21 June: The Global Day for Amyotrophic Lateral Sclerosisguimera
ALS is a progressive neurological disease that causes the motor neurons controlling voluntary muscles to break down and die. This results in worsening muscle weakness, atrophy, and spasticity over time. There is no cure for ALS, but symptoms can be treated to prolong survival and quality of life. The cause is largely unknown, though some genetic factors have been identified. Most people live 3-5 years after diagnosis but about 10% of cases are inherited and can have longer survival times. Research continues toward finding effective treatments that target the underlying causes and pathways of the disease.
This document provides information about amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. It discusses that ALS is a progressive neurodegenerative disease that affects motor neurons in the brain and spinal cord, leading to muscle weakness, paralysis, and eventually death. Early symptoms can include muscle weakness, twitching, slurred speech, and difficulty breathing. There is no known cure for ALS, but some treatments can help manage symptoms and prolong survival for a few months. Donations can help support research to find an effective treatment for ALS.
ALS ( Amyotrophic Lateral Sclerosis) / Lou Gehrig's DiseaseSiddharthRajah
A PPT made by Siddharth Rajah a biology student in his high school on the deadly nervous disease called ALS. It has affected many people like Stephen Hawking. Want to know more about this? You can see my PPT on it which I made for my Grade 11 Biology Project.
amyotrophic lateral sclerosis & Gehrig's disease & moror neuron disease Medical Students
Gehrig's disease ALS motor neurone disease (MND), or Lou Gehrig's disease, is a specific disease which causes the death of neurons controlling voluntary muscles.
ALS, also known as Lou Gehrig's disease, is a neurodegenerative disease that causes the motor neurons in the brain and spinal cord to progressively degenerate. This leads to muscle weakness and atrophy throughout the body. While the causes are largely unknown, about 5-10% of ALS cases are inherited. The disease usually starts in the limbs and causes symptoms like muscle cramps, weakness, and atrophy. Over time, it spreads and also affects muscles used for breathing, swallowing, and speaking. Currently, there is no cure for ALS and the goal of treatment is to manage symptoms and prolong life using medications, respiratory support, and multidisciplinary care.
ALS is a disease that causes the loss of neurons in the brain and spinal cord, weakening muscles and potentially affecting movement, speech, swallowing, and breathing. It typically affects people in their 40s and 50s and is more common in men. While the mind and memory are unaffected, the disease is usually fatal within 3 to 5 years as muscles continue to weaken. Notable people who have been diagnosed with ALS include physicist Stephen Hawking and footballer Sedat Balkanlı.
Amyotrophic lateral sclerosis (ALS) is a debilitating disease that disrupts motor neurons, causing rapid muscle weakness, atrophy, spasticity, and difficulties with speech, swallowing, and breathing. The cause is unknown but may involve mutations in the SOD1 gene. The only FDA-approved treatment, Rilutek, can slow progression but also endangers liver health. Physical and speech therapy can help delay muscle degeneration and promote independence. There is no cure or prevention for ALS, which affects 20,000-30,000 Americans each year, usually between ages 40-60, with men more likely than women.
21 June: The Global Day for Amyotrophic Lateral Sclerosisguimera
ALS is a progressive neurological disease that causes the motor neurons controlling voluntary muscles to break down and die. This results in worsening muscle weakness, atrophy, and spasticity over time. There is no cure for ALS, but symptoms can be treated to prolong survival and quality of life. The cause is largely unknown, though some genetic factors have been identified. Most people live 3-5 years after diagnosis but about 10% of cases are inherited and can have longer survival times. Research continues toward finding effective treatments that target the underlying causes and pathways of the disease.
This document provides information about amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. It discusses that ALS is a progressive neurodegenerative disease that affects motor neurons in the brain and spinal cord, leading to muscle weakness, paralysis, and eventually death. Early symptoms can include muscle weakness, twitching, slurred speech, and difficulty breathing. There is no known cure for ALS, but some treatments can help manage symptoms and prolong survival for a few months. Donations can help support research to find an effective treatment for ALS.
ALS ( Amyotrophic Lateral Sclerosis) / Lou Gehrig's DiseaseSiddharthRajah
A PPT made by Siddharth Rajah a biology student in his high school on the deadly nervous disease called ALS. It has affected many people like Stephen Hawking. Want to know more about this? You can see my PPT on it which I made for my Grade 11 Biology Project.
amyotrophic lateral sclerosis & Gehrig's disease & moror neuron disease Medical Students
Gehrig's disease ALS motor neurone disease (MND), or Lou Gehrig's disease, is a specific disease which causes the death of neurons controlling voluntary muscles.
ALS, also known as Lou Gehrig's disease, is a neurodegenerative disease that causes the motor neurons in the brain and spinal cord to progressively degenerate. This leads to muscle weakness and atrophy throughout the body. While the causes are largely unknown, about 5-10% of ALS cases are inherited. The disease usually starts in the limbs and causes symptoms like muscle cramps, weakness, and atrophy. Over time, it spreads and also affects muscles used for breathing, swallowing, and speaking. Currently, there is no cure for ALS and the goal of treatment is to manage symptoms and prolong life using medications, respiratory support, and multidisciplinary care.
ALS is a disease that causes the loss of neurons in the brain and spinal cord, weakening muscles and potentially affecting movement, speech, swallowing, and breathing. It typically affects people in their 40s and 50s and is more common in men. While the mind and memory are unaffected, the disease is usually fatal within 3 to 5 years as muscles continue to weaken. Notable people who have been diagnosed with ALS include physicist Stephen Hawking and footballer Sedat Balkanlı.
Amyotrophic lateral sclerosis (ALS) is a debilitating disease that disrupts motor neurons, causing rapid muscle weakness, atrophy, spasticity, and difficulties with speech, swallowing, and breathing. The cause is unknown but may involve mutations in the SOD1 gene. The only FDA-approved treatment, Rilutek, can slow progression but also endangers liver health. Physical and speech therapy can help delay muscle degeneration and promote independence. There is no cure or prevention for ALS, which affects 20,000-30,000 Americans each year, usually between ages 40-60, with men more likely than women.
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons in the brain and spinal cord. The document discusses the pathology, epidemiology, clinical presentation, diagnosis, and management of ALS. Key points include that ALS causes the degeneration of upper and lower motor neurons, leading to muscle weakness, atrophy, and fasciculations. The average age of onset is in the mid-50s. Diagnosis is based on clinical signs and requires the exclusion of other potential causes through laboratory testing. Currently, riluzole is the only approved treatment and modestly prolongs survival. Management involves a multidisciplinary approach to address symptoms like weakness, fatigue, nutrition, and
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons, leading to their degeneration and death. This causes muscles to weaken and atrophy, resulting in paralysis. Eventually, respiratory muscles are affected and the disease becomes fatal. ALS has causes linked to glutamate toxicity, mutations in the SOD1 gene, and oxidative stress damaging motor neurons. There is no cure for ALS and available treatments can only moderately slow progression of the disease.
Amyotrophic Lateral Sclerosis (ALS) is also known as Lou Gehrig’s disease. It is a progressive, rarely occurring neurological disease that mainly involves the nerve cells (neurons) which are responsible for controlling voluntary muscle movements. With time, it leads to muscle weakness, gradually affecting the functions of the body.
Lou Gehrig's Disease, also known as amyotrophic lateral sclerosis (ALS), is a progressive neurodegenerative disease that affects neurons in the brain and spinal cord. It causes weakness and paralysis as the motor neurons die and the brain loses ability to initiate and control muscle movement. There is no cure for ALS, though some drugs can treat symptoms, and researchers are investigating potential genetic and viral causes as the disease sometimes runs in families. Famous individuals like baseball player Lou Gehrig and physicist Stephen Hawking had ALS.
Amyotrophic lateral sclerosis (ALS), AKA "Lou Gehrig's Disease," is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in ALS eventually leads to their death. When the motor neurons die, the ability of the brain to initiate and control muscle movement is lost. With voluntary muscle action progressively affected, patients in the later stages of the disease may become totally paralyzed.
The document discusses amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. ALS is a progressive neuromuscular condition that affects motor neurons in the brain and spinal cord. Key symptoms include muscle weakness, atrophy, spasms, and increased reflexes. While sensory and cognitive functions remain intact, over time patients have increasing problems with movement, swallowing, speaking and breathing. There is currently no cure for ALS, though treatments aim to reduce symptoms and multidisciplinary care can help prolong life expectancy and quality of life. Occupational therapy focuses on maintaining independence through adaptive equipment and strategies.
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal neurodegenerative disease that affects motor neurons in the brain and spinal cord. It leads to the degeneration and death of motor neurons, resulting in paralysis. There is no known cure for ALS, and the disease is usually fatal within 3 years of diagnosis. The disease causes motor neurons to gradually break down and die, affecting muscle movement. Over time, increased numbers of motor neurons stop working, resulting in paralysis and increased disability. Eventually, the paralysis will reach the respiratory muscles, leading to death.
Amyotrophic lateral sclerosis (ALS) is a rare neurological disease that primarily affects the nerve cells (neurons) responsible for controlling voluntary muscle movement (those muscles we choose to move). Voluntary muscles produce movements like chewing, walking, and talking.
ALS is a progressive neurodegenerative disease that affects motor neurons in the brain and spinal cord. It causes the motor neurons to gradually degenerate and die, resulting in muscle weakness and atrophy. Over time, this leads to increasing paralysis as more motor neurons are damaged. While the exact causes are unknown, excitotoxicity from glutamate and mutations in genes like SOD1 are thought to be involved in the neurodegeneration. The main treatment is riluzole, which extends life by a few months. Other therapies focus on managing symptoms and maintaining function and quality of life for as long as possible. Regular dental care is important for oral health and to reduce risks of pneumonia. Adaptations may be needed to accommodate physical
Lou Gehrig's Disease (ALS) is a progressive neurodegenerative disease that attacks motor neurons in the brain and spinal cord, leading to muscle weakness and atrophy. Eventually, it causes paralysis and death, usually within 3-5 years of diagnosis. ALS is named after baseball player Lou Gehrig, who was diagnosed with it in 1939. Symptoms vary but may include muscle twitching, weakness, difficulty speaking, swallowing or breathing. There is no known cure for ALS, but some drugs can help slow progression of symptoms.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes progressive weakness due to the loss of motor neurons in the brain and spinal cord. The cause of ALS is largely unknown, though some genetic and environmental factors have been associated with increased risk. While currently there is no cure for ALS, treatments aim to slow progression and manage symptoms such as spasticity, pain, and respiratory failure through medications, nutrition support, and respiratory assistance.
Amyotrophic lateral sclerosis (als) nursing care plan and managementNursing Path
Amyotrophic lateral sclerosis (ALS) is a progressive disease that causes the loss of motor neurons in the spinal cord and brainstem, leading to muscle weakness and atrophy. Risk factors include autoimmune, oxidative stress, smoking, and free radical damage. As motor neurons die, the muscles they control weaken and waste away. Currently, there is no cure and treatment focuses on managing symptoms to maintain function and quality of life for as long as possible. Nursing care involves managing mobility, communication, swallowing, and breathing impairments through exercise, nutrition support, respiratory treatments, and education to support patients and their families.
ALS is a neurodegenerative disease that affects motor neurons in the brain and spinal cord. It causes progressive muscle weakness and atrophy. There is currently no cure, and the average survival time is 3-5 years from symptom onset. Riluzole is the only approved treatment shown to modestly prolong survival. Supportive care focuses on managing symptoms like spasticity, secretions, and respiratory failure to prolong function and quality of life. The ice bucket challenge raised significant funds for ALS research. Diagnosis requires ruling out other causes and demonstrating both upper and lower motor neuron signs that progress over time.
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal neurological disease that causes progressive muscle weakness and paralysis. The exact causes are unknown but may include genetic and environmental factors. Symptoms start with muscle weakness and progress to include slurred speech, difficulty swallowing, and eventually paralysis of the diaphragm leading to respiratory failure. While there is no cure, treatments can help manage symptoms and some medications may slow disease progression. The average life expectancy is 2-5 years from diagnosis but can vary significantly.
Motor neuron diseases are a group of rare neurodegenerative disorders that progressively cause nerves in the brain and spinal cord to lose function, affecting voluntary muscle movement. The most common type in adults is amyotrophic lateral sclerosis (ALS), which affects both upper and lower motor neurons. There is no cure for motor neuron diseases, so treatment focuses on managing symptoms and maximizing quality of life through supportive care, rehabilitation, and FDA-approved drugs that may slow progression. Prognosis depends on the specific type of motor neuron disease and age of onset, with some forms being fatal and others non-fatal but still impacting quality of life over time.
Motor neuron disease (MND) refers to conditions characterized by degeneration of upper and lower motor neurons. Amyotrophic lateral sclerosis (ALS) is the most common form of MND and involves both upper and lower motor neurons. ALS is clinically defined based on involvement of motor neurons and includes features such as muscle weakness, atrophy, fasciculations, and stiffness. The pathology of ALS involves degeneration and death of motor neurons in the brain, brainstem, and spinal cord leading to muscle denervation and atrophy. While the cause of ALS is largely unknown, factors such as oxidative stress, protein aggregation, mitochondrial dysfunction, and glutamate excitotoxicity are hypothesized to contribute to motor neuron de
Diagnosis and clinical management of amyotrophic lateral sclerosis (2)rzgar hamed
This document provides an overview of amyotrophic lateral sclerosis (ALS), including its diagnosis, clinical presentation, disease course, treatment and management. Some key points:
- ALS is a progressive neurodegenerative disease that affects motor neurons, leading to weakness. Median survival is 2-4 years from symptom onset.
- Diagnosis involves assessing for signs of both upper and lower motor neuron dysfunction via clinical exam, electrodiagnostic testing, and ruling out other potential causes.
- Symptoms vary depending on site of onset but commonly include limb weakness, bulbar dysfunction, and respiratory impairment. Disease progression eventually involves multiple regions.
- Currently the only FDA-approved treatments are riluzole, which extends survival
The document discusses several neuromuscular disorders including amyotrophic lateral sclerosis (ALS), multiple sclerosis, and muscular dystrophy. It provides details on ALS such as its symptoms, causes, risk factors, and complications. ALS causes motor neurons to break down and leads to muscle weakness and atrophy. It typically begins in the hands, feet or limbs and eventually affects movement, speech, swallowing and breathing. While most cases have no known cause, genetic mutations and environmental factors may play a role. Complications include breathing and eating problems as well as potential dementia. Tests like EMGs, MRIs and biopsies can help diagnose ALS and rule out other conditions.
Motor neuron diseases are characterized by the dysfunction and degeneration of motor neurons. The most common type is amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, which involves both upper and lower motor neurons. Other types include primary lateral sclerosis, which affects only upper motor neurons, and progressive muscular atrophy, which predominantly impacts lower motor neurons. Spinal muscular atrophy is a genetic disorder caused by a defect in the SMN1 gene that results in lower motor neuron loss and proximal muscle weakness.
Motor neurone disease pathogenesis and therapeutic potentialmeducationdotnet
Motor Neurone Disease (MND), also known as amyotrophic lateral sclerosis (ALS), is a fatal neurodegenerative disease that causes the death of motor neurons. While most research has focused on mutations in superoxide dismutase 1 (SOD1), recent evidence suggests abnormal SOD1 folding may be present in both familial and sporadic ALS. This could provide a unifying pathogenesis and help develop more targeted treatments. Current drug trials primarily target downstream effects like glutamate excitotoxicity and oxidative stress, but emerging research on gene silencing and stem cells may lead to therapies that address the underlying causes of MND.
El documento habla sobre Visual FoxPro, un lenguaje de programación orientado a objetos y bases de datos producido por Microsoft. Describe que Visual FoxPro permite el manejo de datos nativos y remotos, y la creación de soluciones flexibles de bases de datos usando sentencias SQL. También menciona que puede usarse para crear aplicaciones y componentes de base de datos de alto rendimiento para sistemas cliente-servidor e Internet. Resalta algunas ventajas como menor costo y facilidad de capacitación, y desventajas como menor integridad, seguridad y capac
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons in the brain and spinal cord. The document discusses the pathology, epidemiology, clinical presentation, diagnosis, and management of ALS. Key points include that ALS causes the degeneration of upper and lower motor neurons, leading to muscle weakness, atrophy, and fasciculations. The average age of onset is in the mid-50s. Diagnosis is based on clinical signs and requires the exclusion of other potential causes through laboratory testing. Currently, riluzole is the only approved treatment and modestly prolongs survival. Management involves a multidisciplinary approach to address symptoms like weakness, fatigue, nutrition, and
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons, leading to their degeneration and death. This causes muscles to weaken and atrophy, resulting in paralysis. Eventually, respiratory muscles are affected and the disease becomes fatal. ALS has causes linked to glutamate toxicity, mutations in the SOD1 gene, and oxidative stress damaging motor neurons. There is no cure for ALS and available treatments can only moderately slow progression of the disease.
Amyotrophic Lateral Sclerosis (ALS) is also known as Lou Gehrig’s disease. It is a progressive, rarely occurring neurological disease that mainly involves the nerve cells (neurons) which are responsible for controlling voluntary muscle movements. With time, it leads to muscle weakness, gradually affecting the functions of the body.
Lou Gehrig's Disease, also known as amyotrophic lateral sclerosis (ALS), is a progressive neurodegenerative disease that affects neurons in the brain and spinal cord. It causes weakness and paralysis as the motor neurons die and the brain loses ability to initiate and control muscle movement. There is no cure for ALS, though some drugs can treat symptoms, and researchers are investigating potential genetic and viral causes as the disease sometimes runs in families. Famous individuals like baseball player Lou Gehrig and physicist Stephen Hawking had ALS.
Amyotrophic lateral sclerosis (ALS), AKA "Lou Gehrig's Disease," is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in ALS eventually leads to their death. When the motor neurons die, the ability of the brain to initiate and control muscle movement is lost. With voluntary muscle action progressively affected, patients in the later stages of the disease may become totally paralyzed.
The document discusses amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. ALS is a progressive neuromuscular condition that affects motor neurons in the brain and spinal cord. Key symptoms include muscle weakness, atrophy, spasms, and increased reflexes. While sensory and cognitive functions remain intact, over time patients have increasing problems with movement, swallowing, speaking and breathing. There is currently no cure for ALS, though treatments aim to reduce symptoms and multidisciplinary care can help prolong life expectancy and quality of life. Occupational therapy focuses on maintaining independence through adaptive equipment and strategies.
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal neurodegenerative disease that affects motor neurons in the brain and spinal cord. It leads to the degeneration and death of motor neurons, resulting in paralysis. There is no known cure for ALS, and the disease is usually fatal within 3 years of diagnosis. The disease causes motor neurons to gradually break down and die, affecting muscle movement. Over time, increased numbers of motor neurons stop working, resulting in paralysis and increased disability. Eventually, the paralysis will reach the respiratory muscles, leading to death.
Amyotrophic lateral sclerosis (ALS) is a rare neurological disease that primarily affects the nerve cells (neurons) responsible for controlling voluntary muscle movement (those muscles we choose to move). Voluntary muscles produce movements like chewing, walking, and talking.
ALS is a progressive neurodegenerative disease that affects motor neurons in the brain and spinal cord. It causes the motor neurons to gradually degenerate and die, resulting in muscle weakness and atrophy. Over time, this leads to increasing paralysis as more motor neurons are damaged. While the exact causes are unknown, excitotoxicity from glutamate and mutations in genes like SOD1 are thought to be involved in the neurodegeneration. The main treatment is riluzole, which extends life by a few months. Other therapies focus on managing symptoms and maintaining function and quality of life for as long as possible. Regular dental care is important for oral health and to reduce risks of pneumonia. Adaptations may be needed to accommodate physical
Lou Gehrig's Disease (ALS) is a progressive neurodegenerative disease that attacks motor neurons in the brain and spinal cord, leading to muscle weakness and atrophy. Eventually, it causes paralysis and death, usually within 3-5 years of diagnosis. ALS is named after baseball player Lou Gehrig, who was diagnosed with it in 1939. Symptoms vary but may include muscle twitching, weakness, difficulty speaking, swallowing or breathing. There is no known cure for ALS, but some drugs can help slow progression of symptoms.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes progressive weakness due to the loss of motor neurons in the brain and spinal cord. The cause of ALS is largely unknown, though some genetic and environmental factors have been associated with increased risk. While currently there is no cure for ALS, treatments aim to slow progression and manage symptoms such as spasticity, pain, and respiratory failure through medications, nutrition support, and respiratory assistance.
Amyotrophic lateral sclerosis (als) nursing care plan and managementNursing Path
Amyotrophic lateral sclerosis (ALS) is a progressive disease that causes the loss of motor neurons in the spinal cord and brainstem, leading to muscle weakness and atrophy. Risk factors include autoimmune, oxidative stress, smoking, and free radical damage. As motor neurons die, the muscles they control weaken and waste away. Currently, there is no cure and treatment focuses on managing symptoms to maintain function and quality of life for as long as possible. Nursing care involves managing mobility, communication, swallowing, and breathing impairments through exercise, nutrition support, respiratory treatments, and education to support patients and their families.
ALS is a neurodegenerative disease that affects motor neurons in the brain and spinal cord. It causes progressive muscle weakness and atrophy. There is currently no cure, and the average survival time is 3-5 years from symptom onset. Riluzole is the only approved treatment shown to modestly prolong survival. Supportive care focuses on managing symptoms like spasticity, secretions, and respiratory failure to prolong function and quality of life. The ice bucket challenge raised significant funds for ALS research. Diagnosis requires ruling out other causes and demonstrating both upper and lower motor neuron signs that progress over time.
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal neurological disease that causes progressive muscle weakness and paralysis. The exact causes are unknown but may include genetic and environmental factors. Symptoms start with muscle weakness and progress to include slurred speech, difficulty swallowing, and eventually paralysis of the diaphragm leading to respiratory failure. While there is no cure, treatments can help manage symptoms and some medications may slow disease progression. The average life expectancy is 2-5 years from diagnosis but can vary significantly.
Motor neuron diseases are a group of rare neurodegenerative disorders that progressively cause nerves in the brain and spinal cord to lose function, affecting voluntary muscle movement. The most common type in adults is amyotrophic lateral sclerosis (ALS), which affects both upper and lower motor neurons. There is no cure for motor neuron diseases, so treatment focuses on managing symptoms and maximizing quality of life through supportive care, rehabilitation, and FDA-approved drugs that may slow progression. Prognosis depends on the specific type of motor neuron disease and age of onset, with some forms being fatal and others non-fatal but still impacting quality of life over time.
Motor neuron disease (MND) refers to conditions characterized by degeneration of upper and lower motor neurons. Amyotrophic lateral sclerosis (ALS) is the most common form of MND and involves both upper and lower motor neurons. ALS is clinically defined based on involvement of motor neurons and includes features such as muscle weakness, atrophy, fasciculations, and stiffness. The pathology of ALS involves degeneration and death of motor neurons in the brain, brainstem, and spinal cord leading to muscle denervation and atrophy. While the cause of ALS is largely unknown, factors such as oxidative stress, protein aggregation, mitochondrial dysfunction, and glutamate excitotoxicity are hypothesized to contribute to motor neuron de
Diagnosis and clinical management of amyotrophic lateral sclerosis (2)rzgar hamed
This document provides an overview of amyotrophic lateral sclerosis (ALS), including its diagnosis, clinical presentation, disease course, treatment and management. Some key points:
- ALS is a progressive neurodegenerative disease that affects motor neurons, leading to weakness. Median survival is 2-4 years from symptom onset.
- Diagnosis involves assessing for signs of both upper and lower motor neuron dysfunction via clinical exam, electrodiagnostic testing, and ruling out other potential causes.
- Symptoms vary depending on site of onset but commonly include limb weakness, bulbar dysfunction, and respiratory impairment. Disease progression eventually involves multiple regions.
- Currently the only FDA-approved treatments are riluzole, which extends survival
The document discusses several neuromuscular disorders including amyotrophic lateral sclerosis (ALS), multiple sclerosis, and muscular dystrophy. It provides details on ALS such as its symptoms, causes, risk factors, and complications. ALS causes motor neurons to break down and leads to muscle weakness and atrophy. It typically begins in the hands, feet or limbs and eventually affects movement, speech, swallowing and breathing. While most cases have no known cause, genetic mutations and environmental factors may play a role. Complications include breathing and eating problems as well as potential dementia. Tests like EMGs, MRIs and biopsies can help diagnose ALS and rule out other conditions.
Motor neuron diseases are characterized by the dysfunction and degeneration of motor neurons. The most common type is amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, which involves both upper and lower motor neurons. Other types include primary lateral sclerosis, which affects only upper motor neurons, and progressive muscular atrophy, which predominantly impacts lower motor neurons. Spinal muscular atrophy is a genetic disorder caused by a defect in the SMN1 gene that results in lower motor neuron loss and proximal muscle weakness.
Motor neurone disease pathogenesis and therapeutic potentialmeducationdotnet
Motor Neurone Disease (MND), also known as amyotrophic lateral sclerosis (ALS), is a fatal neurodegenerative disease that causes the death of motor neurons. While most research has focused on mutations in superoxide dismutase 1 (SOD1), recent evidence suggests abnormal SOD1 folding may be present in both familial and sporadic ALS. This could provide a unifying pathogenesis and help develop more targeted treatments. Current drug trials primarily target downstream effects like glutamate excitotoxicity and oxidative stress, but emerging research on gene silencing and stem cells may lead to therapies that address the underlying causes of MND.
El documento habla sobre Visual FoxPro, un lenguaje de programación orientado a objetos y bases de datos producido por Microsoft. Describe que Visual FoxPro permite el manejo de datos nativos y remotos, y la creación de soluciones flexibles de bases de datos usando sentencias SQL. También menciona que puede usarse para crear aplicaciones y componentes de base de datos de alto rendimiento para sistemas cliente-servidor e Internet. Resalta algunas ventajas como menor costo y facilidad de capacitación, y desventajas como menor integridad, seguridad y capac
Theory and Research Proposal Senior ProjectKyra Dillard
This document discusses research on the relationship between playing violent video games and increased aggression in adolescents. It summarizes several studies that found adolescents who played violent video games were more likely to exhibit aggressive behaviors compared to those who played non-violent games. The document also discusses social learning theory, which suggests that behavior is learned through observation, and that adolescents may learn aggressive behaviors by observing and mimicking violence in video games.
La empresa Oficina de Servicios IntegralesSAC planea implementar una guía de buenas prácticas basada en ITIL v3 para mejorar sus servicios de TI. Esto incluye (1) implementar una red inalámbrica y (2) adoptar un nuevo sistema financiero para el área de contabilidad. El objetivo es mejorar el acceso a la red y brindar soporte más efectivo a los procesos contables de la organización.
Chris Bonello grew up on a farm surrounded by nature, developing early interests in dinosaurs, the environment, and art that led him to study paleontology, environmental science, and graphic design over several colleges. He enjoys using both digital and traditional art forms along with problem solving and finds fulfillment through creative hobbies like Dungeons & Dragons and personal art projects.
This study investigated whether exposure to violent video games increases hostility and aggressiveness in players. The researcher surveyed 10 male college students before and after playing violent video games like Grand Theft Auto and Mortal Kombat. According to social learning theory, people may imitate rewarded violent behaviors from games. The results showed that Mortal Kombat and brief exposure to any violent game increased aggressive behaviors and emotions in some participants. However, the small sample size limits the ability to generalize the findings.
The document is a curriculum vitae for Vinod Panchal. It summarizes his career objective, work experience, skills and qualifications. The summary highlights that he has over 7 years of experience as a QA lead supporting web applications. He has experience with projects involving regulations like FATCA and CRS. His technical skills include testing tools, databases, programming languages and bug reporting tools.
Infografía el nuevo profesional de marketingAdgravity
La tecnología ha transformado totalmente el mundo del marketing. Ahora junto a la parte creativa, existen unas necesidades multidisciplinares que pasan por el planteamiento de estrategias Cross-Channel, el manejo de herramientas y plataformas programáticas y el análisis de una ingente cantidad de datos. ¿Quieres impactar a tu target? Pues éste es el perfil que necesitas.
The National E-Health Transition Authority (NEHTA) facilitates e-health in Australia through initiatives like healthcare identifiers and secure messaging standards. NEHTA was established in 2005 by Australian governments and its board comprises state health department heads. NEHTA is working to establish individual and provider identifiers to ensure the right information is associated with the right person, pending new healthcare identifier legislation. The healthcare identifier service will assign individual and provider identifiers to support interoperability when operational in July 2010. NEHTA is also addressing data quality challenges for healthcare identifiers like existing mental models, interoperability in a federated system, and privacy issues.
This document describes an FPGA-based graphics pipeline and three advanced 3D rendering effects implemented in VHDL as part of a diploma thesis. The graphics pipeline includes vertex processing, rasterization, shading, and texture mapping. The three effects implemented are Perlin noise mapping to create a ramp texture, a particle system, and displacement mapping using Perlin noise. The project aims to understand how a simple GPU works at a low level and implement graphics algorithms in a hardware description language for FPGA. Evaluation of the implemented graphics pipeline and effects is also discussed.
a summary of Amyotrophic lateral sclerosis, a disease of the nervous system, its causes, symptoms, and complications, and how it affects the quality of life, as well as one of the famous sport figures that died from the disease.
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord. As the motor neurons die, it leads to the loss of ability to initiate and control muscle movement. Early symptoms include increasing muscle weakness, especially in the arms and legs, as well as speech, swallowing, and breathing difficulties. While the cause is unknown, it progressively leads to paralysis as muscles atrophy from lack of signals from motor neurons. There is currently no cure, but one FDA-approved drug can modestly slow progression and other potential treatments are being studied. Devices and therapies can help manage symptoms and prolong survival, though each person
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a motor neuron disease that affects nerve cells in the brain and spinal cord, causing muscle weakness. As the disease progresses, it causes the loss of function in voluntary muscles as motor neurons degenerate and die, resulting in muscle atrophy. Early symptoms may include twitching or stiffness in muscles, slurred speech, or difficulty swallowing. As the disease worsens, patients experience increasing difficulty with tasks like breathing, speaking, walking, and moving, which can lead to paralysis and eventual death usually within 3-5 years due to respiratory failure.
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a motor neuron disease that affects nerve cells in the brain and spinal cord, causing muscle weakness. As the disease progresses, it causes the loss of function in voluntary muscles as motor neurons degenerate and die, resulting in muscle atrophy. Early symptoms may include twitching or stiffness in muscles, slurred speech, or difficulty swallowing. As the disease worsens, patients experience increasing difficulty with tasks like breathing, speaking, walking, and moving, which can lead to paralysis and eventual death usually within 3-5 years due to respiratory failure.
A Look at the Medical and Social Aspects of.docxwrite31
Alzheimer's disease typically affects patients later in life and is associated with cognitive decline such as memory loss and deteriorating ability to reason and maintain emotions. Recent research suggests 80% of Alzheimer's cases are genetically transmitted, though environment can influence onset and progression. Genetically-linked Alzheimer's is transmitted through an autosomal dominant gene and can develop whether the gene is homozygous or heterozygous. Alzheimer's causes decreased acetylcholine production and increased amyloid proteins which form obstructive plaques in the brain, as well as age-related neuron and synapse loss impairing cognitive function. Symptoms relate to lost cognitive abilities, though psychological and physical aspects are also affected.
Motor neuron diseases are a group of neurodegenerative disorders that progressively cause nerves in the brain and spinal cord to lose function, affecting voluntary muscle movement. The most common type in adults is amyotrophic lateral sclerosis (ALS), which affects both upper and lower motor neurons. There is no cure and treatments focus on managing symptoms and maximizing independence. Prognosis depends on the specific type of motor neuron disease and age of onset, with some forms being fatal and others non-fatal but still reducing quality of life over time.
Lou Gehrig's Disease, also known as amyotrophic lateral sclerosis (ALS), is a disease that causes motor neurons in the brain and spinal cord to die. This leads to weakness and paralysis as the brain loses ability to control voluntary muscles. ALS was named after baseball player Lou Gehrig, who died from the disease in 1941. There is probably a genetic link as the disease often runs in families. While thinking and memory remain intact, diagnosis is difficult as symptoms are similar to other treatable neuromuscular disorders. Examinations would show muscle weakness and wasting. There are drugs to treat symptoms but no cure, and the cause is still unknown though a virus may be involved.
This document discusses several neuromuscular disorders including Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), Spinal Cord Injury, Huntington's Chorea, and Spinal Muscle Atrophy. It provides details on ALS such as the pathophysiology, signs and symptoms, course of the disease, etiology, epidemiology, diagnosis, treatment, and complications. Comparisons are made between ALS and other disorders such as MS, Spinal Cord Injury, Huntington's Chorea, and Spinal Muscle Atrophy.
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive neurodegenerative disease that affects motor neurons in the brain and spinal cord. As the motor neurons die, it leads to the loss of ability to initiate and control muscle movement, resulting in increasing muscle weakness and eventual paralysis. While the cause is unknown, early symptoms often include weakness in the limbs, difficulty speaking, swallowing, or breathing. There is currently no cure and treatments can only modestly slow progression, but assistive devices and therapies can help maintain independence for as long as possible.
ALS, also known as Lou Gehrig's disease, is a neurodegenerative disease that results in the progressive loss of motor neurons. Early symptoms include muscle weakness and atrophy. As the disease progresses, individuals lose the ability to control voluntary muscles including those involved in breathing. Management focuses on treating symptoms to prolong survival and quality of life, as there is no cure. The only approved medications are riluzole and edaravone, which modestly slow progression. Non-invasive ventilation can prolong survival by treating respiratory symptoms but most will eventually require invasive ventilation or die from respiratory failure.
The chapter discusses two neurodegenerative diseases: Alzheimer's disease and Huntington's disease. Alzheimer's disease typically presents with early problems in memory and visuospatial abilities and accounts for about 65% of dementia cases in the United States. The majority of Alzheimer's disease cases are late onset and usually develop after age 65. Huntington's disease is an autosomal dominant disorder characterized by involuntary movements and deterioration of cognitive function. There is no cure for either disease.
This document provides information about Alzheimer's disease and dementia. It discusses key facts such as prevalence, causes, stages of Alzheimer's, and effects on the brain. Alzheimer's is the most common cause of irreversible dementia. It progresses through early, middle, and late stages as brain cells deteriorate. Providing a predictable routine, adapted activities, and positive communication can help reduce fear and confusion for those with Alzheimer's or dementia.
This document provides a review of amyotrophic lateral sclerosis (ALS). It begins with an introduction that defines ALS and discusses its classification. It then covers the epidemiology, clinical features, diagnosis, etiology, pathogenesis, and differential diagnosis of ALS. Some key points include that ALS is a rare neurodegenerative disease that causes motor neuron death and muscle paralysis. It can be sporadic or familial. Common symptoms include muscle weakness, spasticity, and difficulty speaking, swallowing, or breathing. The cause is largely unknown but may involve genetic mutations, oxidative stress, protein misfolding, or mitochondrial dysfunction.
Motor neuron diseases are a group of neurodegenerative disorders that affect motor neurons in the brain and spinal cord, leading to progressive muscle weakness. The most common type is amyotrophic lateral sclerosis (ALS), which affects both upper and lower motor neurons. Symptoms start in one area, such as weakness in the arms or slurred speech, and gradually spread. As motor neurons die, muscles waste away and it becomes difficult to move, swallow, breathe and speak. There is no cure and the cause is largely unknown, though some risk factors include age, sex, family history and head trauma. Treatment focuses on managing symptoms and maximizing function and comfort through supportive care, devices, therapy and medications like riluzole.
Dementia is a syndrome involving the deterioration of memory, thinking, behavior and the ability to perform everyday activities. It is caused by damage to brain cells that interferes with communication between cells. Alzheimer's disease is the most common form of dementia, potentially contributing to 60-70% of cases. Dementia is diagnosed based on medical history, exams, tests and characteristic changes in thinking and functioning. While there is no cure, medications and therapies can help reduce symptoms or slow progression for some time.
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Alzheimer's disease is a progressive neurological disorder that causes memory loss and cognitive decline. It is the most common cause of dementia and starts mildly but gets worse over time as more parts of the brain are damaged. In 2010, around 4.7 million Americans aged 65 and older had Alzheimer's. The disease is caused by death of brain cells and formation of amyloid plaques and tau tangles, which shrink the brain and impair communication between neurons. Risk factors include age, family history, genetics, and medical conditions that impact brain health. While there is no cure, current medications can temporarily improve cognitive symptoms.
Alzheimer's disease is a type of dementia that causes problems with memory, thinking, and behavior. It develops slowly and symptoms worsen over time, interfering with daily tasks. While there is no single test, physicians can usually determine the cause through medical history, exams, and tests to rule out other conditions. Genes play a role, with some increasing risk and others directly causing early-onset Alzheimer's. Currently there are no ways to prevent the disease, though treatments can help cognitive and behavioral symptoms. As the disease progresses through mild, moderate, and severe stages, individuals require increased care and support.
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2. Amyotrophic Lateral Sclerosis, also
known as Lou Gehrig’s disease, is a
neurological disease that attacks
the body’s nerve cells. These nerve
cells are responsible for controlling
the voluntary muscles in the body,
such as the arms, legs, and face..
3. Symptoms of Amyotrophic Lateral Sclerosis (ALS)
Degeneration occurs in both the upper and lower motor
neurons, resulting in these neurons being unable to send
messages to the muscles. This causes the muscles to weaken
and waste away, experiencing fine twitches known as
fasciculations.
4. Eventually, the brain will no longer be able to start and control the body’s
voluntary movements. Control of the eye muscles, bladder, and bowel
functions are not harmed as ALS does not affect people’s ability to see or
go to the washroom.
5. Studies found that patients with ALS suffer from depression or
impaired cognitive functions, such as decision-making and memory.
This disease can happen randomly, or be inherited. About 90 to 95%
of ALS cases occurred randomly with no clear risk factors associated,
leaving the remaining 5 to 10% of cases to be inherited by a family
gene.
6. Treatments for ALS
Treatments for ALS include the first drug treatment for ALS called
riluzole, released in 1995. This helps to reduce damage of the motor
neurons by decreasing the release of glutamate.
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