This document discusses fractional factorial designs of experiments. It explains that full factorial designs require testing all possible combinations of factors and levels, which can become infeasible with more than a few factors. Fractional factorial designs exploit this redundancy by selecting a subset of the full factorial design. This allows studying many factors using fewer experimental runs. The document provides examples of selecting fractional factorial designs and discusses orthogonal arrays, which provide balanced and efficient experimental designs according to Taguchi methods.
Experimental methods are widely used in industrial settings and research activities. In industrial settings, the main goal is to extract the maximum amount of unbiased information regarding the factors affecting production process form few observations, whereas in research, ANOVA techniques are used to reveal the reality. Drawing inferences from the experimental result is an important step in design process of product. Therefore, proper planning of experimentation is the precondition for accurate conclusion drawn from the experimental findings. Design of experiment is powerful statistical tool introduced by R.A. Fisher in England in the early 1920 to study the effect of different parameters affecting the mean and variance of a process performance characteristics
Taguchi's orthogonal arrays are highly fractional orthogonal designs. These designs can be used to estimate main effects using only a few experimental runs.
Consider the L4 array shown in the next Figure. The L4 array is denoted as L4(2^3).
L4 means the array requires 4 runs. 2^3 indicates that the design estimates up to three main effects at 2 levels each. The L4 array can be used to estimate three main effects using four runs provided that the twthree-factoro factor and three factor interactions can be ignored.
In this session you will learn:
Test Case Design and Techniques
Black-box: Three major approaches
Steps for drawing cause-Effect Diagram:
Behavior Testing
Random Testing
White Box Techniques
Path Testing
Statement Coverage
Data Flow Testing
For more information: https://www.mindsmapped.com/courses/quality-assurance/qa-software-testing-training-for-beginners/
Experimental methods are widely used in industrial settings and research activities. In industrial settings, the main goal is to extract the maximum amount of unbiased information regarding the factors affecting production process form few observations, whereas in research, ANOVA techniques are used to reveal the reality. Drawing inferences from the experimental result is an important step in design process of product. Therefore, proper planning of experimentation is the precondition for accurate conclusion drawn from the experimental findings. Design of experiment is powerful statistical tool introduced by R.A. Fisher in England in the early 1920 to study the effect of different parameters affecting the mean and variance of a process performance characteristics
Taguchi's orthogonal arrays are highly fractional orthogonal designs. These designs can be used to estimate main effects using only a few experimental runs.
Consider the L4 array shown in the next Figure. The L4 array is denoted as L4(2^3).
L4 means the array requires 4 runs. 2^3 indicates that the design estimates up to three main effects at 2 levels each. The L4 array can be used to estimate three main effects using four runs provided that the twthree-factoro factor and three factor interactions can be ignored.
In this session you will learn:
Test Case Design and Techniques
Black-box: Three major approaches
Steps for drawing cause-Effect Diagram:
Behavior Testing
Random Testing
White Box Techniques
Path Testing
Statement Coverage
Data Flow Testing
For more information: https://www.mindsmapped.com/courses/quality-assurance/qa-software-testing-training-for-beginners/
Find out more about quality assurance training and specifically about Test Case Design and Techniques. Topics covered in this session are:
Test Case Design and Techniques
Black-box: Three major approaches
Steps for drawing cause-Effect Diagram:
Behavior Testing
Random Testing
White Box Techniques
Path Testing
Statement Coverage
Data Flow Testing
For more information, visit: https://www.mindsmapped.com/courses/quality-assurance/quality-assurance-training-learn-manual-and-automation-testing/
In this quality assurance training session, you will learn Test case design. Topics covered in this course are:
• Test Case Design and Techniques
• Black-box: Three major approaches
• Steps for drawing cause-Effect Diagram:
• Behavior Testing
• Random Testing
• White Box Techniques
• Path Testing
• Statement Coverage
• Data Flow Testing
To know more, visit this link: https://www.mindsmapped.com/courses/quality-assurance/software-testing-quality-assurance-qa-training-with-hands-on-exercises/
In this quality assurance training, you will learn Test Case Design and Technique. Topics covered in this session are:
• Test Case Design and Techniques
• Black-box: Three major approaches
• Steps for drawing cause-Effect Diagram:
• Behavior Testing
• Random Testing
• White Box Techniques
• Path Testing
• Statement Coverage
• Data Flow Testing
For more information, visit this link: https://www.mindsmapped.com/courses/quality-assurance/software-testing-training-beginners-and-intermediate-level/
In this session you will learn:
Test Case Design and Techniques
Black-box: Three major approaches
Steps for drawing cause-Effect Diagram:
Behavior Testing
Random Testing
White Box Techniques
Path Testing
Statement Coverage
Data Flow Testing
For more information, click here:
https://www.mindsmapped.com/courses/quality-assurance/software-testing-tutorial/
The design of experiments (DOE, DOX, or experimental design) is the design of any task that aims to describe and explain the variation of information under conditions that are hypothesized to reflect the variation.
The term is generally associated with experiments in which the design introduces conditions that directly affect the variation, but may also refer to the design of quasi-experiments, in which natural conditions that influence the variation are selected for observation.
In its simplest form, an experiment aims at predicting the outcome by introducing a change of the preconditions, which is represented by one or more independent variables, also referred to as "input variables" or "predictor variables."
The change in one or more independent variables is generally hypothesized to result in a change in one or more dependent variables, also referred to as "output variables" or "response variables."
Find out more about quality assurance training and specifically about Test Case Design and Techniques. Topics covered in this session are:
Test Case Design and Techniques
Black-box: Three major approaches
Steps for drawing cause-Effect Diagram:
Behavior Testing
Random Testing
White Box Techniques
Path Testing
Statement Coverage
Data Flow Testing
For more information, visit: https://www.mindsmapped.com/courses/quality-assurance/quality-assurance-training-learn-manual-and-automation-testing/
In this quality assurance training session, you will learn Test case design. Topics covered in this course are:
• Test Case Design and Techniques
• Black-box: Three major approaches
• Steps for drawing cause-Effect Diagram:
• Behavior Testing
• Random Testing
• White Box Techniques
• Path Testing
• Statement Coverage
• Data Flow Testing
To know more, visit this link: https://www.mindsmapped.com/courses/quality-assurance/software-testing-quality-assurance-qa-training-with-hands-on-exercises/
In this quality assurance training, you will learn Test Case Design and Technique. Topics covered in this session are:
• Test Case Design and Techniques
• Black-box: Three major approaches
• Steps for drawing cause-Effect Diagram:
• Behavior Testing
• Random Testing
• White Box Techniques
• Path Testing
• Statement Coverage
• Data Flow Testing
For more information, visit this link: https://www.mindsmapped.com/courses/quality-assurance/software-testing-training-beginners-and-intermediate-level/
In this session you will learn:
Test Case Design and Techniques
Black-box: Three major approaches
Steps for drawing cause-Effect Diagram:
Behavior Testing
Random Testing
White Box Techniques
Path Testing
Statement Coverage
Data Flow Testing
For more information, click here:
https://www.mindsmapped.com/courses/quality-assurance/software-testing-tutorial/
The design of experiments (DOE, DOX, or experimental design) is the design of any task that aims to describe and explain the variation of information under conditions that are hypothesized to reflect the variation.
The term is generally associated with experiments in which the design introduces conditions that directly affect the variation, but may also refer to the design of quasi-experiments, in which natural conditions that influence the variation are selected for observation.
In its simplest form, an experiment aims at predicting the outcome by introducing a change of the preconditions, which is represented by one or more independent variables, also referred to as "input variables" or "predictor variables."
The change in one or more independent variables is generally hypothesized to result in a change in one or more dependent variables, also referred to as "output variables" or "response variables."
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Pharynx and Clinical Correlations BY Dr.Rabia Inam Gandapore.pptx
mel705-15.ppt
1. Fractional Factorial Designs of Experiments
P M V Subbarao
Professor
Mechanical Engineering Department
Selection of Few Significant Parameters
for Experimentation…..
6. Why Fractional Factorials?
Full Factorials
No. of combinations
For
two-levels
In engineering, this is the sample
size -- no. of prototypes to be built.
Continuous development of
Knowledge is introducing
more and more factors
7. Why so many Treatments?
“There tends to be a redundancy in full factorial designs”
– redundancy in terms of an excess number of interactions that can be
estimated …
Fractional factorial designs exploit this redundancy …”
philosophy
8. How to select a subset of 4 runs from a 23=8 -run design?
Many possible “fractional” designs
11. Third Choice
Wow!
Balanced design
All factors occur and low and high levels
same number of times; Same for interactions
Columns are orthogonal. Projections …
12. How to select a subset full factorial design
• We note that the product of any two columns is zero.
• Also the column sums are zero.
• Hence the three columns may be considered as vectors that form an
orthogonal set.
• In fact while calculating the sample variance earlier these properties
were used without being spelt out.
13. Want to study 5 factors (1,2,3,4,5) using a 2^4 = 16-run design
i.e., construct half-fraction of a 2^5 design
= 2^{5-1} design
14. DOE - Taguchi Method
• Dr. Taguchi of Nippon Telephones and Telegraph
Company, Japan has developed a method based on "
ORTHOGONAL ARRAY " experiments.
• This gives much reduced " variance " for the
experiment with " optimum settings " of control
parameters.
• "Orthogonal Arrays" (OA) provide a set of well
balanced (minimum) experiments serve as objective
functions for optimization.
15. Taguchi Method : When to Select a ‘larger’ OA
to perform “Factorial Experiments”
• We always ‘think’ about ‘reducing’ the number of
experiments (to minimize the ‘resources’ – equipment,
materials, manpower and time)
• However, doing ALL / Factorial experiments is a good
idea if
– Conducting experiments is ‘cheap/quick’ but
measurements are ‘expensive/take too long’
– The experimental facility will NOT be available later to
conduct the ‘verification’ experiment
– We do NOT wish to conduct separate experiments for
studying interactions between Factors
16. Taguchi Method Design of Experiments
• The general steps involved in the Taguchi Method are as follows:
• 1. Define the process objective, or more specifically, a target value
for a performance measure of the process.
• 2. Determine the design parameters affecting the process.
• The number of levels that the parameters should be varied at must
be specified.
• 3. Create orthogonal arrays for the parameter design indicating the
number of and conditions for each experiment.
• The selection of orthogonal arrays is based on the number of
parameters and the levels of variation for each parameter, and will
be expounded below.
• 4. Conduct the experiments indicated in the completed array to
collect data on the effect on the performance measure.
• 5. Complete data analysis to determine the effect of the different
parameters on the performance measure.
17.
18. Determining Parameter Design Orthogonal Array
• The effect of many different factors on the performance characteristic
in a condensed set of experiments can be examined by using the
orthogonal array experimental design proposed by Taguchi.
• The main factors affecting a process that can be controlled (control
Factors) should be determined.
• The levels at which these parameters should be varied must be
determined.
• Determining what levels of a variable to test requires an in-depth
understanding of the process, including the minimum, maximum, and
current value of the parameter.
• If the difference between the minimum and maximum value of a
parameter is large, the values being tested can be further apart or more
values can be tested.
• If the range of a parameter is small, then less values can be tested or
the values tested can be closer together.
• Typically, the number of levels for all parameters in the experimental
design is chosen to be the same to aid in the selection of the proper
orthogonal array.