2. Learning Objective
To train students to analyze genetics data for
research
To learn the details of proteins structure and their
bioactive configuration
To learn about computational analysis of proteins
structure and functions
To learn about computational tools for protein and
nucleic acid analysis
6. Bioinformatics
The combination of
Biology and Informatics
Originally refers to the use of computational
tools to organize and analyze genetic and
protein sequence data
First coined by Dr. Hwa Lim in 1988
7. Bioinformatics
It is an interdisciplinary approach requiring
advanced knowledge of computer
mathematics and statistical methods for
understanding of biological phenomena at
the molecular level
8. Bioinformatics
The NCBI defines bioinformatics as:
"Bioinformatics is the field of science in which
biology, computer science, and information
technology merge into a single discipline”
9. What is Bioinformatics
Easy Answer
Using computers to solve molecular biology
problems; Intersection of molecular biology and
computer science
Hard Answer
Computational techniques (e.g. algorithms, artificial
intelligence, databases) for management and
analysis of biological data and knowledge
10. What is Bioinformatics
Bioinformatics = Biology + Information
Computation methods are necessary to analyze the
massive amount of information that coming out of
the genome projects
12. Bioinformatics
It is an interdisciplinary field that develops methods
and software tools for understanding biological data
As an interdisciplinary field of science, bioinformatics
combines computer science, statistics, mathematics,
and engineering to analyze and interpret biological
data
13. Components of Bioinformatics
Creation of databases
Development of algorithms and statistics
Analysis of data interpretation
14. National Centre for Biotechnology Information
(NCBI)
The NCBI houses a series of
databases relevant to biotechnology and
biomedicine and is an important resource for
bioinformatics tools and services
15. National Centre for Biotechnology Information
(http://www.ncbi.nlm.nih.gov/)
Developed by National Library of Medicine (NLM) at the
National Institutes of Health (NIH)
A comprehensive website for biologists including
Biology-related databases
tools for viewing and analyzing
automated systems for storing and retrieval
28. GenBank vs RefSeq
A GenBank genome assembly contains assembled genome
sequences submitted by investigators
A RefSeq genome assembly represents an NCBI-derived copy of a
submitted GenBank assembly
RefSeq records are maintained by NCBI
NCBI staff may remove short sequences or reported
contaminants from the assembly
29. GenBank vs RefSeq
All RefSeq genome assemblies include annotation
The GenBank assembly is an archival record that is owned by the
submitter. In rare cases where NCBI makes updates to the
GenBank assembly, for example, to remove contaminated
sequences, the original submitter will be notified
