MobileDiagnosis® is an appropriate technology for tele-microscopy that was tested in rural health units in Uganda, Bangladesh, and Afghanistan. Health workers and laboratory technicians were able to take quality microscope images using mobile phones with only basic written instructions. The ability to immediately enlarge images on phone screens facilitated difficult diagnoses and enhanced learning when images were jointly observed and discussed. Images shared on a web-based platform also allowed distant diagnosis and clinical/educational support from overseas experts. Initial experience shows this approach can be easily used for distance learning and tutoring, with local health workers enthusiastically responding to feeling part of a wider network.