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The Effects of Depression and Stress on Cognitive Functioning in Humans Samantha Tobin
Research Question Is depression associated with memory problems?
H Y P O T H E S I S An individual suffering from depression is more likely to have an impaired cognitive function than an individual not suffering from the effects of stress caused by the disease P U R P O S E ,[object Object]
Effect of stress
each individual’s cognitive function and also analyze images of the brain
Is there any correlation between the participant’s responses and hippocampalvolume?

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Murray completed research proposal presentation

  • 1. The Effects of Depression and Stress on Cognitive Functioning in Humans Samantha Tobin
  • 2. Research Question Is depression associated with memory problems?
  • 3.
  • 5. each individual’s cognitive function and also analyze images of the brain
  • 6. Is there any correlation between the participant’s responses and hippocampalvolume?
  • 7.
  • 8. Methods Participants Have a random population complete the Beck Depression Inventory (BDI) Scores below 7= nondysphoric (“healthy”) Score above 11 = dysphoric (high levels of anxiety and depressive symptoms) Materials Beck Depression Inventory Cognitive test 3.0 Testa Magnetic Resonance Image (MRI) Procedure BDI test: split into two groups (dysphoric and nondysphoric), memorize words and complete cognitive test. MRI scan: Compare the brain activity in depressed vs. healthy participants Statistical Analyses Difference scores: subtract participants delayed recall scores from immediate recall scores and compare the difference between the four groups (depressed/healthy and delayed/immediate recall)
  • 9. Relevance Connects the previously distinct findings of effects of stress and depression on the brain and cognitive function Importance Understanding Depression

Editor's Notes

  1. PURPOSEto investigate the different levels of stress that the brain is subjected to and to what extent this stress affects the cognitive functioning in healthy versus clinically depressed people.study will test each individual’s cognitive function and also analyze images of the brain Is there any correlation between the participant’s responses and hippocampal volume. examine the long-term effects of stress
  2. One’s ability to understand and recall information and behavior has been linked to the level of stress that individual is subjected to.Moderate, healthy amounts of this hormone have been suggested to actually benefit the function of the brain (coping)smaller grey matter volume in [the] obitofrontal cortex, a reduction of hippocampal volume, and deficits of grey matter in temporal and parietal cortex -ZouInhibits ability to recover from stress and impairs memory
  3. Apart from being depressed, the participants in the two groups were comparable in age, sex, race, and level of education. All participants were physicallyhealthyand had no family history of mental illness and showed no signs of a neurodegenerative disorder, head injury, history of stroke or substance abuse MATERIALSCog test = memorize 10 neutral wordsPROCEDURE (immediate/ delayed recall)STAT ANALYS 4 groups= depressed1 vs depressed 2, depressed 1 vs not, depressed 2 vs not 2, not1 vs not 2. depressed people should have a higher difference bc over time their memory deteriorates Have participants take BDI test again and eliminate those who’s scores changed significantly