This document summarizes research on Māori attempted suicide in Aotearoa/New Zealand. It includes a review of Māori medical records of attempted suicide cases and a case-control study comparing Māori individuals who attempted suicide to controls.
The key findings were that over half of Māori attempted suicide cases involved poisoning, rates were highest among youth ages 15-24, and indicators of compromised cultural identity and poorer health status were associated with higher risk of attempted suicide compared to those with secure cultural identities.
The research aims to help inform culturally-appropriate suicide prevention strategies for Māori by better understanding the roles of culture and health factors in
Joseph Lloveras - Spain - Tuesday 29 - Organ Allocation Optimizing donor-rec...incucai_isodp
This study examined outcomes of 835 renal transplant recipients who received kidneys from cadaveric donors over age 65 between 1990-2009. Key findings:
1) Graft and patient survival rates decreased as donor age increased, but long-term survival was still better than remaining on dialysis.
2) Most kidneys from donors over 65 went to recipients over 60 due to donor-recipient age matching practices.
3) While short-term outcomes like delayed graft function were higher with older donors, long-term graft survival was similar after accounting for death with functioning grafts.
3 forette prevention of alzheimer ifa 2012] 2ifa2012
The document discusses potential approaches for preventing Alzheimer's disease and dementia. It notes that while some observational studies have found associations between certain factors and reduced dementia risk, large randomized controlled trials have not shown that anti-inflammatory agents, antioxidants, or estrogen therapy can prevent Alzheimer's disease. The document does provide evidence from randomized trials that treating hypertension through blood pressure lowering agents can reduce incidence of dementia. It summarizes trials showing reduced dementia risk when treating hypertension with calcium channel blockers, ACE inhibitors, and diuretics.
Achieving target refraction after cataract surgeryRiyad Banayot
This study evaluates the difference between target and actual refraction after phacoemulsification and intraocular lens implantation at St John Eye Hospital – Hebron, Palestine.
The document is a survey report conducted by students to investigate the understanding level of male and female students at Taylor's University about HIV/AIDS. It contains the survey questions, methodology of conducting the survey, tables of responses collected, and analysis of the data. The analysis includes bar charts comparing the responses between male and female students. It shows that for most questions, both genders had similar levels of understanding about HIV/AIDS, with neither being more knowledgeable overall.
The document is a statistics assignment from a school of architecture, building and design. It involves conducting a survey of 300 students (150 male, 150 female) at Taylor's University about their understanding of HIV/AIDS. The survey collected data on students' knowledge of topics like symptoms of HIV/AIDS, how it is transmitted, treatment, etc. The data was analyzed using tables, charts and calculations to compare understanding between male and female students and draw conclusions. Most questions were answered correctly by both genders with modes indicating transmission occurs through sexual contact and condoms offer the best protection.
Joseph Lloveras - Spain - Tuesday 29 - Organ Allocation Optimizing donor-rec...incucai_isodp
This study examined outcomes of 835 renal transplant recipients who received kidneys from cadaveric donors over age 65 between 1990-2009. Key findings:
1) Graft and patient survival rates decreased as donor age increased, but long-term survival was still better than remaining on dialysis.
2) Most kidneys from donors over 65 went to recipients over 60 due to donor-recipient age matching practices.
3) While short-term outcomes like delayed graft function were higher with older donors, long-term graft survival was similar after accounting for death with functioning grafts.
3 forette prevention of alzheimer ifa 2012] 2ifa2012
The document discusses potential approaches for preventing Alzheimer's disease and dementia. It notes that while some observational studies have found associations between certain factors and reduced dementia risk, large randomized controlled trials have not shown that anti-inflammatory agents, antioxidants, or estrogen therapy can prevent Alzheimer's disease. The document does provide evidence from randomized trials that treating hypertension through blood pressure lowering agents can reduce incidence of dementia. It summarizes trials showing reduced dementia risk when treating hypertension with calcium channel blockers, ACE inhibitors, and diuretics.
Achieving target refraction after cataract surgeryRiyad Banayot
This study evaluates the difference between target and actual refraction after phacoemulsification and intraocular lens implantation at St John Eye Hospital – Hebron, Palestine.
The document is a survey report conducted by students to investigate the understanding level of male and female students at Taylor's University about HIV/AIDS. It contains the survey questions, methodology of conducting the survey, tables of responses collected, and analysis of the data. The analysis includes bar charts comparing the responses between male and female students. It shows that for most questions, both genders had similar levels of understanding about HIV/AIDS, with neither being more knowledgeable overall.
The document is a statistics assignment from a school of architecture, building and design. It involves conducting a survey of 300 students (150 male, 150 female) at Taylor's University about their understanding of HIV/AIDS. The survey collected data on students' knowledge of topics like symptoms of HIV/AIDS, how it is transmitted, treatment, etc. The data was analyzed using tables, charts and calculations to compare understanding between male and female students and draw conclusions. Most questions were answered correctly by both genders with modes indicating transmission occurs through sexual contact and condoms offer the best protection.
Introduction to a conference at the University of York on September 4, 2014 on men's health and long-term conditions - including mortality rates, cancer, heart disease, suicide and diabetes
Using linked medical records, this study explored outcomes for people with mental illness discharged from inpatient care over several decades. Some key findings include:
- There is significant risk of death within the first year of discharge, especially from natural causes.
- Mortality rates within 30 days of discharge have markedly decreased over time, especially from natural causes.
- Admission rates for those over 65 with mental illness have significantly decreased while rates of community-based care have increased.
- Working with encrypted medical records presents challenges for outcomes research but record linkage is still advantageous for studying mental health outcomes over long periods.
This study evaluated thyroid nodules in 35 patients with acromegaly using ultrasound elastography. The study found a high prevalence (56.7%) of stiff thyroid nodules in acromegaly, especially in patients with active disease. However, cytological analysis found that these stiff nodules were not malignant and were likely fibrotic in nature. Therefore, ultrasound elastography appears to have limited value for diagnosing thyroid cancer in patients with acromegaly.
Session 12 - Introduction to Information ToolsMedXellence
This document summarizes tools for gathering performance improvement evidence, including the Template Analysis Tool (TAT). TAT provides clinic and provider-specific templates to analyze appointment categories, statuses, and dates. It summarizes appointment data for specific clinics, providers, and time periods to evaluate access and utilization. The document discusses using TAT and other sources like the Tricare Operations Center to examine metrics like empaneled patients, visits per 1000 patients, and provider availability. The goal is to provide actionable data to support decision making and demonstrate improvement tools for staff.
Value chain analysis for products and by-products of egg laying birds in peri...ILRI
Presentation by Joshua Onono, Pablo Alarcon, Barbara Haesler, Eric Fevre, Maurice Karani, Patrick Muinde, James Akoko, Maud Carron and Jonathan Rushton at the 14th conference of the International Society for Veterinary Epidemiology and Economics (ISVEE), Merida, Yucatan, Mexico, 3-7 November 2015.
Examining data trends in NSW emergency departments from 2010-2015, Criterion Conferences
• A population based study of ED utilisation and length of stay
• Implementing prediction models
• Leveraging ambulance resources
Speaker: Michael Dinh Emergency Physician Royal Prince Alfred Hospital, NSW
El 27 de noviembre de 2014, la Fundación Ramón Areces celebró una nueva conferencia del ciclo que organiza sobre 'Envejecimiento, Sociedad y Salud: envejecimiento y enfermedad' en colaboración con el Centro de Estudios del Envejecimiento. En esta ocasión, la investigadora María Blasco, directora del Centro Nacional de Investigaciones Oncológicas (CNIO), habló sobre 'El origen de la enfermedad'.
Discussing problems vs. finding solutions: an operational framework for dealing with imperfect detection in species distribution modelling
P. Sólymos a and S.M. Matsuoka b and E.M. Bayne a and S.R. Lele c
a Department of Biological Sciences
University of Alberta
Edmonton, Alberta, Canada
solymos@ualberta.ca, bayne@ualberta.ca
b U.S. Fish and Wildlife Service
Migratory Bird Management
Anchorage, Alaska, USA.
Steve_Matsuoka@fws.gov
c Department of Mathematical and Statistical Sciences
University of Alberta
Edmonton, Alberta, Canada
slele@ualberta.ca
Keywords: abundance, distance sampling, species distribution models
Abstract: Methods for dealing with imperfect detection have gained increasing attention in species distribution models (SDMs), yet there seems to be more discussion of the problems than efficient solutions. Part of the issue is that many historical and current data sets have been collected without multiple-visits to locations, thus conventional models based on multiple visits are not applicable. Another problem is the lack of standardized protocols when combining disparate data sets in order to cover larger geographic areas for SDMs. We show that recently proposed methodologies (single visit based N-mixture models; Sólymos et al. 2012) allow for correcting for detection error without replicate surveys; and that using a subset of the data to develop correction factors based on a combination of removal and distance sampling can be used to correct for imperfect detection while dealing with variation in survey protocols (QPAD approach; Sólymos et al. 2013). The QPAD approach can be used in combination with common modelling techniques including GLMs, GAMs, GLMMs, and regression trees. A common feature of these methods is the use of conditional maximum likelihood estimators that lead to reduced computation when fitting complex models to large data sets. These methods are also cost effective enabling ecologists to cover a larger geographical region than possible when having to return to sites. We use bird point count surveys from the Boreal Avian Modelling Project and the Alberta Biodiversity Monitoring Institute to demonstrate some of the possible applications of these methodologies for conservation and management of species over large spatial scales.
References
Sólymos, P., Lele, S. R., and Bayne, E. (2012) Conditional likelihood approach for analyzing single visit abundance survey data in the presence of zero inflation and detection error. Environmetrics, 23:197-205.
Sólymos, P., Matsuoka, S. M., Bayne, E. M., Lele, S. R., Fontaine, P., Cumming, S. G., Stralberg, D., Schmiegelow, F. K. A., and Song, S. J. (2013) Calibrating indices of avian density from non-standardized survey data: making the most of a messy situation. Methods in Ecology and Evolution, 4:1047-1058.
The document discusses using genomic information to improve disease prevention strategies. It describes shifting focuses from 19th century environmental causes, to 20th century social/behavioral factors, to 21st century personalized approaches using genetic information. Personal genomics could enable primary prevention by identifying disease risks and targeting lifestyle changes. It could also enable secondary prevention through early disease detection. Validation of genomic tools and assessing clinical utility and outcomes are important to evaluate. Personalized approaches may improve over traditional screening programs by more accurately identifying those at higher risk.
Current Situation in Control Strategies and Health Systems in Asia - Sri Lanka by Rasnayaka M Mudiyanse, Senior Lecturer in Paediatrics at the University of Peradeniya and Consultant Paediatrician at the Teaching Hospital in Peradeniya.
Multiplexing cytotoxicity measurements in spheroids on normal and tumour tissueDelyanIvanov
The presentation highlights affordable, convenient, and amenable to validation methods to determine cytotoxic dose-response in spheroids
We have used readily-available standard lab equipment and open source platforms
A free Fiji( ImageJ) macro is disclosed aimed at automated image analysis of 3D spheroids
Suicidal Ideation in Geriatric Population of Jaipur City-Physical, Social and economical problem of geriatrics lead to disturbance in their psychological health and may lead to psychiatric disorders. This study is aimed to found out the suicidal tendencies in geriatric population of Jaipur city. For the study 990 geriatric individuals were identified by 30 cluster technique was adopted to cover whole city. Questions related to suicidal ideation were asked along with other socio-demographic variables. Collected data were analyzed as percentage and proportion and to find out the associated socio-demographic factors chi-square test was used. Suicidal Ideation was found in 6.77% of elderly and this Suicidal Ideation was found to be associated with age, education and present occupation of elderly. It was found significantly more in elderly who lost their spouses. Housing condition and personal hygiene were found to be directly proportional to suicidal ideation i.e. poorer the housing condition and personal hygiene more the chances to have suicidal ideation.
This document summarizes the results of the ARISE trial, which compared the Angio-Seal vascular closure device to manual compression using a radial artery approach in 240 patients undergoing coronary procedures for acute coronary syndrome. The trial found no significant differences in vascular complications, major bleeding, transfusion needs, or other safety outcomes between the two approaches at 30 days. Specifically, the risk difference for the primary endpoint of vascular complications was -0.83% (95% CI, -9.31-7.65) in favor of Angio-Seal, meeting the prespecified non-inferiority criterion. The results demonstrate that Angio-Seal is not inferior to manual compression in terms of safety and effectiveness when
The document appears to be a survey containing respondents' answers to questions about experiences with unidentified flying objects (UFOs) and other paranormal phenomena. Some key details:
- 76.22% of respondents reported seeing an intelligently controlled craft in the sky or ground not made by humans.
- 60.40% of those who saw a UFO said that other witnesses also saw it.
- 41.64% believe they possess knowledge about advanced technology or physics they have not learned.
- 80.52% reported experiencing altered states like out of body experiences.
- 56.61% believe they have observed a non-human intelligent entity.
So in summary, the
Dr Ayman Ewies - Abnormal Uterine Bleeding in Pre-menopausal Women: When Shou...AymanEwies
This document summarizes a study on abnormal uterine bleeding in pre-menopausal women. The study examined 3006 endometrial samples from women aged 30 to 50 who presented with abnormal uterine bleeding. It found that the rate of atypical hyperplasia and carcinoma increased with each successive 5-year age group, with the highest rates occurring in women aged 45-50. Specifically, atypical hyperplasia was 3.85 times more likely and carcinoma was 4.03 times more likely in women aged 45-50 compared to those under 40. While abnormal growths can occur under age 40, the study supports guidelines recommending endometrial sampling for women over 45 presenting with abnormal uterine bleeding.
D1 Highly Active Antiretroviral Treatment (HAART) DHHS Guidelines 2009 DuffusDSHS
The document discusses guidelines for initiating highly active antiretroviral treatment (HAART) based on CD4 count and viral load. Guidelines from 1998-2009 increasingly recommended treating HIV at higher CD4 counts and without a specific viral load threshold. Studies show the magnitude of CD4 increase is greatest when starting HAART at low counts, but normalization is more likely the earlier therapy begins. A CD4 count below 350 cells/mm3 increases the risk of cardiovascular and other non-AIDS complications.
This document summarizes the 5-year clinical outcomes from the LEADERS trial, which compared the Biolimus A9-eluting stent with a biodegradable polymer to the Sirolimus-eluting stent with a durable polymer. The main findings over 5 years of follow-up were:
1) The Biolimus stent was non-inferior to the Sirolimus stent for the primary endpoint of major adverse cardiac events (MACE), comprising cardiac death, heart attack (MI), or clinically-indicated target vessel revascularization (TVR).
2) There were no significant differences between the stents in rates of cardiac death, heart attack (MI), or stent thrombosis.
This document outlines a research study comparing social marketing and community development approaches for Māori suicide prevention. It defines key terms, reviews literature on Māori suicide statistics and risk factors, describes social marketing and community development initiatives in New Zealand. Key informant interviews provided insights from experts. While both approaches have benefits, community development aligns more with Māori culture but data is lacking. Further research is needed to objectively compare the effectiveness of these approaches for Māori.
This document summarizes a workshop on suicide and the media held in New Zealand in September 2013. It discusses the Mindframe National Media Initiative, which aims to influence responsible media representation of suicide and mental illness issues. The workshop covered evidence on the impacts of media reporting on suicide, challenges in media coverage of suicide, and guidelines for discussing suicide safely and constructively in the media. It also addressed working collaboratively with the media and providing helpful information for audiences while avoiding sensationalism.
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Introduction to a conference at the University of York on September 4, 2014 on men's health and long-term conditions - including mortality rates, cancer, heart disease, suicide and diabetes
Using linked medical records, this study explored outcomes for people with mental illness discharged from inpatient care over several decades. Some key findings include:
- There is significant risk of death within the first year of discharge, especially from natural causes.
- Mortality rates within 30 days of discharge have markedly decreased over time, especially from natural causes.
- Admission rates for those over 65 with mental illness have significantly decreased while rates of community-based care have increased.
- Working with encrypted medical records presents challenges for outcomes research but record linkage is still advantageous for studying mental health outcomes over long periods.
This study evaluated thyroid nodules in 35 patients with acromegaly using ultrasound elastography. The study found a high prevalence (56.7%) of stiff thyroid nodules in acromegaly, especially in patients with active disease. However, cytological analysis found that these stiff nodules were not malignant and were likely fibrotic in nature. Therefore, ultrasound elastography appears to have limited value for diagnosing thyroid cancer in patients with acromegaly.
Session 12 - Introduction to Information ToolsMedXellence
This document summarizes tools for gathering performance improvement evidence, including the Template Analysis Tool (TAT). TAT provides clinic and provider-specific templates to analyze appointment categories, statuses, and dates. It summarizes appointment data for specific clinics, providers, and time periods to evaluate access and utilization. The document discusses using TAT and other sources like the Tricare Operations Center to examine metrics like empaneled patients, visits per 1000 patients, and provider availability. The goal is to provide actionable data to support decision making and demonstrate improvement tools for staff.
Value chain analysis for products and by-products of egg laying birds in peri...ILRI
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Examining data trends in NSW emergency departments from 2010-2015, Criterion Conferences
• A population based study of ED utilisation and length of stay
• Implementing prediction models
• Leveraging ambulance resources
Speaker: Michael Dinh Emergency Physician Royal Prince Alfred Hospital, NSW
El 27 de noviembre de 2014, la Fundación Ramón Areces celebró una nueva conferencia del ciclo que organiza sobre 'Envejecimiento, Sociedad y Salud: envejecimiento y enfermedad' en colaboración con el Centro de Estudios del Envejecimiento. En esta ocasión, la investigadora María Blasco, directora del Centro Nacional de Investigaciones Oncológicas (CNIO), habló sobre 'El origen de la enfermedad'.
Discussing problems vs. finding solutions: an operational framework for dealing with imperfect detection in species distribution modelling
P. Sólymos a and S.M. Matsuoka b and E.M. Bayne a and S.R. Lele c
a Department of Biological Sciences
University of Alberta
Edmonton, Alberta, Canada
solymos@ualberta.ca, bayne@ualberta.ca
b U.S. Fish and Wildlife Service
Migratory Bird Management
Anchorage, Alaska, USA.
Steve_Matsuoka@fws.gov
c Department of Mathematical and Statistical Sciences
University of Alberta
Edmonton, Alberta, Canada
slele@ualberta.ca
Keywords: abundance, distance sampling, species distribution models
Abstract: Methods for dealing with imperfect detection have gained increasing attention in species distribution models (SDMs), yet there seems to be more discussion of the problems than efficient solutions. Part of the issue is that many historical and current data sets have been collected without multiple-visits to locations, thus conventional models based on multiple visits are not applicable. Another problem is the lack of standardized protocols when combining disparate data sets in order to cover larger geographic areas for SDMs. We show that recently proposed methodologies (single visit based N-mixture models; Sólymos et al. 2012) allow for correcting for detection error without replicate surveys; and that using a subset of the data to develop correction factors based on a combination of removal and distance sampling can be used to correct for imperfect detection while dealing with variation in survey protocols (QPAD approach; Sólymos et al. 2013). The QPAD approach can be used in combination with common modelling techniques including GLMs, GAMs, GLMMs, and regression trees. A common feature of these methods is the use of conditional maximum likelihood estimators that lead to reduced computation when fitting complex models to large data sets. These methods are also cost effective enabling ecologists to cover a larger geographical region than possible when having to return to sites. We use bird point count surveys from the Boreal Avian Modelling Project and the Alberta Biodiversity Monitoring Institute to demonstrate some of the possible applications of these methodologies for conservation and management of species over large spatial scales.
References
Sólymos, P., Lele, S. R., and Bayne, E. (2012) Conditional likelihood approach for analyzing single visit abundance survey data in the presence of zero inflation and detection error. Environmetrics, 23:197-205.
Sólymos, P., Matsuoka, S. M., Bayne, E. M., Lele, S. R., Fontaine, P., Cumming, S. G., Stralberg, D., Schmiegelow, F. K. A., and Song, S. J. (2013) Calibrating indices of avian density from non-standardized survey data: making the most of a messy situation. Methods in Ecology and Evolution, 4:1047-1058.
The document discusses using genomic information to improve disease prevention strategies. It describes shifting focuses from 19th century environmental causes, to 20th century social/behavioral factors, to 21st century personalized approaches using genetic information. Personal genomics could enable primary prevention by identifying disease risks and targeting lifestyle changes. It could also enable secondary prevention through early disease detection. Validation of genomic tools and assessing clinical utility and outcomes are important to evaluate. Personalized approaches may improve over traditional screening programs by more accurately identifying those at higher risk.
Current Situation in Control Strategies and Health Systems in Asia - Sri Lanka by Rasnayaka M Mudiyanse, Senior Lecturer in Paediatrics at the University of Peradeniya and Consultant Paediatrician at the Teaching Hospital in Peradeniya.
Multiplexing cytotoxicity measurements in spheroids on normal and tumour tissueDelyanIvanov
The presentation highlights affordable, convenient, and amenable to validation methods to determine cytotoxic dose-response in spheroids
We have used readily-available standard lab equipment and open source platforms
A free Fiji( ImageJ) macro is disclosed aimed at automated image analysis of 3D spheroids
Suicidal Ideation in Geriatric Population of Jaipur City-Physical, Social and economical problem of geriatrics lead to disturbance in their psychological health and may lead to psychiatric disorders. This study is aimed to found out the suicidal tendencies in geriatric population of Jaipur city. For the study 990 geriatric individuals were identified by 30 cluster technique was adopted to cover whole city. Questions related to suicidal ideation were asked along with other socio-demographic variables. Collected data were analyzed as percentage and proportion and to find out the associated socio-demographic factors chi-square test was used. Suicidal Ideation was found in 6.77% of elderly and this Suicidal Ideation was found to be associated with age, education and present occupation of elderly. It was found significantly more in elderly who lost their spouses. Housing condition and personal hygiene were found to be directly proportional to suicidal ideation i.e. poorer the housing condition and personal hygiene more the chances to have suicidal ideation.
This document summarizes the results of the ARISE trial, which compared the Angio-Seal vascular closure device to manual compression using a radial artery approach in 240 patients undergoing coronary procedures for acute coronary syndrome. The trial found no significant differences in vascular complications, major bleeding, transfusion needs, or other safety outcomes between the two approaches at 30 days. Specifically, the risk difference for the primary endpoint of vascular complications was -0.83% (95% CI, -9.31-7.65) in favor of Angio-Seal, meeting the prespecified non-inferiority criterion. The results demonstrate that Angio-Seal is not inferior to manual compression in terms of safety and effectiveness when
The document appears to be a survey containing respondents' answers to questions about experiences with unidentified flying objects (UFOs) and other paranormal phenomena. Some key details:
- 76.22% of respondents reported seeing an intelligently controlled craft in the sky or ground not made by humans.
- 60.40% of those who saw a UFO said that other witnesses also saw it.
- 41.64% believe they possess knowledge about advanced technology or physics they have not learned.
- 80.52% reported experiencing altered states like out of body experiences.
- 56.61% believe they have observed a non-human intelligent entity.
So in summary, the
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This document summarizes a study on abnormal uterine bleeding in pre-menopausal women. The study examined 3006 endometrial samples from women aged 30 to 50 who presented with abnormal uterine bleeding. It found that the rate of atypical hyperplasia and carcinoma increased with each successive 5-year age group, with the highest rates occurring in women aged 45-50. Specifically, atypical hyperplasia was 3.85 times more likely and carcinoma was 4.03 times more likely in women aged 45-50 compared to those under 40. While abnormal growths can occur under age 40, the study supports guidelines recommending endometrial sampling for women over 45 presenting with abnormal uterine bleeding.
D1 Highly Active Antiretroviral Treatment (HAART) DHHS Guidelines 2009 DuffusDSHS
The document discusses guidelines for initiating highly active antiretroviral treatment (HAART) based on CD4 count and viral load. Guidelines from 1998-2009 increasingly recommended treating HIV at higher CD4 counts and without a specific viral load threshold. Studies show the magnitude of CD4 increase is greatest when starting HAART at low counts, but normalization is more likely the earlier therapy begins. A CD4 count below 350 cells/mm3 increases the risk of cardiovascular and other non-AIDS complications.
This document summarizes the 5-year clinical outcomes from the LEADERS trial, which compared the Biolimus A9-eluting stent with a biodegradable polymer to the Sirolimus-eluting stent with a durable polymer. The main findings over 5 years of follow-up were:
1) The Biolimus stent was non-inferior to the Sirolimus stent for the primary endpoint of major adverse cardiac events (MACE), comprising cardiac death, heart attack (MI), or clinically-indicated target vessel revascularization (TVR).
2) There were no significant differences between the stents in rates of cardiac death, heart attack (MI), or stent thrombosis.
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This document outlines a research study comparing social marketing and community development approaches for Māori suicide prevention. It defines key terms, reviews literature on Māori suicide statistics and risk factors, describes social marketing and community development initiatives in New Zealand. Key informant interviews provided insights from experts. While both approaches have benefits, community development aligns more with Māori culture but data is lacking. Further research is needed to objectively compare the effectiveness of these approaches for Māori.
This document summarizes a workshop on suicide and the media held in New Zealand in September 2013. It discusses the Mindframe National Media Initiative, which aims to influence responsible media representation of suicide and mental illness issues. The workshop covered evidence on the impacts of media reporting on suicide, challenges in media coverage of suicide, and guidelines for discussing suicide safely and constructively in the media. It also addressed working collaboratively with the media and providing helpful information for audiences while avoiding sensationalism.
Dr Nicole Coupe - Preventing Māori suicide: Improving care and interventionMHF Suicide Prevention
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Suicide prevention - Auckland Council Social and Community Development ForumMHF Suicide Prevention
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Keri Lawson-Te Aho discusses suicide prevention for Māori in the first of three online seminars. She shares a story from her own whānau, looks at how the issue is different for Māori including culturally-specific risk and protective factors, and suggests a paradigm shift is needed to respond to Māori suicide more effectively. For more information about this seminar series, see: http://www.spinz.org.nz/page/323-webinars
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This document provides information on suicide prevention for Asian communities in New Zealand. It summarizes statistics on suicide rates nationally and among Asian populations from 2004-2009. It also discusses risk and protective factors for suicide, noting the importance of family, community, and culturally appropriate services. Current gaps are identified in research and resources for understanding suicidality in Asian communities in New Zealand.
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This document summarizes patterns of suicidal behavior among inmates in New Zealand prisons over the past 20 years. There were two distinct peaks in prison suicides, in 1984-1985 and 1994-1995, which were influenced by changes in health and correctional policies. Screening tools and mental health services have since been developed and expanded for prisoners to help address suicide risk, though continued collaboration between health and corrections sectors is still needed.
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2. While most people gamble recreationally, problem gamblers represent 0.5-3% of the population and have high rates of suicidal ideation, attempts, and completions, though gambling-related suicides are relatively rare.
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This document summarizes a study on the relationship between self-mutilation and suicidal behavior in young women. Key findings include: 1) Self-mutilation is distinct from suicidal behavior in intent but provides temporary relief from suicidal thoughts; 2) Sexual abuse is a major risk factor for both behaviors as a way to regain control; 3) Counseling should focus on empowerment, trust, and addressing trauma non-judgmentally.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)MuskanShingari
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
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The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
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Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga
GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort.
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
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Giloy in Ayurveda - Classical Categorization and SynonymsPlanet Ayurveda
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
Giloy in Ayurveda - Classical Categorization and Synonyms
Kainamu Whakamomori: Maori Attempted Suicide in Aotearoa
1. Kainamu Whakamomori: Attempted
Suicide in Aotearoa
Dr Nicole M. C oupe KÄI TAH U , TE ATIAWA
Pos t Doctoral Fellow
N ga P ae o te Maram atanga
n.m.coupe@mas s ey.ac.nz
2. Summary
Aotearoa contemporary context
Maori attempted suicide medical record review
Maori attempted suicide case control study
Translating research into suicide prevention
3. Definitions
Changes in coding
Differences in DHB reporting and patient management
Hospitalisations are numbers of episodes rather than
individual people
Readmissions same condition counted as additional
discharges
People transferred between hospitals are counted each time
4. Intentional self harm rates
A otearoa Non-Mäori Mäori
100,000 No. 100,000 No. 100,000 No.
Total 1 31 .5 5292 1 34.1 4573 1 1 5.1 71 9
Fem ale 1 78.6 361 0 1 85.0 31 43 1 43.9 467
M ale 84.2 1 682 83.3 1 430 85.0 252
5. Suicide & Intentional Self Harm Rates
Age standardised
rate (per 100,000)
450
400 Male
350 Female
300
250
200
150
100
50
0
10- 15- 20- 25- 30- 35- 40- 45- 50- 55- 60- 65- 70- 75- 80- 85+
Age groups (years)
Total 20-24 years (300.0/100,000)
Males 25-29 years (201.6/100,000)
Females 15-19 years (425.4/100,000)
Mäori 20-24 years (277.5/100,000)
Males 20-25 years (210.0/100,000)
Females 20-24 years (343.4/100,000)
6. Suicide & Intentional Self Harm Rates
Age standardised
rate (per 100,000)
450
400 Male
350 Female
300
250
200
150
100
50
0
5-14 15-24 25-44 45-64 65+
Age groups (years)
15-24 years both males and females
Rates decrease with life style age group
7. DHB intentional self harm
West Coast (250.3) &
Canterbury (218.7)
Waitemata, Auckland,
Counties, Waikato, Hutt
Valley, Nelson
Marlborough, Otago
125-187/100,000
Capital & Coast (61.9) &
Southland (63.1)
8. Hospitalisation & Deprivation
Increase
hospitalisations Age standardised
rate (per 100,000)
with increased 180
160
deprivations 140
120
100
Least deprived 80
60
areas 83/100,000 40
20
0
Most deprived 1 2 3
NZDep2001 quintile
4 5
areas
154.7/100,000
9. Other researchers of suicide attempts
Bennett – Päkeh ä youth suicid e
Tiatia – Pacific youth suicid e
Beautrais – Serious suicid e attem pts
H atcher – Problem solving therapy after suicid e
attem pt
N ad a-Raja, C ollings, C oggan
10. Mäori attempted suicide
M äori M ed ical Record Review
M äori Attem pted Suicid e C ase C ontrol
12. Mäori Medical Record Review
R e cord s from E m e rge ncy D e p artm e nts b e twe e n Ju ly 1 s t 1 999 –
D e ce m b e r 31 s t 2000
N = 252 ind ivid u als / 0 p re s e ntations - 1 8m th s
31
61 % fe m ale ; 85% s ole M äori, 43% C ou ntie s M anu kau , 25% e m p loye d ,
21 % u ne m p loye d , 1 7% b e ne ficiarie s , 56% living with wh änau
70% P ois oning (53% p re s crip tion m e d ications , 20% analge s ics ), 1 5%
cu tting or p ie rcing
H om e , 1 800-2400 h ou rs , 37% p re s e ntations alcoh ol (fe m ale s
you nge r), 1 5% M arij ana
u
71 % firs t tim e rs – re p e at p re s e ntations (74% 2x, 1 7% 3x, 9% 5x)
E D s e rvice 53 % m e d ications , 88% p s ych iatric, 1 6% cu ltu ral
inform e d , 1 3% ab s cond e d or re fu s e d s e rvice s
87% with p os t d is ch arge p lans , 67% h om e , 1 8% p s ych iatric care ,
F ollow u p C M H S , H os p ital p s ych s e rvice s G P , C u ltu ral S e rvice s 4%
13. Conclusion
1 M äori e ve ry 2 d ays p re s e nts to
Au ckland E D for D S H
20% p re s e nte d following O D analge s ics
50% p re viou s ly b e e n to E D and 33%
m ore th an twice
O ve rnigh t ad m is s ions allow cu ltu rally
ap p rop riate as s e s s m e nt and follow u p
14. Kaupapa Mäori Methodology
C om m u nity d rive n S e lf id e ntification
re s e arch
P articip ant
M äori p rincip al
controlle d inte rvie w
inve s tigator
Tim e
M äori re s e arch te am
P lace
M äori d e cis ion
Koh a
m aking
P artne rs h ip s with D is s e m ination
non-M äori
15. Mäori case control study
C AS E S : C O N TR O LS :
n= 250 n= 250
M äori (s e lf M äori (s e lf
Id e ntification) id e ntification)
1 6 – 50 ye ars
1 6 – 50 ye ars
Atte m p te d s u icid e
P op u lation b as e d
(d iagnos e d )
Au ckland R e gion
Au ckland re gion
227 s ite s ; 3045
3 h os p itals (Au ckland ,
h ou s e h old s
M id d le m ore , N orth
S h ore )
16. Method Mäori case control study
Q u e s tionnaire (> 400 qu e s tions )
C u ltu ral Ind icators
D e m ograp h ic & s ocio-e conom ic factors
G e ne ral H e alth Q u e s tionnaire (G H Q – 28)
H os p ital Anxie ty & D e p re s s ion S cale (H AD S ) & M e ntal H e alth
F actors
S u b s tance U s e (C AG E )
H e alth s e rvice acce s s ib ility
S ocial s u p p orts
E nvironm e ntal factors
S u icid ality (C ID I)
Be ck’s S cale of S u icid e Inte nt (S IS – 1 4)
17. Results
C as e s e le ction
1 s t Au gu s t 2000 to 1 3th Janu ary 2002 (1 5m th s )
Inte rvie ws com p le te N ov 2002 (27m th s )
21 4 (85.5% ) cas e s & 203 (81 .2% ) controls
19. Measuring culture
Identity Profiles
Cultural indicators Secure Positive Notional Compromised
2: Identify as Mäori Yes Yes Yes No
4: No. of Mäori generations 3+ 2 1 Any response
8.1: Times to own marae 5+ 2-4 0-1 Any response
9.4: Role whänau plays in life > large Small <small Any response
10: Interest Mäori land Yes Yes/dk No Any response
basic -
15: Te reo Mäori ability adv - native learner No ability Any response
Q.2 = yes + Q.2 = yes + Q.2 = yes
3 other 2 other + 3 other Q.2 = no
positive positive negative + any other
Minimum criteria responses responses responses response
21. Whakamomori: Mäori suicide prevention model
Variable OR C onfidenc e P value
D e m o graphics Age 0.99 Intervals
0.95 -1 .04 0.8
G e nd e r F e m al e 0.75 0.31 -1 .80 0.5
Mal e 1
C ultural Id e ntity S e cure 1 0.2
P o s itive 3.31 1 .1 0-9.95
No tio nal 1 .56 0.1 9-1 9.95
C o m pro m is e d 1 .7 0.23-1 2 .38
Health S tatus GHQ–28 1.28 1.20-1.35 <0.0001
Inte rpe rs o nal At l as t o nce
e 2 .04 0.69-5.88 0.2
Abus e No 1
Al ho l (C AG E )
co Two ite m s 1 .51 0.61 -1 .64 0.4
Le s s than 2 1
Marij
uana Us e 1 .55 0.68-3.85 0.3
D o n’t us e 1
E d ucatio n S cho o l l ave r ≤
e 1 .84 0.75 -4.51 0.2
S cho o l l ave r >
e 1
E m pl ym e nt
o Ye s 1 .03 0.36-2.93 0.96
No 1
Inco m e U nd e r$2 0,000 0.84 0.31 -2.28 0.7
At l as t $2 0,000
e 1
22. Whakamomori: Mäori suicide prevention model
Variable OR C onfidenc e P value
D e m o graphic Age Intervals
0.99 (0.96-1 .03) 0.8
G e nd e r F e m al
e 0.88 (0.43-1 .81 ) 0.7
Mal e 1
C ul
tural Id e ntity S ec ure 1 0.003
P o s itive 2.48 (1 .21 -5.08)
No tio nal 8.32 (2.51 -27.61 )
C o m pro m is e d 4.3 (1 .31 -1 4.1 )
Inte rpe rs o nal A t leas t onc e 2.27 ( 1.15-4.35) 0.02
Abus e No 1
S ubs tance U s e
Al ho l (C AG E )
co Two items 1.85 ( 1.00-3.45) 0.05
Mo re than two 1
Marij
uana Us e 2.27 ( 1.24-4.16) 0.008
D o n’t us e 1
E d ucatio n S cho o l l ave r ?
e 1 .69 (0.77-3.71 ) 0.07
S cho o l l ave r > 1
e
E m pl ym e nt
o Ye s 0.77 (0.37-1 .60) 0.5
Inco m e Le s s than 1 .73 (0.88-3.40) 0.1
At l as t $20,000 1
e
23. Translation research - implementation
Whakawhanaungatanga – Self Harm & Suicide
Prevention Collaborative
Case Finding Assessment Tool – Early
detection and management of people at risk of
suicide in primary care setting
24. Whakawhanaungatanga
Implementation of
guidelines into
Emergency
Departments
Mental Health
Services
Maori Health Services
25. Methodology
Tools
National targets
Mapping an individual clients pathway
through secondary care
Plan – Do – Study – Act Cycles
26. National Targets
90% of people attending the ED identified with self-harm
or suicidality are seen within 1 hour
100% of people presenting with self-harm or suicidality
will have documented assessment.
100% of people presenting with self-harm or suicidality
will be provided with a written copy of their care plan on
discharge (also significant others/ whänau if appropriate)
100% of people presenting with self harm or suicidality
will have a follow up appointment within 48-hours of
discharge.
90% of people who do not attend that appointment will be
contacted within 48 hrs.
27. Client Pathway Map
What is a typical problem at each point of the process?
Are there examples of best practice?
Identify measures to monitor improved processes
Test changes
28. Plan – Do – Study – Act
What are we trying to
accomplish?
An aim with a clear outcome
target is essential to assign
resources & garner support
What changes can we make
to result in improvement?
The hypothesis generation
step…where we test ideas
before implementing changes
How will we know that a
change is an improvement?
Measurement to demonstrate
improvement
29. Who’s In
Emergency departments, mental health & Maori health
services in DHB’s
Northland
Waitemata
Counties Manukau
Waikato
Lakes
Taranaki
Mid Central
Hutt Valley
West Coast
Southland
30. Primary Care tool development
Detection & Management of people at risk of
suicide in the primary care setting
Depression
Anxiety
Interpersonal abuse
Substance use (alcohol & drugs)
Gambling
Smoking
Eating Disorder
31. Methodology
Kaupapa Epidemiology
Randomised control trial
− Raukura Hauora o Tainui (PHO), West Auckland PHO,
North Shore PHO and Tairawhiti PHO
− N=1000 face validity
− N=1200 content validity
Kaupapa
− Maori co-leadership, data collection & analysis,
participants
Editor's Notes
Not possible to compare to previous years as the definition of intentional self harm has been extended
Area of high concentration Mäori suicide and suicidal behaviours
Epidemiology driven by kaupapa Mäori processes
Identification of case and controls
Several validated questionnaires employed Over 400 questions in total
15 months selection 27 months interviewing High response rates for Mäori
Cultural identity indicators 6 items identity genealogy marae access whanau (family) access whenua (land) access Mäori language ability Production of 4 discrete identity profiles
Cultural identity profiles with respect to possible confounders age & gender SES GHQ-28 HADS Substances Abuse Only significant factors secure identity protective wrt age, gender, substances & abuse Notional identity increases risk by age, gender and SES
Mäori Suicide prevention model combining demographics, cultural identity, health status, abuse, substances and SES Having a poor general health status is the only significant factor to affect the level of Mäori attempted suicide
Removing general health status from the model reveals more significant factors that may affect the level of Mäori attempted suicide cultural identity abuse marujuana