1) The study compared the administration of niruha basti using the classical method with a modified bastiyantra versus an enema can.
2) With the classical method, the basti dravya entered the colon homogenously within 60 seconds due to uniform positive pressure, reaching the proximal colon.
3) With the enema can, it took 10 minutes for the basti dravya to enter the colon in phases and in a smaller amount, only reaching the sigmoid colon.
4) The classical method of administration may better help achieve the desired effects of basti by more fully delivering the ingredients to the proximal colon.
Mr. Shashidhara A Kellur Assistant Professor Department of Physical Education and Sports Sciences Vijayanagara Sri Krishnaadevaraya University Ballari Karnataka INDIA
Mr. Shashidhara A Kellur Assistant Professor Department of Physical Education and Sports Sciences Vijayanagara Sri Krishnaadevaraya University Ballari Karnataka INDIA
Anuradha e. lecture 4 Sthanik Chikitsa (Local Ayurvedic Gynaecological thera...Anuradha Roy
Ayurveda has a great potential for management of various gynaecological conditions by sthanik chikitsa or local ayurvedic therapy. A description with open end of research areas are described here.
“A COMPARATIVE CLINICAL STUDY ON THE EFFECT OF NASYA WITH KARPASASTHYADI TAIL...Dr febin jose
Avabahuka is a common condition which badly affects the routine domestic activities of patients like combing; bathing etc. interference in occupation by the illness is equally true both in patients with sedentary office work as well as heavy field work. Ayurveda has a great role to manage this disease successfully. Nasya is one among the treatments told by Acharyas for the management of this disease. A comparative clinical study on Nasya with Karpasasthyadi Taila and Nagara Taila had been taken to assess the effect of Nasya Karma and the drug in managing Avabahuka. The comparative effect in managing the same disease is also assessed.
OBJECTIVE OF THE STUDY
1. To evaluate the efficacy of Karpasasthyadi Taila Nasya in Avabahuka.
2. To evaluate the efficacy of Nagara Taila Nasya in Avabahuka.
3. To compare efficacy of Karpasasthyadi Taila Nasya and Nagara Taila Nasya in Avabahuka.
Two groups were made and the results obtained in both the individual groups were compared. The study design selected for the present study was prospective comparative clinical trial. The sample size for the present study was 30 patients suffering from Avabahuka as per the selection criteria. Patients were randomly distributed to both the groups of equal size.
Group A - 15 patients received Nasya with Karpasasthyadi Taila.
Group B – 15 patients received Nasya with Nagara Taila.
In group A 15 patients (100%) had got Prayika Shamana(61-99%) , and no patient (00%) had got no response to the treatment ie Guna Alabha. In group B 13 patients (81%) had got Prayika Shamana(61-99%),02 patients(19%) had got Amshika Shamana (31-60%), and no patient (00%) had got no response to the treatment ie Guna Alabha.
In Group A Shoola B T -53% and after follow up 91%, and in Sthabthatha i.e. Unnamana - B T- 42% and after follow up 66%, Avannamana B T- 43% and after follow up 84%,Akunchana B T-39 % and after follow up 81% and Prasarana B T- 61% and after follow up 87%, Triyakgamana BT-60% and after follow up 77%.
In Group B Shoola B T -51% and after follow up 81%, and in Sthabthatha ie Unnamana - B T- 34% and after follow up 63%, Avannamana B T- 30% and after follow up 76%,Akunchana B T-31 % and after follow up 69% and Prasarana B T- 43% and after follow up 80%, Triyakgamana BT-35% and after follow up 65%.
Group A had got good results while comparing with Group B.That means Nasya with Karpasasthyadi Taila had got good effect than Nasya with Nagara Taila in Avabahuka for the present study.
Key words; Nasya, Avabahuka, Karpasasthyadi Taila, Nagara Taila,
Anuradha e. lecture 4 Sthanik Chikitsa (Local Ayurvedic Gynaecological thera...Anuradha Roy
Ayurveda has a great potential for management of various gynaecological conditions by sthanik chikitsa or local ayurvedic therapy. A description with open end of research areas are described here.
“A COMPARATIVE CLINICAL STUDY ON THE EFFECT OF NASYA WITH KARPASASTHYADI TAIL...Dr febin jose
Avabahuka is a common condition which badly affects the routine domestic activities of patients like combing; bathing etc. interference in occupation by the illness is equally true both in patients with sedentary office work as well as heavy field work. Ayurveda has a great role to manage this disease successfully. Nasya is one among the treatments told by Acharyas for the management of this disease. A comparative clinical study on Nasya with Karpasasthyadi Taila and Nagara Taila had been taken to assess the effect of Nasya Karma and the drug in managing Avabahuka. The comparative effect in managing the same disease is also assessed.
OBJECTIVE OF THE STUDY
1. To evaluate the efficacy of Karpasasthyadi Taila Nasya in Avabahuka.
2. To evaluate the efficacy of Nagara Taila Nasya in Avabahuka.
3. To compare efficacy of Karpasasthyadi Taila Nasya and Nagara Taila Nasya in Avabahuka.
Two groups were made and the results obtained in both the individual groups were compared. The study design selected for the present study was prospective comparative clinical trial. The sample size for the present study was 30 patients suffering from Avabahuka as per the selection criteria. Patients were randomly distributed to both the groups of equal size.
Group A - 15 patients received Nasya with Karpasasthyadi Taila.
Group B – 15 patients received Nasya with Nagara Taila.
In group A 15 patients (100%) had got Prayika Shamana(61-99%) , and no patient (00%) had got no response to the treatment ie Guna Alabha. In group B 13 patients (81%) had got Prayika Shamana(61-99%),02 patients(19%) had got Amshika Shamana (31-60%), and no patient (00%) had got no response to the treatment ie Guna Alabha.
In Group A Shoola B T -53% and after follow up 91%, and in Sthabthatha i.e. Unnamana - B T- 42% and after follow up 66%, Avannamana B T- 43% and after follow up 84%,Akunchana B T-39 % and after follow up 81% and Prasarana B T- 61% and after follow up 87%, Triyakgamana BT-60% and after follow up 77%.
In Group B Shoola B T -51% and after follow up 81%, and in Sthabthatha ie Unnamana - B T- 34% and after follow up 63%, Avannamana B T- 30% and after follow up 76%,Akunchana B T-31 % and after follow up 69% and Prasarana B T- 43% and after follow up 80%, Triyakgamana BT-35% and after follow up 65%.
Group A had got good results while comparing with Group B.That means Nasya with Karpasasthyadi Taila had got good effect than Nasya with Nagara Taila in Avabahuka for the present study.
Key words; Nasya, Avabahuka, Karpasasthyadi Taila, Nagara Taila,
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
3. • The Journal of Ayurveda and Integrative Medicine (J-AIM) is an
open-access, peer reviewed journal published jointly by The
Institute of Trans-disciplinary Health Sciences and Technology (TDU)
and The World Ayurveda Foundation (WAF), and published on
Elsevier.
ABSTRACTING AND INDEXING
• Web of Science
• PubMed
• Scopus
• EMBASE/Excerpta Medica
• Emerging Sources Citation Index (ESCI)
• CAB Abstracts
• Directory of Open Access Journals (DOAJ)
• ISSN: 0975-9476
• Editor-in-Chief Bhushan Patwardhan, Center for Complementary
and Integrative Health, Savitribai Phule Pune University
3
4. • Manohar S. Gundeti,
• Ashwinikumar A. Raut 1,
• Nitin M. Kamat 2
• RRA Podar Ayurveda Cancer Research Institute, Under
Central Council for Research in Ayurvedic
Sciences,Department of AYUSH, GoI,Mumbai, 1
• Clinical Research and Integrative Medicine, ICMR
Advanced Centre for Reverse Pharmacology in
Traditional Medicine at MedicalResearch Centre-
Kasturba Health Society, Mumbai, 2
• Department of Kayachikitsa, Ayurveda Mahavidyalaya,
Sion, Mumbai, India
4
5. • Basti is one of the five procedures of panchakarma in Ayurveda.
Classically, it is advocated in the diseases of vata.
• It is mainly of two types viz. asthapana and anuvasana.
According to the classical texts basti administration is done with
the help of animal bladder (bastiputaka) and specially prepared
metal/wooden nozzle/catheter (bastinetra), the whole
assembly is called as bastiyantra. Nowadays, except in some of
the Vaidya traditions in Kerala, basti administration is often done
using enema-can or douche-set.
• In the aforesaid classical procedure active pressure is expected
to be given on the bastiputaka whereas, in conventionally used
enema-can only passive or gravitational force plays a role. This is
important in the context of ‘basti danakala or pidanakala i.e.
time for basti administration’.
• Key words: Basti, basti pidanakala, bastiputaka, colon, enema-can5
6. Basti, the prime treatment in shodhana is considered as
one of the most important treatments for many diseases
according to Ayurvedic classical literature.
It is the best treatment modality for all types of vata diseases. The type
of basti where decoction is the major part is called as asthapana basti
or niruha basti and the basti in, which major part is oil or other sneha
(oleaginous substance) is called as anuvasana.[1]
The desired effect of basti depends on several determinants and basti-
danakala is one of the important determinant variables.
In this study, we have addressed this basti-danakala determinant with
the help of barium contrast to assess the difference in administration
time and reach of bastidravya in the colon with two different methods
of - (1) bastinetra with bastiputaka method (classically used) and (2)
enema-can method (commonly used).
6
7. Two apparently healthy male adult individuals (Subject-A and B)
who had matra basti on previous day and with prior sneha-sveda
in the morning were administered niruha basti comprising of
Makshika (honey) 150 ml,Saindhava(rock salt) 15 g, Tila taila 150
ml, kalka (paste of fresh herbs or dried powders) 30 g, added to
Erandamula kvatha(decoction of castor roots in water) to make
total 960 ml with classical method and with conventional enema
can method respectively, after taking written informed consent.
7
8. • Barium sulphate B.P (Microbar HD) 25 g were added
in both the niruha bastidravya after its preparation.
• In subject-A, the Vaidya administered basti with
uniform pressure and gradual squeezing of the
bastiputaka.
• In the subject-B the enema-can was kept hanging on
a stand four feet above the bed.
• Basti administration was done on the X-ray table and
radiographs were taken immediately after the
administration
8
9. • The basti administration time in the subject-A was about
60 s where stipulated amount of basti dravya entered in
the colon homogenously with uniform positive pressure.
The radiograph of subject-A [Figure 1] shows complete
filling of sigmoid colon and further propelling of the basti
dravya through colon towards Ileo-caecal (IC) junction
where it has almost filled the ascending colon.
• In subject-B it took about 10 min for administration of
basti dravya with interruption. The radiograph of subject-
B [Figure 1] shows added filling of sigmoid colon,
propelling the basti dravya through colon, reaching the IC
junction but the amount of basti dravya is less at that
point in comparison to subject-A.
9
11. The term basti/vasti comes from usage of animal urinary
bladder for administration of the basti dravya.[2] In the
absence of bladder artificial basti putaka prepared by thin
skin of aquatic bird/goat or a wax coated cotton bag may be
used.[3]
The purpose of using bladder is “uniform contractility with
uniform flow.” The minimum positive pressure on bladder
filled with basti dravya will contract uniformly and pour out
with uniform flow within a short-time .Niruha basti has
uniqueness in the preparation of basti yantra, basti dravya
and its administration.
11
12. “Bastidravya” is prepared by adding ingredients like makshika,
lavana, sneha, kalka and kvatha together in a sequence,[4]
which forms a homogenous oil in water (O/W) emulsion.[5]
Usage of animal bladder for preparation of basti putaka
was possible and justified in earlier days, however, is not
feasible and practical today.
As an alternative, a plastic bag of 50 microns thickness and
having 1.5 l capacity is used as basti putaka, and is disposed of
after single use.[6]
• It is filled with basti dravya, and tied with metal basti netra to
form basti yantra [Figure 2]
12
13. • Bastinetra is a tubular structure usually made up of brass,
having tapering end and wider base, which resembles cow’s
tail.
• It has three rings on external surface called as karnika (ridges),
the last two at the bottom are used to tie the basti putaka
with netra.[7]
13
15. • Commonly, at many places, basti is administered using
enema-can/douche set instead of classical bastiyantra due to
its easy availability and handling.
• This set consists of plastic/metal can and attached plastic tube
with nozzle having lock (to which sometimes the simple
rubber catheter is attached) [Figure 3].
• The enema-can is held to the stand approximately four feet
above the patient. Here, only gravitational force plays the role
through passive pressure.[8]
15
17. • In this method, at times kalka material blocks the tube causing
stagnation of flow of basti dravya and delay in administration.
• This delay causes separation of homogenous emulsion of
bastidravya in the enema-can into unctuous/oil aqueous/
decoction and kalka component
• Sometimes, kalka does not enter in the colon at all. The delay
in administering the bastidravya in colon is a bastidosha called
ativilambita, which is not desirable.
• According to, the classical text of Ayurveda ,basti pidanakala/
basti-danakala for niruha basti is 30 matra. There are different
traditional methods of measuring a matra.
17
18. • In the context of basti-danakala, Sharangadhara describes
one shotika as one matra.[9] A matra is also one “single eye
closure.”
• In general, the calculation of thirty matra according to,
Ayurvedic Formulary of India Part-I, comes around 46 s.[10]
• However, in the context of niruha basti Nampoothiri et al.have
estimated basti-danakala to 60 s.[11]
• In the subject-A stipulated quantity of bastidravya as a
homogenous emulsion entered into the colon within 60 s,
which required positive pressure by the
Vaidya/Administrator [Figure 4]
18
19. Figure 4: Basti administration with
bastinetra and putaka method
19
20. • In the subject-B the procedure took nearly 10 min, which
was devoid of positive pressure. The homogenous emulsion
in subject-B entered in colon in three phases namely
water (decoction), oil, and kalka component in that order.
• It serves only for filling the colon with bastidravya, which
probably would not help to attain desired effect of basti.
• The retention time of the basti for subject-A was 5 min
and for subject-B it was 15 min, although, both had
madhyama-koshtha.
20
21. • The classical texts of Ayurveda have given liberty to the Vaidya
to think and modify the instruments, line of treatment and
modality wherever required, without losing its core
principles.[12]
• Here, in the subject-A, niruha basti is administered with the
classical method but the bastiyantra is modified wherein
disposable plastic bag is used instead of the animal
bladder/leather bag.
• When the homogenous emulsion of basti dravya enters the
colon with“uniform positive pressure” within short-time, it
reaches up to proximal colon, i.e. nearer to caecum and
probably exerts procedure effect.[13]
21
22. • Human colon is supposed to be sluggish in absorption and
motility. It is involved in various functions, including
absorption of water and electrolytes, transport of intraluminal
contents, and production of short-chain fatty acids (SCFA ).
• SCFAs (butyrate, propionate, and acetate),which have an
integral position in colonic health are principally synthesized in
more acidic environment of the proximal colon.
• The salvage of water and electrolyte is primarily accorded to
the proximal colon although, distal colon and rectum
contribute to this task but to a lesser extend [14]
22
23. • Butyrate promotes the absorption of water, sodium, and
chloride from the proximal colon.[15]
• The ICCSM (Interstitial Cells of Cajal in sub-mucosal surface
of the circular muscle), the primary pacemaker cells are
solely present in proximal portion of colon.[16]
• Loss of ICC in animals due to infection, surgical treatment
and treated with chemicals correlated with loss of
pacemaker activity, propagation defects, reduced
neurotransmission, and loss of response to stretch.[17]
• The parasympathetic supply to the proximal colon i.e., the
intestinal branches originate from the posterior division of
the vagus nerve, which are secretomotor to glands and
motor to muscular coats of gut.[18]
• Thus proximal colon has significant role in colonic motility
and absorption.
23
24. • We assume that due to uniform positive pressure
homogenous emulsion of bastidravya reaches quickly to
proximal colon where it probably stimulates ICCSM, which
in turn initiates colonic propagating activity and chain of
reactions like churning of contents in proximal colon and
production of SCFA, absorption of electrolytes, water and
other active principles through carrier mediated transport
mechanism.
• Other factors like luminal distention and chemical stimuli
by niruha-bastidravya contribute to this process.
• This can happen with the classical method and not by the
adopted conventional method in which the tube and can
cannot give sufficient pressure for bastidravya to reach
proximal colon as a homogenous emulsion.
24
25. The reach of the bastidravya and its retention time in colon
may differ due to the factors such as vaya (age), prakruti
(bodily constitution), bala (strength), satva (psyche), agni
(digestive capacity), koshtha (inherent condition of the
digestive system), desha (region), satmya (compatibility) of
the subject to basti procedure and bastidravya, kala (season/
time of administration of basti, i.e., morning or evening,
particular day during the course of yoga/karma/kala basti),
total quantity of the bastidravya, ratio of ingredients used
in the basti (makshika, saindhava, sneha, kalka, kvatha), herbs
used for decoction and kalka, besides skill and positive
pressure used by the administrator.
25
26. • Niruha basti is an active panchakarma procedure, which has to be
performed by a skilled Vaidya with an optimum uniform positive
pressure, while maintaining stipulated time of basti-danakala so as
to reach the bastidravya as homogenous emulsion up to the
proximal colon.
• It would be interesting further to study, the impact of niruha basti
by the classical method on proximal colon in terms of colonic
motility, its central nervous influences, SCFA production,
transportation of gut contents, and absorption of water and
electrolytes.
• The message is loud and clear that while adapting to novel methods
of technology we need to have the fidelity to classical principles and
practices of Ayurveda.[19]
26
27. The authors acknowledge Dr. Madhav Gundeti for providing
a facility to do the study. The authors are thankful to
Dr. A. B. Vaidya, Research Director, MRC-KHS, Mumbai for
his direction and final reading of the manuscript
27
28. 1.Shastri A, editor. Sushruta Samhita of Sushruta,Chikitsasthana, Netrabastipramanvibhag chikitsitam. 5th ed.,
Ch. 35, Ver. 18. Varanasi: Chaukhambha Orientalia; 1979.p. 154.
2. Srikanthamurthy K, editor. Ashtanga Sangraha of Vagbhata,Sutrasthana, Bastividhidhyaya. 2nd ed., Vol. 1, Ch.
28,Ver. 2. Varanasi: Chaukhambha Orientalia; 1998. p. 485.
3. Srikanthamurthy K, editor. Ashtanga Sangraha of Vagbhata,Sutrasthana, Bastividhidhyaya. 2nd ed., Vol. 1, Ch.
28,Ver. 23. Varanasi: Chaukhambha Orientalia; 1998. p. 494.
4. Tripathi B, editor. Ashtanga Hridaya of Vagbhata,Sutrasthana, Bastividhi adhyaya. 1st ed., Ch. 19, Ver. 45.
Delhi: Chaukhambha Sanskrit Pratishthan; 1999. p. 236.
5. Savrikar SS, Lagad CE. Study of Preparation andStandardization of 'Maadhutailika Basti’ with special
reference to Emulsion Stability. Ayu 2010;31:1-6.
6. Nampoothiri MR, Mahadevan L. Principles and Practice of Vasti. 1st ed. Derisanamcope: Y. Mahadeva Iyer’s
Sri Sarada Ayurvedic Hospital; 2007. p. 49.
7. Sharma P, editor. Caraka Samhita of Caraka, Siddhisthana,Bastisutriyasiddhi. 1st ed., Vol. 2, Ch. 3, Ver. 7-9.
Varanasi:Chaukhambha Orientalia; 1983. p. 605-6.
8.Kasture HS. Panchakarma Samhita. Bastivignyaniyam adhyaya, 1st ed. Ch. 7, Ver. 114, Ahmedabad: Gujrat
Ayurvedic Charitable Trust; 2000, p. 98
28
29. 9. Srikanthamurthy K, editor. Sharangadhara Samhita of Sharangadhara, Uttarakhanda, Basti vidhi. 1st ed., Ch.
5,Ver. 28. Varanasi: Chaukhambha Orientalia; 1984. p. 212.
10. Ayurvedic Formulary of India, Metric Equivalents of Classical weights and measures 2nd ed., Appendix V,
Part I. New Delhi:Govt. of India, MoH and FW, Dept of ISM&H; 2003. p. 483.
11. Nampoothiri MR, Mahadevan L. Principles and Practice of Vasti. 1st ed. Derisanamcope: Y. Mahadeva Iyer’s
SriSarada Ayurvedic Hospital; 2007. p. 101.
12. Sharma P, editor. Caraka Samhita of Caraka, Vimanasthana,Rogbhishagjitiya Adhyaya. 1st ed., Ch. 8, Ver.
5/127.Varanasi: Chaukhambha Orientalia; 1981. p. 384.
13. Gupta PK, Sigh RH. A conceptual study on vasti effect. Anc Sci Life 2001;20:54-9.
14. Szmulowicz UM, Hull TL. Colonic physiology. In: Beck DE, editor. The ASCRS Textbook of Colon and Rectal
Surgery.2nd ed.New York: Springer; 2011. p. 23-39. Available from
http://www.springer.com/cda/content/./9781441915818-c1.pdf. [Last accessed 2012 Sep 12].
15. Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost FJ,Brummer RJ. Review article: The role of butyrate
on Colonic function. Aliment Pharmacol Ther 2008;27:104-19.
16. Camborová P, Hubka P, Sulková I, Hulín I. The pacemakeractivity of interstitial cells of Cajal and gastric
Electrical activity. Physiol Res 2003;52:275-84.
17. Sanders KM. Interstitial cells of Cajal at the clinical and scientifi c interface. J Physiol 2006;576:683-7.
18. Williams PL, Warwick R. Gray’s Anatomy, Neurology, The parasympathetic Nervous system. 36th ed.
Edinburgh:Churchill Livingstone; 1980. p. 1123.
19. Raut AA. Integrative endeavor for renaissance in Ayurveda.J Ayurveda Integr Med 2011;2:5-8.
29
30. Article is simple concised and relavent in
the present scenario.
Author had made an effort to put forth
ayurvedic principles in a scientific platform
Mode of action of basthi is explained in
detail
Discussion part is very novel , he took
various references and explained well.
30
31. Statement of the authour regarding segmentation of basthi dravya in enema can
method is not justified.
Position and time of administration of basthi is not mentioned.
Author didn’t mentioned the age of subjects
Generally the retention time of basthi dravya with basthi putaka method will be
more according to some other studies but its less in this study, so we cannot come
into a proper conclusion.
Units of time -author had mentioned 1 in sec (60 secs) and the other in minute (15
min).
Samyak niruha lakshana attained or not is not mentioned.
In materials and methods , The drugs in the kalka are not sepicified, and also the
proportion of kwatha is also not mentioned
As this is a pilot study –title is not justified
31