This document discusses challenges regarding energy efficiency and renewable energy in Mediterranean buildings. It summarizes three EU-funded projects - ELIH-MED, MARIE, and PROFORBIOMED - that brought together over 60 partners including regional authorities and universities. The projects produced a joint policy paper with strategic recommendations to promote low-carbon transition in Mediterranean buildings. Specifically, the paper calls for 1) a new multi-level governance model for building energy policies led by regions and cities, 2) adoption of regional energy efficiency strategies, and 3) increased use of EU funds for building energy renovation.