"Deadman speaks always" to solve a case police required cause and time of death of an unknown body.
By analyzing the insects it would be easy and Breakthrough for a case as concerned.
Ethics in Clinical Research and Historical Perspective of Nazi Trials, Nuremb...ShantanuThakre3
What is Ethics ?
The word ‘ethics’ is derived from the Greek word,
ethos, which means custom or character. Ethics is
the systematic study of values, so as to decide
what is right and what is wrong. Ethics is concerned
with what is good for individuals and society.
What is Clinical Research ?
Clinical Research is a branch of healthcare science that determines the safety and effectiveness of medications, devices, diagnostic products and treatment regimens intended for human use. These may be used for prevention, treatment, diagnosis or for relieving symptoms of a disease.
Importance of Ethics in Clinical Research :-
1. Ethics is important in clinical research because it keeps the researcher from committing errors while seeking knowledge and truth.
2. Ethical guidelines for clinical research were formulated only after discovery of inhumane behavior with participants during research experiments.
3. In clinical research human beings are involved, as opposed to animals, atoms or asteroids, as the object of study.
4. It focuses on improving human health and well-being, typically by identifying better methods to treat, cure or prevent illnesses.
5. The Ethics Committee stands as the bridge between the researcher and the ethical guidelines of the country
For ninth grade, this is the first chapter and purpose to introduce them biological terms and about the Islamic beliefs about life; and also to know about the Muslim scientists
Ethics in Clinical Research and Historical Perspective of Nazi Trials, Nuremb...ShantanuThakre3
What is Ethics ?
The word ‘ethics’ is derived from the Greek word,
ethos, which means custom or character. Ethics is
the systematic study of values, so as to decide
what is right and what is wrong. Ethics is concerned
with what is good for individuals and society.
What is Clinical Research ?
Clinical Research is a branch of healthcare science that determines the safety and effectiveness of medications, devices, diagnostic products and treatment regimens intended for human use. These may be used for prevention, treatment, diagnosis or for relieving symptoms of a disease.
Importance of Ethics in Clinical Research :-
1. Ethics is important in clinical research because it keeps the researcher from committing errors while seeking knowledge and truth.
2. Ethical guidelines for clinical research were formulated only after discovery of inhumane behavior with participants during research experiments.
3. In clinical research human beings are involved, as opposed to animals, atoms or asteroids, as the object of study.
4. It focuses on improving human health and well-being, typically by identifying better methods to treat, cure or prevent illnesses.
5. The Ethics Committee stands as the bridge between the researcher and the ethical guidelines of the country
For ninth grade, this is the first chapter and purpose to introduce them biological terms and about the Islamic beliefs about life; and also to know about the Muslim scientists
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
2. WHAT IS FORENSIC ENTOMOLOGY?
• Forensic entomology is the science of collecting
and analysing insect evidence to aid in forensic
investigations.
• Its main application is in the determination
of the minimum time since death in cases of suspicious
death, either by estimating the age of the oldest necrophagous
insects that developed on the corpse, or by analysing
the insect species composition on the corpse.
• There are three areas of application:
a)Insect damage to structures
b)Infestation of foodstuffs
c)Insects that inhabit human remains
Fig-1-Dipteran insects Calliphoridae, Sarcophagidae and Muscidae on
fresh porcupine corpse are among the first colonisers/
Source-blowflying.weebly.com
1
3. APPLICATION
OF INSECT IN
FORENSIC
ENTOMOLOGY
Estimation of Time Since Death/Post Mortem Interval (PMI)
The primary application of insects answering questions in death investigation is
to estimate when the victim died
Estimation of Location or Point of Death
Another application of entomology is using the ranges of a specific insect
species’ geographic distribution to establish from where a body originated
Identification of Area of Trauma in Extensively Decomposed Body
Insects can be used to identify areas of trauma ondecomposed remains when
major changes have taken place in the soft tissues on the body
Entomotoxicology
The maggots may be used to determine the presence or absence of drugs when
human body tissues are badly decomposed to do toxicology on the tissue
Identification of Suspect/Criminal
Techniques for analyzing molecular DNA structures of insects for species
identification and the human DNA in insects that feed on humans
1
2
3
4
5
2
4. INSECTS AS EVIDENCE
• Forensic entomologists use their knowledge of
insects and their life cycles and behaviors to give
them clues about a crime.
• Most insects used in investigations are in two
major orders:
a)Flies (Diptera) and
b)Beetles (Coleoptera)
• Species succession may also provide clues for
investigators.
• Some species may to feed on a fresh corpse, while
another species may prefer to feed on one that
has been dead for two weeks.
• Investigators will also find other insect species
that prey on the insects feeding on the corpse.
3
5. WHAT IS FORENSIC
PATHOLOGY?
• Forensic pathology is the study of injuries and/or disease in
order to determine the cause of death.
• Forensic pathologists are also often asked to confirm the
identity of the corpse.
What does a Forensic Pathologist do?
• Performs autopsies/post mortem examinations to find out
the cause of death.
• Presents a report about the pathologic process, injury, or
disease that results in or initiates events which lead to a
person's death, and the manner of death, most are one of
the following:
• Accidental
• Natural
• Homicide
• Suicide
• Undetermined
Fig-2
Source-blowflying.weebly.com
4
6. • The autopsy also provides an opportunity for other issues raised by the death to be addressed, such as the
collection of trace evidence or determining the identity of the deceased.
• The forensic pathologist examines and documents wounds and injuries, at autopsy, at the scene of a crime and
occasionally in a clinical setting, such as rape investigation or deaths in custody.
• Forensic pathologists collect and examine tissue specimens under the microscope (histology) to identify the
presence or absence of natural disease and other microscopic findings such as asbestos bodies in the lungs or
gunpowder particles around a gunshot wound.
• They collect and interpret toxicological specimens of body tissues and fluids to determine the chemical cause of
accidental overdoses or deliberate poisonings.
• Forensic pathologists work closely with the medico-legal authority for the area concerned with the investigation
of sudden and unexpected deaths: the coroner (England and Wales), procurator fiscal (Scotland), or coroner or
medical examiner (United States).
PROCESS IN FORENSIC PATHOLOGY
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7. ROLE OF PATHOLOGIST
• Cause of Death – medical diagnosis denoting disease or injury
• Mechanism of Death – altered physiology by which
disease/injury produces death (arrhythmia, exsanguination)
• Manner of Death
1. Homicide
2. Suicide
3. Accidental
4. Natural Causes
5. Unknown
• Time of Death
• Determine type of wound
• Measure the dimensions (length, width, depth)
• Position relative to anatomical landmarks
• Determine initial location if wound involves cutting, slashing,
etc.
• Anatomic: involves evaluation of tissues
removed from living or dead individuals.
Examples are autopsy, surgical, and
cytopathology.
• Clinical: involves the evaluation of the
body fluids by laboratory means. Examples
are hematology, microbiology, blood
banking, toxicology, and immunology.
BRANCHES OF PATHOLOGY
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8. • Forensic entomology: applications and limitations
J. Amendt • C. S. Richards • C. P. Campobasso •R. Zehner • M. J. R. Hall
• A. Eriksson
Forensic Pathology
Forensic Epidemiology, 2016, pp. 151-177
• Dr. Arif Rasheed Malik, Prof. (2017). Forensic Medicine V/S Forensic Pathology. (A Difference That Everyone
Should Know). Annals of King Edward Medical University. 23. 10.21649/akemu.v23i1.1504.
• Weedn, Victor. (2006). Forensic Pathology. JAMA. 296. 704. 10.1001/jama.296.6.707.
REFERENCES
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