This document discusses how cartilage and joint function rely on proteoglycans in synovial fluid, which are largely comprised of hyaluronic acid and chondroitin sulfate. Loss of balance in these molecules leads to joint degeneration. NuBuildxx is designed to impede joint degeneration by providing a gel containing hyaluronic acid and chondroitin sulfate, with each component inherent to proteoglycan aggregates, to provide a setting for joint recovery.