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CONTRAST MEDIA
NEGATIVE
AIR & ITS CONSTITUTION
POSITIVE
IODINE COMPOUND BaSo4
GIT
WATER SOLUBLEPOWDEROILY
1) POWDER CONTRAST in a form of tablets
e.g. Biloptin, Cistobil.
2) OILY CONTRAST
e.g. myodil, dinosil & lipidol.
3) WATER SOLUBLE ( addition of sugar).
OIL BASED CONTRAST MEDIA
 It was first introduced in myelography by
sicard as first generation contrast media in
1921 then It was used for Bronchography,
HSG,Pyelography and Lymphography
 It is rarely used now a days in some
special Cases like COPD & Pulmonary
hypertension
 Made from fatty acids
 Iodine added to Easter groups
 Insoluble in water
 Long persistence in body
 Infrequently used except for specific exam
 Cannot be used with plastic syringes
 High viscosity
 High surface tension
 Slow absorption & excretion
 Chances of embolism
PROPERTY WATER SOLUBLE OIL SOLUBLE
VISCOSITY Low High
SURFACE TENSION Low High
DRAINAGE Permit filling of Ductal system
under low pressure&facilitate
prompt drainage
Diameter of duct may be distorted
& it is poorly eliminated from
finer duct. It may cause Ductal
obstruction
PHYSIOLOGIC PROPERTY More physiologic,i.e.miscibility
with saliva is more
Less physiologic
PATIENT DISCOMFORT Ductal injection accompanied by
little pain or discomfort
Greater degree of discomfort
,pressure may push calculi
backward & it may damage ductal
epithelium
ALLERGIC REACTION Not significant reaction occur May cause severe foreign body
react
OPACIFICATION Opacification is low but it can coat
& outline calculi more adequately
Opacification satisfactory. Denser
contrast may obscure debris &
small non-opaque calculi
ABSORPTION & EXCRETION Rapid slow
EMBOLISM No chances Chances of embolism
Myodil (Glaxo) is an oily organic iodine containing
contrast material which was used for myelography.
Residual contrast remains for years. Has been
implicated in development of arachnoiditis, perhapse of
the order of 1%.
EXAMPLE :
1. Arachnoiditis
2. Myelogram
Lipiodol is a ethiodized oil, is a poppyseed oil used by injection as
a radio-opaque contrast agent that is used to outline structures in
radiological investigations.
Ethiodized oil is composed of iodine combined with ethyl esters of fatty
acids of poppyseed oil, primarily as ethyl monoiodostearate and ethyl
diiodostearate.
EXAMPLE :
1. HYSTEROSALPINGOGRAPHY
(HSG)
2. LYMPHANGIOGRAPHY
 Pantopaque was introduced in 1944 as a oil contrast medium
 The first Low- Osmolar Contrast Medium(LOCM) to be produced
was Metrizamide (Amipaque)
 Oil never completely re- absorbed
DOSAGE
 Generally 6-17 ml
 Recommended by manufacturer and varies with the medium
concentration.
PANTOPAQUE MYELOGRAPHY CONTRAST
MYELOGRAPHY PROCEDURE
 Rubin insufflated oxygen (later carbon dioxide) under pressure
through the cervical canal into the uterine cavity. Tubal patency was
determined by presence of air under the diaphragm on X-ray, by
auscultation of air flow into the abdomen or a drop in pressure
during insufflation
 Heuser was the first to report on the use of lipiodol in HSGs
(Heuser, 1925)
 Lipiodol- oil soluble, low viscosity, less toxic, became widely
accepted
HSG PROCEDURE
CONTRAST MEDIA
LIPID SOLUBLE
CONTRAST (lipiodol)
 Sharp image
 Minimal pain
 Delayed absorption
 Risk of lipogranuloma formatation
in case of tubal block or
hydrosalpinx
 Intravasation of contrast and
possible risk of oil embolism
 Need of delayed film
 Pregnancy rate doubled
 Less often used
WATER SOLUBLE
CONTRAST (urograffin)
 Ampullary rugae clearly visualised
 Gets absorbed within hours, does
not leave residue
 Granuloma formation rare
 Pain persists after procedure
 Prompt demonstration of tubal
patency, delayed film not needed.
 Widely used and preferred
DACRYOCYSTOGRAPHY
 Involves the injection of radio-opaque contrast medium into the canaliculi followed
by capture of magnified images.
 The test is usually performed on both sides simultaneously.
 Not to be performed in a patient with acute dacryocystitis.
TECHNIQUE
 The inferior puncta are dilated.
 Plastic catheters are inserted into the inferior canaliculi on either side; alternatively
the upper puncta may be used.
 Contrast medium, usually 1–2 mL of Lipiodol, is simultaneously injected on
both sides and postero-anterior radiographs are taken.
 Ten minutes later an erect oblique film is taken to assess the effect of gravity on
tear drainage. Digital subtraction provides a higher quality image capture than
conventional
 Ethiodol and Lipiodal
 Directly injected into a vessel of an extremity
 Blue dye used –absorbed by lymphatic vessel
 Oil based usually used for lymph Angiogram
 Water based is irritating to the Lymphatic System causes
Pain and buming to patient
 Duct orifice is sprayed with topical anaesthetic
 Duct is cannulated, (dialator may be required), contrast
introduced with fluoroscopic guidance
 Contrast (oil based or water soluble iodinated)
(concentration = 240mg/ml)
 Should be injected manually until pt feels discomfort
 Quantity needed may vary btw 1-2 ml
SAILOGRAPHY
Lateral Submandibular
radiographs
Cannulation of duct with
intravenous catheter (22 gauge).
 Densely radiopaque ,that shows good contrast
 High viscosity, that shows excretion from the gland
 Adequate radio-opacity for demonstration of leakage.
 If leakage occurs to the bronchi and lungs, these contrast
Media could be considered relatively safe as they are not
Hyperosmolar and are in any case the CM normally used for
bronchography
 The oily contrast is a high viscosity but not fill the nerve roots
well.
 Too dense, hence poor visibility of spinal cord through contrast
column.
 High incidence of arachnoiditis(25%).
 It Cannot be used in CT.
 Oil Embolism May Occur By Accidental Intravascular Injection.
 Absorbed at the rate of one ml per year and hence persists for a
long time .
 Due to high viscosity ,there is increased possibility of CSF leak.
DISCOMFORT ,SIDE EFFECT & REACTIONS
VISCOSITY: (Thick, sticky)
Thicker-Harder to inject, more heat and Vessel irritation
Warming contrast will help
1. TOXITY-(higher=greater viscosity)
2. MISCIBILITY – easily mixes with blood
3. OSMOLALITY – is a measure of the total
4. Number of particles in solution
OIL CONTRAST MEDIA IN RADIOLOGY

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OIL CONTRAST MEDIA IN RADIOLOGY

  • 1.
  • 2. CONTRAST MEDIA NEGATIVE AIR & ITS CONSTITUTION POSITIVE IODINE COMPOUND BaSo4 GIT WATER SOLUBLEPOWDEROILY
  • 3. 1) POWDER CONTRAST in a form of tablets e.g. Biloptin, Cistobil. 2) OILY CONTRAST e.g. myodil, dinosil & lipidol. 3) WATER SOLUBLE ( addition of sugar).
  • 4. OIL BASED CONTRAST MEDIA  It was first introduced in myelography by sicard as first generation contrast media in 1921 then It was used for Bronchography, HSG,Pyelography and Lymphography  It is rarely used now a days in some special Cases like COPD & Pulmonary hypertension
  • 5.  Made from fatty acids  Iodine added to Easter groups  Insoluble in water  Long persistence in body  Infrequently used except for specific exam  Cannot be used with plastic syringes  High viscosity  High surface tension  Slow absorption & excretion  Chances of embolism
  • 6. PROPERTY WATER SOLUBLE OIL SOLUBLE VISCOSITY Low High SURFACE TENSION Low High DRAINAGE Permit filling of Ductal system under low pressure&facilitate prompt drainage Diameter of duct may be distorted & it is poorly eliminated from finer duct. It may cause Ductal obstruction PHYSIOLOGIC PROPERTY More physiologic,i.e.miscibility with saliva is more Less physiologic PATIENT DISCOMFORT Ductal injection accompanied by little pain or discomfort Greater degree of discomfort ,pressure may push calculi backward & it may damage ductal epithelium ALLERGIC REACTION Not significant reaction occur May cause severe foreign body react OPACIFICATION Opacification is low but it can coat & outline calculi more adequately Opacification satisfactory. Denser contrast may obscure debris & small non-opaque calculi ABSORPTION & EXCRETION Rapid slow EMBOLISM No chances Chances of embolism
  • 7. Myodil (Glaxo) is an oily organic iodine containing contrast material which was used for myelography. Residual contrast remains for years. Has been implicated in development of arachnoiditis, perhapse of the order of 1%. EXAMPLE : 1. Arachnoiditis 2. Myelogram
  • 8. Lipiodol is a ethiodized oil, is a poppyseed oil used by injection as a radio-opaque contrast agent that is used to outline structures in radiological investigations. Ethiodized oil is composed of iodine combined with ethyl esters of fatty acids of poppyseed oil, primarily as ethyl monoiodostearate and ethyl diiodostearate. EXAMPLE : 1. HYSTEROSALPINGOGRAPHY (HSG) 2. LYMPHANGIOGRAPHY
  • 9.  Pantopaque was introduced in 1944 as a oil contrast medium  The first Low- Osmolar Contrast Medium(LOCM) to be produced was Metrizamide (Amipaque)  Oil never completely re- absorbed DOSAGE  Generally 6-17 ml  Recommended by manufacturer and varies with the medium concentration.
  • 12.  Rubin insufflated oxygen (later carbon dioxide) under pressure through the cervical canal into the uterine cavity. Tubal patency was determined by presence of air under the diaphragm on X-ray, by auscultation of air flow into the abdomen or a drop in pressure during insufflation  Heuser was the first to report on the use of lipiodol in HSGs (Heuser, 1925)  Lipiodol- oil soluble, low viscosity, less toxic, became widely accepted
  • 14. CONTRAST MEDIA LIPID SOLUBLE CONTRAST (lipiodol)  Sharp image  Minimal pain  Delayed absorption  Risk of lipogranuloma formatation in case of tubal block or hydrosalpinx  Intravasation of contrast and possible risk of oil embolism  Need of delayed film  Pregnancy rate doubled  Less often used WATER SOLUBLE CONTRAST (urograffin)  Ampullary rugae clearly visualised  Gets absorbed within hours, does not leave residue  Granuloma formation rare  Pain persists after procedure  Prompt demonstration of tubal patency, delayed film not needed.  Widely used and preferred
  • 15. DACRYOCYSTOGRAPHY  Involves the injection of radio-opaque contrast medium into the canaliculi followed by capture of magnified images.  The test is usually performed on both sides simultaneously.  Not to be performed in a patient with acute dacryocystitis. TECHNIQUE  The inferior puncta are dilated.  Plastic catheters are inserted into the inferior canaliculi on either side; alternatively the upper puncta may be used.  Contrast medium, usually 1–2 mL of Lipiodol, is simultaneously injected on both sides and postero-anterior radiographs are taken.  Ten minutes later an erect oblique film is taken to assess the effect of gravity on tear drainage. Digital subtraction provides a higher quality image capture than conventional
  • 16.
  • 17.  Ethiodol and Lipiodal  Directly injected into a vessel of an extremity  Blue dye used –absorbed by lymphatic vessel  Oil based usually used for lymph Angiogram  Water based is irritating to the Lymphatic System causes Pain and buming to patient
  • 18.
  • 19.  Duct orifice is sprayed with topical anaesthetic  Duct is cannulated, (dialator may be required), contrast introduced with fluoroscopic guidance  Contrast (oil based or water soluble iodinated) (concentration = 240mg/ml)  Should be injected manually until pt feels discomfort  Quantity needed may vary btw 1-2 ml SAILOGRAPHY
  • 20. Lateral Submandibular radiographs Cannulation of duct with intravenous catheter (22 gauge).
  • 21.  Densely radiopaque ,that shows good contrast  High viscosity, that shows excretion from the gland  Adequate radio-opacity for demonstration of leakage.  If leakage occurs to the bronchi and lungs, these contrast Media could be considered relatively safe as they are not Hyperosmolar and are in any case the CM normally used for bronchography
  • 22.  The oily contrast is a high viscosity but not fill the nerve roots well.  Too dense, hence poor visibility of spinal cord through contrast column.  High incidence of arachnoiditis(25%).  It Cannot be used in CT.  Oil Embolism May Occur By Accidental Intravascular Injection.  Absorbed at the rate of one ml per year and hence persists for a long time .  Due to high viscosity ,there is increased possibility of CSF leak.
  • 23. DISCOMFORT ,SIDE EFFECT & REACTIONS VISCOSITY: (Thick, sticky) Thicker-Harder to inject, more heat and Vessel irritation Warming contrast will help 1. TOXITY-(higher=greater viscosity) 2. MISCIBILITY – easily mixes with blood 3. OSMOLALITY – is a measure of the total 4. Number of particles in solution