This document discusses the need for a paradigm shift from "innovation follows research" to "research follows innovation". It analyzes different countries' approaches to research, development and innovation. France aims for "decompartmentalization" between universities, industry and hospitals to foster cross-fertilization. The European Union recognizes that more must be done to convert knowledge into commercial opportunities and close the innovation gap. Overall, the document argues that societies must adapt more quickly to change and place greater emphasis on applying research and developing innovations to tackle societal challenges.