Intravaginal and intrauterine drug delivery system

1. INTRAVAGINAL AND INTRAUTERINE
DRUG DELIVERY SYSTEM
Prepared by ,
Mr. Snehal Patel
Assistant Professor,
Sumandeep Vidyapeeth,
Vadodara, Gujarat, India.

2. INTRAVAGINAL AND INTRAUTERINE DRUG
DELIVERY SYSTEM
• Controlled release of intravaginal systems are used for delivery of
contraceptive steroid hormones.
• The advantage of this route includes
1. No first pass effect.
2. Improved bioavailability
3. Lesser drug dose in compression to that required by the oral dose.
• Two types of medicated intrauterine devices (IUDs) have been developed
to produce effective contraception for 12 months or more.
1. Copper medicated IUD
2. Progesterone releasing IUD

4. COPPER MEDICATED IUD
• It consists of polypropylene or polyethylene plastic support of
number 7 or letter T with certain amount of copper wire wound
around them.
• T shape IUD is popular since its shape conforms to the uterine cavity
and resist displacement and rotation within the cavity as well as
expulsion from the cavity. The copper wire of surface area 200 mm2
shows maximum contraceptive activity.
• Oxidation of copper in the body fluids releases its ion slowly and
exerts its effect locally. The device is effective for more than 3 years.

5. PROGESTERON RELEASING IUD
• It is also a T shaped polyethylene device with a progesterone
reservoir.
• The device releases progesterone at a rate of 65 mcg/day for a period
of one year.

6. THANK YOU