3. 1) POWDER CONTRAST in a form of tablets
e.g. Biloptin, Cistobil.
2) OILY CONTRAST
e.g. myodil, dinosil & lipidol.
3) WATER SOLUBLE ( addition of sugar).
4. OIL BASED CONTRAST MEDIA
It was first introduced in myelography by
sicard as first generation contrast media in
1921 then It was used for Bronchography,
HSG,Pyelography and Lymphography
It is rarely used now a days in some
special Cases like COPD & Pulmonary
hypertension
5. Made from fatty acids
Iodine added to Easter groups
Insoluble in water
Long persistence in body
Infrequently used except for specific exam
Cannot be used with plastic syringes
High viscosity
High surface tension
Slow absorption & excretion
Chances of embolism
6. PROPERTY WATER SOLUBLE OIL SOLUBLE
VISCOSITY Low High
SURFACE TENSION Low High
DRAINAGE Permit filling of Ductal system
under low pressure&facilitate
prompt drainage
Diameter of duct may be distorted
& it is poorly eliminated from
finer duct. It may cause Ductal
obstruction
PHYSIOLOGIC PROPERTY More physiologic,i.e.miscibility
with saliva is more
Less physiologic
PATIENT DISCOMFORT Ductal injection accompanied by
little pain or discomfort
Greater degree of discomfort
,pressure may push calculi
backward & it may damage ductal
epithelium
ALLERGIC REACTION Not significant reaction occur May cause severe foreign body
react
OPACIFICATION Opacification is low but it can coat
& outline calculi more adequately
Opacification satisfactory. Denser
contrast may obscure debris &
small non-opaque calculi
ABSORPTION & EXCRETION Rapid slow
EMBOLISM No chances Chances of embolism
7. Myodil (Glaxo) is an oily organic iodine containing
contrast material which was used for myelography.
Residual contrast remains for years. Has been
implicated in development of arachnoiditis, perhapse of
the order of 1%.
EXAMPLE :
1. Arachnoiditis
2. Myelogram
8. Lipiodol is a ethiodized oil, is a poppyseed oil used by injection as
a radio-opaque contrast agent that is used to outline structures in
radiological investigations.
Ethiodized oil is composed of iodine combined with ethyl esters of fatty
acids of poppyseed oil, primarily as ethyl monoiodostearate and ethyl
diiodostearate.
EXAMPLE :
1. HYSTEROSALPINGOGRAPHY
(HSG)
2. LYMPHANGIOGRAPHY
9. Pantopaque was introduced in 1944 as a oil contrast medium
The first Low- Osmolar Contrast Medium(LOCM) to be produced
was Metrizamide (Amipaque)
Oil never completely re- absorbed
DOSAGE
Generally 6-17 ml
Recommended by manufacturer and varies with the medium
concentration.
12. Rubin insufflated oxygen (later carbon dioxide) under pressure
through the cervical canal into the uterine cavity. Tubal patency was
determined by presence of air under the diaphragm on X-ray, by
auscultation of air flow into the abdomen or a drop in pressure
during insufflation
Heuser was the first to report on the use of lipiodol in HSGs
(Heuser, 1925)
Lipiodol- oil soluble, low viscosity, less toxic, became widely
accepted
14. CONTRAST MEDIA
LIPID SOLUBLE
CONTRAST (lipiodol)
Sharp image
Minimal pain
Delayed absorption
Risk of lipogranuloma formatation
in case of tubal block or
hydrosalpinx
Intravasation of contrast and
possible risk of oil embolism
Need of delayed film
Pregnancy rate doubled
Less often used
WATER SOLUBLE
CONTRAST (urograffin)
Ampullary rugae clearly visualised
Gets absorbed within hours, does
not leave residue
Granuloma formation rare
Pain persists after procedure
Prompt demonstration of tubal
patency, delayed film not needed.
Widely used and preferred
15. DACRYOCYSTOGRAPHY
Involves the injection of radio-opaque contrast medium into the canaliculi followed
by capture of magnified images.
The test is usually performed on both sides simultaneously.
Not to be performed in a patient with acute dacryocystitis.
TECHNIQUE
The inferior puncta are dilated.
Plastic catheters are inserted into the inferior canaliculi on either side; alternatively
the upper puncta may be used.
Contrast medium, usually 1–2 mL of Lipiodol, is simultaneously injected on
both sides and postero-anterior radiographs are taken.
Ten minutes later an erect oblique film is taken to assess the effect of gravity on
tear drainage. Digital subtraction provides a higher quality image capture than
conventional
16.
17. Ethiodol and Lipiodal
Directly injected into a vessel of an extremity
Blue dye used –absorbed by lymphatic vessel
Oil based usually used for lymph Angiogram
Water based is irritating to the Lymphatic System causes
Pain and buming to patient
18.
19. Duct orifice is sprayed with topical anaesthetic
Duct is cannulated, (dialator may be required), contrast
introduced with fluoroscopic guidance
Contrast (oil based or water soluble iodinated)
(concentration = 240mg/ml)
Should be injected manually until pt feels discomfort
Quantity needed may vary btw 1-2 ml
SAILOGRAPHY
21. Densely radiopaque ,that shows good contrast
High viscosity, that shows excretion from the gland
Adequate radio-opacity for demonstration of leakage.
If leakage occurs to the bronchi and lungs, these contrast
Media could be considered relatively safe as they are not
Hyperosmolar and are in any case the CM normally used for
bronchography
22. The oily contrast is a high viscosity but not fill the nerve roots
well.
Too dense, hence poor visibility of spinal cord through contrast
column.
High incidence of arachnoiditis(25%).
It Cannot be used in CT.
Oil Embolism May Occur By Accidental Intravascular Injection.
Absorbed at the rate of one ml per year and hence persists for a
long time .
Due to high viscosity ,there is increased possibility of CSF leak.
23. DISCOMFORT ,SIDE EFFECT & REACTIONS
VISCOSITY: (Thick, sticky)
Thicker-Harder to inject, more heat and Vessel irritation
Warming contrast will help
1. TOXITY-(higher=greater viscosity)
2. MISCIBILITY – easily mixes with blood
3. OSMOLALITY – is a measure of the total
4. Number of particles in solution