This document summarizes an ongoing project that aims to inform the adaptation of agricultural systems in Africa and Asia to progressive climate change over coming decades. The project uses crop modeling and climate impact assessments to evaluate vulnerabilities and develop adaptation strategies. Key aspects of the work include using the EcoCrop model to assess climate suitability of crops, analyzing available climate data and uncertainties, selecting priority crops and regions to study, and exploring genetic and management adaptations to test via modeling and promote to farmers. The overall goal is to contribute to the CCAFS program by analyzing climate-vulnerable areas and facilitating climate-resilient agriculture.