It was a systematic review and network meta-analysis aimed to evaluate the efficacy of adjunctive locally delivered antimicrobials, compared to sub gingival instrumentation alone or plus a placebo, on changes in probing pocket depth (PPD) and clinical attachment level (CAL), in patients with residual pockets during supportive periodontal care.
OMICS Publishing Group, Journal of Clinical Pharmacology & Biopharmaceutics (CPB) emphasizes the phases of drug development from absorption, disposition, metabolism, excretion interactions and rational design of drug products to deliver the drug at a specific rate to the body in order to optimize the therapeutic effect and minimize any adverse effects. The CPB acts as an interface between academics, those in research and developments, explicates the research on various developmental applications for contemporary drug development and utilization.
Traditionally, physicians recruited clinical trial subjects, but pharmaceutical companies have become ever more involved through centralized campaigns. Physicians are vital to a trial and the pharmaceutical effort helps shift some of the recruitment demands away from the site to allow them to focus on the subjects. Thus, it is practical to understand if different recruitment methods could change or skew the study population. This study determines if differences or similarities occurred between subjects recruited by physicians and pharmaceutical companies. It discovered that some of both occurred. The pharmaceutical company efforts helped recruit potential subjects from the general population that were similar to subjects recruited by the physicians, but this particular campaign was limited by language which affected recruitment of Hispanic subjects. The social impact of this study provides insight about pharmaceutical company recruitment. Since the National Library of Medicine has indicated that clinical trials should reflect the broader diseased population, the efforts of the pharmaceutical company can help support the physicians’ efforts by recruiting from the broader population. Together, both efforts can create a global good by allowing the trial to reflect the population of post-approval use. These findings still raise a question about the proper balance between the two recruitment groups so that the intended characteristics of the diseased population are maintained. Because differences between physician and pharmaceutical recruited subjects can exist, the potential of one group to bias the trial results exist. As such, some analysis by recruitment method can help ensure that variations in the study population are minimal without skewing the data to create positive study results.
This presentation gives effective solutions to outliers issue in bioequivalence trials. It described what would be acceptable to Regulatory agencies as well as some new approaches.
OMICS Publishing Group, Journal of Clinical Pharmacology & Biopharmaceutics (CPB) emphasizes the phases of drug development from absorption, disposition, metabolism, excretion interactions and rational design of drug products to deliver the drug at a specific rate to the body in order to optimize the therapeutic effect and minimize any adverse effects. The CPB acts as an interface between academics, those in research and developments, explicates the research on various developmental applications for contemporary drug development and utilization.
Traditionally, physicians recruited clinical trial subjects, but pharmaceutical companies have become ever more involved through centralized campaigns. Physicians are vital to a trial and the pharmaceutical effort helps shift some of the recruitment demands away from the site to allow them to focus on the subjects. Thus, it is practical to understand if different recruitment methods could change or skew the study population. This study determines if differences or similarities occurred between subjects recruited by physicians and pharmaceutical companies. It discovered that some of both occurred. The pharmaceutical company efforts helped recruit potential subjects from the general population that were similar to subjects recruited by the physicians, but this particular campaign was limited by language which affected recruitment of Hispanic subjects. The social impact of this study provides insight about pharmaceutical company recruitment. Since the National Library of Medicine has indicated that clinical trials should reflect the broader diseased population, the efforts of the pharmaceutical company can help support the physicians’ efforts by recruiting from the broader population. Together, both efforts can create a global good by allowing the trial to reflect the population of post-approval use. These findings still raise a question about the proper balance between the two recruitment groups so that the intended characteristics of the diseased population are maintained. Because differences between physician and pharmaceutical recruited subjects can exist, the potential of one group to bias the trial results exist. As such, some analysis by recruitment method can help ensure that variations in the study population are minimal without skewing the data to create positive study results.
This presentation gives effective solutions to outliers issue in bioequivalence trials. It described what would be acceptable to Regulatory agencies as well as some new approaches.
Medical Conferences, Pharma Conferences, Engineering Conferences, Science Conferences, Manufacturing Conferences, Social Science Conferences, Business Conferences, Scientific Conferences Malaysia, Thailand, Singapore, Hong Kong, Dubai, Turkey 2014 2015 2016
Global Research & Development Services (GRDS) is a leading academic event organizer, publishing Open Access Journals and conducting several professionally organized international conferences all over the globe annually. GRDS aims to disseminate knowledge and innovation with the help of its International Conferences and open access publications. GRDS International conferences are world-class events which provide a meaningful platform for researchers, students, academicians, institutions, entrepreneurs, industries and practitioners to create, share and disseminate knowledge and innovation and to develop long-lasting network and collaboration.
GRDS is a blend of Open Access Publications and world-wide International Conferences and Academic events. The prime mission of GRDS is to make continuous efforts in transforming the lives of people around the world through education, application of research and innovative ideas.
Global Research & Development Services (GRDS) is also active in the field of Research Funding, Research Consultancy, Training and Workshops along with International Conferences and Open Access Publications.
International Conferences 2014 – 2015
Malaysia Conferences, Thailand Conferences, Singapore Conferences, Hong Kong Conferences, Dubai Conferences, Turkey Conferences, Conference Listing, Conference Alerts
KIF1A.ORG is a parent-led organization established in 2017 to launch the world’s first translational research program dedicated to discovering treatment for people affected by KIF1A Associated Neurological Disorder (KAND). There is no cure or treatment for this neurodegenerative disorder. Yet.
Our organization supports researchers who engage in collaborative and translational work to rapidly discover treatment for this generation of KAND patients. We have made tangible progress over the last three years, but time is running out. 2020 is a transformational year for KIF1A with a clear path to clinical trials.
This Path to Treatment outlines our immediate therapeutic strategy with defined objectives and resources needed to bring treatment options to families affected by KAND.
Learn more and join our mission at www.kif1a.org or contact us at impact@kif1a.org.
NIH Drug Discovery and Development - NCTT and CTSAsCTSI at UCSF
Presented at the UC Braid Retreat: Imagine a statewide research engine of pooled resources, data, and expertise that accelerates the “translation” of academic research to direct patient benefit. That's the goal of the University of California Biomedical Research Acceleration, Integration, and Development (UC BRAID) program.
Stakeholder Engagement in a Patient-Reported Outcomes Implementation by a Pra...Marion Sills
Kwan BM, Sills MR, Graham D, Hamer MK, Fairclough DL, Hammermeister KE, Kaiser A, Diaz-Perez MJ, Schilling LM. Stakeholder Engagement in a Patient-Reported Outcomes Implementation by a Practice-Based Research Network. JABFM. In Press.
Nursing Evidence Based Practice PPT for BSN Nurses.
This ppt assess effectiveness of using NPWT for DFUs with providing highest level of evidence. DFUs are a prevalent issue in many countries and is treated via dressings which take a long time to heal but utilizing this method will certainly make the recovery faster.
Medical Conferences, Pharma Conferences, Engineering Conferences, Science Conferences, Manufacturing Conferences, Social Science Conferences, Business Conferences, Scientific Conferences Malaysia, Thailand, Singapore, Hong Kong, Dubai, Turkey 2014 2015 2016
Global Research & Development Services (GRDS) is a leading academic event organizer, publishing Open Access Journals and conducting several professionally organized international conferences all over the globe annually. GRDS aims to disseminate knowledge and innovation with the help of its International Conferences and open access publications. GRDS International conferences are world-class events which provide a meaningful platform for researchers, students, academicians, institutions, entrepreneurs, industries and practitioners to create, share and disseminate knowledge and innovation and to develop long-lasting network and collaboration.
GRDS is a blend of Open Access Publications and world-wide International Conferences and Academic events. The prime mission of GRDS is to make continuous efforts in transforming the lives of people around the world through education, application of research and innovative ideas.
Global Research & Development Services (GRDS) is also active in the field of Research Funding, Research Consultancy, Training and Workshops along with International Conferences and Open Access Publications.
International Conferences 2014 – 2015
Malaysia Conferences, Thailand Conferences, Singapore Conferences, Hong Kong Conferences, Dubai Conferences, Turkey Conferences, Conference Listing, Conference Alerts
KIF1A.ORG is a parent-led organization established in 2017 to launch the world’s first translational research program dedicated to discovering treatment for people affected by KIF1A Associated Neurological Disorder (KAND). There is no cure or treatment for this neurodegenerative disorder. Yet.
Our organization supports researchers who engage in collaborative and translational work to rapidly discover treatment for this generation of KAND patients. We have made tangible progress over the last three years, but time is running out. 2020 is a transformational year for KIF1A with a clear path to clinical trials.
This Path to Treatment outlines our immediate therapeutic strategy with defined objectives and resources needed to bring treatment options to families affected by KAND.
Learn more and join our mission at www.kif1a.org or contact us at impact@kif1a.org.
NIH Drug Discovery and Development - NCTT and CTSAsCTSI at UCSF
Presented at the UC Braid Retreat: Imagine a statewide research engine of pooled resources, data, and expertise that accelerates the “translation” of academic research to direct patient benefit. That's the goal of the University of California Biomedical Research Acceleration, Integration, and Development (UC BRAID) program.
Stakeholder Engagement in a Patient-Reported Outcomes Implementation by a Pra...Marion Sills
Kwan BM, Sills MR, Graham D, Hamer MK, Fairclough DL, Hammermeister KE, Kaiser A, Diaz-Perez MJ, Schilling LM. Stakeholder Engagement in a Patient-Reported Outcomes Implementation by a Practice-Based Research Network. JABFM. In Press.
Nursing Evidence Based Practice PPT for BSN Nurses.
This ppt assess effectiveness of using NPWT for DFUs with providing highest level of evidence. DFUs are a prevalent issue in many countries and is treated via dressings which take a long time to heal but utilizing this method will certainly make the recovery faster.
A study on drug utilisation evaluation of Bronchodilators using defined daily...Dr. Afreen Nasir
Conference proceeding: Nasir A. A study on drug utilisation evaluation of Bronchodilators using a defined daily dose method. Pharmacy Education Journal [Internet]. 2023 Aug;23(5):23–24. Available from: https://doi.org/10.46542/pe.2023.235.138
Four strategies to upgrade clinical trial quality in this computerized world ...Pubrica
• Biostatistics Services is important for collecting, reviewing, presenting, and interpreting data in clinical research.
• Applications of clinical biostatistics services are in different areas, such as epidemiology, clinical trials, population genetics, the biology of structures, and more.
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Short-term improvement of clinical parameters and microbial diversity in peri...M ALTAMIMI
Indocyanine green-mediated photodynamic therapy is effective against chronic periodontitis. Here, we evaluated the efficiency of indocyanine green-based adjunctive antimicrobial photodynamic therapy in non- surgical treatment of chronic periodontitis patients
The 2019 Diagnostic Summit brought together diagnostic developers in academia and industry as well as end-users in the pharmaceutical and healthcare sector to gain a comprehensive picture of diagnostics in prenatal, oncology, infectious disease, point-of-care, and liquid biopsy.
This important Summit enabled delegates to learn what novel technologies, platforms and applications are emerging that will impact future healthcare delivery and pharmaceutical research.
Bringing together European leading experts via presentations, workshops and case studies the Summit was a must attend event! We explored:
Current diagnostic testing in GP surgeries and Pharmacies
How Diagnostics can be funded and funding barriers
Advances in Prenatal Molecular Diagnostics
Diagnostic Regulations
Point of care testing
Advanced Diagnostics for infectious diseases
Adapting and evaluating Innovation
Education on testing and accuracy
Patient and Clinical pathways
Key health areas examined in the Summit included:
Sexual Health
Diabetes
Cancer
Antibiotic Resistance
Sepsis
Obesity
Urinary Infections
Pharmacoeconomic Evaluation of an Antibiotic Streamlining ServiceMarielleFares1
This presentation describes a pharmacist-led antibiotic streamlining service initiative in hospitals in Beirut, and impact on drug costs, length of stay, and rate of hospital admissions
By preventing confounding from other circumstances, a successful clinical trial reduces the heterogeneity of the assessment and offers an objective assessment of the intervention.
With the exception of the intervention that each group receives, randomization ensures that every patient has an identical likelihood of obtaining any of the therapies being studied.
This presentation explains the various controversies in different topics in periodontics. Discusses the controversies in Classification of periodontal diseases,
Diagnosis of periodontal diseases,
Prognosis,
Tooth mobility & splinting,
Gingival curettage one stage full-mouth disinfection versus quadrant SRP,
Systemic antimicrobials in periodontal therapy, Non-surgical versus surgical periodontal therapy,
Postsurgical antimicrobial medication,
Periodontal pack,
Periodontal-endodontic relationship,
Periodontal and systemic diseases,
Implant therapy in periodontally compromised patients.
Similar to Local Treatment in Periodontal pocket Journal Presentation (20)
CONSCIOUS SEDATION USE ON ANXIETY REDUCTION, AND PATIENT AND SURGEON SATISF...Dr. B.V.Parvathy
EFFECT OF CONSCIOUS
SEDATION USE ON ANXIETY REDUCTION, AND PATIENT
AND SURGEON
SATISFACTION IN DENTAL
IMPLANT SURGERIES: A
SYSTEMATIC REVIEW AND META-ANALYSIS
Orthodontics-Periodontics Relationship
ntroduction
Biological basis for orthodontic therapy
Periodontal tissue response to orthodontic force
Effects of orthodontic tooth movement on the periodontium
Orthodontic tooth movement in adults with periodontal tissue breakdown
Specific factors associated with orthodontic tooth movement
Implants and orthodontic therapy
Systematics of combined ortho – perio treatment
Periodontally Accelerated Osteogenic Orthodontics (PAOO)
Minor periodontal surgery and orthodontic treatment
Review of literature
To evaluate the effects of B. lactis HN019 on clinical periodontal parameters (plaque accumulation and gingival bleeding), on the immunocompetence of gingival tissues [expression of BD-3, Toll-like receptor 4 (TLR4), cluster of differentiation (CD)-57 and CD-4], and on immunological properties of saliva (IgA levels) and adhesion to buccal epithelial cells and antimicrobial properties in non-surgical periodontal therapy in GCP patients.
INTRODUCTION
KEY ELEMENTS IN TISSUE ENGINEERING
- Progenitor cells
- Scaffold
- Signalling molecules
DESIRED PROPERTIES AND WAYS TO ENHANCE THE REGENERATIVE CAPACITY OF SCAFFOLDS
4. GENE THERAPY IN PERIODONTAL TISSUE ENGINEERING
5. RECENT DEVELOPMENTS
6. CRITICAL ANALYSIS OF PRESENT STATUS OF TISSUE ENGINEERING FOR PERIODONTICS.
4. CONCLUSION
5. REFERENCES
To evaluate the efficacy of the GPCS for palatal hemostasis during and after the FGG harvesting procedure.
A secondary objective was to evaluate if the placement of the suture improved the operator
visibility thereby reducing the surgical time.
Comparative study of DFDBA and FDBA block grafts.pptxDr. B.V.Parvathy
To evaluate and compare the effectiveness of demineralized freeze dried block graft and freeze dried block graft with chorion membrane as barrier membrane clinically and radiographically for the treatment of residual deep intra bony defects.
Abstract
Focused Clinical Question: Debates and questions related to the newly developed two-vector system
for classification of periodontal diseases have emerged as to how to accurately assign stage and grade
to the periodontitis cases. The aim of the present manuscript is to demonstrate the essential thought
processes that are needed in utilizing the new periodontitis classification system to diagnose two gray
zone cases.
Summary: Clinical case 1 includes an 83-year old patient diagnosed with periodontitis and classified as
Generalized Stage III Grade B periodontitis, while clinical case 2 , a 73-year old male was classified as
presenting Generalized Stage IV Grade B periodontitis. Although clinical and radiographic evaluations
revealed similarities between the cases, the thought process that includes clinical judgement is
described to guide a more accurate diagnosis following the guidelines of the new classification
system.
Conclusion: The two cases demonstrated here offer an opportunity for clinicians to recognize the
essential role of sound clinical judgment in certain cases when applying the new periodontal disease
classification system and also to clarify questions emerging from implementing this classification
system.
Key words: Staging and grading of periodontal diagnosis, Periodontal Diseases, Periodontal Diagnosis,
Abstract
Aim: The aim of this study was to determine whether the combined connective tissue
graft (CTG) with injectable platelet‐rich fibrin (i‐PRF) with coronally advanced flap
(CAF) improved root coverage of deep Miller Class I or II gingival recessions com‐
pared with CTG alone with CAF.
Material and Methods: Seventy‐two patients with Miller class I and II gingival reces‐
sions were enrolled. Thirty‐six patients were randomly assigned to the test group
(CAF+CTG+i‐PRF [700 rpm for 3 min]) or control group (CAF+CTG). Clinical evalua‐
tions were made at 6 months.
Results:At 6months, complete root coveragewas obtained at 88% of the sites treated
with CAF+CTG+i‐PRF and 80% of the sites treated with CAF+CTG. Difference be‐
tween the two groups was not statistically significant. At 6 months, the recession
depth (RD) reduction and increase in keratinized tissue height (KTH) of the test sites
were significantly better compared with the control sites.
Conclusions: According to the results, the addition of i‐PRF to the CAF+CTG treat‐
ment showed further development in terms of increasing the KTH and decreasing
RD. However, this single trial is not sufficient to advocate the true clinical effect of
i‐PRF on recession treatment with CAF+CTG and additional trials are needed.
KEYWORDS
connective tissue graft, injectable platelet‐rich fibrin, root coverage
DEFINITION
ETIOLOGY
HISTORICAL PRESPECTIVE
TERMINOLOGIES WHICH HAVE BEEN USED TO DESCRIBE OCCLSAL TRAUMA
REVIEW OF LITERATURE
OCCLUSAL FORCES DURING JAW MOVEMENTS
CLASSIFICATION
STAGES OF TISSUE RESPONSE TO EXCESSIVE OCCLUSAL FORCES
EXAMINATION AND DIAGNOSIS
DEFINITION
INDICATION AND OBJECTIVES
PROCEDURES FOR INCREASING WIDTH OF ATTACHED GINGIVA
PROCEDURES FOR ROOT COVERAGE
TECHNIQUES FOR CORRECTION OF ABERRANT FRENUM
PAPILLA RECONSTRUCTION
RIDGE AUGMENTATION
PROCEDURES FOR INCREASING VESTIBULAR DEPTH
CROWN LENGTHENING PROCEDURES
The Efficacy of Pocket Elimination/Reduction Compared to Access Flap Surgery: A SystematicReview and Meta-analysis
To assess the efficacy and adverse effects of resective
surgery compared to access flap in patients with
periodontitis.
Impact of Different Surgical Protocols on Dimensional Changes of Free Soft Ti...Dr. B.V.Parvathy
To determine if there is a difference in the amount of shrinkage during
healing of free soft tissue autografts (FSTA) using different surgical
techniques—suturing the vestibular flap margin apically to the base of
the recipient bed versus leaving the flap margin free and unsutured.
Regenerative Surgical Treatment of Furcation Journal PresentationDr. B.V.Parvathy
AIM
To evaluate the performance and the added values of surgical regenerative techniques in terms of tooth loss, furcation closure/conversion, horizontal bone level gain and other periodontal parameters of teeth affected by periodontitis-related furcation defects, at least 12 months after surgery.
i-prf &MN in gingival augmentation in thin phenotypeDr. B.V.Parvathy
To evaluate the effect of gingival thickness (GT) and keratinized tissue width (KTW) using injectable platelet rich fibrin (i-PRF) alone and with microneedling (MN) in individuals with thin periodontal phenotypes.
2 Stage Crown Lengthening VS 1 Stage Journal PresentationDr. B.V.Parvathy
This randomized controlled trial aimed to assess the efficacy of a two-
stage crown lengthening intervention (SCL) in the aesthetic zone
compared with a one-stage crown lengthening procedure (CCL).
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Anti ulcer drugs and their Advance pharmacology ||
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Local Treatment in Periodontal pocket Journal Presentation
1.
2. Chen-Ying Wang, Yu-Hao Yang, Hua Li, Ping-Yi Lin, Yu-Ting Su, Mark Yen-Ping Kuo, Yu-
Kang Tu
Adjunctive local treatments for patients withresidual pockets during
supportive periodontal care: A systematicreviewand network meta-
analysis
03 OCTOBER 2020
3. AIM
It was a systematic review and network meta-analysis aimed
to evaluate the efficacy of adjunctive locally delivered
antimicrobials, compared to sub gingival instrumentation
alone or plus a placebo, on changes in probing pocket depth
(PPD) and clinical attachment level (CAL), in patients with
residual pockets during supportive periodontal care.
4. CLINICAL RELEVANCE
Scientific rationale
A large number of adjunctive local antimicrobial agents have been used
for treating residual pockets, and this network meta-analysis compared
the treatment effects of these agents on probing pocket depth (PPD)
reduction and clinical attachment level (CAL) gain.
Principle findings
Adjunctive local antimicrobial agents achieved small additional
treatment effects on PPD reduction compared with scaling and root
planing (SRP) alone for a follow-up period of up to 6 months.
Tetracycline fiber (TCF) and chlorhexidine chip (CHC) were ranked best
among all adjunctive therapies.
5. Practical implications
The use of adjunctive local antimicrobial agents may be clinically
beneficial if significant reduction of PPD compared to SRP alone can be
achieved. It may reduce the probability of further tooth loss. TCF and
CHC achieved superior results than other antimicrobials.
6. INTRODUCTION
According to Tonetti, Greenwell, and Kornman;2018:
Periodontitis is a disease characterized by microbially associated,
host mediated inflammation that results in loss of periodontal attachment.
Supragingival professional mechanical plaque removal and sub gingival
instrumentation comprising scaling and root planing (SRP) are the first
two steps of periodontal therapy for patients with periodontitis.
(Sanz et al. 2020)
Its efficacy has been well documented in several systematic reviews in
terms of gains in clinical attachment levels (CAL) and reductions in
probing pocket depth (PPD).
7. The maintenance phase of periodontal therapy is required after SRP to
prevent the recurrence of disease and prolong the favourable results of
the active treatments. However, residual pockets may still exist during
maintenance, especially, in sites, where thorough debridement and
complete removal of calculus is hard to attain, such as those with initial
deep PPD or adjacent to anatomical structures (e.g., developmental
grooves, fossae, furcation area, root concavities).
Several methods have been introduced to treat residual pockets, such as
antimicrobials, host modulation, and regenerative therapy.
Antimicrobials, administered systemically or locally, have been the most
commonly used agents and their effects have been investigated in
numerous studies.
8. Systemic administration of antibiotics as adjuncts to SRP for treating
residual pockets has shown favourable outcomes. Even though, adverse
effects, such as gastrointestinal disturbances or development of
antimicrobial resistance, and the low compliance of patients are major
concerns.
Sustained-release local antimicrobial agents may enhance the results of
mechanical debridement yielding additional PPD reduction.
Antimicrobial photodynamic therapy (aPDT), which has a potential
bactericidal effect against various periodontal pathogens has also been
used as an adjunct to SRP in the maintenance phase.
Several systematic reviews have evaluated the advantage of adjunctive
therapy to SRP in the treatment of periodontitis.
9. These reviews had limitations:
1. Most reviews were not aimed at residual pockets in maintenance
care.
2. None of these reviews was able to determine the relative efficacy of
different antimicrobial agents because some of these antimicrobial
agents have not been directly compared by any trials.
The relative effectiveness of adjunctive antimicrobial agents on the
treatment of residual pockets is still unclear.
10. So this is a systematic review and network meta-analysis, traditional
meta-analysis undertakes pair-wise comparisons between treatments, but
when the number of available treatments is large, pair-wise comparisons
may be inefficient or unfeasible. Network meta-analysis combines both
direct and indirect evidence to compare multiple treatments
simultaneously. It provides a consistent statistical framework for direct
and indirect comparisons of different treatments.
11. MATERIALS AND METHODS
Literature search was performed with electronic databases and by hand
until May 31st, 2020. Primary outcome was the changes in PPD. The
treatment effects between groups were estimated with weighted mean
differences (WMD) with 95% confidence intervals (CI) and prediction
intervals (PI) by using random-effects network meta‐analysis.
Criteria for considering studies in this review:
PICOS framework was used to formulate research question,
Population: Non-medically compromised patients with residual pockets
during supportive periodontal care.
Interventions: For the test group, an adjunctive locally delivered
antimicrobial was used either in single or repeated sessions as adjuncts to
SRP.
Comparisons: Control groups received SRP, alone or with a placebo.
Outcomes: Primary outcome is PPD reduction. Secondary outcome is
CAL gain.
12. Data collection, extraction, and management
Data was extracted and entered into a spreadsheet software:
(a) authors’ names, journal name, year of publication;
(b) characteristics of participants (number of patients per group, age
distribution, sex);
(c) type and duration of interventions;
(d) outcome measures;
(e) source of funding and conflicts of interest, if available.
They also divided the included studies into three groups based on the
follow-up period: short-term follow-up (≤ 3 months), medium-term
follow-up (4–6 months), and long-term follow-up (> 6 months).
In a follow-up period more than 12 months, only the results at the 12
month were used in the meta-analysis.
13.
14. RESULTS
Twenty-two studies were included. Significantly greater PPD reduction
was achieved in chlorhexidine chip group (WMD: 0.65mm, 95%
CI: 0.21–1.10) and tetracycline fiber group (WMD: 0.64 mm, 95%
CI: 0.20–1.08) over 6-month follow-up. Other adjunctive antimicrobial
agents achieved non-significant improvements compared to scaling and
root planing alone.
All differences between adjunctive therapies were statistically
non-significant. Similar findings were observed for CAL gain.
15. Characteristics of studies included in the network meta-analysis.
N: Sample size; PPD: Probing pocket depth; CAL: Clinical attachment
level; SRP: scaling and root planing; NR: Not reported;
Multi(n): multicenter study(number of centers); PDT: Photodynamic
therapy.
16.
17.
18.
19.
20.
21.
22.
23. Summary of all pairwise comparisons in terms of PPD reduction and
CAL gain.
Short-term follow-up
26. Discussion
The network meta-analysis suggested that the adjunctive use of TCF and
CHC provides significantly additional clinical benefits to the treatment
of patients in the maintenance phase of periodontitis for a follow-up
period of up to 6 months. Other adjunctive antimicrobial agents showed
only limited clinical improvement.
Residual pocket depth after the initial cause-related therapy is related to
further attachment loss, there is significant increase in the probability of
tooth loss.
The efficacy of repeated SRP in residual pockets is rather limited, as only
11-16% of sites with poor responses to previous SRP might be brought to
a successful treatment endpoint.
27. In another study evaluating the outcome of re-instrumentation of residual
pockets, overall probability of achieving PPD ≤ 4 mm was about 45%,
while for sites with a PPD of > 6 mm, the probability was only 12%.
Periodontal surgery is an efficient method in treating deep periodontal
defects, but it can cause significant stress, pain and discomfort.
Non-surgical adjunctive treatments provide an alternative to periodontal
surgery to reduce the risk of tooth loss.
Antimicrobial Agents
Some antimicrobials require an effective concentration being maintained
for a sufficiently long duration at their target sites. The concentration
required for efficacy is often estimated from the Minimum Inhibitory
Concentration (MIC).
28. Antimicrobial agents in solid formulation generally maintains MIC
longer than gel type. MTZ is reported to maintain MIC within 24 hours,
whereas MIN can maintain its concentration about 4 days. In contrast,
the concentration of CHC remains above MIC for up to 9 days. Sustained
concentration of TCF can be maintained over 10 days. This may partly
explain why TCF and CHC achieved superior results when compared
with other antimicrobial agents in gel solution.
Photodynamic Therapy
The effectiveness of PDT depends on three factors: photosensitizer,
visible light, and oxygen. Different types of photosensitizer, light
application devices, output power, wavelengths, and duration of
exposure have been reported. Some photosensitizers may not be able to
attain sufficiently high concentrations to be absorbed by bacteria.
29. The microenvironment of residual pockets that contain less oxygen than
healthy sites might also hinder the effectiveness of PDT. Here, adjunctive
PDT achieved additional benefits only in 3-month follow-up. No studies
reported adverse events during the application of PDT.
Inconsistency different frequencies of PDT application.
Chondros et al. applied PDT only once at baseline as an adjunct to SRP,
and no additional benefits in PPD reduction and CAL gain were achieved
while significant PPD reduction and CAL gain were achieved after a
single use of adjunctive PDT in other studies.
Lulic et al. performed repeated applications of PDT five times at 14-day
intervals and found significant PPD reduction and CAL gain in 6 months
of follow-up. However, in a study comparing different frequencies of
PDT application (once vs twice with a 1-week interval), no significant
difference was observed.
30. According to previous studies, after SRP, subgingival microbiota
containing large numbers of pathogenic microorganisms repopulate
within 2 months in the absence of improved plaque control. More
recently, various studies have indicated that the application of adjunctive
antimicrobial agents results in significant reduction of bacteria for a 6
month follow-up period. Therefore, in a person whose oral hygiene can
be adequately achieved, locally delivered antimicrobial agents may help
in maintaining a low concentration of microorganisms for a longer
period of time than SRP alone does.
31. In the follow-up period shorter than 6 months, all adjunctive treatments
showed superior results to SRP alone, but no significant differences were
observed between different adjunctive treatments. Other factors, such as
ease of handling, probability of adverse events, or development of
resistant bacteria, may be taken into consideration. Typically, a gel-like
biomaterial is easier than fiber or chip materials to inject into the sulcus.
Adverse events may occur during or after the placement of local
antimicrobial agents. Generally, most studies have not reported severe
adverse events. The most commonly reported events were temporary
discomfort in the tooth and gingival tissue (i.e., gingival redness, tooth
pain, tooth hypersensitivity, stomatitis). The discomfort is alleviated or
subsided even without the use of analgesics in a short period of time.
Periodontal pathogens may develop antibiotic resistance when with
antibiotics are systemically or locally administered, whereas PDT and
CHC should be free of this consideration.
32. CONCLUSION
Adjunctive local antimicrobial agents achieved small additional PPD
reduction and CAL gain in residual pockets for a follow-up of up to 6
months. Tetracycline fiber and chlorhexidine chip achieved better results
than other antimicrobials.