mRNA vaccines

1. mRNA Vaccines and Their Future
in Therapeutics
Academic Presentation
M.Pharm Level

2. Introduction
• mRNA vaccines use messenger RNA to instruct
cells to produce antigens that trigger an
immune response.

3. Mechanism
• mRNA is delivered via lipid nanoparticles into
host cells, where it is translated into antigenic
protein, activating immunity.

4. Applications
• Used in prevention of infectious diseases
(COVID-19) and potential in cancer
immunotherapy.

5. Advantages
• Rapid development, no risk of infection, and
scalable manufacturing.

6. Limitations
• Stability issues, cold chain requirements, and
short-lived immune response in some cases.

7. Recent Developments
• mRNA platforms under study for influenza,
HIV, and personalized cancer vaccines.

8. Future Prospects
• Expansion into therapeutic vaccines and
autoimmune disease management.

9. Conclusion
• mRNA vaccines represent a major
breakthrough in modern immunization
technology.

10. References
• 1. Pardi N, et al. Nat Rev Drug Discov.
2018;17:261–279.
• 2. Sahin U, et al. Nature. 2020;585:567–571.