This document summarizes M&E approaches for key population programs in Ghana from 2004-2016. It discusses the perils and pitfalls faced in early projects like SHARP that focused on general population data due to limited key population data. Later projects like SHARPER and LINKAGES standardized M&E tools and developed promising practices like using evidence-based data to better target services, conducting key population bio-behavioral surveys, and establishing a national key population technical working group. The document stresses the importance of handling sensitive key population data carefully and gaining community trust to ensure proper data can be used for effective decision making.