The document discusses heterotrophic nutrition and the human digestive system. It describes how different organisms obtain nutrition from food sources in various ways like saprophytic and parasitic nutrition. It then explains the human digestive system in detail, including the roles of the mouth, stomach, small intestine, liver, pancreas and digestive enzymes in breaking down food and absorbing nutrients. The small intestine has villi and microvilli that increase surface area for absorption. Peristalsis helps move food through the digestive tract.
Introduction to digestive system
Organs of digestive tract
Mouth and their different enzymes and actions
salivary glands
Oesophagus
Stomach
Small Intestine and funcions
Large Intestine and functions
Anus
Assessary Organs
Liver
Pancreas
Digestive system Physiology
Ingestion
Digestion
Absorption
Assimilation.
Excretion
Introduction to digestive system
Organs of digestive tract
Mouth and their different enzymes and actions
salivary glands
Oesophagus
Stomach
Small Intestine and funcions
Large Intestine and functions
Anus
Assessary Organs
Liver
Pancreas
Digestive system Physiology
Ingestion
Digestion
Absorption
Assimilation.
Excretion
Human have a special digestive system than the other animals. We have to know how our body digest our food after having a meal. So, let's check it out.
This lecture illustrates the basics of the digestive system and the roles each section within the GI tract plays in the digestion and absorption of our macro-nutrients
Human have a special digestive system than the other animals. We have to know how our body digest our food after having a meal. So, let's check it out.
This lecture illustrates the basics of the digestive system and the roles each section within the GI tract plays in the digestion and absorption of our macro-nutrients
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
2. HETEROTROPIC NUTRITION
The form of nutrition differs depending on the type and availability
of food material as well as how it is obtained by the organism. For
example, whether the food source is stationary (such as grass) or
mobile (such as a deer), would allow for differences in how the food
is accessed and what is the nutritive apparatus used by a cow and a
lion.
There is a range of strategies by which the food is taken in and used
by the organism. Some organisms break-down the food material
outside the body and then absorb it (Saprophytic nutrition).
Examples are fungi like bread moulds, yeast and mushrooms.
(Saprophytes)
Note: The term nutritive apparatus refers to strategy used by an organism to obtain its nutrition
from food source.
Apparatus: The complex structure of a particular organization or system.
3. Others take in whole material and break it down inside their bodies.
What can be taken in and broken down depends on the body design
and functioning. Some other organisms derive nutrition from plants
or animals without killing them. This parasitic nutritive strategy is
used by a wide variety of organisms like cuscuta (amarbel), ticks,
lice, leeches and tape-worms (parasites).
HETEROTROPIC NUTRITION
HOW DO ORGANISMS OBTAIN THEIR NUTRITION
Since the food and the way it is obtained differ, the digestive system
is different in various organisms. In single-celled organisms, the
food may be taken in by the entire surface. But as the complexity of
the organism increases, different parts become specialised to
perform different functions.
4. For example, Amoeba takes in food using temporary
finger-like extensions of the cell surface which fuse
over the food particle forming a food-vacuole. Inside
the food vacuole, complex substances are broken
down into simpler ones which then diffuse into the
cytoplasm. The remaining undigested material is
moved to the surface of the cell and thrown out. In
Paramoecium, which is also a unicellular organism,
the cell has a definite shape and food is taken in at a
specific spot. Food is moved to this spot by the
movement of cilia which cover the entire surface of
the cell.
NUTRITION IN AMOEBA
5. NUTRITION IN HUMAN BEINGS
The alimentary canal is
basically a long tube extending
from the mouth to the anus. The
tube has different parts. Various
regions are specialised to
perform different functions.
What happens to the food once
it enters our body?
Human alimentary
alimentary canal/ digestive tract/
gut/ gastrointestinal tract/
6. 1. Take 1 mL starch solution (1%) in two test tubes (A and B).
2. Add 1 mL saliva to test tube A and leave both test tubes
undisturbed for 20-30 minutes.
3. Now add a few drops of dilute iodine solution to the test tubes.
In which test tube do you observe a colour change?
What does this indicate about the presence or absence of starch in
the two test tubes?
What does this tell us about the action of saliva on starch?
BIOLOGICAL CATALYSTS -ACTIVITY
7. DIGESTIVE SYSTEM
Digestive system: Digestive Tract/ Alimentary Canal and all the
associative Glands together form this system.
We eat various types of food which has to pass through the same
digestive tract. Naturally the food has to be processed to generate
particles which are small and of the same texture. This is achieved by
crushing the food with our teeth. Since the lining of the canal is soft,
the food is also wetted to make its passage smooth. When we eat
something we like, our mouth ‘waters’. This is actually not only water,
but a fluid called saliva (contains amylase/ptyalin) secreted by the
salivary glands. Another aspect of the food we ingest is its complex
nature. If it is to be absorbed from the alimentary canal, it has to be
broken into smaller molecules.
8. DIGESTIVE SYSTEM
This is done with the help of
biological catalysts called
enzymes. The saliva contains an
enzyme called salivary amylase
that breaks down starch which is
a complex molecule to give
simple sugar (maltose). The food
is mixed thoroughly with saliva
and moved around the mouth
while chewing by the muscular
tongue.
9. DIGESTIVE SYSTEM
Digestive juices and enzymes Substance digested Product formed
Saliva
Amylase
Starch Maltose
Gastric juice
Protease (pepsin)
Hydrochloric acid
Proteins Partly digested proteins
Pancreatic juice
Proteases (trypsin)
Lipases
Amylase
Proteins
Fats emulsified by bile
Starch
Peptides and amino acids
Fatty acids and glycerol
Maltose
Intestinal enzymes
Peptidases/Proteases
Sucrase
Lactase
Maltase
Peptides
Sucrose (sugar)
Lactose (milk sugar)
Maltose
Amino acids
Glucose and fructose
Glucose and galactose
Glucose
Bile from the liver
Bile salts
Fats globules Fat droplets
10. DIGESTIVE SYSTEM
It is necessary to move the food in a regulated manner along the
digestive tube so that it can be processed properly in each part. The
lining of canal has muscles that contract rhythmically in order to
push the food forward (Peristalsis). These peristaltic movements
occur all along the gut.
From the mouth, the food is taken to the stomach through the food-
pipe or oesophagus. The stomach is a large organ which expands
when food enters it. The muscular walls of the stomach help in mixing
the food thoroughly with more digestive juices. The digestion in
stomach is taken care of by the gastric glands present in the wall of the
stomach. These release hydrochloric acid, a protein digesting enzyme
called pepsin, and mucus. The hydrochloric acid creates an acidic
medium which facilitates the action of the enzyme pepsin.
11. DIGESTIVE SYSTEM
What other function do you think is served by the acid?
The mucus protects the inner lining of the stomach from the action of
the acid under normal conditions. We have often heard adults
complaining about ‘acidity’. Can this be related to what has been
discussed above? The exit of food from the stomach is regulated by a
sphincter muscle which releases it in small amounts into the small
intestine. From the stomach, the food now enters the small intestine.
This is the longest part of the alimentary canal which is fitted into a
compact space because of extensive coiling. The length of the small
intestine differs in various animals depending on the food they eat.
Herbivores eating grass need a longer small intestine to allow the
cellulose to be digested. Meat is easier to digest, hence carnivores like
tigers have a shorter small intestine.
12. TO KNOW MORE
Some enzymes secreted by small intestine
Erepsin: converts peptones and polypeptides into amino acids.
Maltase: converts maltose into glucose.
Lactase: converts lactose into glucose and galactose
Sucrase: converts sucrose into glucose and fructose
Some enzymes secreted by pancreas
The two major pancreatic proteases are
Trypsin & Chymotrypsin: digest proteins into
peptides and peptides into smaller peptides.
Pancreatic Lipase: converts fat (triglycerides) into
mnoglyceride and fatty acids
Pancreatic amylase : converts starch into maltose.
Nuclease: cleaves nucleic acids into nucleotides.
13. A sphincter is a circular muscle that normally maintains constriction of a natural body passage
or orifice and which relaxes as required by normal physiological functioning.
The sphincter of oddi is the muscular valve (muscles) surrounding the exit of the common bile
duct and pancreatic duct into the duodenum. The sphincter is normally closed and opens only
in response to a meal to allow digestive juices to enter the duodenum for the digestion of food .
The major duodenal papilla is a rounded projection at the opening of the common bile duct
and pancreatic duct into the duodenum. The major duodenal papilla is the primary
mechanism for the secretion of bile and other enzymes that facilitate digestion.
The ampulla of Vater, also known as the hepatopancreatic ampulla or the hepatopancreatic
duct, is formed by the union of the pancreatic duct and the common bile duct. The ampulla is
specifically located at the major duodenal papilla.
TO KNOW MORE
14. The small intestine is the site of the complete digestion of
carbohydrates, proteins and fats. It receives the secretions of the liver
and pancreas for this purpose. The food coming from the stomach is
acidic and has to be made alkaline for the pancreatic enzymes to act.
Bile juice from the liver (stores in gall bladder) accomplishes this in
addition to acting on fats. Fats are present in the intestine in the form
of large globules which makes it difficult for enzymes to act on them.
Bile salts break them down into smaller globules increasing the
efficiency of enzyme action. This is similar to the emulsifying action
of soaps on dirt . The pancreas secretes pancreatic juice which
contains enzymes like trypsin for digesting proteins and lipase for
breaking down emulsified fats and amylase for digesting starch.
SMALL INTESTINE
15. The walls of the small intestine contain glands which secrete intestinal
juice. The enzymes present in it finally convert the proteins to amino
acids, complex carbohydrates into glucose and fats into fatty acids and
glycerol.
Digested food is taken up by the walls of the intestine. The inner lining of
the small intestine has numerous finger-like projections/outgrowths
called villi which increase the surface area for absorption. The villi are
richly supplied with blood vessels which take the absorbed food to each
and every cell of the body, where it is utilised for obtaining energy,
building up new tissues and the repair of old tissues.
The unabsorbed food is sent into the large intestine where its wall absorb
more water from this material. The rest of the material is removed from
the body via the anus. The exit of this waste material is regulated by the
anal sphincter.
SMALL INTESTINE
18. TO KNOW MORE
Dental caries
Dental caries or tooth decay causes gradual softening of enamel and
dentine. It begins when bacteria acting on sugars produce acids that
softens or demineralises the enamel. Masses of bacterial cells
together with food particles stick to the teeth to form dental plaque.
Saliva cannot reach the tooth surface to neutralise the acid as plaque
covers the teeth. Brushing the teeth after eating removes the plaque
before the bacteria produce acids. If untreated, microorganisms may
invade the pulp, causing inflammation and infection.
19. QUESTIONS
1. What is the role of the acid in our stomach?
2. What is the function of digestive enzymes?
3. How is the small intestine designed to absorb digested food?
4. Name the enzymes that are secreted by the following organs:
a) Salivary gland b) Stomach c) Pancreas
5. What do you mean by peristalsis?
6. What are villi and what is their role?
7. What is the role of mucus in the stomach?
8. Write a short note on:
a) Sphincter muscles b) Bile juice/salts
c) Dental caries or tooth decay d) Pancreatic juice
20. QUESTIONS
1. Distinguish between autotrophs and heterotrophs?
2. What do you mean by saprophytic nutrition and parasitic
nutrition? Explain with suitable examples.
3. Explain the mode of nutrition in amoeba with the help of a
labelled diagram?
4. Draw the labelled diagram of human digestive system.
5. Which bio-chemical substances in our body are called biological
catalysts?
6. Write the function of the enzymes secreted by the glands present
in the small intestine.
21. QUESTIONS
1. Match the column A with the column B correctly.
Column-A Column-B
Pepsin breaks down fats
Amylase breaks down proteins
Lipase breaks down starch
Bile Juice emulsifies fats
2. Name the site of complete digestion of proteins, carbohydrates
and fats in human digestive system.
3. Name the muscles in digestive tract that regulate the exit of food
from one part to another.
4. Herbivores have longer small intestine than that of carnivores.
Give reason.
5. How does pH changes from mouth to small intestine and why?
