This document summarizes a presentation given at DevOpsDays Jakarta 2020 about modern application architecture and microservices. It discusses how application landscapes are transforming to use more cloud, DevOps practices, and container-based workloads. It also covers challenges around security with modern applications and microservices. Specific topics discussed include API security, attacks on applications and infrastructure, and the F5 application security framework. The presentation advocates for an API gateway and management to help secure microservices applications and provides examples of benefits. It also discusses site reliability engineering practices, automation approaches like the application factory, and integrating security into the software development lifecycle.