The Office for Life Sciences (OLS) in partnership with Innovate UK is working to support developers of innovative medical devices, diagnostics and regulated digital health products to evaluate their products in a real-world clinical setting. Funding is being made available through a series of competitions that will run over the next 2 years. The first round of the competition was run in early 2018.
The second round of the competition ‘Support for SMEs to evaluate innovative medical technologies competition’ opened on 2 July. Up to £1.5m funding is available to support small and medium-sized enterprises (SMEs) generate an evidence base that will enable the evaluation of products that address priorities areas for NHS England. This support is intended to allow companies to collect and analyse clinical performance and cost effectiveness data within an NHS setting.
Watch the webcast via KTN's YouTube channel: https://www.youtube.com/c/KnowledgeTransferNetwork
Presentation by Andy Cairns, Programme Manager, Innovation Agency: Welcome and introduction at the Funding - Liverpool City Region SME workshop on Thursday 7 February 2019 at The Accelerator, Liverpool
Horizon 2020: Funding opportunities for academic & business research partners...Iraklis Agiovlasitis
A guide for funding opportunities through Horizon 2020, targeted at academic & business research partnerships in the medical imaging sector.
Presented on the PSMR 2014 Conferece / 3rd Conference on PET/MR and SPECT/MR, 19th -21st May 2014, at Kos, Greece.
How can patients and providers best contribute to the HTA process?EUnetHTA
How can patients and providers best contribute to the HTA process? Anna Nachtnebel, LBI-HTA, Simone Warren, ZIN
Presentation from the 3rd face to face training course for EUnetHTA Stakeholders organised by EUnetHTA JA2 WP2; April 23rd, 2015, Brussels.
Scaling up innovation in healthcare - A Methodology Framework 2015Marc Lange
This presentation introduce a methodology scaling-up developed by "doers and shapers" internationally known for their expertise in eHealth and digital health
Presentation by Andy Cairns, Programme Manager, Innovation Agency: Welcome and introduction at the Funding - Liverpool City Region SME workshop on Thursday 7 February 2019 at The Accelerator, Liverpool
Horizon 2020: Funding opportunities for academic & business research partners...Iraklis Agiovlasitis
A guide for funding opportunities through Horizon 2020, targeted at academic & business research partnerships in the medical imaging sector.
Presented on the PSMR 2014 Conferece / 3rd Conference on PET/MR and SPECT/MR, 19th -21st May 2014, at Kos, Greece.
How can patients and providers best contribute to the HTA process?EUnetHTA
How can patients and providers best contribute to the HTA process? Anna Nachtnebel, LBI-HTA, Simone Warren, ZIN
Presentation from the 3rd face to face training course for EUnetHTA Stakeholders organised by EUnetHTA JA2 WP2; April 23rd, 2015, Brussels.
Scaling up innovation in healthcare - A Methodology Framework 2015Marc Lange
This presentation introduce a methodology scaling-up developed by "doers and shapers" internationally known for their expertise in eHealth and digital health
Introduction to the SBRI Competition: Vaccines for Epidemic DiseasesKTN
On Tuesday 12th October 2021, KTN held the event, Introduction to the SBRI Competition: Vaccines for Epidemic Diseases, in partnership with Innovate UK. This event served as a call for applications for the opening of the new SBRI Competition - Vaccines for Epidemic Diseases: Readiness for clinical development and regulatory submission.
https://apply-for-innovation-funding.service.gov.uk/competition/1046/overview
How to use the EUnetHTA submission template to support production of core Hea...EUnetHTA
How to use the EUnetHTA submission template to support production of core Health Technology Assessments? Zoe Garrett, NICE
Presentation from the 3rd face to face training course for EUnetHTA Stakeholders organised by EUnetHTA JA2 WP2; April 23rd, 2015, Brussels.
How to use HTA for decision-making based on HTA Core InformationEUnetHTA
How to use HTA for decision-making based on HTA Core Information, Anna Nachtnebel, LBI-HTA, Simone Warren, ZIN
Presentation from the 3rd face to face training course for EUnetHTA Stakeholders organised by EUnetHTA JA2 WP2; April 23rd, 2015, Brussels.
How do uk med tech startups cope with the capital pressureRina Nir
This was presented at the UK MedTec 2014 event by Dr. Dror Nir, managing partner in RadBee.
Dror analyses the financial eco-system of the UK MedTech segment based on data that was published in reports by the department of Business Innovations and Skills (BIS) in 2013, E&Y and KPMG. The bottom-line outcome of his analysis is that the majority of UK MedTech companies, particularly the startups, are straggling to survive with very little opportunities to carry on innovations.
New approach for sustaining long-term innovation is suggested.
Μάκης Παπαταξιάρχης - 6th Clinical Research ConferenceStarttech Ventures
Ομιλία: Μάκης Παπαταξιάρχης, Διευθύνων Σύμβουλος Janssen Ελλάδος, Pharmaceutical Companies of Johnson & Johnson, Πρόεδρος του PhRMA Innovation Forum, Πρόεδρος του AmCham Pharmaceutical Committee
Market report on the opportunities in the Norwegian healthcare market, prepared for the Team Finland Digital Hospitals growth program by Fintra in partnership with Oslo Medtech.
Agri-Tech Catalyst Round 10 - Food Systems and NutritionKTN
Open to UK and African organisations who want to collaborate on an Agri-Tech project around food chain innovation in Africa.
Are you working on Agri-Tech innovation and would like to implement some of your ideas in Africa?
If so, you could get funding thanks to the Agri-Tech Catalyst Competition, Round 10, opening on 20 July.
The funding available through the competition is for Agri-Tech projects on food chain innovations in Africa. These projects need to be delivered by a UK and an African organisation working together.
Find out more here: https://ktn-uk.co.uk/news/agri-tech-catalyst-competition-round-10
Open to UK and African organisations who want to collaborate on an Agri-Tech project around food chain innovation in Africa.
Are you working on Agri-Tech innovation and would like to implement some of your ideas in Africa?
If so, you could get funding thanks to the Agri-Tech Catalyst Competition, Round 10, opening on 20 July.
The funding available through the competition is for Agri-Tech projects on food chain innovations in Africa. These projects need to be delivered by a UK and an African organisation working together.
Find out more here: https://ktn-uk.co.uk/news/agri-tech-catalyst-competition-round-10
Introduction to the SBRI Competition: Vaccines for Epidemic DiseasesKTN
On Tuesday 12th October 2021, KTN held the event, Introduction to the SBRI Competition: Vaccines for Epidemic Diseases, in partnership with Innovate UK. This event served as a call for applications for the opening of the new SBRI Competition - Vaccines for Epidemic Diseases: Readiness for clinical development and regulatory submission.
https://apply-for-innovation-funding.service.gov.uk/competition/1046/overview
How to use the EUnetHTA submission template to support production of core Hea...EUnetHTA
How to use the EUnetHTA submission template to support production of core Health Technology Assessments? Zoe Garrett, NICE
Presentation from the 3rd face to face training course for EUnetHTA Stakeholders organised by EUnetHTA JA2 WP2; April 23rd, 2015, Brussels.
How to use HTA for decision-making based on HTA Core InformationEUnetHTA
How to use HTA for decision-making based on HTA Core Information, Anna Nachtnebel, LBI-HTA, Simone Warren, ZIN
Presentation from the 3rd face to face training course for EUnetHTA Stakeholders organised by EUnetHTA JA2 WP2; April 23rd, 2015, Brussels.
How do uk med tech startups cope with the capital pressureRina Nir
This was presented at the UK MedTec 2014 event by Dr. Dror Nir, managing partner in RadBee.
Dror analyses the financial eco-system of the UK MedTech segment based on data that was published in reports by the department of Business Innovations and Skills (BIS) in 2013, E&Y and KPMG. The bottom-line outcome of his analysis is that the majority of UK MedTech companies, particularly the startups, are straggling to survive with very little opportunities to carry on innovations.
New approach for sustaining long-term innovation is suggested.
Μάκης Παπαταξιάρχης - 6th Clinical Research ConferenceStarttech Ventures
Ομιλία: Μάκης Παπαταξιάρχης, Διευθύνων Σύμβουλος Janssen Ελλάδος, Pharmaceutical Companies of Johnson & Johnson, Πρόεδρος του PhRMA Innovation Forum, Πρόεδρος του AmCham Pharmaceutical Committee
Market report on the opportunities in the Norwegian healthcare market, prepared for the Team Finland Digital Hospitals growth program by Fintra in partnership with Oslo Medtech.
Agri-Tech Catalyst Round 10 - Food Systems and NutritionKTN
Open to UK and African organisations who want to collaborate on an Agri-Tech project around food chain innovation in Africa.
Are you working on Agri-Tech innovation and would like to implement some of your ideas in Africa?
If so, you could get funding thanks to the Agri-Tech Catalyst Competition, Round 10, opening on 20 July.
The funding available through the competition is for Agri-Tech projects on food chain innovations in Africa. These projects need to be delivered by a UK and an African organisation working together.
Find out more here: https://ktn-uk.co.uk/news/agri-tech-catalyst-competition-round-10
Open to UK and African organisations who want to collaborate on an Agri-Tech project around food chain innovation in Africa.
Are you working on Agri-Tech innovation and would like to implement some of your ideas in Africa?
If so, you could get funding thanks to the Agri-Tech Catalyst Competition, Round 10, opening on 20 July.
The funding available through the competition is for Agri-Tech projects on food chain innovations in Africa. These projects need to be delivered by a UK and an African organisation working together.
Find out more here: https://ktn-uk.co.uk/news/agri-tech-catalyst-competition-round-10
Open to UK and African organisations who want to collaborate on an Agri-Tech project around food chain innovation in Africa.
Are you working on Agri-Tech innovation and would like to implement some of your ideas in Africa?
If so, you could get funding thanks to the Agri-Tech Catalyst Competition, Round 10, opening on 20 July.
The funding available through the competition is for Agri-Tech projects on food chain innovations in Africa. These projects need to be delivered by a UK and an African organisation working together.
Find out more here: https://ktn-uk.co.uk/news/agri-tech-catalyst-competition-round-10
New Funding & Development Opportunities for InnovatorsIsabelle Sparrow
On November 8th GM AHSN invited innovators from the region to an event at the Nowgen Centre in Manchester. The event provided information about some of the current funding and support opportunities available to healthcare innovators, including programmes from GM AHSN's Innovation Nexus, SBRI Healthcare and the Business Growth Hub.
Industrial Strategy:Prospering from the energy revolution - Rob Saunders, In...KTN
Key technology components for local energy systems
briefing event
The webcast recording is now available. Click here to watch it: https://www.youtube.com/watch?v=gPyTb_-qhgo
Find out more about Energy interest group at https://ktn-uk.co.uk/interests/energy
Join the Energy LinkedIn group at https://www.linkedin.com/groups/3380615/
WEBINAR: ISCF transforming foundation industries: fast start projects - Compe...KTN
Innovate UK will fund up to £5m in R&D and Innovation projects for the foundation industries (cement, ceramics, chemicals, paper, glass and metals). These will be cross-sector, collaborative, fast start, short duration, industrial research and development (R&D) projects. More details about the funding scope can be found here.
This funding competition is part of the Industrial Strategy Challenge Fund (ISCF) for Transforming Foundation Industries and aims to bring businesses from different foundation industries together to work on common resource and energy efficiency opportunities.
Find out more: https://ktn-uk.co.uk/news/iscf-transforming-foundation-industries-fast-start-projects-briefing-events
Transforming Food Production Briefing Event for UK-China Bilateral - Precisio...KTN
A component of the ISCF Transforming Food Production (TFP) is the International activities based on bilateral agreements to ensure new technologies take advantage of overseas markets. UK businesses can apply for a share of up to £5 million to work with Chinese partners to develop new integrated precision farming technology and help achieve net-zero emissions. This funding is from the Industrial Strategy Challenge Fund.
The aim of this competition is to encourage the use of data-intensive methods for commercial farming.
Find out more: https://ktn-uk.co.uk/news/live-now-webcast-transforming-food-production-briefing-event-for-uk-china-bilateral
Agri-Tech Catalyst Round 9 – Livestock and AquacultureKTN
The main focus of the webinar is to help inform UK participants of the needs of African partners in the area covered, and African partners of the capabilities of UK partners, to aid consortia building.
The webinar provides an overview of the Agri-Tech Catalyst funding programme, and then cover specific issues affecting Livestock and Aquaculture in Africa.
Agri-Tech Catalyst Funding Scheme:
Within Round 9 of the Agri-Tech Catalyst Competition, up to £5 million of funding will be available from the Department for International Development (DFID) and the Global Challenges Research Fund (GCRF) for early-stage feasibility studies, mid stage industrial research and late-stage experimental development. Projects must work on agri-tech and food chain innovations with partners in eligible African countries.
Up to £5 million of funding is available from the Department for International Development (DFID) and the Global Challenges Research Fund (GCRF). This is for projects working on agri-tech and food chain innovations with partners in eligible African countries. The aim of this competition is to increase the pace of innovation in the development of agricultural and food systems in Africa. Your project must result in more use of innovations by farmers and food systems organisations such as manufacturers, processors, retailers, distributors and wholesalers.
Find out more about this webinar: https://ktn-uk.co.uk/news/agri-tech-catalyst-funding-to-support-agricultural-and-food-systems-innovation-in-africa-round-9
Transforming Foundation Industries - Investor Partnership Launch EventKTN
At this launch event, held by KTN on 23rd March 2021, attendees found out about the TFI Investor Partner Programme, met the investors and discovered what investors are looking for.
Presentation from the briefing event for ISCF Digital Security by Design competition: Technology Enabled Business-Led Demonstator Stage 1 Expression of Interest
Agri-Tech Catalyst Round 9 – Food Systems and NutritionKTN
The main focus of the webinar is to help inform UK participants of the needs of African partners in the area covered, and African partners of the capabilities of UK partners, to aid consortia building.
The webinar provides an overview of the Agri-Tech Catalyst funding programme, and then cover specific issues affecting Food Systems and Nutrition in Africa.
Agri-Tech Catalyst Funding Scheme:
Within Round 9 of the Agri-Tech Catalyst Competition, up to £5 million of funding will be available from the Department for International Development (DFID) and the Global Challenges Research Fund (GCRF) for early-stage feasibility studies, mid stage industrial research and late-stage experimental development. Projects must work on agri-tech and food chain innovations with partners in eligible African countries.
Up to £5 million of funding is available from the Department for International Development (DFID) and the Global Challenges Research Fund (GCRF). This is for projects working on agri-tech and food chain innovations with partners in eligible African countries. The aim of this competition is to increase the pace of innovation in the development of agricultural and food systems in Africa. Your project must result in more use of innovations by farmers and food systems organisations such as manufacturers, processors, retailers, distributors and wholesalers.
Find out more about this webinar: https://ktn-uk.co.uk/news/agri-tech-catalyst-funding-to-support-agricultural-and-food-systems-innovation-in-africa-round-9
Presentation by Mike Kenny, Associate Commercial Director, Innovation Agency at the Health Sector Business Breakfast, 16 March at Northwich Memorial Court
Competition Briefing - Open Digital Solutions for Net Zero Energy KTN
This briefing provided more information on the scope and application process for Innovate UK's Small Business Research Initiative (SBRI) competition to develop open software, hardware and data solutions that address the challenges of transforming to a net zero energy system in the UK.
An Introduction to Eurostars - an Opportunity for SMEs to Collaborate Interna...KTN
This webinar highlighted opportunities within the EUREKA Eurostars programme and how Innovate UK KTN and partners can help your business to innovate and go international.
Prospering from the Energy Revolution: Six in Sixty - Technology and Infrastr...KTN
Hear about one of the key facets of PFER, a £104m programme focussed on the integration of power, heat and transport and the business models needed to enable Smart Local Energy Systems (SLES) to scale towards net zero.
UK Catalysis: Innovation opportunities for an enabling technologyKTN
Read about how accelerating innovations in catalysis will play a vital role in enabling the UK to meet its net zero targets in the areas of hydrogen production, Power-to-X, carbon dioxide utilisation and the use of alternative feedstocks.
Industrial Energy Transformational Fund Phase 2 Spring 2022 - Competition Bri...KTN
The Phase 2 competition for England, Wales and Northern Ireland opens on the 31st January 2022 and runs until 29th April 2022 and is worth up to £60 million in funding.
Horizon Europe ‘Culture, Creativity and Inclusive Society’ Consortia Building...KTN
This webinar highlights relevant call topics within Cluster 2 which focuses on challenges pertaining to democratic governance, cultural heritage and the creative economy, as well as social and economic transformations.
Horizon Europe ‘Culture, Creativity and Inclusive Society’ Consortia Building...KTN
This webinar highlights relevant call topics within Cluster 2 which focuses on challenges pertaining to democratic governance, cultural heritage and the creative economy, as well as social and economic transformations.
Building Talent for the Future 2 – Expression of Interest BriefingKTN
This competition briefing is supporting the creation, delivery, and growth of PEMD industry-focused course content, materials, and support for skills plus training.
Performance Projects specialises in niche vehicle and motorsport innovation, designing, building and supplying complex subsystems through to whole vehicles.
How to Create a Good Horizon Europe Proposal WebinarKTN
This webinar provides you with the essential hands-on knowledge and skills to transform your innovative project ideas into competitive project proposals in response to calls under Horizon Europe.
Horizon Europe Tackling Diseases and Antimicrobial Resistance (AMR) Webinar a...KTN
Innovate UK KTN Global Alliance in partnership with the Foreign, Commonwealth and Development Office (FCDO) the UK Science and Innovation Network in Ireland and the Nordics, and UK National Contact Points (NCPs) from Innovate UK (UKRI) hosted a workshop to help delegates form international collaborations and strategic partnerships.
Custom Interconnect Ltd (CIL) is a global provider of engineering solutions for mission critical applications. Based in Andover it has the most advanced electronic assembly facility in the UK, ranging from 6 SMT lines, 3D AOI, flying probe test, X-Ray/CT-Scan, laser depanelling, vacuum assisted vapour phase, 7 auto wire-bonders and 3 auto die bonders, and a scanning acoustic microscope.
ZF is a global technology company that supplies systems for passenger cars, commercial vehicles and industrial technology, enabling the next generation of mobility. ZF allows vehicles to see, think and act. In the four technology domains Vehicle Motion Control, Integrated Safety, Automated Driving, and Electric Mobility, ZF offers comprehensive solutions for established vehicle manufacturers and newly emerging transport and mobility service providers.
FluxSys was formed in 2013, from their base in Wellesbourne, Warwickshire they support their UK and international clients with the specification, design and prototyping of a wide range of electric machines and drives.
FluxSys uses its skills, experience and independence within customers’ projects to support their electrification journeys and skills development, utilising knowledge sharing in an open & collaborative manner with like-minded clients and technical experts.
Made Smarter Innovation: Sustainable Smart Factory Competition BriefingKTN
This competition briefing outlines how this funding opportunity aims to support industrial research that addresses digital innovations to improve the sustainability of manufacturing processes.
Driving the Electric Revolution – PEMD Skills HubKTN
Watch this briefing webinar to find out more about this new competition which supports the development of the Skills Hub, a training platform to support the PEMD sector.
Medicines Manufacturing Challenge EDI Survey Briefing WebinarKTN
In anticipation of the Medicines Manufacturing Challenge sending out an EDI survey to those involved in any projects funded under the programme, this webinar provides more context behind the request, an overview of the Innovate UK Equality, Diversity and Inclusion (EDI) programmes, and an opportunity for attendees to ask questions and get involved.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
2. Agenda
• 10:30 Welcome, Housekeeping and Introduction – KTN
• 10:40 Background to call – Office for Life Sciences/Innovate UK
• 10:50 Competition Scope - Innovate UK Innovation Lead
• 11:20 Competition process – Innovate UK Competitions Team
• 11:50 Feedback from Round 1 and lessons learned – Innovate UK
• 12:15 Q&A
• 12:30-13:30 Lunch and Networking
•Morning
5. The Future. Faster
As a network partner of Innovate UK,
KTN combines expertise in all sectors
with the ability to cross boundaries
Connecting with KTN can lead
to potential collaborations,
horizon-expanding events and
innovation insights relevant to
your needs
7. How it works
— Attend events
— Receive expert advice
& insights
— Get help with
crossing sectors
— Introductions to
new collaborations
8. Business support offered by KTN
— Access to funding and finance
— Horizon 2020 guidance
— Embedding design and
sustainability in innovation
9. Activities and projects
From roadmaps to steering groups
from influencing government policy
to special interest groups,
our activities and projects
evolve constantly
to reflect industry needs
11. SME support to evaluate
innovative medical
technologies: round 2
03/07/2018
12. Overview
- Introduction to the Accelerated Access Review
- The competition
- Priority areas
- Eligible products
- Options for support
- State aid rules – an introduction to Article 28
- Key dates
- Round one and key messages
13. The Accelerated Access Review
- Independent report to Government
- Outlined a process for identifying and pulling
transformative innovations into the NHS
quickly
- Noted the need for the generation of patient
data that define the benefits of innovation
- Encouraged the NHS to work more
collaboratively with innovators to provide
the type of data health care systems need to
make decisions
https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/565072/AAR_final.pdf
14. Accelerated Access Review
- Published November 2017
- Sets out a raft of methods to implement the
recommendations in the AAR that will
maximise the appropriate use of innovative
products
- Includes new the creation of an Accelerated
Access Collaborative to align national bodies
around accelerating innovation
- £6m scheme to support SMEs in obtaining an
effective evidence base for their medtech
products
https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/664685/AAR_Response.pdf
15. Industrial Strategy: Life Sciences Sector Deal
Implementation of the AAR by:
- streamlining pathways and supporting small and
medium-sized businesses
- creation of the Accelerated Access Collaborative
- a streamlined pathway for breakthrough
products to market and then to patients
- £86m of government funding focused on
supporting innovators and the NHS locally
- a digital health catalyst
- improved commercial capacity and capability for
NHS England
https://www.gov.uk/government/publications/life-sciences-sector-deal
16. SME support to evaluate innovative medical technologies
- Second round of the competition in 2018
- Provides support for small and medium-sized enterprises (SMEs)
- It allows companies to collect and analyse clinical performance and cost
effectiveness data in an NHS setting
- Support for SMEs to develop an evidence base for their products to
facilitate the adoption of the innovations to delivery savings or improve
patient care
- Up to £1.5m funding is available - funded by the Office for Life Sciences
- Additional rounds of the competition are planned
17. All applications must be business-led
Support options:
1: Study planning and preparation
- Total project costs up to £50,000
2: Collection of clinical performance and cost-effectiveness data study
- Total project costs up to £250k
Projects must start by 1 January 2019 and be completed by the end of
December 2019.
Project size
18. Eligible products:
- includes medical devices, diagnostics and regulated digital
healthcare products
- must be CE marked
- cannot have been marketed in the UK for more than 5 years
- have a potentially significant impact, including increasing patient
access to innovative technologies where appropriate
Competition Scope
19. Priority areas
Priority will be given to products that address the priorities outlined in the
Next steps on the NHS 5 year forward view
- reduce cancellations or unnecessary appointments in primary and
secondary care
- reduce the burden on A&E services, for example by diverting footfall
- improve patient safety and avoid patient harm
- speed up diagnosis, such as improving the scope of lower cost diagnostic
imaging
- enable earlier diagnosis of cancer
- support the management of long term conditions
https://www.england.nhs.uk/wp-content/uploads/2017/03/NEXT-STEPS-ON-THE-NHS-FIVE-YEAR-FORWARD-VIEW.pdf
20. Proposals should include
- how your product is likely to have a significant impact
- evidence of the product’s clinical performance and cost effectiveness
- evidence that you are working with appropriate stakeholders including
NICE, NHS England, NIHR and AHSNs
- details of the development or implementation of plans for data
collection within the NHS
- outline how studies will generate data on the costs and benefits of a
product, allowing evaluation by NICE
21. Projects must
- focus on understanding evidence gaps and testing product performance
to explain the operational impact of your product on the NHS
- produce evidence of the impact of your technology
- expand the evidence base by adding data that can contribute to the
health technology appraisal process, for instance by comparing the use
of the new product with the current standard of care
- support identification of potential breakthrough technologies
- support the establishment of improved methods and systems, and
demonstrate how the product combined with health care system
adaptation delivers better outcomes at lower cost
22. Compliance with State Aid Rules
- This competition is being run under Article 28: Innovation Aid for SMEs
as described in the State Aid Manual (see page 41).
- It is important that you review the rules under innovation aid for SMEs
before you apply.
- Support up to 50% of eligible costs is available in this competition
- Grant support DOES NOT vary between eligible costs
- Ineligible costs include:
- Costs of instruments, equipment and materials
https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/607691/bis-15-148-state-aid-manual-update.pdf
23. Article 28
Two categories are particularly relevant
in this competition:
- Secondment of highly qualified
personnel
- Costs of innovation advisory and
support services
If in doubt check with the State Aid
Manual and/or ask for advice
THIS
NOT THIS
24. - Opens 2 July 2018
- Closes noon 22 August 2018
- Applicants informed 2 November 2018
Full project brief and scope
- https://apply-for-innovation-funding.service.gov.uk/competition/190/overview
Further support is available:
- via our competition helpline on 0300 321 4357
- or email support@innovateuk.gov.uk
Additional competitions will follow
Competition dates and support
30. Option 1 - Study planning and
preparation
Option 2 - Collection of clinical
performance and cost-effectiveness data
study
Project
Eligibility
Lead must be a UK based SME
have a medical or diagnostic device, or a regulated digital health product with a CE
marking, that has been marketed for less than 5 years
carry out your project within the NHS
have a product that is aligned with the specific priority healthcare areas defined in
the Next steps on the NHS 5 year forward view
Project cost Up to £50k Up to £250k
Project length Projects must start by 1st January 2019 and finish by the 31st December 2019
Eligibility criteria
31. Making more than one application and
resubmissions
• SMEs can only submit one application to this round of the competition.
• If an application is unsuccessful, you can use the feedback received to reapply for the same project
into either another round of this competition or another competition. A project proposal can only be
submitted twice
32. Other Innovate UK projects
• If you have an outstanding final claim and Independent Accountant Report (IAR) on any
live Innovate UK project, you will not be eligible to apply for grant funding in this
competition, as a lead or a partner organisation.
• If you applied to a previous competition as the lead or sole company and were awarded
funding by Innovate UK, but did not make a substantial effort to exploit that award, we will
award no more funding to you.
33. Timeline Dates
Competition Opens 2nd July 2018
Briefing Event 3rd July 2018
Submission Deadline NOON 22nd August 2018
Applicants informed 2nd November 2018
Key Dates
34. How to apply using the Innovation Funding Service (IFS)
39. Spell check using your web browser
online guidance
assign the
question to a
collaborator
Formatting for
your content
Word count
Answering a question
42. Project Details (Section 1)
• Application Details
- Title, Timescales, Research Category, Innovation Area & Resubmission (y/n)
• Project Summary
- Short summary and objectives of the project including what is innovative about it
• Public Description
- Description of your project which will be published if you are successful
• Scope
- How does your project align with the scope of this competition?
- If your project is not in scope, it will be ineligible for funding and not sent for assessment
44. Application form
Question 1 Need or challenge
Question 2 Approach and innovation
Question 3 Team and resources
Question 4 Market awareness
Question 5 Outcomes and route to market
Question 6 Wider impacts
Question 7 Project management
Question 8 Risks
Question 9 Additionality
Question 10 Costs and value for money
Appendix Q3
Appendix Q7
Appendix Q8
Appendix Q2
Application Questions (Section 2)
Detailed Guidance
Available on IFS
45. 45
What is the business need, technological challenge or market opportunity
driving your innovation?
Question 1: Need or challenge
• Show evidence of the potential for your product to have a significant impact on patients, or the efficiency of care delivery by the NHS
• When the product was first marketed in the UK
If you are applying for option 1 funding:
Explain/ justify why the study planning and preparation funding is necessary for you to keep developing your product
give details of any gap analysis you have carried out into the clinical performance and cost-effectiveness of your product
provide any specific advice you have received on evidence gaps, justifying any further work needed to define these gaps
summarise the evidence requirement you are trying to fill
If you are applying for option 2 funding:
show that you have performed an initial product evidence gap analysis using the NICE META tool, a comparable approach
or other product specific advice
explain how your proposed study will fill the identified gaps
tell us what evidence your study will gather and analyse
46. 46
What approach will you take?
Question 2: Approach and innovation
What approach will you take?
If you are applying for option 1 funding:
• tell us how you will use the funding to develop and execute plans for data collection
• describe how you plan to contact and work with relevant stakeholders, including NICE, NHS
England, NIHR and AHSNs
If you are applying for option 2 funding:
• describe what work needs to be carried out during the study, and why
• describe how the study data will be collected and analysed
- describe how you plan to contact and work with NICE, NHS England, NIHR, AHSNs and other
stakeholders about the development of these plans
You may upload an appendix PDF document (max 1MB, 2 A4 pages) of
graphics/diagrams to demonstrate the innovation in your technology/product/service
47. 47
Who is in the project team and what are their roles?
Question 3: Team and resources
• Describe the roles, skills and relevant experience of all members of the project
team
• State the resources, equipment and facilities required for the project and how
you will access them
• Provide details of any key external parties, including sub-contractors
• (if collaborative) describe the current relationships between the project partners
and how these will change as a result of the project
• Are there any gaps in the team that will need to be filled?
You may upload an appendix PDF document (max 1MB, 4 A4 pages) to describe
the skills and experience of the main people who will be working on the project
48. 48
What does the market you are targeting look like?
Question 4: Market awareness
What is the market(s) (domestic and/or international) that you will be targeting in the
project and any other potential markets?
You should consider:
• the size of the addressable market(s) for the project outcome(s)
• the structure and dynamics of the market, and predicted growth rates within clear
timeframes
• the main supply/value chains and business models in operation
• the current UK position in addressing this market
For highly innovative projects, where the market may be unexplored, explain:
• what the route to market could or might be
• what its size might be
• how the project will seek to explore the market potential
For other markets, briefly describe the size and key features of those
49. 49
How do you propose to grow your business and increase your productivity
into the long term as a result of the project?
Question 5: Outcomes and route to market
Describe or explain:
• how you will use the project’s clinical data
• how you plan to develop the product further after your project is complete
• whether the data generated will contribute to a NICE medtech or diagnostics
guidance document, refinement of the product, or knowledge about the
impacts to the care pathway
• your current position in the markets and supply or value chains outlined, and
whether you will be extending or establishing your market position
• your target customers and/or end users, and the value to them, for example,
why would they use or buy it?
50. 50
What impact might this project have outside the project team?
Question 6: Wider impacts
• Summarise the anticipated benefit of your product for one of the clinical or
operational areas listed in the competition scope.
• What are the economic benefits from the project, to those outside the project?
• Highlight the expected social and/or environmental impacts, either positive or
negative
• Explain any expected regional impacts of the project
51. 51
How will you manage the project effectively?
Question 7: Project management
• Outline the main work packages of the project, indicating for each:
• The relevant research category
• The lead partner assigned
• The total cost of each package
• Describe your approach to project management and the management reporting
lines
• Outline your project plan in sufficient detail to identify any links or dependencies
between work packages or milestones
You may upload a project plan/Gantt chart in PDF format (max 1MB, 2 A4 pages) as
an appendix
52. 52
What are the main risks for this project?
Question 8: Risks
• Identify the key risks and uncertainties of the project, including the technical,
commercial, managerial and environmental risks
• Explain how these risks will be mitigated
• List any project inputs on the critical path to completion (such as resources,
expertise, data sets)
• Are the outputs likely to be subject to regulatory requirements, certification,
ethical issues, etc.? If so how will you manage these?
You may upload a risk register in PDF format (max 1MB, 2 A4 pages) as an
appendix
53. 53
Describe the impact that an injection of public funding would have on
this project.
Question 9: Additionality
• Tell us if this project could go ahead without public funding. If so, what
difference would the public funding make (such as faster to market, more
partners, reduced risk)?
• Describe the likely impact of the project on the businesses of the partners
involved
• Why are you unable to wholly fund the project from your own resources or
other forms of private-sector funding?
• Explain how this project would change the nature of the partners’ R&D activity
(and related spend)
54. 54
How much will the project cost and how does it represent value for money
for the team and the taxpayer?
Question 10: Costs and value for money
• Justify the total project cost and the grant being requested, in line with the project
goals
• How will the partners finance their contributions to the project?
• Explain how this project represents value for money for you and the taxpayer.
• How will you finance your 50% contribution to the project?
• How you will cover any costs, such as material costs, that are not covered under
article 28 as listed on page 42 of the state aid manual?
• Describe any sub-contractor costs and why they are critical to the project
58. Eligible Costs
• Costs of obtaining, validating and defending patents and other intangible assets;
• Secondment of highly qualified personnel* from a research organisation or large
enterprise, working on research, development and innovation activities in a newly created
function within the beneficiary, not replacing existing personnel;
• Costs of innovation advisory and support services including consultancy, and training in the
areas of knowledge transfer, acquisition, protection and exploitation of intangible assets,
use of standards and regulations embedding them and the quality labelling, testing and
certification for the purpose of developing more effective products, processes or services.
*degree educated staff with ata least 5 years relevant professional experience, which may
include doctoral training
60. Overheads
Innovate UK’s definition:
Additional costs and operational expenses incurred
directly as a result of the project. These could
include additional costs for administrative staff,
general IT, rent and utilities
Indirect (administration) overheads
• please ensure they are additional and
directly attributable to the delivery of
the project
Direct overheads
• E.g. office utilities, IT infrastructure,
laptop provision not covered by capital
usage
• must be directly attributable to the
project
• Provide detailed breakdown together
with methodology/basis of
apportionment
66. What we ask you:
• Organisation size
• Date of last financial year
• Financial overview
• Annual turnover
• Annual profits
• Annual export
• R&D spend
• No. full time employees
68. Funding
Funding rules
You could get funding of up to 50% of your eligible project costs - this will
need to be manually adjusted in IFS
69. Funding
• Each organisation
must accept the grant
terms and conditions
• The lead applicant
will not be able to
submit the
application without
all organisations
accepting the grant Ts
and Cs.
72. Non-grant claiming partners
• Lead must invite partner to join the application
• Partner must select “not requesting funding” option in finances section of
IFS
• Partner must complete “Your project costs” section to provide value of
their contribution
• Partner will not be named in the Grant Offer Letter if your project is
successful
75. Checking your finances are complete
IFS checks
• all organisations have marked
their finances as complete
76. Review application before submission
IFS will check your application is
complete
All questions must be “marked as
complete”
Leave plenty of time to validate your
submission
Deadlines are absolute
82. Application Assessment
All applications are assessed by independent assessors drawn from industry
and academia
- What do they look for?
• Clear and concise answers
• The right amount of information
• not too much detail
• no assumptions
• Quantification and justification
• A proposal that presents a viable opportunity for growth, a level of innovation that necessitates
public sector investment and has the right team and approach to be successful
Keep your assessors engaged
and interested in your proposal.
You want them to be fascinated
and excited by your idea!
85. IFS for successful applicants
Project Set up:
• 7 steps to complete
• Applicable to all grant claiming
partners
• Must be completed within 30 days
• Projects must start within 90 days or
funding may be withdrawn
• Project change requests cannot be
submitted before the project starts
86. Grant claims and payments
• All grants are claimable quarterly in arrears
• Claims can only be made for costs incurred and paid between the project start and end
dates
• Claims may be subject to an independent audit (including all academic partners)
according to grant size
• Claims are only paid once quarterly reporting and necessary audits are complete
• Projects over 6 months are monitored on a quarterly basis including a visit from the
appointed Monitoring Officer. Anything outside of this will be discussed on a case by case
basis.
• The monitoring will be carried out against a detailed project plan and financial forecast
90. Learning from Round 1
03/07/2018
SME support to
evaluate innovative
medical technologies:
round 2
91. Overview
• Round one competition outcome
• Specific lessons learned
• General aspects of assessment process
• Innovate UK expectations
92. Competition summary
Round one
• Opened 29 January 2018
• £1m funding available
• 25 applications
• 12 ineligible
• 13 assessed and 8 awarded funding
• Approximately £0.5m funding awarded
• Diverse range of funded projects involving medical devices,
diagnostic tests and digital platforms
93. Competition specific issues
• Ineligible applications:
• Product not CE marked
• Product still under development – not available for sale
• Total project costs outside limits
• % grant claimed
• Ineligible costs
94. • We must receive your application by noon on the closing date
• Your application will be sent and scored by 5 expert assessors – the assessors will
comment on your response to each question
• We will brief our assessors and the expert panel
• Assessors will be provided with a matrix against which to mark each question
• A quality line will be drawn and applicants above this line will be invited to present to
an interview panel
• All applicants will receive the assessor feedback, and those invited to interview will be
asked to address the feedback in a short written document ahead of the interview
General Competition Process
95. Applications:
• Make sure the application is in scope, we can give advice on scope but not how to fill
in the application form
• By far the most important issue – Answer the question, and the highlighted points,
the assessors will be marking against these points using clear guidance
• We have a quality threshold of 70%, if below this it is very unlikely a project will be
funded
Application Process
96. Question 1: Need or challenge
• What is the business need, citizen challenge, technological challenge or
market opportunity behind your innovation?
• Provide evidence of:
• the potential for your product to have a significant impact on patients or
the efficiency of care delivery by the NHS
• when the product was first marketed in the UK, as only products that
have been marketed for less than 5 years are eligible for support
•
Be guided by the application form
97. Good applications
• Try to be realistic about what amount of work can be completed in the
available time, and the costs
• Make sure you apply forthe correct total project costs and grantamount
• Get someone elseto review the application if possible, this can be the
KTN,particularly as space on the form can be quite limited
98. • Innovate UK funded projects are actively monitored
• Funding release quarterly in arrears
• All partners expected to attend quarterly meeting to report on progress
• Expectation that projects will start on time
• Progress and expenditure expected to follow forecasts
• Changes to scope and or financial including virements must be fully justified and are
subject to approval
Innovate UK – expectations
99. - Opens 2 July 2018
- Closes noon 22 August 2018
- Applicants informed 2 November 2018
• Full project brief and scope
- https://apply-for-innovation-funding.service.gov.uk/competition/190/overview
• Further support is available:
- via our competition helpline on 0300 321 4357
- or email support@innovateuk.gov.uk
• Additional competitions will follow
Competition dates and support
101. Overview of challenges and waves
3 July 2018
Dr Ian McKay ian.mckay@innovateuk.ukri.org
Innovate UK: Industrial Strategy
102. • Background to the Industrial Strategy and ISCF grand challenges
• Review of wave one
• Preview of wave two
• From data to early diagnosis and precision medicine
• Healthy ageing
• Update on wave three
• Other funding opportunities
Presentation overview
103. £31bn National Productivity Innovation Fund
Industrial Strategy Challenge Fund
£1.7bn over four years
Innovation, Applied Science & Research
£4.7bn R&D
Funding
(over four years
to FY20/21)
104. • Builds on the UK’s world-class research base and delivers the science that
business needs to transform existing industries and create new ones
• Accelerates commercial exploitation of the UK’s most exciting technologies to
ensure that scientific investment truly delivers economic impact, jobs and
growth right across the country
• Programmes supported by the fund must be for the benefit of UK companies
and the economy and powered by multi-disciplinary research and business-
academic collaboration
• From April 2018, delivered by UK Research and Innovation
Industrial Strategy Challenge Fund
105. ISCF Wave 1 Challenges
Medicines manufacturing technologies
Batteries for clean and flexible energy storage
Robots for a safer world
Self-driving vehicles
Manufacturing and materials of the future
Satellites and space technology
106. Digital Health Technology Catalyst
£35m to develop digital health or digitally-enabled medical technologies to:
• improve patient outcomes
• transform healthcare delivery
• enable more efficient delivery of healthcare
+
Medicines Manufacturing
£146m to develop first-of-a-kind technologies for the manufacture of tomorrow’s
medicines, accelerating patient access to new drugs and treatments:
• pharmaceuticals
• vaccines
• advanced therapies
Wave 1: Medicines Manufacturing
108. Industrial Strategy Grand Challenges
AI and Data
Economy
Ageing
Society
Clean
Growth
Future of
Mobility
109. 109
Audience of the future / Next generation services (pioneer) / Quantum technology (pioneer)
Artificial intelligence and data economy
Clean growth
Energy revolution
Transforming
construction
Transforming
food production
Ageing Society
Medicines manufacturing
Data to early diagnosis and
precision medicine
Healthy ageing
Future of mobility
Faraday battery challenge
Extreme robotics
National space test facility
How the ISCF challenges fit with the
Industrial Strategy Grand Challenges
110. The report is organised into 7 themes:
• Health Advanced Research Programme
(HARP) proposal
• reinforcing the UK science offer
• growth and infrastructure
• NHS collaboration
• data
• skills
• regulation
111. • Three complementary strands:
• Genomics – ensure UK leads in exploitation of large scale whole genome
sequencing for diagnostics and precision medicine, £100m
• Digital Innovation Hubs – linking routine NHS data with rich data from
R&D programmes, providing analytic tools and informatics support for
businesses alongside local access to integrated UK-wide data, £38m
• Digital pathology, radiology/imaging and diagnosis– centres of
excellence in digital pathology and radiology/imaging with AI and
machine learning and investment in CR&D to advance diagnostic tools for
early diagnosis, £72m (£50m + £22m)
Data to early diagnosis and precision medicine
112. • Aims to position the UK at the forefront of large scale WGS for
diagnostics and precision medicine
• Whole Genome Sequencing of all 500,000 UK Biobank volunteers
• Potential for additional sequencing of up to 25,000 cancer patients (tumour
and germline genome) – funds permitting
• Overarching aim to support generation of
novel diagnostic tools and precision
therapies, in partnership with industry
ISCF: Genomics investment
113. • Delivered by UKRI in partnership with HDR UK and the NHS, building on
investments from NHS England and the devolved nations
• Hubs will provide expert research data services, supporting analytical tool
development and a range of innovative user requirements
• A single UK-wide health research data fabric will ensure interoperability
across all Hubs
• ~£38m over 4 years
ISCF: Digital Innovation Hubs
114. • Up to £50 million investment in a network of 5 – 6 Centres of Excellence
across the UK
• Split roughly £30m digital pathology, £20m radiology/in vivo imaging
• Applications can focus on digital pathology and/or radiology/in vivo imaging
• Maximum grant up to £10 million – this does not increase for multicentre bids
• Competition opens 6 June 2018, close 1 August 2018 at noon
• Projects to commence by 1 December 2018
• Maximum project length 36 months
• Programmes must be collaborative and at least 2 collaborators must apply
for grant.
Creating a network of digital pathology, imaging and AI
centres - a CR&D competition
115. Addressing the needs that improve quality
of life in the ISCF HA target audience
ISCF HA
Undesirable life
curve shows years
of dependency
years
Activitiesofdailyliving
(inorderoftypicallosspattern)
Public domain
116. Behaviora
l Studies
Innovatio
n
Clusters
Three elements Best current thinking….
Innovation Clusters
Collaboration activity continues through the summer
Opportunity for us to gain insight
Out to competition later in the year
Behavioural Studies
Dependant on the Innovation Cluster time line
Out to competition later in the year
CR&D Academia and SMEs
Out later in the year
Bids in post New year
Start around the new financial year
CR&D
Academi
a & SMEs
@innovateuk #healthyageingPublic domain
117. Innovation cluster
Lead Partner
Dynamic relationships
Short, rapid, innovation cycles
SME pipeline
Evaluation at local, programme
and national level
Economic and Social Impact
Build on existing collateral
Sustainable
SMEs
Local
Authorities
Third Sector/
NGOs
Clinical
Commissioning
Groups
Academia
Retail
companie
s
Logistics
companie
s
Large
Corporates
Marketing
Big Data
Health
Trusts
Care
Provider
s
HEIs/IROs
Design
Users &
carers
@innovateuk
#healthyageing
Community
Groups
Social
Enterprises
Utilities
Seed
Funders,
Venture
Capitalists
Public domain
118. • 252 Expressions of Interest received by the closing date
• c. £12.5bn requested from the Industrial Strategy Challenge Fund
• with c. £11.5bn additional funding coming from industry
Next steps and indicative timetable:
• Early July – Identify short-list of proposed challenges
• Summer – UKRI helps develop short-listed Expression of Interests
• Early September – deep-dive workshops with experts
• Mid October – UKRI reviews short listed challenges and makes
recommendations to ministers
• November (to be confirmed) – Announcement of selected challenges
Wave 3 Challenges
119. • Open programme funding competition round 1
• £20m opened 10 May closes 11 July, Round 2 closes 12 September
• Includes KTP applications
• Part of rolling programme of open competitions
• Precision medicine technologies: shaping the future
• £5m opened 14 May closes 11 July
• Creating a network of digital pathology, imaging and AI centres
• £50m funding available opened 6 June closes 1 August
Current funding competitions:
120. • Manufacturing readiness and scale up of genomic analysis technologies
• £5m opens 18 June, registration 11 July, closes 18 July
• Innovation loans: July 2018 open competition
• £10m competition opens 2 July, closes 29 August
• Precision Medicine Investment Accelerator 2018
• Opens 23 July closes 3 October
https://apply-for-innovation-funding.service.gov.uk/competition/search
Competition support 0300 321 4357 or support@innovateuk.gov.uk
https://www.ktn-uk.co.uk/
Current funding competitions: