Metatarsalgia is a painful inflammation of the ball of the foot caused by overuse from high-impact sports, ill-fitting shoes that put pressure on the metatarsal bones, or underlying foot issues. Symptoms include pain in the ball of the foot that gets worse with activity. Treatment focuses on rest, orthotics, pads and changes to activities and footwear. For most cases, conservative care relieves pain, but surgery may be needed in severe cases to realign bones causing persistent pain.