This document discusses different modes of innovation including science-based (STI) and practice-based (DUI) innovation. It outlines key differences in knowledge production, innovation types and processes, methods, environments, and communication between the two modes. Practice-based innovation involves heterogeneous knowledge production and interpretive methods within networks and arenas, focusing on organizational and social innovations. The document argues that regions face a "triple debt" threat to sustainability and must transform innovation systems through intellectual cross-fertilization, user-driven processes, and new modes of management to create "productivity innovations" and respond to challenges.