The document describes the integumentary system, which includes the skin, hair, nails, and glands. It discusses the layers of the skin (epidermis and dermis), associated glands like sweat and sebaceous glands, the structure and layers of hair, and the parts and function of nails. The integumentary system acts as a protective barrier for the body, regulates temperature, and has sensory, excretory and synthetic functions.
The integumentary system comprises the skin and its appendages. Skin + derivatives= Integument.
It aims to protect the body from various kinds of damage, such as loss of water or damages from outside.
The integumentary system in chordates includes hair, scales, feathers, hooves, and nails.
It may serve to water proof, and protect the deeper tissues.
Excrete wastes, and regulate body temperature.
It is the attachment site for sensory receptors to detect pain, sensation, pressure, and temperature.
The integumentary system comprises the skin and its appendages. Skin + derivatives= Integument.
It aims to protect the body from various kinds of damage, such as loss of water or damages from outside.
The integumentary system in chordates includes hair, scales, feathers, hooves, and nails.
It may serve to water proof, and protect the deeper tissues.
Excrete wastes, and regulate body temperature.
It is the attachment site for sensory receptors to detect pain, sensation, pressure, and temperature.
Integumentary system
-The organs of the integumentary system include the skin and its accessory structures including hair, nails, and glands, as well as blood vessels, muscles and nerves.
-Dermatology is the medical specialty for the diagnosis and treatment of disorders of the integumentary system.
Structure Of The Skin
The skin (cutaneous membrane) covers the body and is the largest organ of the body by surface area and weight.
Its area is about 2 square meters (22 square feet) and weighs 4.5-5kg (10-11 lb), about 7% of body weight.
It is 0.5 – 4 mm thick, thinnest on the eyelids, thickest on the heels, the average thickness is 1 – 2 mm.
It consists of two major layers:
Outer, thinner layer called the epidermis, consists of epithelial tissue. Inner, thicker layer called the dermis.
Beneath the dermis is a subcutaneous layer (also called hypodermis) which attaches the skin to the underlying tissues and organs.
1. EPIDERMIS
-Covers, protects and waterproofs.
Contains five main layers:
- Stratum Basale
- Stratum Spinosum
- Stratum Granulosum
- Stratum lucidum
- Stratum corneum
The epidermis has a number of important characteristics:
The epidermis is composed of keratinized stratified squamous epithelium.
-It contains four major types of cells:
Keratinocytes (90% of the cells): It produce keratin which is a tough fibrous protein that provides protection.
-Melanocytes: which produce the pigment melanin that protects against damage by ultraviolet radiation.
-Langerhans cells: involved in immune responses, arise from red bone marrow.
-Merkel cells: which function in the sensation of touch along with the adjacent tactile discs.
2. DERMIS
-It is a deeper layer of skin, composed of connective tissue containing collagen and elastic fibers.
-It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands.
-The epidermis is avascular and cells of this layer get their oxygen and nutrients from capillaries in the dermis.
-The dermis can be divided into papillary layer and reticular layer.
Hypodermis :
- The hypodermis (also called the subcutaneous layer) is a layer directly below the dermis and serves to connect the skin to the underlying fascia (fibrous tissue) of the bones and muscles.
--Two types of glands are present in the skin over most of the body
These are sweat glands and sebaceous glands.
--Function Of Skin
Protection:
Sensation:
Heat regulation:
Storage and synthesis:
Synthesis of vitamin D:
Excretion and homeostasis:
Secretion:
Absorption:
Water resistance:
Colour :
Healing of wounds:
Aids in the diagnosis:
The branch of science concerned with the bodily structure of humans, animals, and other living organisms, especially as revealed by dissection and the separation of parts.
The integumentary system is an organ system consisting of the skin, hair, nails, and exocrine glands. The skin is only a few millimeters thick yet is by far the largest organ in the body. The average person's skin weighs 10 pounds and has a surface area of almost 20 square feet.
In this slide Structure of Skin and Hair, Hair Growth Cycle were described followed by skin related diseases such as Acne, dry skin, pigmentation, wrinkles etc.
Integumentary system
-The organs of the integumentary system include the skin and its accessory structures including hair, nails, and glands, as well as blood vessels, muscles and nerves.
-Dermatology is the medical specialty for the diagnosis and treatment of disorders of the integumentary system.
Structure Of The Skin
The skin (cutaneous membrane) covers the body and is the largest organ of the body by surface area and weight.
Its area is about 2 square meters (22 square feet) and weighs 4.5-5kg (10-11 lb), about 7% of body weight.
It is 0.5 – 4 mm thick, thinnest on the eyelids, thickest on the heels, the average thickness is 1 – 2 mm.
It consists of two major layers:
Outer, thinner layer called the epidermis, consists of epithelial tissue. Inner, thicker layer called the dermis.
Beneath the dermis is a subcutaneous layer (also called hypodermis) which attaches the skin to the underlying tissues and organs.
1. EPIDERMIS
-Covers, protects and waterproofs.
Contains five main layers:
- Stratum Basale
- Stratum Spinosum
- Stratum Granulosum
- Stratum lucidum
- Stratum corneum
The epidermis has a number of important characteristics:
The epidermis is composed of keratinized stratified squamous epithelium.
-It contains four major types of cells:
Keratinocytes (90% of the cells): It produce keratin which is a tough fibrous protein that provides protection.
-Melanocytes: which produce the pigment melanin that protects against damage by ultraviolet radiation.
-Langerhans cells: involved in immune responses, arise from red bone marrow.
-Merkel cells: which function in the sensation of touch along with the adjacent tactile discs.
2. DERMIS
-It is a deeper layer of skin, composed of connective tissue containing collagen and elastic fibers.
-It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands.
-The epidermis is avascular and cells of this layer get their oxygen and nutrients from capillaries in the dermis.
-The dermis can be divided into papillary layer and reticular layer.
Hypodermis :
- The hypodermis (also called the subcutaneous layer) is a layer directly below the dermis and serves to connect the skin to the underlying fascia (fibrous tissue) of the bones and muscles.
--Two types of glands are present in the skin over most of the body
These are sweat glands and sebaceous glands.
--Function Of Skin
Protection:
Sensation:
Heat regulation:
Storage and synthesis:
Synthesis of vitamin D:
Excretion and homeostasis:
Secretion:
Absorption:
Water resistance:
Colour :
Healing of wounds:
Aids in the diagnosis:
The branch of science concerned with the bodily structure of humans, animals, and other living organisms, especially as revealed by dissection and the separation of parts.
The integumentary system is an organ system consisting of the skin, hair, nails, and exocrine glands. The skin is only a few millimeters thick yet is by far the largest organ in the body. The average person's skin weighs 10 pounds and has a surface area of almost 20 square feet.
In this slide Structure of Skin and Hair, Hair Growth Cycle were described followed by skin related diseases such as Acne, dry skin, pigmentation, wrinkles etc.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
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Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
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Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
2. At the end of this lesson, the students
should be able to
- Describe skin of the human body
- Discuss glands of the skin
- Explain the structure and function of hair
- Discuss about nails
3. INTEGUMENTARY SYSTEM:
The integumentary system is the largest organ of the body. It forms
a physical barrier between the external environment and the
internal environment and protect the body.
The integumentary system includes:
1.Skin (epidermis, dermis)
2.Hypodermis
3.Associated glands
4.Hair
5.Nails.
1. SKIN:
4. Skin occupy 16% of our total body weight
Skin is made up by two layers:
i.Epidermis:
It is a superficial layer of the skin
It contains four principal types of cells:
keratinocytes, melanocytes, Langerhans cells,
and Merkel cells.
5. About 90% of epidermal cells are keratinocytes which are arranged
in four or five layers and produce the protein keratin, tough layer.
About 8% of the epidermal cells are melanocytes which produce
pigment melanin. Melanin is a yellow-red or brown-black pigment
that contributes to skin color and absorbs damaging ultraviolet (UV)
light.
Langerhans cells develop from red bone marrow and migrate to
the epidermis. They protect us from microbes.
Merkel cells located in the deepest layer of the epidermis, it detect
touch sensations.
6.
7. Layers of Epidermis: (from deep to superficial):
a.Stratum basale or germinatum – single row of cells
attached to dermis; youngest cells
b.Stratum spinosum – Made up of bundles of protein resist
tension
c.Stratum granulosum – layers of flattened keratinocytes
producing keratin.
d.Stratum lucidum- (only found in thick skin – that is, the
palms of the hands, the soles of the feet and the digits)
e.Stratum corneum – horn cornified superficial layer
9. ii.Dermis:
It is a deep layer of skin made up by fibre and it having
good tensile strength.
It is divided in papillary and reticular region.
a)The Papillary Dermis: The papillary dermis is the more
superficial of the two, and lies just beneath the epidermal
junction. It is relatively thin and is made up of loose
connective tissue, which includes:
oCapillaries
oElastic fibers
oReticular fibers
oCollagen
10. b)The Reticular dermis: The reticular dermis is the
deeper and thicker layer of the
dermis, which lies above the subcutaneous layer of the
skin. It contains dense connective tissue, which
includes:
oBlood vessels
oElastic fibers (interlaced)
oCollagen fibers (in parallel layers)
oFibroblasts
oMast cells
oNerve endings
oLymphatics
11. FUNCTION OF THE SKIN
1. Protection
2. Temperature regulation
3. Excretion
4. Synthesis
5. Sensory reception
12. COLOR OF THE SKIN AND ITS FACTOR
1. melanin
2. carotene.
3. color of blood
13. 2.HYPODERMIS:
The hypodermis lies between the dermis and underlying organs.
It is also known as subcutaneous layer.
It is composed of loose areolar tissue and adipose tissue.
This layer provides additional cushion and insulation through its fat storage
function and connects the skin to underlying structures such as muscle.
3.ASSOCIATED GLANDS:
Integumentary system has four types of exocrine glands, which secrete their
product or substance outside the cells and body.
1. Sudoriferous glands:
Sweat glands excrete sweat via very small openings at the skin’s surface.
The purpose of sudoriferous glands is to emit perspiration to help cool the body
off when the body temperature rises. Types: Eccrine and Apocrine glands
14. 2. Ceruminous glands:
Located in the ear canal. It produce ear wax known as cerumen.
Cerumen prevent entry of dust, bacteria and harmful agent in
the ear.
3. Mammary glands:
There are two mammary glands located one at each side of the
front of the chest wall.
Both men and women have mammary glands, but in men,
these glands are underdeveloped. In females, the glands
function to produce breast milk after giving birth.
15. 4. Sebaceous glands
• Simple branched alveolar glands found in the
dermis. Their main functions are lubrication and
protection. They are connected to hair follicles
and secret oily secretion called sebum.
16. 4.HAIR:
Hair is derived from the epidermis but grows its roots deep into the
dermis.
Its structure divides into the externally visible hair shaft and the hair
follicle within the skin.
Hair is primarily comprised of a fibrous protein and contains a very
small amount of lipids (fats) and water.
Hair comes from follicles, which are simple organs made up of cells
called epithelial cells
17. Function of the HAIR:
Insulation
Against glare
Screen
Trap
Protect
18. Structure of the Hair
Hair has two parts, the shaft the part above skin and the root
embedded in the skin.
19. NAILS:
Nails consist of several segments, including:
i. The nail plate: The part of the nail that is visible.
ii.The nail bed: The skin that lies beneath the nail plate.
iii.The cuticle: The thin line of tissue that is located at the base of the nail and
overlaps the nail plate.
iv.The nail folds(eponychium): The folds of the skin located on the sides of the
nail plate.
v.The lunula: The white-colored half-moon-shaped area located at the base of
the nail plate. (the “little moon”)
vi.The matrix: Part of the nail that is not visible, located underneath the cuticle,
this is the area responsible for the growth of the fingernail.
vii.The area beneath the free edge of the nail, furthest from the cuticle, is called
the hyponychium. It consists of a thickened layer of stratum
20.
21. Functions of integumentary system:
It act as barrier so it provides physical protection against bacteria and
germs.
It heal abrasions, cuts and other injuries.
It protect us from the sun’s ultraviolet (UV) rays and sunburn.
It remove waste by excreting sebum, sweat and other waste from our
body.
It maintain our body temperature by heat evaporating and absorbing as
needed.
It give us sensation for heat, cold and detect other sensations.
It helps to synthesizes vitamin D.
It Stores fat for a source of energy
It Keeps the body from becoming dehydrated