This document discusses regional foresight and innovation activities. It argues that regions must develop self-generative capabilities to continuously innovate and renew themselves in order to remain competitive. Regions and companies must be able to rapidly generate and apply new knowledge to adapt to changing global economic conditions. The success of regions is based on the success of companies operating within them. Finland is used as an example of a country that has transformed its economy to be knowledge-and innovation-based through focused efforts. Regional foresight activities should aim to create dynamic innovation systems with strong interactions between actors rather than follow static models.