This document discusses wound management and its costs on the healthcare system. It estimates that 1.5-2 million people in Europe suffer from acute or chronic wounds each year. While wound dressings are often seen as the main cost driver, nursing time and hospital costs actually account for 80-85% of total wound management costs. Demand for wound management is increasing due to aging populations and diseases like diabetes. However, nurse resources are limited and becoming more strained. To address this, the document argues that health systems must find more efficient ways to manage wounds to reconcile increasing demand with limited resources. Estimates suggest wound management costs could increase by 30% or more in some countries by 2020 without changes to efficiency.
ALE Presentation: A Multiple Cause Analysis of Massachusetts Trends in HIV an...David Meyers
In this presentation that I created for my Applied Learning Experience for my Master's education, I outline trends over the past ten years in HIV and Hepatitis C Mortality from across the state of Massachusetts.
Objective: Diabetic nephropathy is one of the most serious complications of diabetes mellitus. It develops in approximately one-third of diabetic patients, years after the onset of metabolic abnormalities.
Study Design: The biopsy specimens were evaluated with the focus on light microscopy. The aim of our study was to reveal differences in the details and the frequency of occurrence of individual histomorphological changes in diabetic nephropathy and other glomerulonephritides.
Results: Diabetic nephropathy accounted for 14 out of 82 analyzed biopsies. Isolated thickening of the glomerular basement membrane was not present in any case, but along with some degree of mesangial expansion, hypercellularity or glomerulosclerosis was seen in 12 out of 14 findings of diabetic nephropathy. In other glomerular diseases, mesangial changes, but without glomerular basement membrane thickening, were the most frequent findings. In addition to glomerular lesions, some of the tubular, interstitial, and vascular changes were seen in 13 out of 14 patients with diabetic nephropathy. In other glomerulonephritides the combination of all these changes was a rare finding.
Conclusion: There are cases where immunofluorescence and electron microscopy cannot be performed or their results are not helpful. In such cases we must rely on light microscopic histomorphological changes.
ALE Presentation: A Multiple Cause Analysis of Massachusetts Trends in HIV an...David Meyers
In this presentation that I created for my Applied Learning Experience for my Master's education, I outline trends over the past ten years in HIV and Hepatitis C Mortality from across the state of Massachusetts.
Objective: Diabetic nephropathy is one of the most serious complications of diabetes mellitus. It develops in approximately one-third of diabetic patients, years after the onset of metabolic abnormalities.
Study Design: The biopsy specimens were evaluated with the focus on light microscopy. The aim of our study was to reveal differences in the details and the frequency of occurrence of individual histomorphological changes in diabetic nephropathy and other glomerulonephritides.
Results: Diabetic nephropathy accounted for 14 out of 82 analyzed biopsies. Isolated thickening of the glomerular basement membrane was not present in any case, but along with some degree of mesangial expansion, hypercellularity or glomerulosclerosis was seen in 12 out of 14 findings of diabetic nephropathy. In other glomerular diseases, mesangial changes, but without glomerular basement membrane thickening, were the most frequent findings. In addition to glomerular lesions, some of the tubular, interstitial, and vascular changes were seen in 13 out of 14 patients with diabetic nephropathy. In other glomerulonephritides the combination of all these changes was a rare finding.
Conclusion: There are cases where immunofluorescence and electron microscopy cannot be performed or their results are not helpful. In such cases we must rely on light microscopic histomorphological changes.
Awareness regarding the systemic effects- PERIO SYSTEMIC RELATIONSHIPNagarajan Srini
For decades, physicians and dentists have paid close attention to their own respective fields, specializing in medicine pertaining to the body and the oral cavity, respectively. However, recent findings have strongly suggested that oral health may be indicative of systemic health. Currently, this gap between allopathic medicine and dental medicine is quickly closing, due to significant findings supporting the association between periodontal disease and systemic conditions such as cardiovascular disease, type 2 diabetes mellitus, adverse pregnancy outcomes, and osteoporosis. Significant effort has brought numerous advances in revealing the etiological and pathological links between this chronic inflammatory dental disease and these other conditions. Therefore, there is reason to hope that the strong evidence from these studies may guide researchers towards greatly improved treatment of periodontal infection that would also ameliorate these systemic illnesses. Hence, researchers must continue not only to uncover more information about the correlations between periodontal and systemic diseases but also to focus on positive associations that may result from treating periodontal disease as a means of ameliorating systemic diseases.
Ascaris lumbricoides and other Gastrointestinal Helminthic Parasites among Qe...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
15m people worldwide suffer a stroke every day. What can be done to combat the disease? This report, sponsored by AstraZeneca, assesses current developments and the economic burden of stroke across the regions of the world.
Abstract—Epidemiological study of Rivers State University of Science and Technology Port Harcourt, Nigeria was carried out to identify the morbidity pattern in the University community in order to establish the current health status and trends. This study utilized secondary morbidity data sourced from Health Services Department. Data on staff mortality were obtained from the Personnel/Establishment Division. Methods employed for data collection were health records survey and data collection sheets. Morbidity information required were date, sex, age, department, card number and diagnosis of each case. Information required for each mortality case was date, sex, age, department, salary level and the cause of death. Of all cases of morbidity, communicable diseases comprised 17.5%; non-communicable diseases 24.1%, generalized disease symptoms 55.2% and others 3.2%. The study revealed that the leading causes of morbidity in the University were fever/headache/cold (36.9%), hypertension (13.6%), generalized body pain (7.5%), abdominal pain/vomiting (6.7%) and diabetes (4.9%). Hypertension emerged the second major cause of morbidity among the staff and males had higher rate of morbidity compared to females. It was also concluded that although mortality was increasing with time but there was no sex wise significant difference in mortality trend. It was recommended among others that Diabetes Mellitus and Hypertension being silent killers should be monitored regularly within the University community. Also the current practice of manual data entry should be replaced with computerized data system for better health records management.
Sexually transmitted diseases in the elderly in South FloridaArete-Zoe, LLC
Florida is attractive for retired Americans, and their population continues to grow. In primary care, sexual health is often overlooked in elderly patients, since they rarely open the topic themselves, and physicians often assume their patients are no longer sexually active. Drugs for erectile dysfunction, as well as attractions of life on the beach, create opportunities that may no longer be out of reach. Mature adults do indeed have girlfriends and friends with benefits, along with their regular partners and spouses.
The number of reported STDs in older adults has been steadily increasing since 2000. The most frequently reported infections are chlamydia, gonorrhea, and HIV. The population of adults over 50 years of age now reached 99 million (32%) and should not be ignored in regards to screening for STDs and related research. Clinical trials rarely study the sexual behavior of people over 50 or even 65 years of age. In the age group between 57 and 85 years of age, nearly 75% were still sexually active at 64, 53% at 74, and 25% at 85 years of age. The sexual life of mature adults is often neglected during preventative screenings. This omission may lead to late diagnosis of HIV or undetected relapse of STDs contracted earlier in life. AIDS-related dementia or neurosyphilis can be easily misdiagnosed as Alzheimer’s disease. Failure to detect STDs in mature adults can result in unnecessary early death and unmitigated exposure of relatives to the disease (Purpora & Claire, 2012).
Many STDs are notifiable diseases that require regular screening of patients who are sexually active or engage in potentially risky sexual behavior. Clinicians need to keep track of relevant federal and state legislation and comply with the reporting requirements as applicable.
A Study on Food Habits and Social Habits as Risk Factors among Patients Under...ijtsrd
AIM A study on food habits and social habits as risk factors among patients undergoing Percutaneous Transluminal Coronary Angioplasty PTCA OBJECTIVE To know the association of food habits and social habits as risk factors for PTCA. To observe various co morbidities among the patients To study the bio chemical parameters in patients such as heamoglobin, PVC, platelet count, bilirubin levels. To observe various social habits in the patient, such as smoking and alcohol consumption. Food consumption pattern. METHODOLOGY The sample population n = 60 of 28 80 years of age were chosen from a multi speciality hospital in Hyderabad. All the patients were of different age groups, sex, socio economic status, ethnicity with different co morbidities. A pre tested format consisting of patients profile, subjective data, objective data, biochemical data, medications and 24 hour dietary recall followed by medical nutrition therapy during the hospital stay. RESULTS Among n=60 subjects from 28 80 years of age, the detailed study identified the common risk factors with respect to cardiovascular diseases. The study showed a higher percentage of age from 28 70 years and is mostly in males. Majority of the patients are with increased BMI and are alcholics smokers. Obesity, Hypertension and Diabetes are predominant and dietary patterns recorded are mostly non vegetarians with high calorie, high fat and high protein consumption. CONCLUSION From the result it is very clear that majority of the patients studied with cardiovascular diseases belong to the age group 28 70 years and is mostly seen in males. Majority of them are accompanied with co morbidities with obesity, hypertension and diabetic. And predominantly follow a high calorie and high fat diet .Thus leading to a conclusion that consumption of high calorie and high fat food, presence of co morbidities and smoking could be the risk factors of PTCA. Mrs. Meena Kumari | Mrs. Y. V. Phani Kumari | Gwyneth Madhulika Bashapaga | Ittamala Jaya Rachel ""A Study on Food Habits and Social Habits as Risk Factors among Patients Undergoing Percatenous Transluminal Coronary Angioplasty (PTCA)"" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-3 , April 2019, URL: https://www.ijtsrd.com/papers/ijtsrd23372.pdf
Paper URL: https://www.ijtsrd.com/other-scientific-research-area/other/23372/a-study-on-food-habits-and-social-habits-as-risk-factors-among-patients-undergoing-percatenous-transluminal-coronary-angioplasty-ptca/mrs-meena-kumari
Awareness regarding the systemic effects- PERIO SYSTEMIC RELATIONSHIPNagarajan Srini
For decades, physicians and dentists have paid close attention to their own respective fields, specializing in medicine pertaining to the body and the oral cavity, respectively. However, recent findings have strongly suggested that oral health may be indicative of systemic health. Currently, this gap between allopathic medicine and dental medicine is quickly closing, due to significant findings supporting the association between periodontal disease and systemic conditions such as cardiovascular disease, type 2 diabetes mellitus, adverse pregnancy outcomes, and osteoporosis. Significant effort has brought numerous advances in revealing the etiological and pathological links between this chronic inflammatory dental disease and these other conditions. Therefore, there is reason to hope that the strong evidence from these studies may guide researchers towards greatly improved treatment of periodontal infection that would also ameliorate these systemic illnesses. Hence, researchers must continue not only to uncover more information about the correlations between periodontal and systemic diseases but also to focus on positive associations that may result from treating periodontal disease as a means of ameliorating systemic diseases.
Ascaris lumbricoides and other Gastrointestinal Helminthic Parasites among Qe...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
15m people worldwide suffer a stroke every day. What can be done to combat the disease? This report, sponsored by AstraZeneca, assesses current developments and the economic burden of stroke across the regions of the world.
Abstract—Epidemiological study of Rivers State University of Science and Technology Port Harcourt, Nigeria was carried out to identify the morbidity pattern in the University community in order to establish the current health status and trends. This study utilized secondary morbidity data sourced from Health Services Department. Data on staff mortality were obtained from the Personnel/Establishment Division. Methods employed for data collection were health records survey and data collection sheets. Morbidity information required were date, sex, age, department, card number and diagnosis of each case. Information required for each mortality case was date, sex, age, department, salary level and the cause of death. Of all cases of morbidity, communicable diseases comprised 17.5%; non-communicable diseases 24.1%, generalized disease symptoms 55.2% and others 3.2%. The study revealed that the leading causes of morbidity in the University were fever/headache/cold (36.9%), hypertension (13.6%), generalized body pain (7.5%), abdominal pain/vomiting (6.7%) and diabetes (4.9%). Hypertension emerged the second major cause of morbidity among the staff and males had higher rate of morbidity compared to females. It was also concluded that although mortality was increasing with time but there was no sex wise significant difference in mortality trend. It was recommended among others that Diabetes Mellitus and Hypertension being silent killers should be monitored regularly within the University community. Also the current practice of manual data entry should be replaced with computerized data system for better health records management.
Sexually transmitted diseases in the elderly in South FloridaArete-Zoe, LLC
Florida is attractive for retired Americans, and their population continues to grow. In primary care, sexual health is often overlooked in elderly patients, since they rarely open the topic themselves, and physicians often assume their patients are no longer sexually active. Drugs for erectile dysfunction, as well as attractions of life on the beach, create opportunities that may no longer be out of reach. Mature adults do indeed have girlfriends and friends with benefits, along with their regular partners and spouses.
The number of reported STDs in older adults has been steadily increasing since 2000. The most frequently reported infections are chlamydia, gonorrhea, and HIV. The population of adults over 50 years of age now reached 99 million (32%) and should not be ignored in regards to screening for STDs and related research. Clinical trials rarely study the sexual behavior of people over 50 or even 65 years of age. In the age group between 57 and 85 years of age, nearly 75% were still sexually active at 64, 53% at 74, and 25% at 85 years of age. The sexual life of mature adults is often neglected during preventative screenings. This omission may lead to late diagnosis of HIV or undetected relapse of STDs contracted earlier in life. AIDS-related dementia or neurosyphilis can be easily misdiagnosed as Alzheimer’s disease. Failure to detect STDs in mature adults can result in unnecessary early death and unmitigated exposure of relatives to the disease (Purpora & Claire, 2012).
Many STDs are notifiable diseases that require regular screening of patients who are sexually active or engage in potentially risky sexual behavior. Clinicians need to keep track of relevant federal and state legislation and comply with the reporting requirements as applicable.
A Study on Food Habits and Social Habits as Risk Factors among Patients Under...ijtsrd
AIM A study on food habits and social habits as risk factors among patients undergoing Percutaneous Transluminal Coronary Angioplasty PTCA OBJECTIVE To know the association of food habits and social habits as risk factors for PTCA. To observe various co morbidities among the patients To study the bio chemical parameters in patients such as heamoglobin, PVC, platelet count, bilirubin levels. To observe various social habits in the patient, such as smoking and alcohol consumption. Food consumption pattern. METHODOLOGY The sample population n = 60 of 28 80 years of age were chosen from a multi speciality hospital in Hyderabad. All the patients were of different age groups, sex, socio economic status, ethnicity with different co morbidities. A pre tested format consisting of patients profile, subjective data, objective data, biochemical data, medications and 24 hour dietary recall followed by medical nutrition therapy during the hospital stay. RESULTS Among n=60 subjects from 28 80 years of age, the detailed study identified the common risk factors with respect to cardiovascular diseases. The study showed a higher percentage of age from 28 70 years and is mostly in males. Majority of the patients are with increased BMI and are alcholics smokers. Obesity, Hypertension and Diabetes are predominant and dietary patterns recorded are mostly non vegetarians with high calorie, high fat and high protein consumption. CONCLUSION From the result it is very clear that majority of the patients studied with cardiovascular diseases belong to the age group 28 70 years and is mostly seen in males. Majority of them are accompanied with co morbidities with obesity, hypertension and diabetic. And predominantly follow a high calorie and high fat diet .Thus leading to a conclusion that consumption of high calorie and high fat food, presence of co morbidities and smoking could be the risk factors of PTCA. Mrs. Meena Kumari | Mrs. Y. V. Phani Kumari | Gwyneth Madhulika Bashapaga | Ittamala Jaya Rachel ""A Study on Food Habits and Social Habits as Risk Factors among Patients Undergoing Percatenous Transluminal Coronary Angioplasty (PTCA)"" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-3 , April 2019, URL: https://www.ijtsrd.com/papers/ijtsrd23372.pdf
Paper URL: https://www.ijtsrd.com/other-scientific-research-area/other/23372/a-study-on-food-habits-and-social-habits-as-risk-factors-among-patients-undergoing-percatenous-transluminal-coronary-angioplasty-ptca/mrs-meena-kumari
The Journal of General Medicine, India’s first on-line medical journal that promises to deliver both quality and varied content that would benefit ALL Doctors across specialties.
BJS commission on surgery and perioperative care post covid-19Ahmad Ozair
Background: Coronavirus disease 2019 (COVID-19) was declared a pandemic by the WHO on 11 March 2020 and global surgical practice was compromised. This Commission aimed to document and reflect on the changes seen in the surgical environment during the pandemic, by reviewing colleagues’ experiences and published evidence. Methods: In late 2020, BJS contacted colleagues across the global surgical community and asked them to describe how severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) had affected their practice. In addition to this, the Commission undertook a literature review on the impact of COVID-19 on surgery and perioperative care. A thematic analysis was performed to identify the issues most frequently encountered by the correspondents, as well as the solutions and ideas suggested to address them. Results: BJS received communications for this Commission from leading clinicians and academics across a variety of surgical specialties in every inhabited continent. The responses from all over the world provided insights into multiple facets of surgical practice from a governmental level to individual clinical practice and training. Conclusion: The COVID-19 pandemic has uncovered a variety of problems in healthcare systems, including negative impacts on surgical practice. Global surgical multidisciplinary teams are working collaboratively to address research questions about the future of surgery in the post-COVID-19 era. The COVID-19 pandemic is severely damaging surgical training. The establishment of a multidisciplinary ethics committee should be encouraged at all surgical oncology centres. Innovative leadership and collaboration is vital in the post-COVID-19 era.
This paper reviews the evolution of the definition of sepsis and the controversy surrounding the sepsis-3 definition and the sepsis screening tool, qSOFA.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path