LIPIDS:
LIPIDS:
structure and functions
structure and functions
V. I. Vernadsky Crimean Federal University
Medical Academy named after S. I. Georgievsky
Department of Biochemistry
Department of Biochemistry
Docent Ekaterina V. Parshkova
Docent Ekaterina V. Parshkova
LIPIDS (from ancient Greek λίπος - fat) -
these are organic compounds of various structures,
poorly soluble in water, but readily soluble in organic
polar solvents (chloroform, benzene, gasoline etc.),
most of the molecules are represented by esters of
mono- or polyalcohols and fatty acids .
*
*Although the term "fats" is sometimes used as a synonym for lipid
Although the term "fats" is sometimes used as a synonym for lipids
s,
, but
but fats
fats
are a subgroup of lipids called triglycerides
are a subgroup of lipids called triglycerides.
.
FUNCTIONS OF LIPIDS
- energetic (1 g ≈ 9,1 kcal)
- structural (cellular (organoids) membranes, myelin -
supporting and insulating substance of the NS)
- protective (for inner organs - insulates and cushion, cuticle of
plants, secrets of waterfowl, water reserve)
- regulatory (thermoregulation, signals transduction (steroid
hormones, sphingolipids), FS vitamins,
pigments, prostaglandins)
Kali Yuga
Kali Yuga of biochemistry
of biochemistry
CLASSIFICATION
CLASSIFICATION
of LIPIDS
of LIPIDS
DIFFERS IN
DIFFERS IN
STRUCTURE
STRUCTURE
SIMPLE
SIMPLE
LIPIDS
LIPIDS
CLASSIFICATION
CLASSIFICATION of LIPIDS
of LIPIDS
Phospholipids
Phospholipids
COMPLEX
COMPLEX
Glycoli
Glycoliр
рids
ids
Steroids
Steroids
Glycerides
(neutral fats, try- dy-
monoacylglycerins)
Waxes
Sphingolipids
Sphingolipids
WAXES
WAXES
cerumen (
cerumen (earwax
earwax)
)
lanolin
lanolin (
(from
from
sheep wool)
sheep wool)
Animal fats (mutton, beef, pork),
vegetable oils (olive, sunflower, corn, linseed).
TRIGLYCERIDES (neutral fats) are esters of higher fatty acids
and alcohol glycerol.
*
*Vegetable oils (generally liquid at room temperature
Vegetable oils (generally liquid at room temperature).
). E
Exception
xception -
- palm, cocoa.
palm, cocoa.
*
*Fats of animal
Fats of animals (
s (usually a
usually are
re solid at room temperature
solid at room temperature).
). E
Exception
xception -
- fish oil
fish oil.
.
NB! T
NB! The melting point depends on the amount of unsaturated acids
he melting point depends on the amount of unsaturated acids!
!
Formation of ester bonds
Formation of ester bonds
F
FATTY ACIDS AND THEIR NOMENCLATURE
ATTY ACIDS AND THEIR NOMENCLATURE
alpha to omega
alpha to omega
alpha to omega
alpha to omega
alpha to omega
alpha to omega
alpha to omega
alpha to omega
alpha to omega
alpha to omega
alpha to omega
alpha to omega
alpha to omega
alpha to omega
alpha to omega
alpha to omega
PHOSPHOLIPIDS
contain fatty acids, alcohol,
phosphoric acid and an
additional group of atoms, in
many cases containing nitrogen.
Glycerophospholipids
Glycerophospholipids
Phospholipids
Phospholipids structure
structure
MEDICINE DESIGN
MEDICINE DESIGN
Phospholipids in cell
Phospholipids in cell
membranes
membranes
GLYCOLIPIDS
GLYCOLIPIDS SPHINGOLIPIDS
SPHINGOLIPIDS
Digalactoseglycerol
sphingomyelin
SPHINGOLIPIDS
SPHINGOLIPIDS
SPHINGOLIPIDS
SPHINGOLIPIDS
Do not confuse the terms
Do not confuse the terms
“myelin” and
“myelin” and “sphingomyelin”
” !!
!!
STEROIDS - sterane derivatives
(cyclopentaneperhydrofenanthrene, gonan)
cholesterol
bile acids
steroid hormones
vitamin D
cardiac glycosides
cholesterol
LIPOPROTEINS
STRUCTURE
Thank you for attention!

Lipids_structure_classification_functions.ppt