This research sought to understand the relationship between chronic kidney disease and low levels of glutathione peroxidase 3 (GPx-3). The study hypothesized that patients with certain stages of chronic kidney disease and GPx-3 deficiency may be at risk of uremic cardiomyopathy. The research showed the function of GPx-3, experimental data from western blots and mouse studies on GPx-3, and limitations. GPx-3 is an antioxidant made in the kidney and transported to circulation where it functions in plasma and on platelets. Methods included western blots to identify proteins, mouse studies to isolate GPx-3 effects, and ELISA kits to quantify GPx-3 levels in vitro.