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JCM
PRESENTATION
BY
DR PRIYANKA.P.S
1st YEARPGSCHOLAR
DEPT OF PANCHAKARMA
UNDER THE VALUABLEGUIDANCEOF ALL THE FACULTIES OF
PANCHAKARMAdepartment
1
Basti: Does the
equipment and method of
administration matter
2
• The Journal of Ayurveda and Integrative Medicine (J-AIM) is an
open-access, peer reviewed journal published jointly by The
Institute of Trans-disciplinary Health Sciences and Technology (TDU)
and The World Ayurveda Foundation (WAF), and published on
Elsevier.
ABSTRACTING AND INDEXING
• Web of Science
• PubMed
• Scopus
• EMBASE/Excerpta Medica
• Emerging Sources Citation Index (ESCI)
• CAB Abstracts
• Directory of Open Access Journals (DOAJ)
• ISSN: 0975-9476
• Editor-in-Chief Bhushan Patwardhan, Center for Complementary
and Integrative Health, Savitribai Phule Pune University
3
• Manohar S. Gundeti,
• Ashwinikumar A. Raut 1,
• Nitin M. Kamat 2
• RRA Podar Ayurveda Cancer Research Institute, Under
Central Council for Research in Ayurvedic
Sciences,Department of AYUSH, GoI,Mumbai, 1
• Clinical Research and Integrative Medicine, ICMR
Advanced Centre for Reverse Pharmacology in
Traditional Medicine at MedicalResearch Centre-
Kasturba Health Society, Mumbai, 2
• Department of Kayachikitsa, Ayurveda Mahavidyalaya,
Sion, Mumbai, India
4
• Basti is one of the five procedures of panchakarma in Ayurveda.
Classically, it is advocated in the diseases of vata.
• It is mainly of two types viz. asthapana and anuvasana.
According to the classical texts basti administration is done with
the help of animal bladder (bastiputaka) and specially prepared
metal/wooden nozzle/catheter (bastinetra), the whole
assembly is called as bastiyantra. Nowadays, except in some of
the Vaidya traditions in Kerala, basti administration is often done
using enema-can or douche-set.
• In the aforesaid classical procedure active pressure is expected
to be given on the bastiputaka whereas, in conventionally used
enema-can only passive or gravitational force plays a role. This is
important in the context of ‘basti danakala or pidanakala i.e.
time for basti administration’.
• Key words: Basti, basti pidanakala, bastiputaka, colon, enema-can5
 Basti, the prime treatment in shodhana is considered as
one of the most important treatments for many diseases
according to Ayurvedic classical literature.
 It is the best treatment modality for all types of vata diseases. The type
of basti where decoction is the major part is called as asthapana basti
or niruha basti and the basti in, which major part is oil or other sneha
(oleaginous substance) is called as anuvasana.[1]
 The desired effect of basti depends on several determinants and basti-
danakala is one of the important determinant variables.
 In this study, we have addressed this basti-danakala determinant with
the help of barium contrast to assess the difference in administration
time and reach of bastidravya in the colon with two different methods
of - (1) bastinetra with bastiputaka method (classically used) and (2)
enema-can method (commonly used).
6
Two apparently healthy male adult individuals (Subject-A and B)
who had matra basti on previous day and with prior sneha-sveda
in the morning were administered niruha basti comprising of
Makshika (honey) 150 ml,Saindhava(rock salt) 15 g, Tila taila 150
ml, kalka (paste of fresh herbs or dried powders) 30 g, added to
Erandamula kvatha(decoction of castor roots in water) to make
total 960 ml with classical method and with conventional enema
can method respectively, after taking written informed consent.
7
• Barium sulphate B.P (Microbar HD) 25 g were added
in both the niruha bastidravya after its preparation.
• In subject-A, the Vaidya administered basti with
uniform pressure and gradual squeezing of the
bastiputaka.
• In the subject-B the enema-can was kept hanging on
a stand four feet above the bed.
• Basti administration was done on the X-ray table and
radiographs were taken immediately after the
administration
8
• The basti administration time in the subject-A was about
60 s where stipulated amount of basti dravya entered in
the colon homogenously with uniform positive pressure.
The radiograph of subject-A [Figure 1] shows complete
filling of sigmoid colon and further propelling of the basti
dravya through colon towards Ileo-caecal (IC) junction
where it has almost filled the ascending colon.
• In subject-B it took about 10 min for administration of
basti dravya with interruption. The radiograph of subject-
B [Figure 1] shows added filling of sigmoid colon,
propelling the basti dravya through colon, reaching the IC
junction but the amount of basti dravya is less at that
point in comparison to subject-A.
9
Figure 1: Radiographs of subject a and b
A B
10
The term basti/vasti comes from usage of animal urinary
bladder for administration of the basti dravya.[2] In the
absence of bladder artificial basti putaka prepared by thin
skin of aquatic bird/goat or a wax coated cotton bag may be
used.[3]
The purpose of using bladder is “uniform contractility with
uniform flow.” The minimum positive pressure on bladder
filled with basti dravya will contract uniformly and pour out
with uniform flow within a short-time .Niruha basti has
uniqueness in the preparation of basti yantra, basti dravya
and its administration.
11
 “Bastidravya” is prepared by adding ingredients like makshika,
lavana, sneha, kalka and kvatha together in a sequence,[4]
which forms a homogenous oil in water (O/W) emulsion.[5]
 Usage of animal bladder for preparation of basti putaka
was possible and justified in earlier days, however, is not
feasible and practical today.
 As an alternative, a plastic bag of 50 microns thickness and
having 1.5 l capacity is used as basti putaka, and is disposed of
after single use.[6]
• It is filled with basti dravya, and tied with metal basti netra to
form basti yantra [Figure 2]
12
• Bastinetra is a tubular structure usually made up of brass,
having tapering end and wider base, which resembles cow’s
tail.
• It has three rings on external surface called as karnika (ridges),
the last two at the bottom are used to tie the basti putaka
with netra.[7]
13
Figure 2: Bastinetra having three
karnika
14
• Commonly, at many places, basti is administered using
enema-can/douche set instead of classical bastiyantra due to
its easy availability and handling.
• This set consists of plastic/metal can and attached plastic tube
with nozzle having lock (to which sometimes the simple
rubber catheter is attached) [Figure 3].
• The enema-can is held to the stand approximately four feet
above the patient. Here, only gravitational force plays the role
through passive pressure.[8]
15
Figure 3: Enema-can set with lock and
catheter
16
• In this method, at times kalka material blocks the tube causing
stagnation of flow of basti dravya and delay in administration.
• This delay causes separation of homogenous emulsion of
bastidravya in the enema-can into unctuous/oil aqueous/
decoction and kalka component
• Sometimes, kalka does not enter in the colon at all. The delay
in administering the bastidravya in colon is a bastidosha called
ativilambita, which is not desirable.
• According to, the classical text of Ayurveda ,basti pidanakala/
basti-danakala for niruha basti is 30 matra. There are different
traditional methods of measuring a matra.
17
• In the context of basti-danakala, Sharangadhara describes
one shotika as one matra.[9] A matra is also one “single eye
closure.”
• In general, the calculation of thirty matra according to,
Ayurvedic Formulary of India Part-I, comes around 46 s.[10]
• However, in the context of niruha basti Nampoothiri et al.have
estimated basti-danakala to 60 s.[11]
• In the subject-A stipulated quantity of bastidravya as a
homogenous emulsion entered into the colon within 60 s,
which required positive pressure by the
Vaidya/Administrator [Figure 4]
18
Figure 4: Basti administration with
bastinetra and putaka method
19
• In the subject-B the procedure took nearly 10 min, which
was devoid of positive pressure. The homogenous emulsion
in subject-B entered in colon in three phases namely
water (decoction), oil, and kalka component in that order.
• It serves only for filling the colon with bastidravya, which
probably would not help to attain desired effect of basti.
• The retention time of the basti for subject-A was 5 min
and for subject-B it was 15 min, although, both had
madhyama-koshtha.
20
• The classical texts of Ayurveda have given liberty to the Vaidya
to think and modify the instruments, line of treatment and
modality wherever required, without losing its core
principles.[12]
• Here, in the subject-A, niruha basti is administered with the
classical method but the bastiyantra is modified wherein
disposable plastic bag is used instead of the animal
bladder/leather bag.
• When the homogenous emulsion of basti dravya enters the
colon with“uniform positive pressure” within short-time, it
reaches up to proximal colon, i.e. nearer to caecum and
probably exerts procedure effect.[13]
21
• Human colon is supposed to be sluggish in absorption and
motility. It is involved in various functions, including
absorption of water and electrolytes, transport of intraluminal
contents, and production of short-chain fatty acids (SCFA ).
• SCFAs (butyrate, propionate, and acetate),which have an
integral position in colonic health are principally synthesized in
more acidic environment of the proximal colon.
• The salvage of water and electrolyte is primarily accorded to
the proximal colon although, distal colon and rectum
contribute to this task but to a lesser extend [14]
22
• Butyrate promotes the absorption of water, sodium, and
chloride from the proximal colon.[15]
• The ICCSM (Interstitial Cells of Cajal in sub-mucosal surface
of the circular muscle), the primary pacemaker cells are
solely present in proximal portion of colon.[16]
• Loss of ICC in animals due to infection, surgical treatment
and treated with chemicals correlated with loss of
pacemaker activity, propagation defects, reduced
neurotransmission, and loss of response to stretch.[17]
• The parasympathetic supply to the proximal colon i.e., the
intestinal branches originate from the posterior division of
the vagus nerve, which are secretomotor to glands and
motor to muscular coats of gut.[18]
• Thus proximal colon has significant role in colonic motility
and absorption.
23
• We assume that due to uniform positive pressure
homogenous emulsion of bastidravya reaches quickly to
proximal colon where it probably stimulates ICCSM, which
in turn initiates colonic propagating activity and chain of
reactions like churning of contents in proximal colon and
production of SCFA, absorption of electrolytes, water and
other active principles through carrier mediated transport
mechanism.
• Other factors like luminal distention and chemical stimuli
by niruha-bastidravya contribute to this process.
• This can happen with the classical method and not by the
adopted conventional method in which the tube and can
cannot give sufficient pressure for bastidravya to reach
proximal colon as a homogenous emulsion.
24
The reach of the bastidravya and its retention time in colon
may differ due to the factors such as vaya (age), prakruti
(bodily constitution), bala (strength), satva (psyche), agni
(digestive capacity), koshtha (inherent condition of the
digestive system), desha (region), satmya (compatibility) of
the subject to basti procedure and bastidravya, kala (season/
time of administration of basti, i.e., morning or evening,
particular day during the course of yoga/karma/kala basti),
total quantity of the bastidravya, ratio of ingredients used
in the basti (makshika, saindhava, sneha, kalka, kvatha), herbs
used for decoction and kalka, besides skill and positive
pressure used by the administrator.
25
• Niruha basti is an active panchakarma procedure, which has to be
performed by a skilled Vaidya with an optimum uniform positive
pressure, while maintaining stipulated time of basti-danakala so as
to reach the bastidravya as homogenous emulsion up to the
proximal colon.
• It would be interesting further to study, the impact of niruha basti
by the classical method on proximal colon in terms of colonic
motility, its central nervous influences, SCFA production,
transportation of gut contents, and absorption of water and
electrolytes.
• The message is loud and clear that while adapting to novel methods
of technology we need to have the fidelity to classical principles and
practices of Ayurveda.[19]
26
The authors acknowledge Dr. Madhav Gundeti for providing
a facility to do the study. The authors are thankful to
Dr. A. B. Vaidya, Research Director, MRC-KHS, Mumbai for
his direction and final reading of the manuscript
27
1.Shastri A, editor. Sushruta Samhita of Sushruta,Chikitsasthana, Netrabastipramanvibhag chikitsitam. 5th ed.,
Ch. 35, Ver. 18. Varanasi: Chaukhambha Orientalia; 1979.p. 154.
2. Srikanthamurthy K, editor. Ashtanga Sangraha of Vagbhata,Sutrasthana, Bastividhidhyaya. 2nd ed., Vol. 1, Ch.
28,Ver. 2. Varanasi: Chaukhambha Orientalia; 1998. p. 485.
3. Srikanthamurthy K, editor. Ashtanga Sangraha of Vagbhata,Sutrasthana, Bastividhidhyaya. 2nd ed., Vol. 1, Ch.
28,Ver. 23. Varanasi: Chaukhambha Orientalia; 1998. p. 494.
4. Tripathi B, editor. Ashtanga Hridaya of Vagbhata,Sutrasthana, Bastividhi adhyaya. 1st ed., Ch. 19, Ver. 45.
Delhi: Chaukhambha Sanskrit Pratishthan; 1999. p. 236.
5. Savrikar SS, Lagad CE. Study of Preparation andStandardization of 'Maadhutailika Basti’ with special
reference to Emulsion Stability. Ayu 2010;31:1-6.
6. Nampoothiri MR, Mahadevan L. Principles and Practice of Vasti. 1st ed. Derisanamcope: Y. Mahadeva Iyer’s
Sri Sarada Ayurvedic Hospital; 2007. p. 49.
7. Sharma P, editor. Caraka Samhita of Caraka, Siddhisthana,Bastisutriyasiddhi. 1st ed., Vol. 2, Ch. 3, Ver. 7-9.
Varanasi:Chaukhambha Orientalia; 1983. p. 605-6.
8.Kasture HS. Panchakarma Samhita. Bastivignyaniyam adhyaya, 1st ed. Ch. 7, Ver. 114, Ahmedabad: Gujrat
Ayurvedic Charitable Trust; 2000, p. 98
28
9. Srikanthamurthy K, editor. Sharangadhara Samhita of Sharangadhara, Uttarakhanda, Basti vidhi. 1st ed., Ch.
5,Ver. 28. Varanasi: Chaukhambha Orientalia; 1984. p. 212.
10. Ayurvedic Formulary of India, Metric Equivalents of Classical weights and measures 2nd ed., Appendix V,
Part I. New Delhi:Govt. of India, MoH and FW, Dept of ISM&H; 2003. p. 483.
11. Nampoothiri MR, Mahadevan L. Principles and Practice of Vasti. 1st ed. Derisanamcope: Y. Mahadeva Iyer’s
SriSarada Ayurvedic Hospital; 2007. p. 101.
12. Sharma P, editor. Caraka Samhita of Caraka, Vimanasthana,Rogbhishagjitiya Adhyaya. 1st ed., Ch. 8, Ver.
5/127.Varanasi: Chaukhambha Orientalia; 1981. p. 384.
13. Gupta PK, Sigh RH. A conceptual study on vasti effect. Anc Sci Life 2001;20:54-9.
14. Szmulowicz UM, Hull TL. Colonic physiology. In: Beck DE, editor. The ASCRS Textbook of Colon and Rectal
Surgery.2nd ed.New York: Springer; 2011. p. 23-39. Available from
http://www.springer.com/cda/content/./9781441915818-c1.pdf. [Last accessed 2012 Sep 12].
15. Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost FJ,Brummer RJ. Review article: The role of butyrate
on Colonic function. Aliment Pharmacol Ther 2008;27:104-19.
16. Camborová P, Hubka P, Sulková I, Hulín I. The pacemakeractivity of interstitial cells of Cajal and gastric
Electrical activity. Physiol Res 2003;52:275-84.
17. Sanders KM. Interstitial cells of Cajal at the clinical and scientifi c interface. J Physiol 2006;576:683-7.
18. Williams PL, Warwick R. Gray’s Anatomy, Neurology, The parasympathetic Nervous system. 36th ed.
Edinburgh:Churchill Livingstone; 1980. p. 1123.
19. Raut AA. Integrative endeavor for renaissance in Ayurveda.J Ayurveda Integr Med 2011;2:5-8.
29
Article is simple concised and relavent in
the present scenario.
Author had made an effort to put forth
ayurvedic principles in a scientific platform
Mode of action of basthi is explained in
detail
Discussion part is very novel , he took
various references and explained well.
30
Statement of the authour regarding segmentation of basthi dravya in enema can
method is not justified.
Position and time of administration of basthi is not mentioned.
Author didn’t mentioned the age of subjects
Generally the retention time of basthi dravya with basthi putaka method will be
more according to some other studies but its less in this study, so we cannot come
into a proper conclusion.
Units of time -author had mentioned 1 in sec (60 secs) and the other in minute (15
min).
Samyak niruha lakshana attained or not is not mentioned.
In materials and methods , The drugs in the kalka are not sepicified, and also the
proportion of kwatha is also not mentioned
As this is a pilot study –title is not justified
31

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Jcm presentation

  • 1. JCM PRESENTATION BY DR PRIYANKA.P.S 1st YEARPGSCHOLAR DEPT OF PANCHAKARMA UNDER THE VALUABLEGUIDANCEOF ALL THE FACULTIES OF PANCHAKARMAdepartment 1
  • 2. Basti: Does the equipment and method of administration matter 2
  • 3. • The Journal of Ayurveda and Integrative Medicine (J-AIM) is an open-access, peer reviewed journal published jointly by The Institute of Trans-disciplinary Health Sciences and Technology (TDU) and The World Ayurveda Foundation (WAF), and published on Elsevier. ABSTRACTING AND INDEXING • Web of Science • PubMed • Scopus • EMBASE/Excerpta Medica • Emerging Sources Citation Index (ESCI) • CAB Abstracts • Directory of Open Access Journals (DOAJ) • ISSN: 0975-9476 • Editor-in-Chief Bhushan Patwardhan, Center for Complementary and Integrative Health, Savitribai Phule Pune University 3
  • 4. • Manohar S. Gundeti, • Ashwinikumar A. Raut 1, • Nitin M. Kamat 2 • RRA Podar Ayurveda Cancer Research Institute, Under Central Council for Research in Ayurvedic Sciences,Department of AYUSH, GoI,Mumbai, 1 • Clinical Research and Integrative Medicine, ICMR Advanced Centre for Reverse Pharmacology in Traditional Medicine at MedicalResearch Centre- Kasturba Health Society, Mumbai, 2 • Department of Kayachikitsa, Ayurveda Mahavidyalaya, Sion, Mumbai, India 4
  • 5. • Basti is one of the five procedures of panchakarma in Ayurveda. Classically, it is advocated in the diseases of vata. • It is mainly of two types viz. asthapana and anuvasana. According to the classical texts basti administration is done with the help of animal bladder (bastiputaka) and specially prepared metal/wooden nozzle/catheter (bastinetra), the whole assembly is called as bastiyantra. Nowadays, except in some of the Vaidya traditions in Kerala, basti administration is often done using enema-can or douche-set. • In the aforesaid classical procedure active pressure is expected to be given on the bastiputaka whereas, in conventionally used enema-can only passive or gravitational force plays a role. This is important in the context of ‘basti danakala or pidanakala i.e. time for basti administration’. • Key words: Basti, basti pidanakala, bastiputaka, colon, enema-can5
  • 6.  Basti, the prime treatment in shodhana is considered as one of the most important treatments for many diseases according to Ayurvedic classical literature.  It is the best treatment modality for all types of vata diseases. The type of basti where decoction is the major part is called as asthapana basti or niruha basti and the basti in, which major part is oil or other sneha (oleaginous substance) is called as anuvasana.[1]  The desired effect of basti depends on several determinants and basti- danakala is one of the important determinant variables.  In this study, we have addressed this basti-danakala determinant with the help of barium contrast to assess the difference in administration time and reach of bastidravya in the colon with two different methods of - (1) bastinetra with bastiputaka method (classically used) and (2) enema-can method (commonly used). 6
  • 7. Two apparently healthy male adult individuals (Subject-A and B) who had matra basti on previous day and with prior sneha-sveda in the morning were administered niruha basti comprising of Makshika (honey) 150 ml,Saindhava(rock salt) 15 g, Tila taila 150 ml, kalka (paste of fresh herbs or dried powders) 30 g, added to Erandamula kvatha(decoction of castor roots in water) to make total 960 ml with classical method and with conventional enema can method respectively, after taking written informed consent. 7
  • 8. • Barium sulphate B.P (Microbar HD) 25 g were added in both the niruha bastidravya after its preparation. • In subject-A, the Vaidya administered basti with uniform pressure and gradual squeezing of the bastiputaka. • In the subject-B the enema-can was kept hanging on a stand four feet above the bed. • Basti administration was done on the X-ray table and radiographs were taken immediately after the administration 8
  • 9. • The basti administration time in the subject-A was about 60 s where stipulated amount of basti dravya entered in the colon homogenously with uniform positive pressure. The radiograph of subject-A [Figure 1] shows complete filling of sigmoid colon and further propelling of the basti dravya through colon towards Ileo-caecal (IC) junction where it has almost filled the ascending colon. • In subject-B it took about 10 min for administration of basti dravya with interruption. The radiograph of subject- B [Figure 1] shows added filling of sigmoid colon, propelling the basti dravya through colon, reaching the IC junction but the amount of basti dravya is less at that point in comparison to subject-A. 9
  • 10. Figure 1: Radiographs of subject a and b A B 10
  • 11. The term basti/vasti comes from usage of animal urinary bladder for administration of the basti dravya.[2] In the absence of bladder artificial basti putaka prepared by thin skin of aquatic bird/goat or a wax coated cotton bag may be used.[3] The purpose of using bladder is “uniform contractility with uniform flow.” The minimum positive pressure on bladder filled with basti dravya will contract uniformly and pour out with uniform flow within a short-time .Niruha basti has uniqueness in the preparation of basti yantra, basti dravya and its administration. 11
  • 12.  “Bastidravya” is prepared by adding ingredients like makshika, lavana, sneha, kalka and kvatha together in a sequence,[4] which forms a homogenous oil in water (O/W) emulsion.[5]  Usage of animal bladder for preparation of basti putaka was possible and justified in earlier days, however, is not feasible and practical today.  As an alternative, a plastic bag of 50 microns thickness and having 1.5 l capacity is used as basti putaka, and is disposed of after single use.[6] • It is filled with basti dravya, and tied with metal basti netra to form basti yantra [Figure 2] 12
  • 13. • Bastinetra is a tubular structure usually made up of brass, having tapering end and wider base, which resembles cow’s tail. • It has three rings on external surface called as karnika (ridges), the last two at the bottom are used to tie the basti putaka with netra.[7] 13
  • 14. Figure 2: Bastinetra having three karnika 14
  • 15. • Commonly, at many places, basti is administered using enema-can/douche set instead of classical bastiyantra due to its easy availability and handling. • This set consists of plastic/metal can and attached plastic tube with nozzle having lock (to which sometimes the simple rubber catheter is attached) [Figure 3]. • The enema-can is held to the stand approximately four feet above the patient. Here, only gravitational force plays the role through passive pressure.[8] 15
  • 16. Figure 3: Enema-can set with lock and catheter 16
  • 17. • In this method, at times kalka material blocks the tube causing stagnation of flow of basti dravya and delay in administration. • This delay causes separation of homogenous emulsion of bastidravya in the enema-can into unctuous/oil aqueous/ decoction and kalka component • Sometimes, kalka does not enter in the colon at all. The delay in administering the bastidravya in colon is a bastidosha called ativilambita, which is not desirable. • According to, the classical text of Ayurveda ,basti pidanakala/ basti-danakala for niruha basti is 30 matra. There are different traditional methods of measuring a matra. 17
  • 18. • In the context of basti-danakala, Sharangadhara describes one shotika as one matra.[9] A matra is also one “single eye closure.” • In general, the calculation of thirty matra according to, Ayurvedic Formulary of India Part-I, comes around 46 s.[10] • However, in the context of niruha basti Nampoothiri et al.have estimated basti-danakala to 60 s.[11] • In the subject-A stipulated quantity of bastidravya as a homogenous emulsion entered into the colon within 60 s, which required positive pressure by the Vaidya/Administrator [Figure 4] 18
  • 19. Figure 4: Basti administration with bastinetra and putaka method 19
  • 20. • In the subject-B the procedure took nearly 10 min, which was devoid of positive pressure. The homogenous emulsion in subject-B entered in colon in three phases namely water (decoction), oil, and kalka component in that order. • It serves only for filling the colon with bastidravya, which probably would not help to attain desired effect of basti. • The retention time of the basti for subject-A was 5 min and for subject-B it was 15 min, although, both had madhyama-koshtha. 20
  • 21. • The classical texts of Ayurveda have given liberty to the Vaidya to think and modify the instruments, line of treatment and modality wherever required, without losing its core principles.[12] • Here, in the subject-A, niruha basti is administered with the classical method but the bastiyantra is modified wherein disposable plastic bag is used instead of the animal bladder/leather bag. • When the homogenous emulsion of basti dravya enters the colon with“uniform positive pressure” within short-time, it reaches up to proximal colon, i.e. nearer to caecum and probably exerts procedure effect.[13] 21
  • 22. • Human colon is supposed to be sluggish in absorption and motility. It is involved in various functions, including absorption of water and electrolytes, transport of intraluminal contents, and production of short-chain fatty acids (SCFA ). • SCFAs (butyrate, propionate, and acetate),which have an integral position in colonic health are principally synthesized in more acidic environment of the proximal colon. • The salvage of water and electrolyte is primarily accorded to the proximal colon although, distal colon and rectum contribute to this task but to a lesser extend [14] 22
  • 23. • Butyrate promotes the absorption of water, sodium, and chloride from the proximal colon.[15] • The ICCSM (Interstitial Cells of Cajal in sub-mucosal surface of the circular muscle), the primary pacemaker cells are solely present in proximal portion of colon.[16] • Loss of ICC in animals due to infection, surgical treatment and treated with chemicals correlated with loss of pacemaker activity, propagation defects, reduced neurotransmission, and loss of response to stretch.[17] • The parasympathetic supply to the proximal colon i.e., the intestinal branches originate from the posterior division of the vagus nerve, which are secretomotor to glands and motor to muscular coats of gut.[18] • Thus proximal colon has significant role in colonic motility and absorption. 23
  • 24. • We assume that due to uniform positive pressure homogenous emulsion of bastidravya reaches quickly to proximal colon where it probably stimulates ICCSM, which in turn initiates colonic propagating activity and chain of reactions like churning of contents in proximal colon and production of SCFA, absorption of electrolytes, water and other active principles through carrier mediated transport mechanism. • Other factors like luminal distention and chemical stimuli by niruha-bastidravya contribute to this process. • This can happen with the classical method and not by the adopted conventional method in which the tube and can cannot give sufficient pressure for bastidravya to reach proximal colon as a homogenous emulsion. 24
  • 25. The reach of the bastidravya and its retention time in colon may differ due to the factors such as vaya (age), prakruti (bodily constitution), bala (strength), satva (psyche), agni (digestive capacity), koshtha (inherent condition of the digestive system), desha (region), satmya (compatibility) of the subject to basti procedure and bastidravya, kala (season/ time of administration of basti, i.e., morning or evening, particular day during the course of yoga/karma/kala basti), total quantity of the bastidravya, ratio of ingredients used in the basti (makshika, saindhava, sneha, kalka, kvatha), herbs used for decoction and kalka, besides skill and positive pressure used by the administrator. 25
  • 26. • Niruha basti is an active panchakarma procedure, which has to be performed by a skilled Vaidya with an optimum uniform positive pressure, while maintaining stipulated time of basti-danakala so as to reach the bastidravya as homogenous emulsion up to the proximal colon. • It would be interesting further to study, the impact of niruha basti by the classical method on proximal colon in terms of colonic motility, its central nervous influences, SCFA production, transportation of gut contents, and absorption of water and electrolytes. • The message is loud and clear that while adapting to novel methods of technology we need to have the fidelity to classical principles and practices of Ayurveda.[19] 26
  • 27. The authors acknowledge Dr. Madhav Gundeti for providing a facility to do the study. The authors are thankful to Dr. A. B. Vaidya, Research Director, MRC-KHS, Mumbai for his direction and final reading of the manuscript 27
  • 28. 1.Shastri A, editor. Sushruta Samhita of Sushruta,Chikitsasthana, Netrabastipramanvibhag chikitsitam. 5th ed., Ch. 35, Ver. 18. Varanasi: Chaukhambha Orientalia; 1979.p. 154. 2. Srikanthamurthy K, editor. Ashtanga Sangraha of Vagbhata,Sutrasthana, Bastividhidhyaya. 2nd ed., Vol. 1, Ch. 28,Ver. 2. Varanasi: Chaukhambha Orientalia; 1998. p. 485. 3. Srikanthamurthy K, editor. Ashtanga Sangraha of Vagbhata,Sutrasthana, Bastividhidhyaya. 2nd ed., Vol. 1, Ch. 28,Ver. 23. Varanasi: Chaukhambha Orientalia; 1998. p. 494. 4. Tripathi B, editor. Ashtanga Hridaya of Vagbhata,Sutrasthana, Bastividhi adhyaya. 1st ed., Ch. 19, Ver. 45. Delhi: Chaukhambha Sanskrit Pratishthan; 1999. p. 236. 5. Savrikar SS, Lagad CE. Study of Preparation andStandardization of 'Maadhutailika Basti’ with special reference to Emulsion Stability. Ayu 2010;31:1-6. 6. Nampoothiri MR, Mahadevan L. Principles and Practice of Vasti. 1st ed. Derisanamcope: Y. Mahadeva Iyer’s Sri Sarada Ayurvedic Hospital; 2007. p. 49. 7. Sharma P, editor. Caraka Samhita of Caraka, Siddhisthana,Bastisutriyasiddhi. 1st ed., Vol. 2, Ch. 3, Ver. 7-9. Varanasi:Chaukhambha Orientalia; 1983. p. 605-6. 8.Kasture HS. Panchakarma Samhita. Bastivignyaniyam adhyaya, 1st ed. Ch. 7, Ver. 114, Ahmedabad: Gujrat Ayurvedic Charitable Trust; 2000, p. 98 28
  • 29. 9. Srikanthamurthy K, editor. Sharangadhara Samhita of Sharangadhara, Uttarakhanda, Basti vidhi. 1st ed., Ch. 5,Ver. 28. Varanasi: Chaukhambha Orientalia; 1984. p. 212. 10. Ayurvedic Formulary of India, Metric Equivalents of Classical weights and measures 2nd ed., Appendix V, Part I. New Delhi:Govt. of India, MoH and FW, Dept of ISM&H; 2003. p. 483. 11. Nampoothiri MR, Mahadevan L. Principles and Practice of Vasti. 1st ed. Derisanamcope: Y. Mahadeva Iyer’s SriSarada Ayurvedic Hospital; 2007. p. 101. 12. Sharma P, editor. Caraka Samhita of Caraka, Vimanasthana,Rogbhishagjitiya Adhyaya. 1st ed., Ch. 8, Ver. 5/127.Varanasi: Chaukhambha Orientalia; 1981. p. 384. 13. Gupta PK, Sigh RH. A conceptual study on vasti effect. Anc Sci Life 2001;20:54-9. 14. Szmulowicz UM, Hull TL. Colonic physiology. In: Beck DE, editor. The ASCRS Textbook of Colon and Rectal Surgery.2nd ed.New York: Springer; 2011. p. 23-39. Available from http://www.springer.com/cda/content/./9781441915818-c1.pdf. [Last accessed 2012 Sep 12]. 15. Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost FJ,Brummer RJ. Review article: The role of butyrate on Colonic function. Aliment Pharmacol Ther 2008;27:104-19. 16. Camborová P, Hubka P, Sulková I, Hulín I. The pacemakeractivity of interstitial cells of Cajal and gastric Electrical activity. Physiol Res 2003;52:275-84. 17. Sanders KM. Interstitial cells of Cajal at the clinical and scientifi c interface. J Physiol 2006;576:683-7. 18. Williams PL, Warwick R. Gray’s Anatomy, Neurology, The parasympathetic Nervous system. 36th ed. Edinburgh:Churchill Livingstone; 1980. p. 1123. 19. Raut AA. Integrative endeavor for renaissance in Ayurveda.J Ayurveda Integr Med 2011;2:5-8. 29
  • 30. Article is simple concised and relavent in the present scenario. Author had made an effort to put forth ayurvedic principles in a scientific platform Mode of action of basthi is explained in detail Discussion part is very novel , he took various references and explained well. 30
  • 31. Statement of the authour regarding segmentation of basthi dravya in enema can method is not justified. Position and time of administration of basthi is not mentioned. Author didn’t mentioned the age of subjects Generally the retention time of basthi dravya with basthi putaka method will be more according to some other studies but its less in this study, so we cannot come into a proper conclusion. Units of time -author had mentioned 1 in sec (60 secs) and the other in minute (15 min). Samyak niruha lakshana attained or not is not mentioned. In materials and methods , The drugs in the kalka are not sepicified, and also the proportion of kwatha is also not mentioned As this is a pilot study –title is not justified 31