CONTENTS LINE OF DEFENCE IMMUNE CELLS MAST CELLS NEUTROPHILS NET’s ANTIGEN PRESENTING CELLS OSTEOIMMUNOLOGY PROSTAGLANDINS MATRIX METALLOPROTEINS

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13. ROLE OF IMMUNE
CELLS IN HOST
MICROBIAL
INTERACTION
PREPARED BY,
DR. BEENA VIJAYAN
PARVATHY

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CONTENTS
• LINE OF DEFENCE
• IMMUNE CELLS
• MAST CELLS
• NEUTROPHILS
• NET’s
• ANTIGEN PRESENTING CELLS
• OSTEOIMMUNOLOGY
• PROSTAGLANDINS
• MATRIX METALLOPROTEINS

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IMMUNITY
Resistance exhibited by the host towards injury caused by microorganisms and their
products.
IMMUNITY SYSTEM
Collection of cells, tissues and molecules that function to defend against infectious
microbes.

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LINE OF DEFENSE

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COMPONENETS OF IMMUNITY SYSTEM
• Cell-Mediated Immunity
• Antibody-Mediated/ Humoral Immunity

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IMMUNE CELLS

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MAST CELLS
• Resident leukocytes.
• Receptors:
 Complement system components -
C3a & C5a
 Fc portion of antibody molecules –
IgE : FcER & IgG : Fc Γr
 TLR’s
• Contains lysosomes.
• Triggered by:
 IgE &IgG antibodies
 Antigens
 Cytokines
 C3a & C5a
 Drugs, Physical activity, Hormones

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NEUTROPHILS
• Polymorphonuclear leukocytes
• Crucial role in host defense.
• Contains 3 functional types of granules
 Azurophilic/Primary granules
Function: Phagocytosis
 Specific/Secondary granules
Named as “adhesomes”
 Gelatinase containing/Secretory/Tertiary granules
Function: Extravasation process

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Regulation of Neutrophil Production &
Distribution
Production Trafficking Clearance
• After entering circulation
• Transendothelial migration
• Chemotaxis
• Opsonization
• Phagocytosis “Abortive phagocytosis”
• Killing & Digestion

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TRANSENDOTHELIAL MIGRATION

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CHEMOTAXIS

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PHAGOCYTOSIS

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KILLING AND DIGESTION

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NEUTROPHIL EXTRACELLULAR TRAPS (NET's)
(Brinkmann et al, 2004)
PMN’s Viable  VITAL NETosis (Yipp B G, 2013)
NET’s after nuclear membrane & granular digestion or cell death  SUICIDAL NETosis
(Brinkmann et al, 2007,2018)

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ANTIGEN PRESENTING CELLS
Dendritic Cells
B Cells
Macrophages/Monocytes

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MACROPHAGES

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1. Adhesion
2. Scanning
3. Co stimulation
4. Differentiation
EVENTS IN T CELLACTIVATION

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PHASES OF IMMUNE REPONSE

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OSTEOIMMUNOLOGY

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PROSTOGLANDINS

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MATRIX METALLOPROTEINS