This document discusses the rise and fall of novel psychoactive substances and online drug markets in Ireland and globally. It describes how head shops proliferated in Ireland in the 2000s selling legal highs until laws were passed in 2009-2010 to control these substances. Meanwhile, online marketplaces like Silk Road emerged, allowing anonymous and global drug trade via cryptomarkets on the deep web. However, many of these markets have since been shut down by law enforcement. The document examines user experiences on these sites and the ongoing cat-and-mouse game between online drug vendors and authorities.