Urmia Lake in Iran has experienced environmental disasters due to lack of integrated natural resource management and human factors. The lake, once rich in biodiversity and home to migrating bird species, supported ecotourism. However, photos show the lake shrinking significantly between 2002 and 2009. This was caused by sectoral planning, policies encouraging agriculture in water-scarce areas, changing crops to more water-intensive varieties, dams constructed upstream without coordination, and overexploitation of groundwater through illegal wells. If not addressed, the drying of the lake threatens the health and safety of 5 million people in the region due to salt storms and disease. Prevention is needed to avert further environmental and humanitarian crises.