This document discusses the center of gravity (COG) in the human body. It defines COG as the point where all the weight of the body is concentrated and balanced. The location of the COG depends on factors like age, sex, movements, and addition or subtraction of weight. It can be determined for the whole body or individual body segments using mathematical formulas or laboratory methods. Knowing the COG is important for tasks like gait training and designing prosthetics to ensure balanced movement and reduce pain or injury.
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Easy to understand and with lot of examples.
Stability principles give athletes rules about holding positions and staying on balance when running. They guide training for improving firmness of positions both for static balance and dynamic balance.
Introduction to kinesiology (Biomechanics- Physiotherapy) vandana7381
Chapter 1: Introduction to Kinesiology ( Biomechanics) for physical therapy students.
Reference: JOINT STRUCTURE AND FUNCTION - by Pamela K. Levangie.
Easy to understand and with lot of examples.
Stability principles give athletes rules about holding positions and staying on balance when running. They guide training for improving firmness of positions both for static balance and dynamic balance.
Zygmunt Smalcerz Clean Clinic Presentation SlidesGregorATG
http://www.allthingsgym.com/2012/03/zygmunt-smalcerz-clean-presentation.html
Zygmunt's "Clean" presentation from the National Champtionships. March, 2012
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This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
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Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
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Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
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2. OUTLINES
- Definition
- Location Of COG
- Factors Affecting Location Of COG in the body
- Determination Of Total body COG
- Mathematical method
- Laboratory method
- Determination Of Segmental Body COG
- Value Of Determination of COG
3. INTRODUCTION
2 Types of Forces affecting HB
↓
Internal Force & External Force
↓
GRF , GF , Resistance , Friction ,Pressure
4. DEFINITION OF CENTRE OF GRAVITY
- Gravitational Force (GF) : Force that pull The Body
Downward.
- Centre of gravity (COG) :
• is the balancing Point
• Where the body is concentrated & equally distributed
• It is the point of exact center where the body rotates in
all directions
• called center of mass
• Sum of all forces = 0 & sum of moments =0
5.
6. LOCATION OF COG
- It Depends on The Body’s Shape & position
- If Distribution of mass is symmetrical :
• Square block or cylinder At the center of object
- If distribution of mass is asymmetrical :
• Limbs of Hb Nearer to the larger & heavier end
- In a normal Person Standing position anterior 2nd sacral
vertebra
N . b : The exact location is not the same between individuals
since there are factors affecting it
7. FACTORS AFFECTING LOCATION OF
COG IN THE BODY
1. Age
2.Sex
3.Movements of segments ( upward /
downward / bending ..)
4.Addition and subtraction of weight
8. AGE
The ratio of body’s mass changes while growing up
leading to a change in COG location
COG drops down as age is increasing
9. COG in newborns is higher than in adults
why ??
There is no balance in body’s mass in newborn . You’ll find upper
body part heavier than lower one High COG
While development , redistribution of body mass occurs lowering
COG reaching ant of 2nd vertebra
Newborn
2 years
5 years
Adults
• Above umbilicus
• At Level of umbilicus
• Below umbilicus
• Anterior to second
sacral vertebra
11. In males :
oThe muscles of upper division weights more than lower
division
oBody build
=> COG higher
o57 % of standing height
In females
oThe pelvis is wider & lower than male’s pelvis
o55% of standing height
12. MOVEMENT OF SEGMENTS
COG moves toward the heavy mass
flexion of right arm
COG moves :
Upward
Forward
To the right
13. While running , COG will move outside of the
body so the person will run forward
to return it to it’s normal place
or else he will fall
15. If the weight was behind the trunk
=> COG moves backward
=> person will make a forward trunk movement or
else the backward weight will pull him back
If the weight was in front the trunk
=> COG will move forward
=> person will make a backward trunk movement
=> leads to increase lumbar lordosis and back pain
later on .
16. SUBTRACTION OF WEIGHT
In case of amputation
oCOG moves away from amputated limb toward the
healthy side
oTo have a normal gait and distributed body segment ,
the artificial limb’s weight & the normal limb’s weight
should be identical
This identical limb will balance in body’s weight thus
returning COG to normal
17. DETERMINATION OFTHE LOCATION OF COG
First , locate the first action line of COG after you hang
or balance the object (Ex. Book( regular body)).
Second , turn around the object 90 degree and locate the
2nd action line .
Third ,the meeting of the 2 action lines is the position of
the COG.
19. DETERMINATION OF
TOTAL BODY COG:
It can be determined using mathematical or laboratory method.
Mathematical Method :
1. With regarding to sex:”Croskey formula” .
2. Without regarding to sex:”Palmar formula”.
20. Regarding to sex:
A. In female the height of COG measured from
heel =Total body height x 55.44 /100
B. In male the height of COG measured from
heel =Total body height x 56.18/100
The percentage location of COG in female is
55.44 and in male is 56.18.
22. EXAMPLE ON CHANGE OF THE
LOCATION OF THE TOTAL BODY COG
BY 2 FORMULAS
A female of 150 cm height .
A. “Palmar formula” =150x55.7/100 +1.4=
84.95cm
B. “Croskey formula” =150x 55.44/100 =83.16
cm.
23. BONY LAND MARKS
• Spine of the scapula.
• Iliac crest.
• Xiphoid process.
• Anterior superior iliac spine .
• Greater trochanter.
24. The most useful bony landmarks for measuring
the height of total body COG are:
Anterior superior iliac spine .
Greater trochanter.
25. MEASUREMENT OF TOTAL
BODY HEIGHT
1. Initially , place an object over the top of the head.
2. Second, calculate the body height from the heel to
the tragus from lateral side.
26. 3. Third , use Palmar or Croskey formula.
4.Forth , find the relation of the total body
center of gravity height to either bony or soft
tissue land mark .
30. TRANSVERSE PLANE
S1=150 N first reading
S2=500Nsecond reading
Weight’s man =700N
S2= Wb + Wm provided by scale
Wm provided bye scale=S2-Wb=500-150=350N
*Wm provided bye scale=Upward force=R
31. TRANSVERSE PLANE
To find X:
At equilibrium: summation T=0
TN + Tm + TR=0
Projection along positive direction
-Wm.X + R.L=0
X=-RL/-Wm
=350.100/700=50cm
The C.O.G in transverse plane of the subject’s body is 50 cm above the ground
when he is standing measured from the foot.
T:Tork: rotator effect created by applied force also known as moment of force
32. FRONTAL PLANE
We apply the same procedure as transverse plane but the person is
standing facing straight ahead
33. SAGITTAL PLANE
We apply the same procedure as transverse plane but the person is
standing facing to one side
34. DETERMINATION OF SEGMENTAL
BODY COG
Body Segments:
The body is made up of eight segments, these
segments are:
1-Head and Neck 5-Hand
2-Trunk 6-Thigh
3-Arm 7-Leg
4-Forearm 8-Foot
35. The location of COG of each body segment is toward the
heavier end, which is approximately 4/7 of segment length
measured from distal end.
How to determine COG of any segment?
-First, the location of proximal and distal end of each
segment should be in appendicular and axial skeleton, then
measure the segmental length of this segment.
-Second, Mathematically multiply the segmental length by
4/7 in order to find the location of segmental COG,
Then measure the final result from the distal end.
36. Segments: Proximal end Distal end
Appendicular skeleton
1.Arm Acromion process Axis of elbow joint
2.Forearm Axis of elbow joint Axis of wrist joint
3.Hand Axis of wrist joint Middle finger tip
4.Thigh Greater trochanter Axis of knee joint
5.Leg Axis of knee joint Lateral malleolus
6.Foot Heel Tip of toes
37. Axial skeleton
7.Head and Neck Sternal notch Tragus
(midpoint between (top of head)
2 shoulders)
8.Trunk Crotch Sternal notch
(midpoint between
2 hip joints )
38. If the body segments move in flexion as in the
upper or lower limb , the COG of the entire part
can be computed from the center of gravity of
each segments.
The single segment may be found outside the
limb if it is flexed.
40. TOTAL BODY COG
During gait training of any patient the key of sucessful handling to
control and support patients at the pelvis which is the COG .
The therapist may assist by grasping the patients belt or steadying
the pelvis .
Total COG help to enhance the performance of athletes .
41.
42. SEGMENTAL COG
In amputee patient it help to design the weight of artifical limb that
will be equal to the amputated limb .
If the artifical limb increase the segmental COG will change so the
total COG will change as a result they may place overload on a
diseased part which cause pain .
43. SEGMENTAL COG
It help to determine the leverage effect of gravity .
In segment is more difficult to lift in extended position than in
flexed .
Change of body segment position
away from the joint cause
an increased need for muscle
activity .
44. REFERENCES
• Hand out
• www.slide.share (Lecture to dr. shimaa Essa)
• Basic Biomechanics Book-chapter13,Equilibrium and human
movement
• Handout
• http://thumb1.shutterstock.com/display_pic_with_logo/374293/37
4293,1271146890,4/stock-vector-full-length-profile-front-back-
view-of-a-standing-naked-man-50821411.jpg
• faculty.mu.edu.sa ( Majmaah University)