 proposals
Calls in core-areas: opt out 24.2% (442 of
1824 proposals) – range from 9,1-29,1%
Other areas: voluntary opt in 27.2% (334 of
1230 proposals) – range from 9 to 50%
Preliminary but encouraging results
20. EC as policy maker on OA: currently
ongoing…
• Analysis of Uptake of ORD Pilot in signed grant
agreements (versus proposals)
• DMP implementation: investigating best-practice; tools to
be developed (2015)
• Top-notch monitoring of OA policies is crucial for further
policy development
21. EC as capacity builder on OA:
coordination and support actions
(ongoing - FP7 funded)
PASTEUR4OA (Open Access Policy Alignment Strategies for European
Union Research) Started 2014
FOSTER (Foster Open Science Training for European Research)
Started 2014
RECODE - (Policy Recommendations for Open Access to Research
Data in Europe) – 2013, finishing
OpenAIRE/OpenAIRE+: supporting the implementation of Open
Access in Europe (publications and data)
Infrastructure projects(with OA components), e.g. GEO/GEOSS,
ELIXIR…
22. EC as policymaker - Open access
policies across the EU
Preliminary findings from
(i) NPR reporting template of 13 EU MS & 1 Associated Country
(ii) Results of 2014 ERA Progress Report
General findings
1. Mostly soft measures rather than legislation: exceptions exist
2. OA to publications > than OA to data. Progress as to infrastructures for
data (repositories), but openness still quite complex an issue and not
addressed in many countries (for data)
3. Bigger and “richer” countries have more comprehensive OA policies and
OA enabling infrastructures, as well as tend to lead or participate more
actively in OA networking initiatives
4. Nevertheless, smaller or less federated countries have the advantage of
easier coordination and better synergistic capabilities
23. ORD in Poland
• OCEAN – a new national research datacentre with focuses on
Big and Open Data is being built. Its tasks will include large
scale data mining as well as long term preservation of
research results.
• There are about 100 digital libraries which contain scientific
papers and several classical scientific repositories.
• Poland is in the FOSTER (Facilitate Open Science Training for
European Research) project, where one of the areas covered
is to provide training on open access to research data.
24. EC as policymaker – A European Open Science
Cloud?
• Rationale and first ideas
• Work in progress.
• Not to be quoted
25. Science 2.0 consultation (July-Sept 2014 + validation WS)
o ~ 85 % agree to some extent that data infrastructures are a bottleneck
o Spontaneous position papers from research stakeholders
Possible actions
1. Mandate the development of common interfaces and data standards
2. Coordinate at European Level the funding/ maintenance and
interoperability of research infrastructures
3. Support the development of a European Open Science Cloud for
research
European
Open Science Agenda
26. A European Open Science Cloud: part of Europe´s ambition to support
the transition to Open Science and make the most of data-driven
science.
o European scientists strongly stated the need for a research data
that is cost-effective, preserves privacy and is IPR-conscious (Science
consultation).
o The cloud provides all EU researchers a virtual environment with
seamless services for data storage, management, analysis and re-use,
disciplines.
o The cloud will federate existing and emerging horizontal and
infrastructures, effectively bridging todays fragmentation and ad-
o The cloud adds value - scale, data-driven science, inter-disciplinarity,
knowledge to innovation - and leverages current and past
investment (10b per year by MS, two decades EU investment).
European
Open Science Cloud
27. Lifesciences
Lead users… Scientific communities …long tail
Physics
Earthsciences
Economics
Social
sciences
Scaleofscientificactivity(data-drivenscience)
Applied-engineering
……
Humanities Citizen science
European
Open Science Cloud
28. Data
layer
Service
layer
Governanc
e
layer
Lifesciences
Lead users… Scientific communities …long tail
Physics
Earthsciences
Economics
Social
sciences
Scaleofscientificactivity(data-drivenscience)
High performance computing
Data fusion across disciplines
Big data analytics
Privacy and personal data protection
… …
Data discovery and catalogue
Data manipulation and export
Data access and re-use
Trust
Leverage of MS investment
Legacy and sustainability
IPR protection
Federation
Applied-engineering
……
Humanities
Data storage
Citizen science
European
Open Science Cloud
Bottom-up governance
29. In summary
• The EC is a strong funder, policy maker and capacity builder
with regard to ORD in particular and OA in general
• It sees it as part of an irreversible change in the modus
operandi of science: open science
• A lot is ongoing and planned
• Much more needs to be done if we want Europe and its
science stakeholders to capitalise on the opportunities ORD,
OA and OS offer.
• The EC follows a bottom up and stakeholder driven apporach