An interactive science notebook (ISN) is a tool for students to organize their thoughts, reflections, and creative interactions with science concepts. It allows students to access and process information using writing, drawing, and discussion. The ISN has two sides - the left for creative student work and the right for information provided by the teacher. The left side encourages creativity through options like concept maps, drawings, poems, and teaching parents. Setting up the ISN properly orients students and provides guidelines for its structured use.