1) The study investigated changes in lumbar intervertebral disc (IVD) water content and morphology during 60 days of bedrest and over 2 years of recovery using MRI.
2) At the end of bedrest, IVD height and area were increased with no change in water content.
3) After bedrest, IVD water content was reduced at 3 and 6 months post-bedrest but returned to pre-bedrest levels by 24 months, indicating a gradual re-adaptation process.
4) IVD height and area remained elevated even at 24 months post-bedrest, suggesting a slower recovery of IVD morphology compared to water content.
Effectiveness of cpm and conventional physical therapy after total knee arthr...FUAD HAZIME
This randomized clinical trial compared the effectiveness of 3 in-hospital rehabilitation programs following primary total knee arthroplasty (TKA): 1) conventional physical therapy alone, 2) conventional physical therapy with 35 minutes of continuous passive motion (CPM) daily, and 3) conventional physical therapy with 2 hours of CPM daily. Outcome measures included range of motion, functional ability, and length of stay. The results showed no significant differences between the groups for any outcomes, suggesting that adding CPM to conventional physical therapy provided no additional benefits after primary TKA.
Does a standard outpatient physiotherapy regime improve the range of knee mot...FUAD HAZIME
This study investigated whether a standard outpatient physiotherapy regime improved range of knee motion after primary total knee arthroplasty (TKA). 150 patients were randomly assigned to either receive 6 weeks of outpatient physiotherapy after TKA (Group A) or no outpatient physiotherapy (Group B). Range of motion measurements found that while Group A achieved greater flexion than Group B, the difference was not statistically significant. The study concluded that outpatient physiotherapy does not improve range of knee motion after primary TKA.
Comparison of the effects of exercise in water and on land on the rehabilitat...FUAD HAZIME
1. The study compared the effects of rehabilitation exercises performed in water versus on land for patients who had undergone ACL reconstruction surgery.
2. Patients were randomly assigned to either a traditional land-based rehabilitation group or a pool rehabilitation group that performed identical exercises in water.
3. Outcome measures included range of motion, muscle strength, joint effusion, laxity, and functional scores, which were assessed at various intervals over the 8-week rehabilitation period.
4. Preliminary results found higher functional scores in the water group, less joint effusion, and similar results between groups for other outcomes. The study aimed to determine if water-based exercises provided benefits over traditional land exercises following ACL reconstruction.
Ann cools 4 screening tennis players [compatibiliteitsmodus]Lennard Funk
This document discusses screening tests for the shoulder girdle in elite tennis players. It describes studies that examined strength, range of motion, and muscle imbalances in adolescent tennis players in Sweden. The studies found increased upward rotation of the scapula on the dominant side, as well as strength imbalances between dominant and non-dominant sides. MRI screening of elite players found high rates of tendinosis, especially in the infraspinatus and supraspinatus tendons. The implications are that screening can help identify risk factors for injury and guide return-to-play criteria focusing on normal strength, range of motion, and function.
A comparison of 2 cpm protocols after total knee arthroplastyFUAD HAZIME
1. The study compared outcomes of two continuous passive motion (CPM) protocols (standard vs early flexion) and a no-CPM control group following total knee arthroplasty.
2. The early flexion CPM group had significantly greater range of flexion than the other groups at 5 days post-op but there were no other significant differences between groups.
3. While early flexion CPM resulted in better short-term range of motion, the study found no substantial benefits of either CPM protocol over no CPM for other outcomes like length of stay, wound healing, or function.
Rischke_Viscoelastic Disc Arthroplasty Provides Superior Back and Leg Pain Re...Kari Zimmers
This study compared outcomes of patients receiving a viscoelastic total disc replacement (VTDR) to patients receiving anterior lumbar interbody fusion (ALIF) for lumbar disc degeneration using data from two independent spine registries. Linear regression models showed that VTDR was associated with significantly greater back and leg pain relief compared to ALIF, with differences of 2.76 and 2.12 points respectively. Additional factors influencing pain relief included female sex, monosegmental surgery, higher preoperative pain levels, and surgical level. The results suggest that viscoelastic total disc replacement may provide superior pain relief compared to anterior lumbar interbody fusion for patients with degenerative lumbar disc disease.
This study compared the effects of cruciate retaining (CR) total knee arthroplasty (TKA), posterior stabilized (PS) TKA, and uni-compartmental knee arthroplasty (UKA) on dynamic balance, pain, and functional performance following rehabilitation. The study assessed 45 patients who received either CR TKA, PS TKA, or UKA, as well as a control group of 15 patients who had knee osteoarthritis but did not undergo surgery. All patients underwent assessments of dynamic balance, pain, and functional performance before and after surgery and rehabilitation. The results showed that patients who received UKA had significantly better dynamic balance scores and lower pain and functional performance times compared to those who received CR or PS TKA, indicating that
Difference in Early Results Between Sub-Acute and Delayed ACL reconstruction:...Henrik Illerström
This randomized controlled trial compared outcomes of sub-acute ACL reconstruction (within 8 days of injury) versus delayed ACL reconstruction (6-10 weeks post-injury). At 3 months, there were no differences in range of motion between groups. At 6 months, the sub-acute group showed less thigh muscle atrophy and better functional strength on hop tests, though isokinetic strength was similar. Both groups improved significantly on KOOS scores after reconstruction, with no differences between groups. The study suggests sub-acute ACL reconstruction is safe and may help preserve strength compared to delayed reconstruction.
Effectiveness of cpm and conventional physical therapy after total knee arthr...FUAD HAZIME
This randomized clinical trial compared the effectiveness of 3 in-hospital rehabilitation programs following primary total knee arthroplasty (TKA): 1) conventional physical therapy alone, 2) conventional physical therapy with 35 minutes of continuous passive motion (CPM) daily, and 3) conventional physical therapy with 2 hours of CPM daily. Outcome measures included range of motion, functional ability, and length of stay. The results showed no significant differences between the groups for any outcomes, suggesting that adding CPM to conventional physical therapy provided no additional benefits after primary TKA.
Does a standard outpatient physiotherapy regime improve the range of knee mot...FUAD HAZIME
This study investigated whether a standard outpatient physiotherapy regime improved range of knee motion after primary total knee arthroplasty (TKA). 150 patients were randomly assigned to either receive 6 weeks of outpatient physiotherapy after TKA (Group A) or no outpatient physiotherapy (Group B). Range of motion measurements found that while Group A achieved greater flexion than Group B, the difference was not statistically significant. The study concluded that outpatient physiotherapy does not improve range of knee motion after primary TKA.
Comparison of the effects of exercise in water and on land on the rehabilitat...FUAD HAZIME
1. The study compared the effects of rehabilitation exercises performed in water versus on land for patients who had undergone ACL reconstruction surgery.
2. Patients were randomly assigned to either a traditional land-based rehabilitation group or a pool rehabilitation group that performed identical exercises in water.
3. Outcome measures included range of motion, muscle strength, joint effusion, laxity, and functional scores, which were assessed at various intervals over the 8-week rehabilitation period.
4. Preliminary results found higher functional scores in the water group, less joint effusion, and similar results between groups for other outcomes. The study aimed to determine if water-based exercises provided benefits over traditional land exercises following ACL reconstruction.
Ann cools 4 screening tennis players [compatibiliteitsmodus]Lennard Funk
This document discusses screening tests for the shoulder girdle in elite tennis players. It describes studies that examined strength, range of motion, and muscle imbalances in adolescent tennis players in Sweden. The studies found increased upward rotation of the scapula on the dominant side, as well as strength imbalances between dominant and non-dominant sides. MRI screening of elite players found high rates of tendinosis, especially in the infraspinatus and supraspinatus tendons. The implications are that screening can help identify risk factors for injury and guide return-to-play criteria focusing on normal strength, range of motion, and function.
A comparison of 2 cpm protocols after total knee arthroplastyFUAD HAZIME
1. The study compared outcomes of two continuous passive motion (CPM) protocols (standard vs early flexion) and a no-CPM control group following total knee arthroplasty.
2. The early flexion CPM group had significantly greater range of flexion than the other groups at 5 days post-op but there were no other significant differences between groups.
3. While early flexion CPM resulted in better short-term range of motion, the study found no substantial benefits of either CPM protocol over no CPM for other outcomes like length of stay, wound healing, or function.
Rischke_Viscoelastic Disc Arthroplasty Provides Superior Back and Leg Pain Re...Kari Zimmers
This study compared outcomes of patients receiving a viscoelastic total disc replacement (VTDR) to patients receiving anterior lumbar interbody fusion (ALIF) for lumbar disc degeneration using data from two independent spine registries. Linear regression models showed that VTDR was associated with significantly greater back and leg pain relief compared to ALIF, with differences of 2.76 and 2.12 points respectively. Additional factors influencing pain relief included female sex, monosegmental surgery, higher preoperative pain levels, and surgical level. The results suggest that viscoelastic total disc replacement may provide superior pain relief compared to anterior lumbar interbody fusion for patients with degenerative lumbar disc disease.
This study compared the effects of cruciate retaining (CR) total knee arthroplasty (TKA), posterior stabilized (PS) TKA, and uni-compartmental knee arthroplasty (UKA) on dynamic balance, pain, and functional performance following rehabilitation. The study assessed 45 patients who received either CR TKA, PS TKA, or UKA, as well as a control group of 15 patients who had knee osteoarthritis but did not undergo surgery. All patients underwent assessments of dynamic balance, pain, and functional performance before and after surgery and rehabilitation. The results showed that patients who received UKA had significantly better dynamic balance scores and lower pain and functional performance times compared to those who received CR or PS TKA, indicating that
Difference in Early Results Between Sub-Acute and Delayed ACL reconstruction:...Henrik Illerström
This randomized controlled trial compared outcomes of sub-acute ACL reconstruction (within 8 days of injury) versus delayed ACL reconstruction (6-10 weeks post-injury). At 3 months, there were no differences in range of motion between groups. At 6 months, the sub-acute group showed less thigh muscle atrophy and better functional strength on hop tests, though isokinetic strength was similar. Both groups improved significantly on KOOS scores after reconstruction, with no differences between groups. The study suggests sub-acute ACL reconstruction is safe and may help preserve strength compared to delayed reconstruction.
This study evaluated the outcomes of a 3-week multidisciplinary residential rehabilitation program for 40 young UK military personnel with prearthritic hip pain. The rehabilitation program improved hip range of motion, as measured by increased flexion and internal rotation, and improved performance on a functional Y-balance test. However, scores on a hip disability questionnaire, pain levels, and a shuttle run test did not significantly improve. The study suggests the rehabilitation program provided short-term benefits for physical function, but not pain or self-reported hip function.
1. The study examined the effect of meniscus removal on anterior cruciate ligament (ACL)-deficient knee laxity using a navigation system.
2. It found that patients who underwent partial or total removal of the medial meniscus had significantly greater anterior tibial translation during Lachman and drawer tests, compared to patients with an isolated ACL injury.
3. Under pivot shift testing, all groups showed similar results except for anterior displacement, which was significantly greater in patients who underwent a meniscectomy.
1) The study evaluated the long-term clinical and radiographic outcomes of 179 cementless total knee arthroplasty procedures performed in 112 patients with rheumatoid arthritis over an average follow-up period of 10.1 years.
2) At the last follow-up, the mean knee and function scores on the Knee Society clinical rating system improved significantly, and 92.7% and 91.1% of knees respectively showed good or excellent results.
3) Radiographically, components were well-aligned and fixed at the last follow-up. The 15-year survival rate was 96.8%, with only one revision for loosening, indicating the cementless technique provided satisfactory long-term results for rheumatoid arthritis patients.
Swine Spine Presentation Patricia 10_28_16Patricia Stan
The document discusses the use of Wisconsin Miniature Swine (WMS) as an animal model for human spinal cord research. Measurements were taken of WMS vertebrae and compared to human dimensions, showing similarities in vertebral body height, end plate dimensions, and spinal canal size. Injections of dye into WMS spines demonstrated diffusion patterns comparable to humans. The results suggest WMS is a useful model for spinal cord injury studies and developing new targeted drug delivery technologies like convection-enhanced delivery, due to its human-like spine anatomy and size.
Pro disc l replacement vs circumferential arthrodesis of spineQueen Mary Hospital
This study compared results of the ProDisc-L total disc replacement to circumferential spinal fusion for treating two-level lumbar degenerative disc disease. 256 patients were randomized to the two procedures. At 24 months, 143 patients received total disc replacement while 60 received spinal fusion. The total disc replacement group had significantly less operative time, blood loss, and shorter hospital stays. Clinical outcomes including ODI, SF-36, and pain/satisfaction scales were measured at multiple points up to 24 months. Radiographic outcomes were also assessed to analyze device success and fusion rates between the two procedures.
Knee strenght after total knee arthroplastyFUAD HAZIME
1) Knee strength was measured in 52 healthy control knees and 32 knees more than 2 years after total knee arthroplasty (TKA).
2) On average, isometric extension peak torque values in TKA patients were reduced by up to 30.7% compared to controls. Isometric flexion peak torque values in TKA patients were on average 32.2% lower than controls.
3) Relatively greater quadriceps strength in TKA patients was associated with better Knee Society Functional Scores, while a higher hamstring to quadriceps ratio was associated with worse scores. Older and more overweight TKA patients also had lower strength.
Patellar denervation for Anterior Knee Pain Management in Knee ArthroplastyDavid Sadigursky
DENERVAÇÃO PATELAR PARA TRATAMENTO DA
DOR ANTERIOR NA ARTROPLASTIA TOTAL DO
JOELHO.
Estudo a respeito da denervaçao peri-patelar para tratamento da dor anterior após artroplastia total do joelho
This study examined the effects of glucosamine supplementation on individuals experiencing regular knee pain. Subjects were randomly assigned to receive either glucosamine or placebo supplementation daily for 12 weeks. Outcomes were assessed using clinical tests, questionnaires, and participant evaluations at baseline and weeks 4, 8, and 12. The glucosamine group reported significantly less knee pain and better quality of life scores on questionnaires at weeks 8 and 12 compared to the placebo group. Additionally, 88% of the glucosamine group reported an improvement in knee pain over the study period versus only 17% in the placebo group. The results suggest glucosamine supplementation can provide pain relief and improved function for those with regular knee pain.
The document evaluates the ability of T2 turbo spin echo axial and sagittal BLADE sequences to reduce or eliminate motion, pulsatile flow, and cross-talk artifacts in lumbar spine MRI examinations. Forty-four patients underwent lumbar spine MRI with both conventional and BLADE sequences. Quantitative analysis found significantly higher SNR and CNR with BLADE sequences. Qualitative analysis by radiologists also found BLADE sequences significantly superior in image quality and elimination of artifacts. The study concludes that BLADE sequences can potentially eliminate motion and other artifacts to produce high quality lumbar spine MRI images.
This study investigated the clinical outcomes and biomechanics of bi-unicondylar arthroplasty (Bi-UKA) compared to total knee arthroplasty (TKA) and healthy controls through three approaches:
1) Gait analysis found that Bi-UKA patients walked faster and with longer strides than TKA patients, exhibiting closer to normal gait patterns.
2) Patient-reported outcomes showed higher Oxford Knee Scores and quality of life scores for Bi-UKA patients compared to TKA patients.
3) A cadaveric study found that Bi-UKA preserved extensor efficiency of the knee better than TKA, particularly during gait.
Electromyographic activity of selected trunk muscles in subjectsJuan Aguirre Vargas
This study evaluated electromyographic activity in trunk muscles of hemiparetic subjects and healthy controls during therapeutic exercises. The following were found:
1) The rectus abdominis muscle on the paretic side of hemiparetic subjects showed greater activation than the corresponding side in controls during several exercises, indicating compensatory strategies.
2) The non-paretic obliquus externus abdominis in hemiparetic subjects showed greater activation during leg elevation compared to other exercises.
3) No differences were found between groups in erector spinae activity or contraction onset times.
Scapular positioning and motor control in children and adults a laboratory st...lichugojavier
1) The study compared clinical measures of scapular positioning and motor control between adults (n=46) and children (n=59).
2) It found that children had significantly greater scapular upward rotation but smaller forward shoulder posture than adults when controlling for height.
3) The study also found no significant differences between children and adults in visual observation of scapular tilting or winging, or on the Kinetic Medial Rotation Test, a measure of scapular motor control. The results provide reference values for interpreting clinical tests of the scapula in adults and children.
This study compared outcomes of first metatarsophalangeal joint fusion using three different techniques: single lag screw fixation, lag screw with circlage wire fixation, and two compression Memory staples. 46 patients underwent one of the three procedures. Time to fusion and complication rates were compared. The Memory staples group had the shortest median time to fusion at 7.6 weeks and lowest nonunion rate, with no hardware-related problems. While no differences were statistically significant, the results suggest Memory staples may have advantages for first metatarsophalangeal joint fusion.
The document reviews three studies on the use of interbody spinal cages for treating compromised spinal columns due to trauma or disease. Specifically, it examines the use of expandable titanium cages and stackable cages, as well as the posterior surgical approach. The studies found that interbody cages can successfully correct kyphotic deformities and maintain spinal stability in patients with spinal trauma or tumors. Complication rates were low. The document concludes that interbody cages and the posterior surgical approach may provide good outcomes for treating certain spinal conditions.
Arthroscopic Single Row Versus Double-Row Suture Anchor Rotator Cuff Repair |...Peter Millett MD
Twenty fresh-frozen cadaveric shoulders were randomly assigned to 4 arthroscopic repair techniques. The repair was performed as either a single-row suture anchor rotator cuff repair technique or 1 of 3 double-row techniques: diamond, mattress double anchor, or modified mattress double anchor. Angle of loading, anchor type, bone mineral density, anchor distribution, angle of anchor insertion, arthroscopic technique, and suture type and size were all controlled. Footprint length and width were quantified before and after repair. Displacement with cyclic loading and load to failure were determined. For more shoulder surgery and rotator cuff studies, visit Peter Millett, MD, The Steadman Clinic, Vail Colorado http://drmillett.com/shoulder-studies
Correlación entre equilibrio estático y autonomía funcional en mujeres de eda...Nadia Mendoza C.
This study examined the correlation between static balance and functional autonomy in elderly women. Stabilometric assessment was used to measure balance, including lateral displacements, anterior/posterior displacements, and elliptical area. Functional tests from the LADEG protocol assessed autonomy, including a 10m walk, getting up from seated/prone positions, moving around, and dressing/undressing. The results showed that women who took longer to get up from the prone position had greater mean amplitudes of lateral and posterior displacements and a larger elliptical area, indicating greater instability. This suggests that balance is correlated with functional tasks requiring rising from the floor in sedentary elderly women.
Reverse shoulder arthroplasty using an implant with a lateral center of rotationSatoshi Kajiyama
Reverse shoulder arthroplasty (RSA) using an implant with a lateral center of rotation was studied to evaluate outcomes, complications, and the influence of surgeon experience. At minimum 2-year follow-up of the first 60 RSAs performed by a single surgeon:
- Mean improvements in range of motion and shoulder function scores were significant and comparable to results reported by the implant's design team.
- Experience influenced results, with better outcomes in the later cases compared to the initial 15 cases.
- Complications including revision surgeries were more common in the early cases, indicating a potential learning curve for the procedure.
Comparison of 3 d shoulder complex kinematic part 1Satoshi Kajiyama
This study compared shoulder complex kinematics between individuals with and without shoulder pain. Transcortical bone pins were inserted into the clavicle, scapula, and humerus of 12 asymptomatic and 10 symptomatic individuals. Angular positions of the sternoclavicular, acromioclavicular, and scapulothoracic joints were measured during shoulder motions. Differences were found between groups for sternoclavicular and scapulothoracic joint positions, with symptomatic individuals demonstrating less sternoclavicular posterior rotation and scapulothoracic upward rotation. However, the magnitude of differences was small and clinical implications are not fully understood.
This document describes an analysis of patient data to study the concomitant use of COX-2 inhibitors like Vioxx, Celebrex, and Bextra with cardiovascular drugs. The analysis segmented over 25 million patients taking antiarthritic drugs by the COX-2 inhibitors they used. Properties were defined to categorize patients by the number of scripts for study drugs over 2 years. The results showed that while most patients only had 1 script, some had 17 or more, and of those patients some were also taking ACE inhibitors. The analysis examined the distribution of combined usage of study drugs and control drug classes.
Este documento presenta el diseño de una situación de aprendizaje basada en la didáctica crítica. La lección se enfoca en la herramienta del pensamiento "considerar todos los factores" y consta de tres partes: apertura, desarrollo y culminación. En la apertura, se presenta un ejemplo para motivar a los estudiantes. En el desarrollo, los estudiantes analizan todos los factores del ejemplo en grupos. En la culminación, los estudiantes concluyen la importancia de considerar todos los factores al tomar
The document describes the golden pheasant, a gamebird native to western China. It summarizes that the male golden pheasant has a distinctive golden yellow crest and bright red and orange plumage. The female has duller brown mottled plumage. It also notes that golden pheasants prefer dense forest habitats in hilly areas, and while they forage on the ground during the day, they roost in high trees at night.
This study evaluated the outcomes of a 3-week multidisciplinary residential rehabilitation program for 40 young UK military personnel with prearthritic hip pain. The rehabilitation program improved hip range of motion, as measured by increased flexion and internal rotation, and improved performance on a functional Y-balance test. However, scores on a hip disability questionnaire, pain levels, and a shuttle run test did not significantly improve. The study suggests the rehabilitation program provided short-term benefits for physical function, but not pain or self-reported hip function.
1. The study examined the effect of meniscus removal on anterior cruciate ligament (ACL)-deficient knee laxity using a navigation system.
2. It found that patients who underwent partial or total removal of the medial meniscus had significantly greater anterior tibial translation during Lachman and drawer tests, compared to patients with an isolated ACL injury.
3. Under pivot shift testing, all groups showed similar results except for anterior displacement, which was significantly greater in patients who underwent a meniscectomy.
1) The study evaluated the long-term clinical and radiographic outcomes of 179 cementless total knee arthroplasty procedures performed in 112 patients with rheumatoid arthritis over an average follow-up period of 10.1 years.
2) At the last follow-up, the mean knee and function scores on the Knee Society clinical rating system improved significantly, and 92.7% and 91.1% of knees respectively showed good or excellent results.
3) Radiographically, components were well-aligned and fixed at the last follow-up. The 15-year survival rate was 96.8%, with only one revision for loosening, indicating the cementless technique provided satisfactory long-term results for rheumatoid arthritis patients.
Swine Spine Presentation Patricia 10_28_16Patricia Stan
The document discusses the use of Wisconsin Miniature Swine (WMS) as an animal model for human spinal cord research. Measurements were taken of WMS vertebrae and compared to human dimensions, showing similarities in vertebral body height, end plate dimensions, and spinal canal size. Injections of dye into WMS spines demonstrated diffusion patterns comparable to humans. The results suggest WMS is a useful model for spinal cord injury studies and developing new targeted drug delivery technologies like convection-enhanced delivery, due to its human-like spine anatomy and size.
Pro disc l replacement vs circumferential arthrodesis of spineQueen Mary Hospital
This study compared results of the ProDisc-L total disc replacement to circumferential spinal fusion for treating two-level lumbar degenerative disc disease. 256 patients were randomized to the two procedures. At 24 months, 143 patients received total disc replacement while 60 received spinal fusion. The total disc replacement group had significantly less operative time, blood loss, and shorter hospital stays. Clinical outcomes including ODI, SF-36, and pain/satisfaction scales were measured at multiple points up to 24 months. Radiographic outcomes were also assessed to analyze device success and fusion rates between the two procedures.
Knee strenght after total knee arthroplastyFUAD HAZIME
1) Knee strength was measured in 52 healthy control knees and 32 knees more than 2 years after total knee arthroplasty (TKA).
2) On average, isometric extension peak torque values in TKA patients were reduced by up to 30.7% compared to controls. Isometric flexion peak torque values in TKA patients were on average 32.2% lower than controls.
3) Relatively greater quadriceps strength in TKA patients was associated with better Knee Society Functional Scores, while a higher hamstring to quadriceps ratio was associated with worse scores. Older and more overweight TKA patients also had lower strength.
Patellar denervation for Anterior Knee Pain Management in Knee ArthroplastyDavid Sadigursky
DENERVAÇÃO PATELAR PARA TRATAMENTO DA
DOR ANTERIOR NA ARTROPLASTIA TOTAL DO
JOELHO.
Estudo a respeito da denervaçao peri-patelar para tratamento da dor anterior após artroplastia total do joelho
This study examined the effects of glucosamine supplementation on individuals experiencing regular knee pain. Subjects were randomly assigned to receive either glucosamine or placebo supplementation daily for 12 weeks. Outcomes were assessed using clinical tests, questionnaires, and participant evaluations at baseline and weeks 4, 8, and 12. The glucosamine group reported significantly less knee pain and better quality of life scores on questionnaires at weeks 8 and 12 compared to the placebo group. Additionally, 88% of the glucosamine group reported an improvement in knee pain over the study period versus only 17% in the placebo group. The results suggest glucosamine supplementation can provide pain relief and improved function for those with regular knee pain.
The document evaluates the ability of T2 turbo spin echo axial and sagittal BLADE sequences to reduce or eliminate motion, pulsatile flow, and cross-talk artifacts in lumbar spine MRI examinations. Forty-four patients underwent lumbar spine MRI with both conventional and BLADE sequences. Quantitative analysis found significantly higher SNR and CNR with BLADE sequences. Qualitative analysis by radiologists also found BLADE sequences significantly superior in image quality and elimination of artifacts. The study concludes that BLADE sequences can potentially eliminate motion and other artifacts to produce high quality lumbar spine MRI images.
This study investigated the clinical outcomes and biomechanics of bi-unicondylar arthroplasty (Bi-UKA) compared to total knee arthroplasty (TKA) and healthy controls through three approaches:
1) Gait analysis found that Bi-UKA patients walked faster and with longer strides than TKA patients, exhibiting closer to normal gait patterns.
2) Patient-reported outcomes showed higher Oxford Knee Scores and quality of life scores for Bi-UKA patients compared to TKA patients.
3) A cadaveric study found that Bi-UKA preserved extensor efficiency of the knee better than TKA, particularly during gait.
Electromyographic activity of selected trunk muscles in subjectsJuan Aguirre Vargas
This study evaluated electromyographic activity in trunk muscles of hemiparetic subjects and healthy controls during therapeutic exercises. The following were found:
1) The rectus abdominis muscle on the paretic side of hemiparetic subjects showed greater activation than the corresponding side in controls during several exercises, indicating compensatory strategies.
2) The non-paretic obliquus externus abdominis in hemiparetic subjects showed greater activation during leg elevation compared to other exercises.
3) No differences were found between groups in erector spinae activity or contraction onset times.
Scapular positioning and motor control in children and adults a laboratory st...lichugojavier
1) The study compared clinical measures of scapular positioning and motor control between adults (n=46) and children (n=59).
2) It found that children had significantly greater scapular upward rotation but smaller forward shoulder posture than adults when controlling for height.
3) The study also found no significant differences between children and adults in visual observation of scapular tilting or winging, or on the Kinetic Medial Rotation Test, a measure of scapular motor control. The results provide reference values for interpreting clinical tests of the scapula in adults and children.
This study compared outcomes of first metatarsophalangeal joint fusion using three different techniques: single lag screw fixation, lag screw with circlage wire fixation, and two compression Memory staples. 46 patients underwent one of the three procedures. Time to fusion and complication rates were compared. The Memory staples group had the shortest median time to fusion at 7.6 weeks and lowest nonunion rate, with no hardware-related problems. While no differences were statistically significant, the results suggest Memory staples may have advantages for first metatarsophalangeal joint fusion.
The document reviews three studies on the use of interbody spinal cages for treating compromised spinal columns due to trauma or disease. Specifically, it examines the use of expandable titanium cages and stackable cages, as well as the posterior surgical approach. The studies found that interbody cages can successfully correct kyphotic deformities and maintain spinal stability in patients with spinal trauma or tumors. Complication rates were low. The document concludes that interbody cages and the posterior surgical approach may provide good outcomes for treating certain spinal conditions.
Arthroscopic Single Row Versus Double-Row Suture Anchor Rotator Cuff Repair |...Peter Millett MD
Twenty fresh-frozen cadaveric shoulders were randomly assigned to 4 arthroscopic repair techniques. The repair was performed as either a single-row suture anchor rotator cuff repair technique or 1 of 3 double-row techniques: diamond, mattress double anchor, or modified mattress double anchor. Angle of loading, anchor type, bone mineral density, anchor distribution, angle of anchor insertion, arthroscopic technique, and suture type and size were all controlled. Footprint length and width were quantified before and after repair. Displacement with cyclic loading and load to failure were determined. For more shoulder surgery and rotator cuff studies, visit Peter Millett, MD, The Steadman Clinic, Vail Colorado http://drmillett.com/shoulder-studies
Correlación entre equilibrio estático y autonomía funcional en mujeres de eda...Nadia Mendoza C.
This study examined the correlation between static balance and functional autonomy in elderly women. Stabilometric assessment was used to measure balance, including lateral displacements, anterior/posterior displacements, and elliptical area. Functional tests from the LADEG protocol assessed autonomy, including a 10m walk, getting up from seated/prone positions, moving around, and dressing/undressing. The results showed that women who took longer to get up from the prone position had greater mean amplitudes of lateral and posterior displacements and a larger elliptical area, indicating greater instability. This suggests that balance is correlated with functional tasks requiring rising from the floor in sedentary elderly women.
Reverse shoulder arthroplasty using an implant with a lateral center of rotationSatoshi Kajiyama
Reverse shoulder arthroplasty (RSA) using an implant with a lateral center of rotation was studied to evaluate outcomes, complications, and the influence of surgeon experience. At minimum 2-year follow-up of the first 60 RSAs performed by a single surgeon:
- Mean improvements in range of motion and shoulder function scores were significant and comparable to results reported by the implant's design team.
- Experience influenced results, with better outcomes in the later cases compared to the initial 15 cases.
- Complications including revision surgeries were more common in the early cases, indicating a potential learning curve for the procedure.
Comparison of 3 d shoulder complex kinematic part 1Satoshi Kajiyama
This study compared shoulder complex kinematics between individuals with and without shoulder pain. Transcortical bone pins were inserted into the clavicle, scapula, and humerus of 12 asymptomatic and 10 symptomatic individuals. Angular positions of the sternoclavicular, acromioclavicular, and scapulothoracic joints were measured during shoulder motions. Differences were found between groups for sternoclavicular and scapulothoracic joint positions, with symptomatic individuals demonstrating less sternoclavicular posterior rotation and scapulothoracic upward rotation. However, the magnitude of differences was small and clinical implications are not fully understood.
This document describes an analysis of patient data to study the concomitant use of COX-2 inhibitors like Vioxx, Celebrex, and Bextra with cardiovascular drugs. The analysis segmented over 25 million patients taking antiarthritic drugs by the COX-2 inhibitors they used. Properties were defined to categorize patients by the number of scripts for study drugs over 2 years. The results showed that while most patients only had 1 script, some had 17 or more, and of those patients some were also taking ACE inhibitors. The analysis examined the distribution of combined usage of study drugs and control drug classes.
Este documento presenta el diseño de una situación de aprendizaje basada en la didáctica crítica. La lección se enfoca en la herramienta del pensamiento "considerar todos los factores" y consta de tres partes: apertura, desarrollo y culminación. En la apertura, se presenta un ejemplo para motivar a los estudiantes. En el desarrollo, los estudiantes analizan todos los factores del ejemplo en grupos. En la culminación, los estudiantes concluyen la importancia de considerar todos los factores al tomar
The document describes the golden pheasant, a gamebird native to western China. It summarizes that the male golden pheasant has a distinctive golden yellow crest and bright red and orange plumage. The female has duller brown mottled plumage. It also notes that golden pheasants prefer dense forest habitats in hilly areas, and while they forage on the ground during the day, they roost in high trees at night.
1. Climate change is projected to increase water-related risks like water shortages and floods through changes in water quantity and quality. This poses challenges for the agriculture sector.
2. Adaptation options like improving water storage, irrigation systems, and rainfed agriculture as well as policies around trade, population growth, and pollution management need to be comprehensively assessed to address impacts on water availability, agricultural production, and food security under climate change.
3. Both water-based technical solutions and non-water policy options will be important to manage the growing problems of water variability, scarcity, and degradation exacerbated by climate change and socioeconomic development.
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Spine Motion Lab MANS 2013 Azam Basheer MDAzam Basheer
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Materials and Methods:
We reviewed the knee MRI scans of 100 pediatric patients (ages between one and 12 yr) who had no knee injury or congenital deformity and had been evaluated by an expert radiologist.
Results:
The ALL was detected in 90% of the pediatric patients with the use of MRI.
Conclusions:
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Level of Evidence:
Level IV.
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1. 294
Introduction
In recent years the adaptation of the intervertebral disc
(IVD) to and its recovery after bedrest has received greater at-
tention. This is in large part due to the findings that IVD her-
niation risk is increased in astronauts1
. However, investigating
the adaptation of the IVD to reduced load is important for the
basic understanding of the interaction between loading on the
spine, the subsequent response of the IVD, and hence IVD
physiology. Bedrest is considered a model of reduced loading
on the lumbar spine.
Magnetic resonance imaging (MRI) is used to study the im-
pact of bedrest on the IVD. Acute (i.e. for a few hours) and
overnight bedrest has been shown to result in increases in lum-
bar IVD size2-5
and water content6-8
. In prolonged (i.e. over a se-
ries of weeks or months) bedrest, our knowledge of the response
of the shape of the IVD (height, width, volume, area) has now
been well established. Increases in IVD height9-14
, volume9,10,14
J Musculoskelet Neuronal Interact 2015; 15(3):294-300
Loss and re-adaptation of lumbar intervertebral
disc water signal intensity after prolonged bedrest
M. Kordi1,2
, D.L. Belavý3,4
, G. Armbrecht3
, A. Sheikh5
, D. Felsenberg3
, G. Trudel5,6
1English Institute of Sport, Manchester, United Kingdom;
2Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK;
3Centre for Muscle and Bone Research, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, Germany;
4Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences,
Deakin University, 221 Burwood Highway, Burwood, Victoria, 3125, Australia;
5Department of Radiology, The Ottawa Hospital, University of Ottawa, Canada;
6Division of Physical Medicine and Rehabilitation, Bone and Joint Research Laboratory, University of Ottawa, Canada
Abstract
The adaptation and re-adaptation process of the intervertebral disc (IVD) to prolonged bedrest is important for understanding
IVD physiology and IVD herniations in astronauts. Little information is available on changes in IVD composition. In this study,
24 male subjects underwent 60-day bedrest and In/Out Phase magnetic resonance imaging sequences were performed to evaluate
IVD shape and water signal intensity. Scanning was performed before bedrest (baseline), twice during bedrest, and three, six and
twenty-four months after bedrest. Area, signal intensity, average height, and anteroposterior diameter of the lumbar L3/4 and
L4/5 IVDs were measured. At the end of bedrest, disc height and area were significantly increased with no change in water signal
intensity. After bedrest, we observed reduced IVD signal intensity three months (p=0.004 versus baseline), six months (p=0.003
versus baseline), but not twenty-four months (p=0.25 versus baseline) post-bedrest. At these same time points post-bedrest, IVD
height and area remained increased. The reduced lumbar IVD water signal intensity in the first months after bedrest implies a re-
duction of glycosaminoglycans and/or free water in the IVD. Subsequently, at two years after bedrest, IVD hydration status re-
turned towards pre-bedrest levels, suggesting a gradual, but slow, re-adaptation process of the IVD after prolonged bedrest.
Keywords: Herniation, Disuse, Diurnal, Low Back Pain, Spaceflight
Original Article Hylonome
The authors have no conflict of interest.
*Author contributions: Mehdi Kordi: Image analysis. Drafting the ar-
ticle. Daniel L. Belavý: Secured funding. Conception and design of
the experiments. Statistical analysis and interpretation of the data.
Drafting the article. GabrieleArmbrecht: Collection and interpretation
of data. Revision of the article. Adnan Sheikh: Interpretation of the
data. Revision of the article. Dieter Felsenberg: Secured funding. Con-
ception and design of the experiments. Revising the article. Guy
Trudel: Secured funding. Conception and design of the experiments.
Interpretation of the data. Revision of the article.
Corresponding author: Daniel L. Belavý B.Phty, PhD; Centre for Physical
Activity and Nutrition Research, School of Exercise and Nutrition Sciences,
Deakin University, 221 Burwood Highway, Burwood, Victoria, 3125, Australia
E-mail: belavy@gmail.com
Edited by: F. Rauch
Accepted 30 July 2015
2. M. Kordi et al.: Intervertebral disc hydration after bedrest
295
and/or sagittal plane IVD area11,15
but no change or reduction in
anteroposterior and transverse IVD diameters12
have been ob-
served in a series of prolonged bedrest studies. Whilst it is useful
to understand adaptations in IVD shape with loading, it is im-
portant to understand changes in IVD composition. An equiva-
lent analogy would be to investigate muscle or bone geometry
without consideration of, respectively, muscle fibre type or bone
mineral density.
Based on data from overnight bedrest6-8
, we can safely as-
sume that water content is increased in the IVD at least in the
first few days of bedrest. Given that IVD hyperhydration results
in reductions in glycosaminoglycan synthesis rates16-18
, what im-
pact might this have on the composition of the IVD during pro-
longed bedrest and also in the readaptation after bedrest? In
prolonged bedrest, one study15
showed a continued increase in
lumbar IVD T2-time (a measure of IVD water and glycosamino-
glycan content19
) at the end of 5 or 17 weeks of bedrest. How-
ever, yet another bedrest study from the same research group20
showed a decrease in lumbar IVD T2-time after 5 weeks of
bedrest. As such, it is unclear whether initial increases in IVD
hydration in acute bedrest persist in prolonged bedrest.
Furthermore the time-course of recovery of the IVD after
bedrest is unclear. Based upon knowledge for other tissues
such as bone (recovery time course of typically 1-2 years de-
pending on bone examined and duration of unloading21,22
) and
muscle (typically 2-12 weeks depending on muscle and dura-
tion of unloading23
), we can assume the time-course for IVD
re-adaptation post-bedrest will be long. For example, the meta-
bolic response of bone after bedrest24
is characterised by an in-
crease in bone formation, reduction of bone resorption and a
gradual turnaround22
in bone mineral density. However, the re-
covery of the IVD post-bedrest still needs to be investigated.
Our aims were to study the changes in IVD composition
(water signal intensity on an In/Out MR-sequence) and mor-
phology during and after prolonged bedrest. Specifically, we
focussed on the recovery of the IVD in a two-year follow-up
period after prolonged bedrest. Data from overnight bedrest6,8
and the response of spine length to loading25
, suggest that the
recovery of IVD hydration after unloading occurs rapidly
(within minutes). Therefore, our primary hypothesis was that
increases in IVD water signal during bedrest would return to
pre-bedrest levels rapidly post-bedrest.
Methods
Bedrest study, ethical approval and sample size
In the 2nd Berlin Bedrest (BBR2-2) study, 24 male subjects
underwent 60d head-down tilt (HDT) bedrest and 2 yr follow-
up and was performed by the Center of Muscle and Bone Re-
search at the Charité in Berlin, Germany. Ethical approval for
BBR2-2 was provided by the ethics committee of the Charité
Universitätsmedizin Berlin. Each subject gave their informed
written consent and was aware of their right to withdraw from
the study without prejudice.
A more detailed account of the BBR2-2 protocol can be
found elsewhere26
. Exclusion criteria relevant to this investi-
gation included any history of chronic low back pain, spinal
injury and surgery. Subjects were randomized to one of three
groups: 1) resistive exercises with whole body vibration during
bedrest, 2) resistive exercise only, 3) control subjects without
countermeasure. Details of the exercise protocols can be found
elsewhere26-28
. The main aim of the BBR2-2 was to compare
the effects of resistive exercise and whole-body vibration
countermeasures for their impact on bone variables29
. Prevent-
ing changes in the IVD was not the primary goal of these in-
terventions. Hence, the present investigation should be
considered an “exploratory study” of the effects the counter-
measures on IVD water signal.
Magnetic resonance imaging protocols
All subjects underwent MRI 8 or 9 d before the start of
bedrest (baseline), after 27 or 28 d of bedrest (mid-HDT), and
after 55 or 56 d of bedrest (end-HDT). During the re-adapta-
tion period, they were imaged 90, 180 and 720 days after
bedrest. MR images were acquired using a 1.5-T Siemens
Magnetom Symphony scanner with a body coil. To allow time
for equalization of body fluid, subjects rested in bed in the hor-
izontal position for 2 hours before scanning. The lower lumbar
vertebrae were imaged in the sagittal plane using a T1 In/Out
(TR=160 milliseconds, TE=2.4/4.6 (in/out) milliseconds, flip
angle=25°, field of view=300 millimeter, slice thickness=6
millimeter, number of slices=3; Figure 1) sequence.
Image analysis
Each data set was assigned (by D. Belavý) a random number
(obtained from www.random.org) to blind the operator (M.
Kordi) who used ImageJ 1.38x (http://rsb.info.nih.gov/ij/) to per-
form the blinded image measurements. The L3/4 and L4/5 IVDs
were measured. IVD area in the sagittal plane was measured as
well as signal intensity in this area. IVD height in the sagittal
plane was measured as the average of the anterior, central and
posterior IVD heights.Anteroposterior diameter was also meas-
ured. IVD variables were averaged from those measured on each
of the images at three anatomical slices through the disc.
Statistical analyses
Linear mixed-effects models were used to examine whether
the ‘study-date’, ‘group’and/or ‘vertebral level’impacted upon
IVD variables over the course of the study. Changes of IVD
variables versus baseline were examined using a priori T-tests.
An alpha-level of 0.05 was taken for statistical significance on
ANOVA. The “R” statistical environment (version 2.10.1,
www.r-project.org) was used.
Results
One subject withdrew after day 30 of bedrest due to an in-
jury to the thoracic spine30
. Two additional subjects did not re-
turn for testing 90-days and beyond after bedrest. One subject
was tested 360 days after bedrest instead of 180 after bedrest
3. M. Kordi et al.: Intervertebral disc hydration after bedrest
296
Figure 1. Magnetic resonance imaging and image measurements Top: Out-of-phase images. Bottom: In-phase images. Left: prior to bed-rest;
right: at end of bed-rest in same subject. Increases in disc height (in particular at the posterior aspect of the disc) and area can be seen in this
subject. Measurements were made of the L3/4 and L4/5 intervertebral discs in the sagittal plane. The inset shows the measurements performed
on each disc in each image. Disc heights were measured at left side of disc (a), centre of disc (b) and right side (c). These values were then av-
eraged to generate average disc height. Disc area (white region of interest traced at (d)) was measured and the signal intensity was also measured
in this region of interest. Transverse disc diameter (black line at (e)) was also measured.
Group Baseline
Bedrest day Days post bedrest
27/28 55/56 90 180 720
Signal intensity
CTR 103.4(13.1) -3.7(9.6)% 3.3(12.9)% -5.4(10.5)% -3.9(10.3)% -4.5(8.9)%
RE 105.9(9.2) 1.0(11.7)% -6.2(18.0)% -2.5(9.7)% -9.0(14.1)% -5.6(13.5)%
RVE 113.7(21.9) -7.9(14.6)% 0.4(17.0)% -11.6(12.1)%† -9.5(12.1)%* -2.4(19.6)%
Average disc height (mm)
CTR 8.9(1.3) 6.8(4.2)%‡ 8.1(3.6)%‡ 4.1(5.3)%* 4.7(3.8)%† 4.0(4.3)%*
RE 8.5(1.4) 5.8(5.0)%† 6.2(6.0)%* 3.5(5.2)% 5.4(5.5)%* 0.3(4.3)%
RVE 8.9(0.8) 5.3(4.1)%† 7.0(5.4)%† 2.7(3.4)% 4.1(3.6)%* -2.8(8.9)%
Disc area (mm²)
CTR 298.5(64.1) 7.5(4.2)%‡ 10.7(4.6)%‡ 5.5(5.4)%† 7.0(4.5)%‡ 2.7(5.2)%
RE 272.6(91.5) 7.2(5.9)%† 8.8(7.4)%† 5.5(3.5)%‡ 5.1(4.4)%† 3.6(4.6)%
RVE 305.6(43.8) 2.6(7.0)% 5.8(3.5)%‡ -0.1(4.5)% 3.0(4.4)% -1.5(10.1)%
Anteroposterior disc diameter (mm)
CTR 36.8(2.8) 0.5(2.1)% 0.3(1.8)% 0.8(2.3)% 1.5(1.5)%† 0.9(2.1)%
RE 35.5(4.2) 0.4(1.8)% 0.0(1.7)% 1.1(1.8)% 0.7(2.2)% 0.7(1.7)%
RVE 36.9(2.0) -0.9(1.2)%* -1.3(1.6)%* -1.2(1.2)%* -1.0(1.4)% -1.4(2.3)%
Number of subjects
CTR 9 9 9 8 8 8
RE 8 8 7 7 7 7
RVE 7 7 7 6 6 6
Values are mean(SD). Baseline values are in absolute units and changes during and after bedrest are in percentage change to baseline. *: p<0.05,
†: p<0.01, ‡: p<0.001 and denotes difference to baseline. CTR: inactive control group, RE: resistive exercise group, RVE: resistive exercise plus
vibration group. Including only those subjects with complete data sets in the analysis did not change the findings of the study (data not shown).
ANOVA showed no significant differences between groups at baseline (p>0.25) nor in their response during or after bed-rest (p>0.08).
Table 1. Disc water signal and morphology in each group.
4. M. Kordi et al.: Intervertebral disc hydration after bedrest
297
as planned as he could not attend the earlier appointment. Ex-
cluding these subjects from the analyses did not change the
findings of the study (data not shown). In all ANOVAs ‘verte-
bral level’ was not significant (p all ≥0.28), therefore data for
L3/4 and L4/5 were pooled. There was no significant differ-
ence between the sub-groups, therefore we focus here on the
aggregate data here but also present the data from each group
in Table 1.
ANOVA showed changes over the course of the study
(‘date’ main-effect) in IVD height (p<0.001), IVD cross-sec-
tional area (p<0.001) and MR water signal intensity (p<0.05)
but not anteroposterior IVD diameter (p=0.67). Changes from
baseline measurements for water signal intensities and IVD
height are shown in Figure 2.
IVD height and area increased during bedrest (p<0.001) and
this remained so 90, 180 and 720 days after bedrest (p
all<0.001). Despite increases in IVD height and area, water
signal intensity did not increase during bedrest. After bedrest,
however, reductions in IVD water signal intensity were ob-
served. The reduction in water signal intensity was statistically
significant 90 and 180 days after bedrest (p=0.004 and
p=0.003, respectively; Figure 2) with signal intensity 720 days
after bedrest returning towards pre-bedrest levels (p=0.25).
Discussion
The MR-sequences implemented in the current study were
specifically targeted at assessing water MR signal intensity in
the lumbar intervertebral discs.Although disc size increase due
to unloading must, in the acute phase, be accompanied by fluid
influx31
, we found no increase in IVD water signal intensity
during bedrest. It is possible that the overall fluid per unit vol-
ume need not necessarily increase to an extent that it can be
detected as a signal intensity increase on MRI. Contrary to our
expectations, we saw significant reductions in disc water signal
intensity, despite continually increased disc height and area, 3
and 6 months after bedrest.
What do the current findings add to the existing literature?
Prior studies15,20
were equivocal findings as to whether IVD T2-
time (which positively correlates with IVD water and gly-
cosaminoglycan content19
) remains increased at the end of
prolonged bedrest. The current study showed no changes in our
IVD water signal intensity during prolonged bedrest. Overall
the existing data in the literature suggest that an acute increase6-
8
in disc hydration occurs at the initiation of bedrest. Due to
persistent unloading and increases in hydration, given our
knowledge from basic science studies of the IVD, it is likely
that adaptations in IVD metabolism then occur. It is possible
that, due to persistent hyperhydration, the IVD begins to lose
glycosaminoglycan. Due to the slow turnover of IVD aggre-
can32
one might assume that a change in IVD metabolism and
glycosaminoclycan content should not occur in the short time-
frame of bedrest. However, other tissues, such as bone, which
is also “slow” tissue in its adaptation to load changes, subse-
quently show metabolic24
(increases in bone resorption and
marginal reductions in bone formation) and subsequently losses
of bone mineral content22,29
due to extreme disuse in bedrest.
As such, it is possible that the acute hyperhydration of the IVD
in bedrest results in a (negative) adaptation of IVD metabolism.
The findings from after bedrest help to understand this.
Figure 2. Changes in lumbar disc signal intensity and dimensions during and after bedrest. Mean (SD) percentage (%) changes from baseline
of average (of anterior, central and posterior) disc height, disc area in the sagittal plane, disc anteroposterior (AP) diatmeter and water signal
intensity during and after bedrest. *: p<0.05, †: p<0.01, ‡: p<0.001 and denotes difference to baseline. HDT: day of head-down tilt bedrest; R:
day of post bedrest recovery. 24 subjects assessed at baseline and day 27/28 of bedrest, 23 on day 55/56 of bedrest and 21 subjects from 90 days
after bedrest onwards. Including only those subjects with complete data sets in the analysis did not change the findings of the study (data not
shown). Data are pooled from the L3/4 and L4/5 intervertebral discs.
5. M. Kordi et al.: Intervertebral disc hydration after bedrest
298
The findings of reduced water signal intensity three and six
months after bedrest may be due to reductions of free water in
the IVD and/or losses of glycosaminoglycan. There is evi-
dence33
from animal models that catabolic pathways are acti-
vated when spinal IVD water content increases, and we know
that an optimal level of IVD hydration is needed16-18
for IVD
glycosaminoglycan synthesis and nutrient incorporation. Po-
tentially, IVD hyper-hydration during prolonged bedrest acti-
vated IVD catabolic pathways in humans resulting in reduced
glycosaminoglycan content during the recovery period. Ani-
mal investigations of interverterbal IVD in spaceflight34,35
,
hindlimb-suspension34-39
and tail vertebra immobilization40,41
have typically34-39,41
found losses in glycosaminoglycan con-
tent. Some authors42
caution against assuming that findings
from animal models of the IVD translate to what occurs in hu-
mans. Whilst we agree with this caveat, there is ample evi-
dence from other organ systems that responses in animal and
human models show some stark similarities, even if specific
findings may differ.
For example, whilst there are some dissimilarities43
, muscle
atrophy in both humans44
and rodents45
in disuse in particular
affects the postural and locomotor musculature of both species.
Similarly, bone losses in animal models45
of disuse do differ
in their location and extent to what is observed in humans46
,
but the major load bearing regions of the body are still affected
in both species. Consequently, we consider it reasonable that,
whilst there will be differences in the extent and character of
adaptations in animal and human IVDs due to unloading, there
will be striking similarities and parallels between the two as
seen for muscle and bone. We therefore interpret our findings
of reductions in IVD MR water signal intensity 3 and 6 months
after bedrest to represent losses of glycosaminoglycan and/or
free water from the IVD.
Two years after bedrest, whilst IVD water signal intensity
was marginally below baseline, this was not statistically sig-
nificant. Disc morphology parameters were also closer to base-
line values. This pattern persisted even when subjects who did
not complete the entire recovery phase were excluded from the
analysis (data not shown). This gradual return to baseline may
represent a long-duration, and slow, re-adaptation of the IVD
after prolonged bedrest. Data from an animal model of unload-
ing39
showed that three weeks of normal ambulation after tail-
suspension restored glycosaminoglycan levels. Considering
other tissues, the re-adaptation process of bone is also slow
after prolonged bedrest22
and spaceflight21
with a two year pe-
riod required for most bone density parameters to return to pre-
bedrest levels. Similarly, for the musculature, recovery takes
a number of weeks post-bedrest23
. Hence, the approach of IVD
parameters to pre-bedrest levels two years after bedrest may
represent the tail-end of the readaptation phase for the IVD.
It is appropriate to discuss some of the limitations of the
current study. In the current study we did not include female
subjects. To reduce variability between subjects, bedrest stud-
ies commonly investigate only one gender. Further work is
needed to understand whether females respond similarly. For
logistical and financial reasons, we had no parallel ambulatory
non-bedrest control group which would have enabled us to
control for effects such as normal aging. With normal aging in
adult individuals under 45 years of age, approximately 0.2-
0.3% per year reduction in MR measures disc water signal oc-
curs 47. We observed losses of signal intensity on the order of
6-7% in the time frame 3-6 months after bedrest. Therefore,
we argue “normal aging” is unlikely to be the main reason to
explain our findings.
In conclusion, the current study found that whilst disc size
increased during bedrest, we could observe no concurrent in-
crease in disc water signal. This does not mean that overall
disc water content did not change, we know that increases in
disc height is inevitably accompanied by increases in disc
water content31
. However, 3 and 6 months after bedrest we
found evidence of reduced disc signal intensity. This finding
was no longer present 2 years after bedrest. This implies that
whilst negative changes in IVD composition likely occurred
in the months after bedrest, that this slowly recovers in the
years after bedrest.
Acknowledgements
We thank the people who volunteered for the bedrest study as well as
the nurses, staff, and entire research team at the Charité for the support
in the implementation of the study. The authors would also wish to thank
Dr Ian Cameron and Elizabeth Coletta for their support. The 2nd Berlin
Bed Rest Study was supported by grant 14431/02/NL/SH2 from the Eu-
ropean Space Agency and grant 50WB0720 from the German Aerospace
Center (DLR). The 2nd Berlin Bed rest Study was also sponsored by
Novotec Medical, Charité Universitätsmedizin Berlin, Siemens, Osteomed-
ical Group, Wyeth Pharma, Servier Deutschland, P&G, Kubivent, Seca,
Astra-Zeneka and General Electric. Guy Trudel was supported by Cana-
dian Institutes of Health Research Grant BRS 67811.
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