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LIVER
ANATOMY
• largest organ
• 1.5 kg
• thin capsule and by visceral peritoneum
• bare area
• two lobes
LIGAMENTS AND PERITONEAL
REFLECTIONS
• fixed in the right upper quadrant
• left triangular ligament
• The right triangular ligament
• falciform ligament (remnant of the umbilical
vein)
• lesser omentum
BLOOD SUPPLY
• coeliac trunk
• along with the splenic artery
• gastroduodenal artery
• right and left hepatic arteries
• right hepatic artery arising from the superior mesenteric
artery
• left gastric branch
HILUM OF THE LIVER
• bile duct to be within the free edge
• the hepatic artery to be above and medial
• portal vein to lie posteriorly
• common hepatic artery branches at a variable level within the
ligament to form two, or often three main arterial branches to the
liver
• The right hepatic artery often crosses the bile duct either anteriorly
or posteriorly before giving rise to the cystic artery
• portal vein left gastric vein joins just above the pancreas
VENOUS DRAINAGE
• The vena cava lies within a groove in the
posterior wall
• The inferior hepatic veins are short vessels
• three large veins
• The right hepatic vein can be exposed fully
outside the liver
INTERNAL ANATOMY
• Couinaud, a French anatomist
• eight segments
• branch of the hepatic artery, portal vein and bile
duct, and drained by a branch of the hepatic vein
• line between the gall bladder fossa and the
middle hepatic vein (Cantlie’s line)
HEPATIC LOBULES
• plates of liver cells separated by the hepatic sinusoids,
large, thin-walled venous channels that carry
• blood to the central vein, a tributary of the hepatic vein,
from the
• portal tracts, which contain branches of the hepatic artery
and
• portal vein. During passage through the sinusoids, the
many functions
• of the liver take place, including bile formation, which is
• channelled in an opposite direction to the blood flow to
drain via
• the bile duct tributaries within the portal tracts.
TESTS OF LIVER FUNCTION
• Bilirubin 5–17 μmol l–1
• Alkaline phosphatase (ALP) 35–130 IU l–1
• Aspartate transaminase (AST) 5–40 IU l–1
• Alanine transaminase (ALT) 5–40 IU l–1
• Gamma-glutamyl transpeptidase (GGT) 10–48 IU l–1
• Albumin 35–50 g l–1
• Prothrombin time (PT) 12–16 s
ULTRASOUND
• bile duct dilatation
• gallstones
• liver tumours
• flow in the hepatic artery, portal vein and
hepatic veins
• guiding the percutaneous biopsy
COMPUTERISED TOMOGRAPHY
• triple-phase, multislice, spiral computerised
tomography (CT)
• less than 1 cm
• Oral contrast enhancement
• The early arterial phase small liver cancers
• venous phase maps the branches of the portal
vein within the liver and the drainage via the
hepatic veins
• Inflammatory liver lesions exhibit rim
enhancement
• haemangioma late venous enhancement
• density cystic lesion
MAGNETIC RESONANCE IMAGING
• iodine-containing intravenous contrast
• magnetic resonance cholangiopancreatography
(MRCP) provides excellent quality, non-invasive
imaging of the biliary tract
• Magnetic resonance angiography (MRA) high-quality
images of the hepatic artery and portal Vein
• patency of the portal vein and its branches
ENDOSCOPIC RETROGRADE
CHOLANGIOPANCREATOGRAPHY
• Claustrophobia
• endoscopic intervention
• common bile duct (CBD) stones
• palliative biliary tract stent
• coagulation profile
• Prophylactic antibiotics
• pancreatitis, cholangitis and bleeding or
perforation of the duodenum related to
sphincterotomy.
PERCUTANEOUS TRANSHEPATIC
CHOLANGIOGRAPHY
• previous pancreatoduodenectomy
• Pólya gastrectomy
• hilar bile duct tumours
• guide external drainage of the bile ducts to
relieve jaundice
• direct stent insertion
ANGIOGRAPHY
• therapeutic intervention
• Prior to liver resection
• anatomy of the hepatic artery
• confirm patency or tumour involvemen of the portal vein
• occlusion of arteriovenous malformations
• embolisation of bleeding sites in the liver and liver tumours
(transarterial embolisation, TAE)
NUCLEAR MEDICINE SCANNING
• Iodoida technetium-99m (99mTc)-labelled
radionuclide that is administered intravenously
• processed by hepatocytes and excreted in the bile
• gamma camera
• sulphur colloid liver scan Kupffer cell activity
• adenomas and haemangiomas lack Kupffer cells
• 18F-2-fluoro-2-deoxy-D-glucose positron
emission tomography (FDG–PET)
• avid uptake of glucose by cancerous tissue
• Deoxyglucose is labelled with the positron
emitter fluorine-18 (18FDG)
LAPAROSCOPY AND LAPAROSCOPIC
ULTRASOUND
• staging of hepatopancreatobiliary cancers
• peritoneal metastases and superficial liver
tumours
• Laparoscopic ultrasound

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Artifacts in Nuclear Medicine with Identifying and resolving artifacts.
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Liver anatomy

  • 2. ANATOMY • largest organ • 1.5 kg • thin capsule and by visceral peritoneum • bare area • two lobes
  • 3. LIGAMENTS AND PERITONEAL REFLECTIONS • fixed in the right upper quadrant • left triangular ligament • The right triangular ligament • falciform ligament (remnant of the umbilical vein) • lesser omentum
  • 4. BLOOD SUPPLY • coeliac trunk • along with the splenic artery • gastroduodenal artery • right and left hepatic arteries • right hepatic artery arising from the superior mesenteric artery • left gastric branch
  • 5. HILUM OF THE LIVER • bile duct to be within the free edge • the hepatic artery to be above and medial • portal vein to lie posteriorly • common hepatic artery branches at a variable level within the ligament to form two, or often three main arterial branches to the liver • The right hepatic artery often crosses the bile duct either anteriorly or posteriorly before giving rise to the cystic artery • portal vein left gastric vein joins just above the pancreas
  • 6. VENOUS DRAINAGE • The vena cava lies within a groove in the posterior wall • The inferior hepatic veins are short vessels • three large veins • The right hepatic vein can be exposed fully outside the liver
  • 7. INTERNAL ANATOMY • Couinaud, a French anatomist • eight segments • branch of the hepatic artery, portal vein and bile duct, and drained by a branch of the hepatic vein • line between the gall bladder fossa and the middle hepatic vein (Cantlie’s line)
  • 8. HEPATIC LOBULES • plates of liver cells separated by the hepatic sinusoids, large, thin-walled venous channels that carry • blood to the central vein, a tributary of the hepatic vein, from the • portal tracts, which contain branches of the hepatic artery and • portal vein. During passage through the sinusoids, the many functions • of the liver take place, including bile formation, which is • channelled in an opposite direction to the blood flow to drain via • the bile duct tributaries within the portal tracts.
  • 9. TESTS OF LIVER FUNCTION • Bilirubin 5–17 μmol l–1 • Alkaline phosphatase (ALP) 35–130 IU l–1 • Aspartate transaminase (AST) 5–40 IU l–1 • Alanine transaminase (ALT) 5–40 IU l–1 • Gamma-glutamyl transpeptidase (GGT) 10–48 IU l–1 • Albumin 35–50 g l–1 • Prothrombin time (PT) 12–16 s
  • 10. ULTRASOUND • bile duct dilatation • gallstones • liver tumours • flow in the hepatic artery, portal vein and hepatic veins • guiding the percutaneous biopsy
  • 11. COMPUTERISED TOMOGRAPHY • triple-phase, multislice, spiral computerised tomography (CT) • less than 1 cm • Oral contrast enhancement • The early arterial phase small liver cancers
  • 12. • venous phase maps the branches of the portal vein within the liver and the drainage via the hepatic veins • Inflammatory liver lesions exhibit rim enhancement • haemangioma late venous enhancement • density cystic lesion
  • 13. MAGNETIC RESONANCE IMAGING • iodine-containing intravenous contrast • magnetic resonance cholangiopancreatography (MRCP) provides excellent quality, non-invasive imaging of the biliary tract • Magnetic resonance angiography (MRA) high-quality images of the hepatic artery and portal Vein • patency of the portal vein and its branches
  • 14. ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY • Claustrophobia • endoscopic intervention • common bile duct (CBD) stones • palliative biliary tract stent
  • 15. • coagulation profile • Prophylactic antibiotics • pancreatitis, cholangitis and bleeding or perforation of the duodenum related to sphincterotomy.
  • 16. PERCUTANEOUS TRANSHEPATIC CHOLANGIOGRAPHY • previous pancreatoduodenectomy • Pólya gastrectomy • hilar bile duct tumours • guide external drainage of the bile ducts to relieve jaundice • direct stent insertion
  • 17. ANGIOGRAPHY • therapeutic intervention • Prior to liver resection • anatomy of the hepatic artery • confirm patency or tumour involvemen of the portal vein • occlusion of arteriovenous malformations • embolisation of bleeding sites in the liver and liver tumours (transarterial embolisation, TAE)
  • 18. NUCLEAR MEDICINE SCANNING • Iodoida technetium-99m (99mTc)-labelled radionuclide that is administered intravenously • processed by hepatocytes and excreted in the bile • gamma camera • sulphur colloid liver scan Kupffer cell activity • adenomas and haemangiomas lack Kupffer cells
  • 19. • 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG–PET) • avid uptake of glucose by cancerous tissue • Deoxyglucose is labelled with the positron emitter fluorine-18 (18FDG)
  • 20. LAPAROSCOPY AND LAPAROSCOPIC ULTRASOUND • staging of hepatopancreatobiliary cancers • peritoneal metastases and superficial liver tumours • Laparoscopic ultrasound