This document discusses operationalizing the Strengthening Capacity for Agricultural Policy and Implementation (SAKSS) in countries in the Southern African Development Community region. It outlines general principles for establishing SAKSS, including having local stakeholder support and commitment of resources. Key architectural elements are described, such as advisory committees and partnerships between government, research institutions, and donors. Challenges include ensuring stakeholder participation and ownership and producing policy-relevant research. The experience of Mozambique establishing SAKSS is provided as an example, highlighting opportunities like government support but also challenges like limited data and inter-institutional collaboration.