The gut microbiota plays a pivotal role in maintaining our health, with its balance and diversity being key to overall well-being. Dysbiosis, or disruptions in this delicate ecosystem, can lead to a range of harmful effects on the body, including digestive problems, immune dysfunction, inflammation, and increased risks of various diseases. Recognizing the significance of gut health and adopting practices that promote a balanced microbiota, such as a healthy diet and lifestyle choices, is crucial for optimizing our physical and even mental health.The gut microbiota is a vast and complex collection of microorganisms that profoundly affects human health.The gut microbiota assists in a range of bodily functions, including: harvesting energy from digested food protecting against pathogens regulating immune function strengthening biochemical barriers of the gut and intestine

2. Name : Javeria Nasir
Roll no: 572207
Registration no: 2019-GCUF-078226
Supervisor: Ma’am Iqra Fayyaz

4. UNVEILING THE POTENTIAL OF
INTESTINAL MICROBES IN
DISEASE MENAGEMENT

5. Introduction

6. What are Gut microbiotas?
The gut microbiota is a vast and complex collection of microorganisms
that profoundly affects human health.The gut microbiota assists in a range
of bodily functions, including:
 harvesting energy from digested food
 protecting against pathogens
 regulating immune function
 strengthening biochemical barriers of the gut and intestine

7. Prevelance
63.7%
Pakistan
population
counts on
average
25.2%

8. Effect
Changes in microbiota composition can affect these functions.
● Digestive Problems
● Immune System Dysfunction
● Inflammation
● Metabolic Disorders

9. Mechanism

10. Role of gut mirobiota

11. Role of Gut Microbiota countinue...
• About 100 trillion bacteria reside in the gut and they produce metabolites that have health effects.
• 70-80% of the body’s immune cells are concentrated in the gut.
• There are 100 million neurons located along the gut which produce various neurotransmitters that regulate
mood and satiety.
• 95% of the body’s total serotonin is located in the gut.

12. Disorders

13. Gut microbiota alters nutrient availability and thus influences the release of biologically active
peptides from enteroendocrine cells, which in turn can affect the gut-brain axis.
Gut brain axis

14. ● Gut microbiota may alter the function of a
neurotransmitter, as shown by studies conducted
on individuals with Parkinson's disease.
Neurotranmitter

15. obesity
Gut microbiota regulates obesity by regulating
energy absorption, central appetite, fat
storage, chronic inflammation, and circadian
rhythms.
Irritable bowel disease
Gut microbiota is thought to play important roles
in the pathogenesis of IBS. This is evident from
the fact that IBS occurs more frequently after
intestinal infection or antibiotics treatment.
Studies have shown that the alterations of the
intestinal microbiota are observed in IBS patients.

16. Treatment

17. Probiotics can alter the gut microbiota and stimulate
the activity of bacterial beneficial to the host while
inhibiting the activity of bacteria that are detrimental
to the host's health
Effects of antibiotics on the host through the gut
microbiome are immense and can affect various
functions including immune regulation, metabolic
activities, and thus overall health
Diet may also affect the composition and function of gut
microbiota, which consequently affects immunity. In animal
models of inflammatory disease, diet may modulate
inflammation in the gastrointestinal tract and in other
peripheral sites.
Antibiotics
probiotics
Dietary modification

18. Conclusion
The gut microbiota plays a pivotal role in maintaining our health, with its balance and diversity
being key to overall well-being. Dysbiosis, or disruptions in this delicate ecosystem, can lead to
a range of harmful effects on the body, including digestive problems, immune dysfunction,
inflammation, and increased risks of various diseases. Recognizing the significance of gut
health and adopting practices that promote a balanced microbiota, such as a healthy diet and
lifestyle choices, is crucial for optimizing our physical and even mental health.

19. ● Manichanh C, Borruel N, Casellas F, Guarner F. The gut microbiota in IBD. Nature reviews
Gastroenterology & hepatology. 2012 Oct;9(10):599-608.Orange abstract background with
bubbles
● Jandhyala SM, Talukdar R, Subramanyam C, Vuyyuru H, Sasikala M, Reddy DN. Role of the normal
gut microbiota. World journal of gastroenterology: WJG. 2015 Aug 8;21(29):8787.Multi colored
psychedelic background
● Robertson RC, Edens TJ, Carr L, Mutasa K, Gough EK, Evans C, Geum HM, Baharmand I, Gill SK,
Ntozini R, Smith LE. The gut microbiome and early-life growth in a population with high
prevalence of stunting. Nature communications. 2023 Feb 14;14(1):654.3d representation of
microscopic pathogens
● Bhattarai Y, Muniz Pedrogo DA, Kashyap PC. Irritable bowel syndrome: a gut microbiota-related
disorder?. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2017 Jan
1;312(1):G52-62.
Refrences

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