Reason of Migraine Headache and Useful Product of Relief Headache
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Migraine headaches are a kind of headache and a recognised condition. Migraine headaches can seasoned from less than a few times 1 year, as well as often while 2-3 occasions per week. The particular soreness is usually severe, throbbing along with usually on a single aspect in the mind. The migraine attack can easily very last from several hours nearly days to weeks.
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This document provides information to help patients manage chronic headaches. It discusses the types and causes of headaches like migraines and recommends a holistic treatment approach involving lifestyle changes, medications, and working with a multidisciplinary team of specialists. Key steps include identifying triggers, using acute and preventive medications appropriately, adopting stress reduction techniques, and being proactive in treatment by communicating with healthcare providers.
Migraine
- Migraine is a recurrent headache disorder that is one of the most common complaints in medicine. It is classified into migraine with aura and without aura.
- The pathophysiology involves complex vascular and neural mechanisms including cortical spreading depression, trigeminal nerve activation, and release of vasoactive substances. Genetic and environmental factors can also play a role in migraine triggers and risk.
- Diagnosis is based on criteria involving recurrent attacks of moderate to severe pulsating headache, photophobia, phonophobia, and possibly nausea. Physical exam is typically normal but may reveal associated neurological symptoms.
Migraine and types
Migraine is a neurological disorder characterized by recurrent headaches that are often severe and pulsating in nature. It is estimated to affect 10% of the worldwide population. There are two main types - migraine with aura, which involves neurological symptoms before or during the headache, and migraine without aura, which involves headaches without preceding neurological symptoms. Potential triggers include hormonal changes, stress, foods, and environmental factors like light and noise. Management involves lifestyle modifications and medications to abort acute attacks or prevent future attacks. Preventive medications include beta blockers, antidepressants, and anti-seizure drugs, while acute treatments include analgesics, triptans, and anti-nausea drugs.
Migraine its presentation and management
This document summarizes information about migraines including what they are, common symptoms, triggers, types (aura vs without aura), overuse of medications leading to chronic migraines, management through lifestyle changes and medications, and resources for more information. Migraines involve recurrent attacks of moderate to severe headaches that can last hours to days, often accompanied by nausea, sensitivity to light/sound, and visual disturbances prior to pain for those with aura. Management focuses on avoiding triggers through lifestyle modifications, medications as directed by a doctor, and self-care techniques like rest, heat/ice, and biofeedback.
Migraine
Dr. Shafi Ullah Khan presents information on migraine including diagnostic criteria, clinical features, classification, pathophysiology, treatment approaches, and future treatment options. Key points include the diagnostic criteria of recurrent headache lasting 4-72 hours with features of nausea/vomiting/photophobia, classification into types such as migraine with and without aura, the trigeminovascular system pathway in migraine pathophysiology, treatment approaches including abortive medications and preventive medications/procedures, and novel emerging treatments under investigation.
Migraine
Migraine is a severe headache that causes throbbing pain, nausea, vomiting, and extreme sensitivity to light and sound. It typically affects one side of the head and can last for hours or days. Some people experience aura, sensory disturbances such as flashes of light, before the headache starts. Migraine often begins in childhood or early adulthood and involves four stages - prodrome, aura, attack, and postdrome - though not everyone experiences all stages. Triggers can include hormonal changes, foods, stress, sensory stimuli, sleep patterns, and medications. Treatment involves both pain relievers during attacks and preventive medications taken daily. Self-care like stress reduction, avoiding triggers, and getting enough sleep can also help
Migraine
This document discusses migraine, a neurological disorder characterized by recurrent headaches. It notes that migraines significantly impact quality of life, with over 25% missing at least a day of work/school and over 30% reducing household productivity. The text describes migraine symptoms like pulsating one-sided headaches along with sensitivity to light and sound. It explains that migraines originate in the brain and involve changes in nerve cell activity and blood flow that can cause visual disturbances and pain. Common types of migraines are also outlined.
Pathophysiology of migraine
Migraine is a central nervous system disorder with a genetic basis. People with migraines have a hyperexcitable brain that is more sensitive to triggers. During migraine attacks, there is a wave of reduced blood flow called cortical spreading depression that starts in the occipital cortex and progresses forward. Repeated attacks can lead to changes in brain structures involved in pain processing like the periaqueductal gray, and an increased risk of white matter lesions. Preventive treatments aim to reduce central nervous system excitability underlying migraine while acute treatments target trigeminal pain pathways activated during attacks.
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You and Your Headache Notes Page Final
This document provides information to help patients manage chronic headaches. It discusses the types and causes of headaches like migraines and recommends a holistic treatment approach involving lifestyle changes, medications, and working with a multidisciplinary team of specialists. Key steps include identifying triggers, using acute and preventive medications appropriately, adopting stress reduction techniques, and being proactive in treatment by communicating with healthcare providers.
Migraine
- Migraine is a recurrent headache disorder that is one of the most common complaints in medicine. It is classified into migraine with aura and without aura.
- The pathophysiology involves complex vascular and neural mechanisms including cortical spreading depression, trigeminal nerve activation, and release of vasoactive substances. Genetic and environmental factors can also play a role in migraine triggers and risk.
- Diagnosis is based on criteria involving recurrent attacks of moderate to severe pulsating headache, photophobia, phonophobia, and possibly nausea. Physical exam is typically normal but may reveal associated neurological symptoms.
Migraine and types
Migraine is a neurological disorder characterized by recurrent headaches that are often severe and pulsating in nature. It is estimated to affect 10% of the worldwide population. There are two main types - migraine with aura, which involves neurological symptoms before or during the headache, and migraine without aura, which involves headaches without preceding neurological symptoms. Potential triggers include hormonal changes, stress, foods, and environmental factors like light and noise. Management involves lifestyle modifications and medications to abort acute attacks or prevent future attacks. Preventive medications include beta blockers, antidepressants, and anti-seizure drugs, while acute treatments include analgesics, triptans, and anti-nausea drugs.
Migraine its presentation and management
This document summarizes information about migraines including what they are, common symptoms, triggers, types (aura vs without aura), overuse of medications leading to chronic migraines, management through lifestyle changes and medications, and resources for more information. Migraines involve recurrent attacks of moderate to severe headaches that can last hours to days, often accompanied by nausea, sensitivity to light/sound, and visual disturbances prior to pain for those with aura. Management focuses on avoiding triggers through lifestyle modifications, medications as directed by a doctor, and self-care techniques like rest, heat/ice, and biofeedback.
Migraine
Dr. Shafi Ullah Khan presents information on migraine including diagnostic criteria, clinical features, classification, pathophysiology, treatment approaches, and future treatment options. Key points include the diagnostic criteria of recurrent headache lasting 4-72 hours with features of nausea/vomiting/photophobia, classification into types such as migraine with and without aura, the trigeminovascular system pathway in migraine pathophysiology, treatment approaches including abortive medications and preventive medications/procedures, and novel emerging treatments under investigation.
Migraine
Migraine is a severe headache that causes throbbing pain, nausea, vomiting, and extreme sensitivity to light and sound. It typically affects one side of the head and can last for hours or days. Some people experience aura, sensory disturbances such as flashes of light, before the headache starts. Migraine often begins in childhood or early adulthood and involves four stages - prodrome, aura, attack, and postdrome - though not everyone experiences all stages. Triggers can include hormonal changes, foods, stress, sensory stimuli, sleep patterns, and medications. Treatment involves both pain relievers during attacks and preventive medications taken daily. Self-care like stress reduction, avoiding triggers, and getting enough sleep can also help
Migraine
This document discusses migraine, a neurological disorder characterized by recurrent headaches. It notes that migraines significantly impact quality of life, with over 25% missing at least a day of work/school and over 30% reducing household productivity. The text describes migraine symptoms like pulsating one-sided headaches along with sensitivity to light and sound. It explains that migraines originate in the brain and involve changes in nerve cell activity and blood flow that can cause visual disturbances and pain. Common types of migraines are also outlined.
Pathophysiology of migraine
Migraine is a central nervous system disorder with a genetic basis. People with migraines have a hyperexcitable brain that is more sensitive to triggers. During migraine attacks, there is a wave of reduced blood flow called cortical spreading depression that starts in the occipital cortex and progresses forward. Repeated attacks can lead to changes in brain structures involved in pain processing like the periaqueductal gray, and an increased risk of white matter lesions. Preventive treatments aim to reduce central nervous system excitability underlying migraine while acute treatments target trigeminal pain pathways activated during attacks.
Do you know what causes headache and migraine
The document discusses different types of headaches, their causes and treatments. It describes tension headaches as caused by stress or fatigue and treated with over-the-counter painkillers. Migraines are more severe and involve light/sound sensitivity, nausea and last longer, treated with NSAIDs, paracetamol or prescription medications. Hangover headaches result from dehydration after alcohol and eye strain headaches from too much screen time. Sinus headaches occur with sinus issues. Viral headaches accompany infections while cluster headaches are severe, one-sided headaches that often occur at night.
Dr.avs practice pearls in diagnosis and prophylaxis of migraine
This document provides guidelines and recommendations for the diagnosis and prophylactic treatment of migraines. It begins with an overview of the International Headache Society criteria for diagnosing migraines based on the presence of head and non-headache symptoms. It then discusses taking a thorough patient history and performing a focused neurological examination to diagnose migraines and rule out secondary causes. Various migraine triggers and types are described. The document recommends candidates for migraine prevention based on monthly headache frequency and impairment. It reviews guidelines for successful prevention and duration of treatment. Potential mechanisms of preventive medications and common side effects of treatments like flunarizine, beta-blockers, and anti-epileptics are summarized. The progression of mig
Migraine - focus on recent advances
Topiramate has been shown to be an effective preventive treatment for migraine in multiple randomized controlled trials. It significantly reduced monthly migraine frequency compared to placebo at doses of 100mg and 200mg per day. Around 50% of patients achieved at least a 50% reduction in migraine days. The onset of efficacy was seen within the first month of treatment. Topiramate is generally well-tolerated, with dose titration helping to manage potential side effects. It offers an important additional option for preventing debilitating migraines.
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This document discusses trigeminal neuralgia, a neuropathic pain condition that causes severe, sporadic facial pain. It provides information on:
1) The etiology, including neurovascular compression as a common cause.
2) Symptoms like brief, severe facial pain that may be triggered by light touch.
3) Treatment options like carbamazepine, microvascular decompression surgery, and percutaneous radiofrequency thermocoagulation of the gasserian ganglion.
4) Imaging techniques like MRI that can identify compressive vascular structures.
Trigeminal neuralgia presentation
Trigeminal neuralgia is a condition caused by compression of the trigeminal nerve, most commonly the superior cerebellar artery compressing the nerve root entry zone. It results in severe unilateral facial pain that is brief but recurrent, affecting one or more branches of the trigeminal nerve. The right side of the face is more commonly involved than the left. While the pain is severe, it typically only lasts seconds to minutes per episode. Left untreated, it can cause extreme suffering and some patients have attempted suicide due to the agony.
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This document discusses approaches to evaluating and diagnosing different types of headaches. It provides guidance on taking a thorough headache history, including questions about timing, characteristics, potential triggers and aggravating/relieving factors. Common headache types like migraine and tension headache are described. The document also outlines acute and preventive treatment strategies for migraine and tension headache, emphasizing the importance of empathy, shared decision making and monitoring response to treatment.
Migraine
Migraine is a common type of headache characterized by unilateral and pulsating severe headache lasting 4-72 hours. It is derived from the Greek word "hemikranios" meaning half of the head. Migraines are caused by various triggers like allergies, lights, noises, stress, sleep changes, smoking, and skipping meals. The primary theory is that migraines are related to increased excitability of the cerebral cortex and abnormal control of pain neurons in the trigeminal nucleus of the brainstem. During a migraine attack, there is dilatation of scalp arteries and reduced regional blood flow in the cortex. The neurobiology and pathophysiology of migraines is complex with involvement of multiple
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This document provides guidelines and recommendations for the diagnosis and prophylactic treatment of migraines. It begins with an overview of the International Headache Society criteria for diagnosing migraines based on the presence of head and non-headache symptoms. It then discusses taking a thorough patient history and performing a focused neurological examination to diagnose migraines and rule out secondary causes. Various migraine triggers and types are described. The document recommends candidates for migraine prevention based on monthly headache frequency and impairment. It reviews guidelines for successful prevention and duration of treatment. Potential mechanisms of preventive medications and common side effects of treatments like flunarizine, beta-blockers, and anti-epileptics are summarized. The progression of mig
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Topiramate has been shown to be an effective preventive treatment for migraine in multiple randomized controlled trials. It significantly reduced monthly migraine frequency compared to placebo at doses of 100mg and 200mg per day. Around 50% of patients achieved at least a 50% reduction in migraine days. The onset of efficacy was seen within the first month of treatment. Topiramate is generally well-tolerated, with dose titration helping to manage potential side effects. It offers an important additional option for preventing debilitating migraines.
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1) The etiology, including neurovascular compression as a common cause.
2) Symptoms like brief, severe facial pain that may be triggered by light touch.
3) Treatment options like carbamazepine, microvascular decompression surgery, and percutaneous radiofrequency thermocoagulation of the gasserian ganglion.
4) Imaging techniques like MRI that can identify compressive vascular structures.
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5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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