(1) The RADIANT study evaluated operator radiation dose during percutaneous coronary procedures using different vascular accesses.
(2) It found that the femoral access was associated with a lower operator radiation dose compared to the radial access.
(3) However, the use of protective anti-radiation drapes and performing procedures through the left radial access helped reduce the higher operator dose associated with the radial approach.
Unrelated Cord Blood Transplantation In Adults with Hematological Malignancie...cordbloodsymposium
This document summarizes research on unrelated cord blood transplantation (UCBT) for adults with hematological malignancies. It provides updates from the Eurocord registry on over 11,000 UCBT cases. It then reviews outcomes from UCBT for specific diseases like acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and myelodysplastic syndrome (MDS). Favorable factors are identified such as disease status, age, and cell dose. Conditioning regimens and complications are also discussed. Surveys of UCBT for ALL and AML provide more detailed analyses of 2-year survival rates based on disease characteristics and transplant factors.
AMIM Février 2017 New diagnostic tools for GCA luqmani marrakesh 020359
Ultrasound shows promise as a diagnostic tool for giant cell arteritis (GCA) that could reduce the need for temporal artery biopsies. A large study found ultrasound had higher sensitivity (54%) than biopsy (39%) for GCA diagnosis, though lower specificity. Using ultrasound first and only doing biopsies for high-risk cases could avoid 87-98% of biopsies while maintaining high sensitivity for GCA detection. Follow-up ultrasounds may help monitor disease activity and detect relapses in GCA patients treated with steroids.
Is there public support for policies promoting healthybrownschool
This document summarizes a study on public support for policies promoting physical activity. The study surveyed over 1,200 adults about their support for various school and community physical activity policies. It found high support for policies requiring physical education in schools. Characteristics like gender, age, and education predicted support for school policies, while race, community walkability, and education predicted support for community policies. The results provide insights into advocacy strategies and which groups to target for increasing policy support. The study is part of a larger research agenda on physical activity policy through a national research network.
The LANCELOT-ACS trial investigated the safety and tolerability of the PAR-1 inhibitor atopaxar in 603 patients with acute coronary syndrome. The trial found that atopaxar achieved potent platelet inhibition through PAR-1 without significantly increasing bleeding risk compared to placebo. There were favorable trends for reduced major cardiac events but dose-dependent increases in liver enzymes and QTc interval prolongation at higher doses. Further studies are still needed to fully establish the safety and efficacy of atopaxar.
Sarah Chiu's presentation from Osteoporosis 2016: Impact of falls on fractures and mortality – an opportunity for intervention and enhancement of fracture prediction?
Find out more at: https://nos.org.uk/conference
This document summarizes research on Māori attempted suicide in Aotearoa/New Zealand. It includes a review of Māori medical records of attempted suicide cases and a case-control study comparing Māori individuals who attempted suicide to controls.
The key findings were that over half of Māori attempted suicide cases involved poisoning, rates were highest among youth ages 15-24, and indicators of compromised cultural identity and poorer health status were associated with higher risk of attempted suicide compared to those with secure cultural identities.
The research aims to help inform culturally-appropriate suicide prevention strategies for Māori by better understanding the roles of culture and health factors in
Dr Zoe Paskins's presentation from Osteoporosis 2016: Risk of fragility fracture over 10 years across eight inflammatory conditions: A UK population study.
Find out more at: https://nos.org.uk/conference
(1) The RADIANT study evaluated operator radiation dose during percutaneous coronary procedures using different vascular accesses.
(2) It found that the femoral access was associated with a lower operator radiation dose compared to the radial access.
(3) However, the use of protective anti-radiation drapes and performing procedures through the left radial access helped reduce the higher operator dose associated with the radial approach.
Unrelated Cord Blood Transplantation In Adults with Hematological Malignancie...cordbloodsymposium
This document summarizes research on unrelated cord blood transplantation (UCBT) for adults with hematological malignancies. It provides updates from the Eurocord registry on over 11,000 UCBT cases. It then reviews outcomes from UCBT for specific diseases like acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and myelodysplastic syndrome (MDS). Favorable factors are identified such as disease status, age, and cell dose. Conditioning regimens and complications are also discussed. Surveys of UCBT for ALL and AML provide more detailed analyses of 2-year survival rates based on disease characteristics and transplant factors.
AMIM Février 2017 New diagnostic tools for GCA luqmani marrakesh 020359
Ultrasound shows promise as a diagnostic tool for giant cell arteritis (GCA) that could reduce the need for temporal artery biopsies. A large study found ultrasound had higher sensitivity (54%) than biopsy (39%) for GCA diagnosis, though lower specificity. Using ultrasound first and only doing biopsies for high-risk cases could avoid 87-98% of biopsies while maintaining high sensitivity for GCA detection. Follow-up ultrasounds may help monitor disease activity and detect relapses in GCA patients treated with steroids.
Is there public support for policies promoting healthybrownschool
This document summarizes a study on public support for policies promoting physical activity. The study surveyed over 1,200 adults about their support for various school and community physical activity policies. It found high support for policies requiring physical education in schools. Characteristics like gender, age, and education predicted support for school policies, while race, community walkability, and education predicted support for community policies. The results provide insights into advocacy strategies and which groups to target for increasing policy support. The study is part of a larger research agenda on physical activity policy through a national research network.
The LANCELOT-ACS trial investigated the safety and tolerability of the PAR-1 inhibitor atopaxar in 603 patients with acute coronary syndrome. The trial found that atopaxar achieved potent platelet inhibition through PAR-1 without significantly increasing bleeding risk compared to placebo. There were favorable trends for reduced major cardiac events but dose-dependent increases in liver enzymes and QTc interval prolongation at higher doses. Further studies are still needed to fully establish the safety and efficacy of atopaxar.
Sarah Chiu's presentation from Osteoporosis 2016: Impact of falls on fractures and mortality – an opportunity for intervention and enhancement of fracture prediction?
Find out more at: https://nos.org.uk/conference
This document summarizes research on Māori attempted suicide in Aotearoa/New Zealand. It includes a review of Māori medical records of attempted suicide cases and a case-control study comparing Māori individuals who attempted suicide to controls.
The key findings were that over half of Māori attempted suicide cases involved poisoning, rates were highest among youth ages 15-24, and indicators of compromised cultural identity and poorer health status were associated with higher risk of attempted suicide compared to those with secure cultural identities.
The research aims to help inform culturally-appropriate suicide prevention strategies for Māori by better understanding the roles of culture and health factors in
Dr Zoe Paskins's presentation from Osteoporosis 2016: Risk of fragility fracture over 10 years across eight inflammatory conditions: A UK population study.
Find out more at: https://nos.org.uk/conference
Kathy Farndon discusses New Zealand's vision for electronic health records by 2014. The vision is for New Zealanders to have a core set of personal health information available electronically to them and their treatment providers regardless of setting. This will enable high quality, integrated healthcare and improve patient safety. Specifically, it will allow people to access test results, receive messages from providers, use tele-monitoring, access health information and reminders, and see care recommendations from all providers for more open communication and coordinated care. Realizing this vision will require collaboration between clinical and IT professionals, leadership investing in suitable IT solutions, and enabling the role of the National Health IT Board.
The document discusses initiatives of the Greater Auckland Integrated HealthCare Networks (GAIHN) which includes 3 DHBs, 10 PHOs, over 300 general practices, and 1.25 million enrolled patients. GAIHN is working on several projects including access to diagnostics, optimizing prescribing, clinical pathways, a regional after hours solution, and more. They are also establishing clinical alliance teams to address acute demand, long term conditions, and reducing inequalities. GAIHN supports national health IT strategies and focuses on sharing resources and information between partners through regional e-referrals, e-shared care plans, and population health repositories to improve outcomes, efficiency and patient experiences across the healthcare system.
The Community Health Aide Program (CHAP) in Alaska addresses healthcare staffing shortages in remote, rural villages by training and certifying local community members as Community Health Aides and Practitioners to provide primary healthcare services under physician supervision and according to standards in the Alaska Community Health Aide/Practitioner Manual. CHAP has been successful in sustainably delivering culturally acceptable healthcare to over 250,000 patients annually in 180 village clinics across Alaska through focused training and support of community health professionals.
This document discusses consumer perspectives and concerns regarding personal health information and health IT. It notes that consumers want health information that supports informed decisions, and they have concerns about privacy, security, and how information may be used and shared without their consent. The document also outlines recommendations from a consumer forum to ensure community understanding and support for appropriate electronic health information use.
This document summarizes the results of the DRAGON trial which compared the radial versus femoral approach for percutaneous coronary intervention (PCI) in over 1,700 patients. The trial found that the radial approach (TRI) was non-inferior to the femoral approach (TFI) for the primary endpoint of major adverse cardiac events at 12 months. TRI also had significantly less major bleeding complications at 7 days compared to TFI, meeting the secondary endpoint for superiority. Propensity score matching was used to adjust for baseline differences between the groups. The trial demonstrated that an ad-hoc radial approach strategy can provide similar clinical outcomes to femoral approach with less bleeding risks.
This document summarizes treatment approaches for triple negative breast cancer (TNBC), including neoadjuvant and adjuvant therapies. It discusses how TNBC is an aggressive disease that is often chemotherapy responsive initially but develops resistance rapidly. Neoadjuvant platinum chemotherapy is shown to increase pathologic complete response rates compared to standard regimens. Ongoing research is exploring eliminating anthracyclines and combining immunotherapy with chemotherapy to further improve outcomes for patients with early and advanced TNBC. Large phase III trials are currently investigating the addition of checkpoint inhibitors like pembrolizumab to neoadjuvant regimens.
Sequencing 60,000 Samples: An Innovative Large Cohort Study for Breast Cancer...QIAGEN
This slidedeck focuses on the design of a large cohort study for assessing breast cancer risk and how an innovative digital sequencing approach is able to solve the previously unmet challenges of this type of NGS study design. Our speaker, Dr. Fergus J. Couch of the Mayo Clinic, presents on the design of this NCI-funded project, which comprises the sequencing of 60,000 samples to assess the risk of breast cancer through association with targeted genes. The design and size of the study requires an accurate, robust and high-throughput sequencing method. The investigators are using a digital DNA sequencing approach from QIAGEN that incorporates molecular barcodes to tag and remove PCR duplicates and increase NGS assay sensitivity. The approach also uses proprietary chemistry that enables uniform sequencing to efficiently utilize sequencing power and deliver optimized results.
1) The study compared the reverse Barbeau test and duplex ultrasound for detecting radial artery patency and occlusion in 400 patients after transradial catheterization.
2) Both methods detected complete radial artery occlusion in 0.4% of patients. Duplex ultrasound identified an additional 0.8% with subocclusions.
3) The reverse Barbeau test is simpler to perform in daily practice, while duplex ultrasound is better for detecting incomplete occlusions. Overall, the methods were comparable in assessing radial artery patency.
Study I examined associations between promoter methylation of 10 tumor suppressor genes (e.g. RASSF1A, GSTP1) in breast tumor tissue and prognosis in a population-based cohort of breast cancer patients followed for 8 years. Methylation of certain genes like GSTP1 and TWIST1 were associated with increased breast cancer mortality. Patients with more methylated genes had higher mortality, with a 41% increased risk of breast cancer death for each additional methylated gene. Overall, DNA methylation shows potential as a prognostic biomarker for breast cancer outcomes.
Hypofractionation in Prostate Cancer: Is Less Enough?
1) The document discusses several studies that have compared hypofractionated radiation therapy (delivering larger doses of radiation in fewer treatments) to standard fractionation for prostate cancer. The PROFIT trial found equivalent 5-year outcomes for intermediate risk prostate cancer patients treated with either 60Gy in 20 fractions over 4 weeks or 78Gy in 39 fractions over 7-8 weeks, with less late gastrointestinal toxicity in the hypofractionated group.
2) The CHHiP trial also found non-inferior 5-year outcomes when comparing 60Gy in 20 fractions to 74Gy in 37 fractions for intermediate risk prostate cancer, with no difference in toxicity.
In this downloadable slideset, Joseph J. Eron, Jr., MD, reviews the evidence behind the latest antiretroviral guidelines and offers a glimpse at potential future agents and strategies currently under investigation.
Format: Microsoft PowerPoint (.ppt)
File size: 2.06 MB
Date posted: 6/1/2016
- A study analyzed data from the DIG trial to examine the effect of digoxin on 30-day hospital admissions in older adults with heart failure.
- The study found that digoxin reduced the absolute risk of all-cause hospital admission within 30 days by 2.7% and the relative risk by 34% compared to placebo. Digoxin also reduced the risk of cardiovascular hospital admissions at 30 days by 47%.
- The beneficial effect of digoxin on reducing 30-day hospital admissions persisted out to 60 and 90 days with no signs of harm, suggesting digoxin provides early benefits without increasing later risks.
This document presents survey results related to perceptions of HPV vaccination. It includes results from surveys of young men and mothers in multiple countries. Some key findings include:
- Young men in all surveyed countries generally agreed that HPV vaccination is as important as other recommended vaccines, is safe, and is supported by doctors.
- Both mothers and young men viewed HPV vaccination of boys favorably, with over 80% of respondents in each group having a favorable view.
- While young men felt little personal effect, their attitude toward HPV vaccination of boys and young men was largely favorable across countries.
The document summarizes findings from a study on the appropriateness of upper endoscopy referrals in Italy. Key findings include:
1) 22% of over 13,000 endoscopies were deemed inappropriate based on guidelines. Relevant findings were found in 51% of appropriate referrals and 32% of inappropriate ones.
2) Common relevant findings included esophagitis, gastric erosions, esophageal varices, and ulcers. New cancers were found in 1.6% of patients.
3) Guidelines had high sensitivity but low specificity for relevant findings and cancer. A simple rule using age and alarm symptoms had similar accuracy to guidelines.
4) Over 20% of endoscopy
Presentation 2.6 Research progress and biosecurity control strategies against...ExternalEvents
http://www.fao.org/documents/card/en/c/28b6bd62-5433-4fad-b5a1-8ac61eb671b1/
FAO Second International Technical Seminar/Workshop on Acute hepatopancreatic necrosis disease (AHPND) There is a way forward! FAO Technical Cooperation Programme: TCP/INT/3501 and TCP/INT/3502.
Dr. Stephen Mulligan is a leading researcher in chronic lymphocytic leukemia (CLL) based in Australia. He is the founding chair of the CLL Global Consortium and director of hematology programs at the University of Sydney. His research interests include mechanisms of drug resistance in CLL and signaling pathways. Recent breakthroughs in CLL described by Dr. Mulligan include trials showing improved progression-free survival for frontline chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab (FCR) compared to bendamustine and rituximab (BR). Oral FCR was also found to be safe and effective in elderly CLL patients with overall response rates over 95%.
1. Management of the neck in head and neck cancer involves addressing clinically negative (N0) and positive (N+) lymph nodes.
2. For N0 necks, elective neck dissection may decrease recurrence rates for high-risk primary sites. For N+ necks, selective neck dissection is adequate for early stage single node involvement without extracapsular spread.
3. Post-operative radiotherapy improves local control for N+ necks with adverse features like multiple nodes, extracapsular spread or positive margins. Concurrent chemoradiotherapy is preferred for advanced N2/N3 disease.
- The addition of selective internal radiation therapy (SIRT) to sorafenib (SOR) did not significantly improve overall survival compared to SOR alone in patients with advanced hepatocellular carcinoma based on two randomized controlled trials.
- Subgroup analyses found potential clinical benefits for younger patients, those with non-alcoholic disease etiology, and those without cirrhosis.
- Regorafenib, a multi-kinase inhibitor, significantly improved progression-free survival, overall survival, and disease control compared to placebo in patients with hepatocellular carcinoma progressing on sorafenib.
- Lenvatinib, an oral multi-kinase inhibitor, demonstrated non-inferior
This randomized controlled trial compared the efficacy of mycophenolate mofetil (MMF) to cyclophosphamide for induction therapy of lupus nephritis. 370 patients were randomized to receive either MMF or cyclophosphamide for 24 weeks in addition to corticosteroids. The primary outcome was renal response, defined as reduction in proteinuria and stabilization or improvement in serum creatinine. Results showed that MMF and cyclophosphamide had similar renal response rates, with 56.4% of MMF patients and 53.9% of cyclophosphamide patients achieving a renal response. Secondary outcomes including complete remission and changes in disease activity indices also did not differ significantly between the two groups. This study demonstrates
P. Genereux, the tryton stent_dedicated bifurcation stent in coronary bifurca...trytonmedical
This document provides disclosure of financial interests and background on the TRYTON dedicated bifurcation stent presented by Dr. Philippe Généreux at TCT 2016. It notes that Dr. Généreux receives consulting fees and is a major shareholder in TRYTON Medical. The document then summarizes the design and deployment of the TRYTON stent, results from the pivotal RCT showing non-inferiority for the primary endpoint but superiority for the secondary angiographic endpoint of side branch diameter stenosis. It concludes by outlining the rationale and design of the TRYTON confirmatory study to further evaluate safety in large side branches.
Kathy Farndon discusses New Zealand's vision for electronic health records by 2014. The vision is for New Zealanders to have a core set of personal health information available electronically to them and their treatment providers regardless of setting. This will enable high quality, integrated healthcare and improve patient safety. Specifically, it will allow people to access test results, receive messages from providers, use tele-monitoring, access health information and reminders, and see care recommendations from all providers for more open communication and coordinated care. Realizing this vision will require collaboration between clinical and IT professionals, leadership investing in suitable IT solutions, and enabling the role of the National Health IT Board.
The document discusses initiatives of the Greater Auckland Integrated HealthCare Networks (GAIHN) which includes 3 DHBs, 10 PHOs, over 300 general practices, and 1.25 million enrolled patients. GAIHN is working on several projects including access to diagnostics, optimizing prescribing, clinical pathways, a regional after hours solution, and more. They are also establishing clinical alliance teams to address acute demand, long term conditions, and reducing inequalities. GAIHN supports national health IT strategies and focuses on sharing resources and information between partners through regional e-referrals, e-shared care plans, and population health repositories to improve outcomes, efficiency and patient experiences across the healthcare system.
The Community Health Aide Program (CHAP) in Alaska addresses healthcare staffing shortages in remote, rural villages by training and certifying local community members as Community Health Aides and Practitioners to provide primary healthcare services under physician supervision and according to standards in the Alaska Community Health Aide/Practitioner Manual. CHAP has been successful in sustainably delivering culturally acceptable healthcare to over 250,000 patients annually in 180 village clinics across Alaska through focused training and support of community health professionals.
This document discusses consumer perspectives and concerns regarding personal health information and health IT. It notes that consumers want health information that supports informed decisions, and they have concerns about privacy, security, and how information may be used and shared without their consent. The document also outlines recommendations from a consumer forum to ensure community understanding and support for appropriate electronic health information use.
This document summarizes the results of the DRAGON trial which compared the radial versus femoral approach for percutaneous coronary intervention (PCI) in over 1,700 patients. The trial found that the radial approach (TRI) was non-inferior to the femoral approach (TFI) for the primary endpoint of major adverse cardiac events at 12 months. TRI also had significantly less major bleeding complications at 7 days compared to TFI, meeting the secondary endpoint for superiority. Propensity score matching was used to adjust for baseline differences between the groups. The trial demonstrated that an ad-hoc radial approach strategy can provide similar clinical outcomes to femoral approach with less bleeding risks.
This document summarizes treatment approaches for triple negative breast cancer (TNBC), including neoadjuvant and adjuvant therapies. It discusses how TNBC is an aggressive disease that is often chemotherapy responsive initially but develops resistance rapidly. Neoadjuvant platinum chemotherapy is shown to increase pathologic complete response rates compared to standard regimens. Ongoing research is exploring eliminating anthracyclines and combining immunotherapy with chemotherapy to further improve outcomes for patients with early and advanced TNBC. Large phase III trials are currently investigating the addition of checkpoint inhibitors like pembrolizumab to neoadjuvant regimens.
Sequencing 60,000 Samples: An Innovative Large Cohort Study for Breast Cancer...QIAGEN
This slidedeck focuses on the design of a large cohort study for assessing breast cancer risk and how an innovative digital sequencing approach is able to solve the previously unmet challenges of this type of NGS study design. Our speaker, Dr. Fergus J. Couch of the Mayo Clinic, presents on the design of this NCI-funded project, which comprises the sequencing of 60,000 samples to assess the risk of breast cancer through association with targeted genes. The design and size of the study requires an accurate, robust and high-throughput sequencing method. The investigators are using a digital DNA sequencing approach from QIAGEN that incorporates molecular barcodes to tag and remove PCR duplicates and increase NGS assay sensitivity. The approach also uses proprietary chemistry that enables uniform sequencing to efficiently utilize sequencing power and deliver optimized results.
1) The study compared the reverse Barbeau test and duplex ultrasound for detecting radial artery patency and occlusion in 400 patients after transradial catheterization.
2) Both methods detected complete radial artery occlusion in 0.4% of patients. Duplex ultrasound identified an additional 0.8% with subocclusions.
3) The reverse Barbeau test is simpler to perform in daily practice, while duplex ultrasound is better for detecting incomplete occlusions. Overall, the methods were comparable in assessing radial artery patency.
Study I examined associations between promoter methylation of 10 tumor suppressor genes (e.g. RASSF1A, GSTP1) in breast tumor tissue and prognosis in a population-based cohort of breast cancer patients followed for 8 years. Methylation of certain genes like GSTP1 and TWIST1 were associated with increased breast cancer mortality. Patients with more methylated genes had higher mortality, with a 41% increased risk of breast cancer death for each additional methylated gene. Overall, DNA methylation shows potential as a prognostic biomarker for breast cancer outcomes.
Hypofractionation in Prostate Cancer: Is Less Enough?
1) The document discusses several studies that have compared hypofractionated radiation therapy (delivering larger doses of radiation in fewer treatments) to standard fractionation for prostate cancer. The PROFIT trial found equivalent 5-year outcomes for intermediate risk prostate cancer patients treated with either 60Gy in 20 fractions over 4 weeks or 78Gy in 39 fractions over 7-8 weeks, with less late gastrointestinal toxicity in the hypofractionated group.
2) The CHHiP trial also found non-inferior 5-year outcomes when comparing 60Gy in 20 fractions to 74Gy in 37 fractions for intermediate risk prostate cancer, with no difference in toxicity.
In this downloadable slideset, Joseph J. Eron, Jr., MD, reviews the evidence behind the latest antiretroviral guidelines and offers a glimpse at potential future agents and strategies currently under investigation.
Format: Microsoft PowerPoint (.ppt)
File size: 2.06 MB
Date posted: 6/1/2016
- A study analyzed data from the DIG trial to examine the effect of digoxin on 30-day hospital admissions in older adults with heart failure.
- The study found that digoxin reduced the absolute risk of all-cause hospital admission within 30 days by 2.7% and the relative risk by 34% compared to placebo. Digoxin also reduced the risk of cardiovascular hospital admissions at 30 days by 47%.
- The beneficial effect of digoxin on reducing 30-day hospital admissions persisted out to 60 and 90 days with no signs of harm, suggesting digoxin provides early benefits without increasing later risks.
This document presents survey results related to perceptions of HPV vaccination. It includes results from surveys of young men and mothers in multiple countries. Some key findings include:
- Young men in all surveyed countries generally agreed that HPV vaccination is as important as other recommended vaccines, is safe, and is supported by doctors.
- Both mothers and young men viewed HPV vaccination of boys favorably, with over 80% of respondents in each group having a favorable view.
- While young men felt little personal effect, their attitude toward HPV vaccination of boys and young men was largely favorable across countries.
The document summarizes findings from a study on the appropriateness of upper endoscopy referrals in Italy. Key findings include:
1) 22% of over 13,000 endoscopies were deemed inappropriate based on guidelines. Relevant findings were found in 51% of appropriate referrals and 32% of inappropriate ones.
2) Common relevant findings included esophagitis, gastric erosions, esophageal varices, and ulcers. New cancers were found in 1.6% of patients.
3) Guidelines had high sensitivity but low specificity for relevant findings and cancer. A simple rule using age and alarm symptoms had similar accuracy to guidelines.
4) Over 20% of endoscopy
Presentation 2.6 Research progress and biosecurity control strategies against...ExternalEvents
http://www.fao.org/documents/card/en/c/28b6bd62-5433-4fad-b5a1-8ac61eb671b1/
FAO Second International Technical Seminar/Workshop on Acute hepatopancreatic necrosis disease (AHPND) There is a way forward! FAO Technical Cooperation Programme: TCP/INT/3501 and TCP/INT/3502.
Dr. Stephen Mulligan is a leading researcher in chronic lymphocytic leukemia (CLL) based in Australia. He is the founding chair of the CLL Global Consortium and director of hematology programs at the University of Sydney. His research interests include mechanisms of drug resistance in CLL and signaling pathways. Recent breakthroughs in CLL described by Dr. Mulligan include trials showing improved progression-free survival for frontline chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab (FCR) compared to bendamustine and rituximab (BR). Oral FCR was also found to be safe and effective in elderly CLL patients with overall response rates over 95%.
1. Management of the neck in head and neck cancer involves addressing clinically negative (N0) and positive (N+) lymph nodes.
2. For N0 necks, elective neck dissection may decrease recurrence rates for high-risk primary sites. For N+ necks, selective neck dissection is adequate for early stage single node involvement without extracapsular spread.
3. Post-operative radiotherapy improves local control for N+ necks with adverse features like multiple nodes, extracapsular spread or positive margins. Concurrent chemoradiotherapy is preferred for advanced N2/N3 disease.
- The addition of selective internal radiation therapy (SIRT) to sorafenib (SOR) did not significantly improve overall survival compared to SOR alone in patients with advanced hepatocellular carcinoma based on two randomized controlled trials.
- Subgroup analyses found potential clinical benefits for younger patients, those with non-alcoholic disease etiology, and those without cirrhosis.
- Regorafenib, a multi-kinase inhibitor, significantly improved progression-free survival, overall survival, and disease control compared to placebo in patients with hepatocellular carcinoma progressing on sorafenib.
- Lenvatinib, an oral multi-kinase inhibitor, demonstrated non-inferior
This randomized controlled trial compared the efficacy of mycophenolate mofetil (MMF) to cyclophosphamide for induction therapy of lupus nephritis. 370 patients were randomized to receive either MMF or cyclophosphamide for 24 weeks in addition to corticosteroids. The primary outcome was renal response, defined as reduction in proteinuria and stabilization or improvement in serum creatinine. Results showed that MMF and cyclophosphamide had similar renal response rates, with 56.4% of MMF patients and 53.9% of cyclophosphamide patients achieving a renal response. Secondary outcomes including complete remission and changes in disease activity indices also did not differ significantly between the two groups. This study demonstrates
P. Genereux, the tryton stent_dedicated bifurcation stent in coronary bifurca...trytonmedical
This document provides disclosure of financial interests and background on the TRYTON dedicated bifurcation stent presented by Dr. Philippe Généreux at TCT 2016. It notes that Dr. Généreux receives consulting fees and is a major shareholder in TRYTON Medical. The document then summarizes the design and deployment of the TRYTON stent, results from the pivotal RCT showing non-inferiority for the primary endpoint but superiority for the secondary angiographic endpoint of side branch diameter stenosis. It concludes by outlining the rationale and design of the TRYTON confirmatory study to further evaluate safety in large side branches.
Localized Prostate Cancer in Puerto Ricoflasco_org
This document summarizes localized prostate cancer screening and treatment options in Puerto Rico. It discusses screening guidelines and biomarkers like PSA, PCA3, and multiparametric MRI. Treatment options covered include active surveillance, surgery (open, robotic, cryotherapy), and radiation therapy (brachytherapy, external beam). Robotic prostatectomy results in less blood loss and shorter catheter time compared to open surgery. Adjuvant radiation after prostatectomy may improve outcomes for men with adverse features like positive margins or extraprostatic extension.
This document provides an annual report on Kuwait's newborn screening program for 2018. It includes statistics on the number of samples received and tested, the screening panel used, positive results, confirmed cases, and performance indicators. A total of 59,655 samples were received in 2018 from various hospitals in Kuwait. Of these, 931 screened positive for various conditions. Further testing confirmed 67 cases across different metabolic disorders and endocrine conditions. Key performance metrics like detection rate, false positive rate, and positive predictive value are provided. The report concludes by thanking the newborn screening team and various doctors for their efforts in the program's success.
The document outlines findings from a study on rural physician retention in Michigan, which found that factors like professional satisfaction, competent medical staff, and safety of the community were most important for retention. It also provides a guide and tools for rural hospitals and clinics to develop formal retention plans to regularly check in with physicians and ensure their needs are being met to keep them in the community long-term.
Similar to The Caring Does Matter (CDM) Initiative: To Improve Cardiovascular Medication Adherence in Pacific People (20)
The Diabetes Discovery Project at Austin Health aimed to use their Cerner EMR system to routinely test HbA1c levels on inpatients over 54 to identify undiagnosed and poorly controlled diabetes. Testing of over 5,000 patients found 5% had undiagnosed diabetes and 29% had known diabetes. Higher HbA1c levels were associated with increased hospital admissions and longer lengths of stay for surgical patients. The project demonstrated using health IT to identify diabetes management opportunities. Ongoing work includes refining protocols and expanding to other patient populations.
This document summarizes a presentation on using data and informatics to improve allied health services. It discusses the history of allied health and challenges with data collection. Examples are provided of projects in New Zealand that used data to enhance patient and clinician experiences, reduce hospital-acquired infections, and inform staffing needs. The presentation emphasizes standardizing data to facilitate benchmarking and applying knowledge gained from data analysis to drive improvements in allied health.
This document presents a proof of concept for using Twitter data to conduct syndromic surveillance for public health monitoring. It analyzed tweets containing the keyword "measles" between 2014-2015 and found 1,408 relevant tweets. The number of tweets mentioning measles was compared to confirmed measles cases from a national surveillance system, showing potential for Twitter data as an early warning system. However, limitations include using a single keyword and the free Twitter API. Future work proposed improving data collection, applying machine learning techniques, and validating tweets with other health data sources.
The document discusses using surface modelling and mapping techniques to analyze healthcare data. It provides three scenarios as examples: 1) Mapping KPIs regionally to identify opportunities for improvement, 2) Mapping data around a specific pharmacy to examine market penetration, and 3) Comparing the market penetration of two smoking cessation medications. Surface mapping allows easy visualization and comparison of multiple data layers, helps protect patient privacy, and can provide insights into how to optimize outcomes.
The document summarizes how providing laptop computers to clinicians in a community allied health service has enhanced clinical care. Each of the 20 clinicians was provided a laptop with mobile data and remote desktop access to complete administrative and electronic tasks in the community rather than returning to the office. This has increased efficiency by allowing timely and collaborative work, which has decreased stress on clinicians and allowed for more timely information sharing with children and families. Some challenges remain around the weight of laptops and continuing reliance on paper records. Future plans include providing iPads and moving to more paperless systems.
This document describes the development of an electronic workflow system called scope to improve surgical practice at a District Health Board (DHB) hospital. The goals were to seamlessly map the patient journey, accurately collect coded data, and leverage trusted data to inform clinicians. The system streamlines waiting lists, captures accurate operating notes, and facilitates morbidity and mortality meetings. Implementation across surgical specialties has achieved good compliance and uptake. Preliminary results found increased quality of notes, discussion of complications, and potential to change practice through advanced data analysis. In conclusion, scope has replaced a disconnected paper system with a seamless electronic solution that fully captures standardized data to improve surgical outcomes.
1. The document discusses how healthcare has progressed beyond just electronic medical records (EMRs) and is now focused on areas like mobile computing, health collaboration, cloud-based back office systems, health intelligence, and clinical grade communications.
2. It provides examples of how technology is enabling cross-campus collaboration, telehealth, clinical collaboration using medical devices and teleradiology, and clinical communications.
3. The document advocates for sustainable eHealth innovation beyond just EMRs and discusses how areas like health analytics, mobility for care, patient-centered care, and emerging technologies can further improve healthcare.
The document discusses empowering healthcare through technology that is safe, works for everyone, and leaves no one behind. It describes how digital technologies are disrupting traditional healthcare models and outlines opportunities to enhance patient and provider experiences through virtual care, remote monitoring, and analytics. Key goals are mentioned like reducing readmissions, increasing effectiveness, and improving clinical productivity. The future of healthcare is envisioned as personalized, connected, data-driven, and empowering every person and organization to achieve more through technology.
The document discusses using analytics and care coordination to reduce hospitalizations and arrests of mental health patients. It notes that around 10% of patients are readmitted to psychiatric hospitals within 30 days of discharge. Care coordination aims to break this cycle through improved outcomes, treatment adherence, continuity of care, and identifying high-risk patients. Analytics tools can provide predictive modeling, population clustering, and care quality analysis to develop insights. The goal is to engage all stakeholders to deliver an integrated care plan through data-driven insights and coordination between providers.
Dr Nic Woods discusses tools for early recognition and management of sepsis using the electronic medical record (EMR). Sepsis poses a major global health challenge and burden. Tools discussed include a sepsis predictive model built into the EMR that can detect signs of sepsis with sensitivities of 68-91% and specificities of 91-97.6%. Clinical decision support and workflows in the EMR are also used to alert clinicians and guide treatment. Evaluations found these tools helped reduce mortality from sepsis by 4.2-17% and lower length of hospital stays. Key points emphasized that predictive models integrated into clinical workflows can positively impact outcomes, but more progress is still needed.
This document discusses allied health professionals and their role in the healthcare system. It lists various allied health roles and describes how they rehabilitate and enable patients by taking a collaborative and holistic approach focused on patient needs. The document emphasizes that allied health professionals help reduce health service needs by facilitating patients' independence and ability to remain in their communities. It argues that capturing allied health data can help provide visibility into their services, allow for quality improvement, and ultimately benefit patients through a more coordinated system where the "right intervention" is delivered at the "right time". The challenges of engaging stakeholders and integrating passive data extraction are also addressed.
This document discusses changes in clinical data collection and the role of clinical coders. It notes that data now comes from many sources through various mediums and is used for many purposes. Clinical coding translates medical descriptions into codes. While technology has improved coding efficiency, the role of clinical coders may change further as technology advances. In particular, widespread electronic health records could significantly impact current clinical coding practices and roles. The document urges clinical coders and organizations to consider how to prepare for and adapt to technological changes to ensure accurate and consistent health data collection into the future.
This document provides background information on New Zealand's national maternity system called BadgerNet. It discusses the existing national programs and governance structure in place. BadgerNet is being rolled out nationally as an end-to-end maternity information system to record information from conception to six weeks postnatal. It will be used across District Health Boards and in the community. The financial model and implementation process are also outlined.
This document summarizes a presentation given by Dr. Shaun Costello on oncology treatment patterns in the South Island of New Zealand. The presentation discusses the creation of the South Island Cancer Clinical Information System (SICCIS) to capture patient-level oncology data across multiple hospitals in the region. This includes implementation of the MOSAIQ electronic medical record system and a shared data repository called METRIQ. The goal is to analyze the treatment patterns and outcomes of cancer patients in order to improve the quality of care in the South Island. Examples of preliminary analyses of the data are shown, including cancer stages, treatments, and radiation doses for lung cancer patients.
The evaluation identified several unintended consequences of the electronic prescribing pilot including new types of errors related to prescribing workflows and system defaults. Key lessons learned were that ongoing training and engagement are needed as workflows change over time. Regular monitoring is required to identify errors and develop strategies to address them, such as simplifying multi-step processes and minimizing alert fatigue. Overall the evaluation found that electronic prescribing has benefits but also risks, and a focus on how systems are implemented and used is as important as the technology itself.
This document discusses emerging technologies in the pharmacy sector. It begins with an overview of the evolution of pharmacy and a discussion of disruptive technologies. It then examines specific emerging capabilities like online healthcare access in Switzerland, remote patient monitoring in Spain, and ingestible sensors. Exciting retail trends are also explored, such as using customer data to predict behaviors, billboards responding to airplane flights, and the potential of Li-Fi wireless networks. The document suggests several technologies may disrupt pharmacies or remain niche capabilities. Overall, it analyzes new digital innovations and how they could impact pharmacy services and the customer experience.
This document discusses the development of a smartphone app to help patients better manage their rheumatoid arthritis. Interviews with rheumatoid arthritis patients and healthcare professionals revealed key themes. Patients were enthusiastic about an app's potential to record symptoms and communicate with their care team. However, healthcare professionals were apprehensive about increased workloads. Both groups saw value in collecting patient-reported outcomes but acknowledged limitations. Next steps include piloting a new "RAconnect" app and conducting a clinical trial to evaluate its impact on disease management compared to standard care.
This document discusses various self-tracking tools and applications for health, fitness, and well-being. It mentions several companies and products including 23andMe for DNA sequencing, UBiome for microbiome sequencing, Dexcom for continuous blood glucose monitoring, and Jawbone UP and Fitbit for activity tracking. It also discusses ideas around open data, genomic APIs, geo-tracking health data, and future technologies like ingestible sensors. Overall, the document explores the growing field of self-quantification and personalized data collection for improving individual health and wellness.
NAVIGATING THE HORIZONS OF TIME LAPSE EMBRYO MONITORING.pdfRahul Sen
Time-lapse embryo monitoring is an advanced imaging technique used in IVF to continuously observe embryo development. It captures high-resolution images at regular intervals, allowing embryologists to select the most viable embryos for transfer based on detailed growth patterns. This technology enhances embryo selection, potentially increasing pregnancy success rates.
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)MuskanShingari
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
Are you looking for a long-lasting solution to your missing tooth?
Dental implants are the most common type of method for replacing the missing tooth. Unlike dentures or bridges, implants are surgically placed in the jawbone. In layman’s terms, a dental implant is similar to the natural root of the tooth. It offers a stable foundation for the artificial tooth giving it the look, feel, and function similar to the natural tooth.
Travel vaccination in Manchester offers comprehensive immunization services for individuals planning international trips. Expert healthcare providers administer vaccines tailored to your destination, ensuring you stay protected against various diseases. Conveniently located clinics and flexible appointment options make it easy to get the necessary shots before your journey. Stay healthy and travel with confidence by getting vaccinated in Manchester. Visit us: www.nxhealthcare.co.uk
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
Giloy in Ayurveda - Classical Categorization and SynonymsPlanet Ayurveda
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
Pictorial and detailed description of patellar instability with sign and symptoms and how to diagnose , what investigations you should go with and how to approach with treatment options . I have presented this slide in my 2nd year junior residency in orthopedics at LLRM medical college Meerut and got good reviews for it
After getting it read you will definitely understand the topic.
The Caring Does Matter (CDM) Initiative: To Improve Cardiovascular Medication Adherence in Pacific People
1. The Caring Does Matter (CDM) Initiative:
To Improve Cardiovascular Medication
Adherence in Pacific People
Jim Warren, Yulong Gu (Helen), John Kennelly
The National Institute
for Health Innovation
2. Why the interest?
• Burning platform
– Increased rates of chronic illness
– Ageing population
– Cost / workforce / delivery meltdown!
– Even if we were satisfied with current quality
of health delivery, it’s not sustainable
• Long-term conditions as the target
• Lots of data
– Computerisation naturally lays down data, which
can be used to improve patient management
3. Chronic conditions, esp. anything
‘vascular’
• Amenable (and interesting) for analysis of
long sequences in transactional electronic
health records (EHRs)
• E.g. blood pressure (BP) is a huge risk factor
– CVD risk doubles for every 20/10 mm Hg
• Also implicated in kidney failure
– Very controllable with medication
– Several classes of medication with different side-
effects and benefits/indications (makes it
interesting!)
• Statins/cholesterol and blood sugar control
also very relevant
4. CDM Initiative
• A feasibility study
– Structured care, based on West Fono program
• To identify and intervene on suboptimal
management of CVR
– Medication adherence gaps - MPR
5. How to identify intervention targets?
• Demographics
• CVR scores
• Prescriptions
6. Pacific adults (20+) grouped into 4:
having high CVR risk (>=10%) and low
MPR (<80%)
having no CVR screening recorded in
the last five years and aged 35 or over
having high CVR risk (>=10%) but
MPR OK (>=80%)
having low CVR risk (<10%) or having
no CVR screening recorded in the last
five years but being younger than 35
7. Group 1 Patient List example
Pt Age Gen- Eth- Anti- Oral Last CVR
ID der nicity hypertensives Cholesterol Diabetes screening CVR
medications date
1 64 M Tongan None <80% None 30-Sep-11 99
2 60 F Samoan OK OK <80% 13-Mar-12 99
3 51 M Samoan None <80% None 6-Sep-11 99
Other
4 81 M OK None <80% 11-Nov-11 30
Pacific
5 63 M Samoan <80% Recent start None 19-Oct-11 22
6 62 M Samoan <80% None None 14-Apr-12 22
7 65 M Samoan <80% <80% <80% 10-Jan-12 21
8 63 M Samoan <80% <80% <80% 17-Jul-11 18
9 58 F Samoan <80% None None 16-May-12 16
10 63 M Fijian None None None 22-Jul-09 15
…
8. 9,128 Pacific adults in 10 clinics
Clinics Practice Pacific patient Pacific patient Pacific patient
ID patient population # (% in total population population
population # practice population) 20+ # 35+ #
A 6884 5144 (75%) 3060 2001
B 12984 1872 (14%) 1038 627
C 5696 1634 (29%) 934 600
D 11939 1481 (12%) 764 470
E 4794 1355 (28%) 726 471
F 5863 1316 (22%) 702 438
G 13112 1114 (8%) 610 384
H 1564 1103 (71%) 669 429
I 4875 583 (12%) 331 194
J 9633 534 (16%) 294 171
Total: 77344 16136 (21%) 9128 5785
9. 1,021 with high CVR & low MPR
Practice High CVR & low MPR # (% No CVR & 35+ # (% in
ID in Pacific 20+ at the clinics) Pacific 35+)
A 522 (17%) 855 (43%)
B 67 (6%) 370 (59%)
C 91 (10%) 297 (50%)
D 58 (8%) 293 (62%)
E 61 (8%) 207 (44%)
F 50 (7%) 272 (62%)
G 55 (9%) 195 (51%)
H 71 (11%) 157 (37%)
I 29 (9%) 51 (26%)
J 17 (6%) 115 (67%)
Total: 1021 (11%) 2812 (49%)
11. Physiological profile of Group 1
Measurements Mean Standard Pt # (%)
deviation measured in
last five years
BP Last systolic BP 133.1 17.69 534 (52%)
Average of last three systolic
133.6 15.54 464
BP results (45%)
Last diastolic BP 82.3 11.84 533 (52%)
Average of last three diastolic
82.1 10.28 462
BP results (45%)
HbA1c Last HbA1c in DCCT-aligned 188 (18%)
7.1 2.03
(%)
Last HbA1c in IFCC- 78 (8%)
63.6 26.24
standardised (mmol/mol)
Last Total-to-HDL cholesterol ratio 4.94 1.02 218 (21%)
Last BMI 33.6 6.60 400 (39%)
13. Feedback from participating clinicians
Enthusiasm for studies addressing the
needs of PI wrt BP management
Acceptance of structured care models
Understanding PI
Lack of resources and capacity
– CDM nurse
– Minimize disruption to existing services
14. Conclusions – so far
• Not a RCT
• Feasibility study
• A lot of data is already there
– It can reveal opportunities for
process improvement
• Going to scale with CDM
– Opportunities and challenges
15. Acknowledgements
• The Caring Does Matter Initiative is funded by
the Ministry of Health’s Pacific Grant Fund.
• We would also like to thank the West Fono
management and staff, esp. Mr. Tevita Funaki
Mr. Anthony Tuitahi, and Ms Tai Boyce for
supporting the program.
• We extend our thanks to the staff of
participating general practices for
accommodating the study.
Further info: h.gu@auckland.ac.nz