Klinefelter syndrome is a genetic condition that results from the presence of an extra X chromosome in males. It is characterized by a 47,XXY karyotype. Common features include tall stature, enlarged breasts, and low testosterone levels leading to decreased fertility. It is diagnosed based on karyotyping and treated with testosterone replacement therapy.

2. KLINE FELTER’S SYNDROME
 1. Edward’s syndrome is the result of
 A) Trisomy-13
 B) Trisomy-18
 C) Trisomy- 21
 D) Deletion of 4
 2. Jacobsen syndrome is due to:
 A) Deletion
 B) Duplication
 C)Translocation
 D) Inversion
 3. Production of excessive amount of
corticotrophin(ACTH) occur in which of the
following diseases?
 A) Cushing syndrome
 B) Alport syndrome
 C) Greig’s syndrome
 D) Greve’s disease

3.  4. A human with a karyotype of 48, XXXY is
an example for
 A) Kilnefelter’s syndrome
 B) Turner’s syndrome
 C)Triple X
 D) Down’s syndrome
 5. Which of the following is not a
chromosomal anamaly?
 A) Criduchat syndrome
 B) Proteus syndrome
 C) Patau Syndrome
 D) jacob’s syndrome
 6. Which of the following is adrenal
disorder?
 A) Cushing syndrome
 B) Myxedema
 C) Accromegaly
 D)Grave’s disease

4.  7. The disease caused due to the deficiency
of phytanic acid alpha oxidase is?
 A)SIDS
 B) Zellweger syndrome
 C) Refsume’s disease
 D) Methyl methonyl aciduria
 8. Kock knee syndrome is due to :
 A) Lead pollution
 B) Mercury pollution
 C) Fluoride pollution
 D) Solid waste pollution

5.  9. After analyzing the karyotype of an
abnormal new born baby doctor diagnosed
that he is having Edwards syndrome. The
reason is
 A) Trisomy- 21
 B) Trisomy-13
 C) Trisomy-18
 D) Trisomy-15
 10. Jacobsen syndrome is due to:
 A) Deletion
 b) Translocation
 C) Duplication
 D) Inversion

6. 10. What is the most common chromosomal pattern associated with
Klinefelter's syndrome?
 A) 46, XY
 B) 47, XYY
 C) 47, XXY
 D) 45, X
 Answer: C) 47, XXY
 11: Which of the following is a characteristic feature of Klinefelter's
syndrome?
 A) Tall stature
 B) Microcephaly
 C) Hyperandrogenism
 D) Osteoporosis
 Answer: A) Tall stature
 12 .Klinefelter's syndrome is associated with an increased risk of:
 A) Breast cancer
 B) Prostate cancer
 C) Testicular cancer
 D) Ovarian cancer
 Answer: C) Testicular cancer

7.  13:In Klinefelter's syndrome, individuals typically have:
 A) Increased testosterone levels
 B) Normal fertility
 C) Female secondary sexual characteristics
 D) Decreased testosterone levels
 Answer: D) Decreased testosterone levels
 14:The extra X chromosome in Klinefelter's syndrome is usually derived from:
 A) Father
 B) Mother
 C) Both parents
 D) Random mutation
 Answer: B) Mother
 15: The primary clinical manifestation of Klinefelter's syndrome during adolescence
is:
 A) Gynecomastia
 B) Hyperpigmentation
 C) Cane
 D) Hirsutism
 Answer: A) Gynecomastia
 16 : Individuals with Klinefelter's syndrome may have learning disabilities, with a
higher incidence of
 :A) Dyslexia
 B) Autism spectrum disorder
 C) Attention-deficit/hyperactivity disorder (ADHD)D) Intellectual disability
 Answer: A) Dyslexia

8.  17:The syndrome is named after Dr. Harry Klinefelter, who first
described it in the:
 A) 1950s
 B) 1960s
 C) 1970s
 D) 1980s
 Answer: A) 1950s
 18: In Klinefelter's syndrome, there is an increased risk of:
 A) Thrombosis
 B) Hypertension
 C) Type 1 diabetes
 D) Osteoarthritis
 Answer: A) Thrombosis
 19: The main hormonal abnormality in Klinefelter's syndrome is:
 A) Increased estrogen levels
 B) Increased LH and FSH levels
 C) Decreased LH and FSH levels
 D) Normal hormonal levels
 Answer: B) Increased LH and FSH levels

9.  20:. What is the chromosomal pattern associated with Klinefelter's syndrome?
 a. 46, XY
 b. 47, XXY
 c. 45, X
 d. 47, XY
 Answer: b. 47, XXY
 21. Which of the following is a common physical characteristic of individuals
with Klinefelter's syndrome?
 a. Broad shoulders
 b. Tall stature
 c. Microcephaly
 d. Gynecomastia
 Answer: d. Gynecomastia
 22 At what stage of development does Klinefelter's syndrome occur?
 a. Fertilization
 b. Embryonic stage
 c. Puberty
 d. Adulthood
 Answer: a.
 .23 What is the primary cause of Klinefelter's syndrome?
 a. Environmental factors
 b. Maternal age
 c. Genetic mutation
 d. Extra X chromosome
 Answer: d. Extra X chromosome

10.  24: What is the chromosomal makeup of an individual with
Klinefelter's syndrome?
 A. XX
 B. XY
 C. XXY
 D. XYY
 Answer: C. XXY
 25. Which of the following is a common symptom of
Klinefelter's syndrome?
 A. Increased facial hair
 B. Gynecomastia (enlarged breasts)
 C. Deepening of the voice
 D. Early balding
 Answer: B. Gynecomastia (enlarged breasts)
 26. At what stage of development does Klinefelter's
syndrome occur?
 A. Fertilization
 B. Embryonic stage
 C. . Adulthood
 Answer: A. Fertilization

11.  27. How does Klinefelter's syndrome
affect fertility in males?
 A. Increased fertility
 B. No impact on fertility
 C. Decreased fertility
 D. Complete infertility
 Answer: C. Decreased fertility
 28. Which of the following medical
interventions is commonly used to manage
Klinefelter's syndrome?
 A. Testosterone replacement therapy
 B. Estrogen therapy
 C. Corticosteroids
 D. Antibiotics
 Answer: A. Testosterone replacement

12.  29. What is the primary cause of Klinefelter's
syndrome
 a. Environmental factors
 b. Maternal age
 c. Genetic mutation
 d. Extra X chromosome
 Answer: d. Extra X chromosome
 30. Which reproductive system abnormality is
commonly associated with Klinefelter's
syndrome?
 a. Ovarian cysts
 b. Testicular atrophy
 c. Uterine fibroids
 d. Polycystic ovaries
 Answer: b. Testicular atrophy