Brief history, classification, Structure, mechanism Interferes with the cell wall synthesis of bacteria Inhibit the formation of peptidoglycan cross links in bacterial cell wall by binding of ß-lactum ring of penicillin to enzyme DD -transpeptidase DD-transpeptidase cannot catalyze the formation of cross links causing imbalance in cell wall production, degrades leading to rapid cell death

1. PENICILLIN
Contents
Introduction
Mechanism of action
Adverse effects

2. Penicillin
• First antibiotic by Scottish scientist , Alexander Fleming in 1928 (seen
fungus and bacteria can not grow together)
• PCN was isolated from fungus Penicillium notatum
• ß-lactum antibiotics
• Active against Gram +ve bacteria (Staphylococci and Streptococci) not
against gram –ve except at high dose

3. Mechanism of Action
• Interferes with the cell wall synthesis of bacteria
• Inhibit the formation of peptidoglycan cross links in bacterial cell
wall by binding of ß-lactum ring of penicillin to enzyme DD -
transpeptidase
• DD-transpeptidase cannot catalyze the formation of cross links
causing imbalance in cell wall production, degrades leading to rapid
cell death

4. Adverse effects
• 10 % people – allergic reactions
• ≥ 1% of people – diarrhoea, hypersensivity,
nausea, rashes, neurotoxicity and urticaria
• Pain and inflammation at the site of
injection
• 0.1 - 1%: fever, vomiting, erythema,
dermatitis, seizures

7. • Penicillin G (Parentral)
• Penicillin V (Oral route)
• Procaine Penicillin
• Benzathine Penicillin

9. SUMMARY
• First antibiotic by Scottish scientist , Alexander Fleming in 1928
• PCN was isolated from fungus Penicillium notatum
• ß-lactum antibiotics
• Active against Gram +ve bacteria (Staphylococci and Streptococci) not
against gram –ve except at high dose
• Interferes with the cell wall synthesis of bacteria

10. Thank You