Representative leadership on behalf of the people only rarely finds a greater shared imperative well-resonated at causes and causalities of the disruptive world than at today’s crossroads. Leading socio-economic transition that addresses a wide range of complex and oftentimes mutually-reinforcing challenges is painstakingly daunting but achievable once perceived as emerging opportunities to a brighter future for all. But value-creating potential driven by the power of technology and innovation shall never make sense of today’s changing world unless the economy and the society win greater shared forward-looking perspective on the purpose highground (see narrative of the Fourth Industrial Revolution). Such is indeed a prerequisite of the transition to knowledge-based economy, particularly on the premise of how science, technology and innovation lead such course with sense-making roles at today’s globalization, but also why socio-economic resilience is indispensable to every forward-looking choice of structural reform mission (see UNCTAD’s technology and innovation report 2021). Undoubtedly, successful transformation of knowledge-based economy and society is a global shared priority but it’s national leadership that this dialog essentially calls for.