Nifurtimox is indicated for treatment of Chagas disease caused by Trypanosoma cruzi in pediatric patients under 18 years old weighing at least 2.5 kg. It is available as 30mg and 120mg tablets. The mechanism of action involves production of toxic metabolites and reactive oxygen species through nitroreductase enzymes that induce DNA damage and death of T. cruzi trypomastigotes, amastigotes, and epimastigotes. Common adverse effects include headache, vomiting, nausea, rash, decreased appetite, abdominal pain, fever, and weight loss. A clinical study of 330 pediatric patients found the 60-day nifurtimox regimen was superior to the non-