2. Anatomy of the Heart
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3. • The heart, located in the mediastinum, is the
central structure of the cardiovascular system.
• It is protected by the bony structures of the
sternum anteriorly, the spinal column posteriorly,
and the rib cage.
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4. ♥ Clinical Tip
• The cone-shaped heart has its tip (apex) just above
the diaphragm to the left of the midline.
• This is why we may think of the heart as being on
the left side, since the strongest beat can be heard
or felt here.
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5. Layers of the Heart
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6. ♥ Clinical Tip
• The pericardial cavity contains a small amount of
lubricating fluid to prevent friction during heart
contraction.
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7. Heart Valves
Properties of Heart Valves:
■ Fibrous connective tissue prevents enlargement
of valve openings and anchors valve flaps.
■ Valve closure prevents backflow of blood during
and after contraction.
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Cardiac Valves and their functions
The human heart contains four valves
Two atrioventricular valves (AV valves):
• Tricuspid valve
• Mitral or bicuspid valve
Two semilunar valves:
• Aortic valve
• Pulmonary valve
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Home work
1. Functions of the heart valves
2. Functions of papillary ms
3. Relations between the Heart Sounds and Heart
Pumping
11. Heart Chambers and Great Vessels
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15. Cardiovascular System
• The cardiovascular system is a closed system
consisting of blood vessels and the heart.
• Arteries and veins are connected by smaller
structures in which electrolytes are exchanged
across cell membranes.
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21. Physiology of the Heart
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23. Physiology of Atria and Ventricles
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REVISE
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End-Diastolic Volume, End-Systolic Volume, and Stroke
Volume Output
• End-diastolic volume: During diastole, the ventricles
increases the volume to about 110 to 120 ml
• The stroke volume output: during systole, the
ventricles empty and the volume decreases about 70 ml
• The end-systolic volume: The remaining volume in
each ventricle, about 40 to 50 ml
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Properties of Cardiac Muscle Fibers
1. Autorhythmicity: The ability to initiate a heart beat
continuously and regularly without external stimulation
2. Excitability: The ability to respond to a stimulus of
adequate strength and duration by generating a
propagated action potential
3. Conductivity: The ability to conduct excitation through
the cardiac tissue
4. Contractility: The ability to contract in response to
stimulation
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THE CARDIAC MUSCLE
• Contractile muscle fibres (myocardium 99%)
Atrial muscle fibres & Ventricular muscle fibres
- Both contract same as in skeletal Muscle
- Duration of contraction much longer
• Excitatory & conductive muscle fibres (autorhythmic 1%
- Few contractile fibrils (very weak contraction)
- Exhibit either automatic rhythmic discharge(AP)
OR
Conduction of the AP through heart
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Specialized Excitatory and Conductive System of
the Heart
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Internodal Pathways
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Locations of autorythmic cells
Sinoatrial node (SA node):
Specialized region in right atrial wall near opening
of superior vena cava.
Atrioventricular node (AV node) :
Small bundle of specialized cardiac cells located at
base of right atrium near septum.
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Locations of autorythmic cells …
Bundle of His (atrioventricular bundle)
oCells originate at AV node & enters interventricular
septum.
oDivides to form right and left bundle branches
which travel down septum, curve around tip of
ventricular chambers and travel back toward atria
along outer walls.
36. Purkinje fibers
Small, terminal fibers that extend from
bundle of His and spread throughout ventricular
myocardium.
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Locations of autorythmic cells …
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Action potential in contractile fibers
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43. ♥ Clinical Tip
• Mechanical and electrical functions of the heart are
influenced by proper electrolyte balance.
• Important components of this balance are sodium,
calcium, potassium, and magnesium.
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44. ♥ NB:
Revise the Heart Anatomy and Physiology
Again before we enter the 2nd Lecture.
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