The document summarizes an Information Systems for Health (IS4H) initiative in the Americas. It discusses strengthening national health information systems to monitor progress on universal health access and coverage. It presents a 4-part plan of action to: [1] strengthen governance and stewardship of health information; [2] improve data management and use of information technologies; [3] enhance information and knowledge management; and [4] promote innovation. The overall goal is to upgrade health systems through interconnected information systems and use of data and technologies to support public health decision-making.