Future trends and perspectives in modern pharmaceutical biotechnologyinemet
PharmaCon2007 Congress, Dubrovnik, Croatia "New Technologies and Trends in Pharmacy, Pharmaceutical Industry and Education" http://www.pharmacon2007.com
Abstract is available at http://www.pharmaconnectme.com
Future trends and perspectives in modern pharmaceutical biotechnologyinemet
PharmaCon2007 Congress, Dubrovnik, Croatia "New Technologies and Trends in Pharmacy, Pharmaceutical Industry and Education" http://www.pharmacon2007.com
Abstract is available at http://www.pharmaconnectme.com
Morphological and functional state of immune organs in rats with experimental...QUESTJOURNAL
Abstract: The work is devoted to the study of morphological and functional state of immune organs - thymus and spleen, in rats Wistar with experimentally induced type 1 diabetes mellitus (DM-1) and to examine the effectiveness of phytopreparation BNO 10.30 (Imupret). For the experiment were involved 20 rats, which were divided into 4 groups: group 1 - control group of healthy rats, 2 - control group that received "Imupret", 3 - rats with experimental DM-1, 4 - rats with experimental diabetes, treated with the drug "Imupret." Functional changes in the immune organs were evaluated by the results of morphometric analysis; morphological picture was evaluated by histological changes. As a result, in animals with DM-1 were found initial pathological changes of these organs: increased volume of white pulp in the spleen, thymus medulla increase, which indicates the initial inflammatory and degenerative processes. According to the results of the correlation analysis there was established a direct relationship between the presence of DM-1and the pathological changes of spleen and thymus (r = 0,529, p <0.05). In this way, the results demonstrate the importance of early diagnostics of immune organs in patients with type-1.
”Contemporary Biomarkers In Periodontitis”- Guest lecture as a part of Dr NTRUHS Zonal CDE programme at Government Dental College and Hospital, Hyderabad, India on 281/1/2011, SIBAR Institute of Dental Sciences, Guntur, India on 29/12/12 and at Meghna Institute of Dental Sciences, Nizamabad, India on 31/7/2013.
Protein was extracted from muscles of Channa striatus and attempts were
made to evaluate in vitro antibacterial activity against clinical bacterial isolates. The
higher concentration of protein (100μg/ml) extracts exhibited a pronounced activity
against Pseudomonas aeruginosa (21 mm), Proteus vulgaris (19 mm), Citrobacter sp
(19 mm), Klebsiella pneumoniae (18 mm), Micrococcus sp (17 mm), Bacillus subtilis (16
mm), Staphylococcus aureus (15 mm), E. coli (14 mm) and Serratia marcescens (5
mm). The minimum inhibitory concentration and minimum bactericidal concentration
were found to be 20-40 μg/ml and 80-100 μg/ml respectively for the extracts of
Channa striatus protein against test organisms. This study confirms that C. striatus fish
protein extracts possess antibacterial activity against a wide range of microbes and
justified that it could be used in the traditional medicine as a remedy for the
treatment of bacterial diseases.
Designing of drug delivery system for biotechnology products considering stab...Smaranika Rahman
"Where there is life, there is DNA, where there is DNA, there is biotechnology." Biotechnology, as the word suggests, is combination of biology and technology. So the importance of biotechnology and biotechnology products in our life is increasing day by day. That's why we have to produce biotechnology products in a safer manner and also maintain that through it's shelf-life.We have also research on improving methods of improving it's stability. In this topic, I also tried to discuss bioinformatic-driven strategies that are used to predict structural changes that can be applied to wild type proteins in order to produce more stable variants. The most commonly employed techniques PEGylation, stochastic approaches, empirical or systematic rational design strategies.
Morphological and functional state of immune organs in rats with experimental...QUESTJOURNAL
Abstract: The work is devoted to the study of morphological and functional state of immune organs - thymus and spleen, in rats Wistar with experimentally induced type 1 diabetes mellitus (DM-1) and to examine the effectiveness of phytopreparation BNO 10.30 (Imupret). For the experiment were involved 20 rats, which were divided into 4 groups: group 1 - control group of healthy rats, 2 - control group that received "Imupret", 3 - rats with experimental DM-1, 4 - rats with experimental diabetes, treated with the drug "Imupret." Functional changes in the immune organs were evaluated by the results of morphometric analysis; morphological picture was evaluated by histological changes. As a result, in animals with DM-1 were found initial pathological changes of these organs: increased volume of white pulp in the spleen, thymus medulla increase, which indicates the initial inflammatory and degenerative processes. According to the results of the correlation analysis there was established a direct relationship between the presence of DM-1and the pathological changes of spleen and thymus (r = 0,529, p <0.05). In this way, the results demonstrate the importance of early diagnostics of immune organs in patients with type-1.
”Contemporary Biomarkers In Periodontitis”- Guest lecture as a part of Dr NTRUHS Zonal CDE programme at Government Dental College and Hospital, Hyderabad, India on 281/1/2011, SIBAR Institute of Dental Sciences, Guntur, India on 29/12/12 and at Meghna Institute of Dental Sciences, Nizamabad, India on 31/7/2013.
Protein was extracted from muscles of Channa striatus and attempts were
made to evaluate in vitro antibacterial activity against clinical bacterial isolates. The
higher concentration of protein (100μg/ml) extracts exhibited a pronounced activity
against Pseudomonas aeruginosa (21 mm), Proteus vulgaris (19 mm), Citrobacter sp
(19 mm), Klebsiella pneumoniae (18 mm), Micrococcus sp (17 mm), Bacillus subtilis (16
mm), Staphylococcus aureus (15 mm), E. coli (14 mm) and Serratia marcescens (5
mm). The minimum inhibitory concentration and minimum bactericidal concentration
were found to be 20-40 μg/ml and 80-100 μg/ml respectively for the extracts of
Channa striatus protein against test organisms. This study confirms that C. striatus fish
protein extracts possess antibacterial activity against a wide range of microbes and
justified that it could be used in the traditional medicine as a remedy for the
treatment of bacterial diseases.
Designing of drug delivery system for biotechnology products considering stab...Smaranika Rahman
"Where there is life, there is DNA, where there is DNA, there is biotechnology." Biotechnology, as the word suggests, is combination of biology and technology. So the importance of biotechnology and biotechnology products in our life is increasing day by day. That's why we have to produce biotechnology products in a safer manner and also maintain that through it's shelf-life.We have also research on improving methods of improving it's stability. In this topic, I also tried to discuss bioinformatic-driven strategies that are used to predict structural changes that can be applied to wild type proteins in order to produce more stable variants. The most commonly employed techniques PEGylation, stochastic approaches, empirical or systematic rational design strategies.
Why you should Celebrate the Wins in a Startup by Geoffrey ByruchGeoffrey Byruch
At any startup, there will always be various ups-and-downs on your road to success. While you can always get lost within the day-to-day operations of the work week, it is absolutely vital for your company and yourself to celebrate the wins every step of the way.
Dev up 2016 Demystifying the scaled agile frameworkAngela Dugan
Just when companies seems to be warming up to agile, here comes SCALED agile. But how is SAFe really different than agile? Does using the SAFe framework undermine the scrum teams? Isn’t SAFe just a glorified version of waterfall that companies adopt when they can’t handle “real” agile? I decided the best solution was to go through the training and spend some time practicing it in the field. What I found was that SAFe leverages the best of Lean, Kanban, and scrum. SAFe is intended for large, enterprise customers delivering extremely complex and interdependent systems, but that doesn’t mean it offers nothing to smaller teams. Since becoming a Safe program consultant, I have coached a number of my smaller customers on improving their software development and delivery processes leveraging techniques from SAFe. In this interactive session, I plan to quickly walk through the tenets of SAFe, share some of my learnings with you, and help you to understand when and how SAFe can benefit your team!
Chair, David M. O'Malley, MD, Ana Oaknin, MD, PhD, and Matthew A. Powell, MD, prepared useful Practice Aids pertaining to endometrial cancer for this CME/MOC/AAPA activity titled “Endometrial Cancer Care in the Age of Immunotherapy: Translating Clinical Evidence Into Meaningful Improvements in Patient Outcomes Across the Disease Continuum.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at https://bit.ly/40bmalK. CME/MOC/AAPA credit will be available until July 3, 2024.
This presentation includes -classification, biological in psoriasis,TNF alpha inbitors, T cell inhibitos, IL-12/23 inhibitors (indications,containdications,guidelines, adverse effects)
In this presentation, I discuss a new standard of treatment in cancers which is immunotherapy. I also discuss the few cancers for which it has been approved.
A new conept of topical pain relief by phytochemicalsKevin KF Ng
The recent discoveries of nociceptive transient receptive ion channels as pain receptors and its blockade by phytochemicals opens a new era for topical pain research .
Lustrumlezing paul stoffels de rol van innovatie voor de gezondheidszorg van ...Michiel Stoffels
Ter gelegenheid van het 40 jarig bestaan van de Universiteit werd een reeks lustrumlezingen georganiseerd. Voor de faculteit Gezondheid en Levenswetenschappen hadden we de eer Dr. Paul Stoffels - Worldwide Chairman , Janssen Pharmaceutical Chief Scientific Officer, Johnson & Johnson - te mogen ontvangen.
Chair, Taofeek K. Owonikoko, MD, PhD, Carl M. Gay, MD, PhD, and Ticiana Leal, MD, prepared useful Practice Aids pertaining to small cell lung cancer for this CME/MOC/NCPD/AAPA activity titled “Progress on the Path to Improving Outcomes in the Treatment of SCLC: Making the Most of Current Standard-of-Care Therapies and Exploring New Promising Research.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/NCPD/AAPA information, and to apply for credit, please visit us at https://bit.ly/3pijZiM. CME/MOC/NCPD/AAPA credit will be available until July 4, 2024.
4. TNF - Atherosclerosis COPD Rheumatoid Arthritis Psoriasis IBD Ankylosing Spondylitis Diseases related to TNF -
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7. Botanical name: Sphaeranthus indicus English Name: East Indian Globe-Thistle Indian Name: Gorakhmundi A much branched, strongly-scented annual with winged stem and the wings toothed. Flowers compound heads, globose avoid, glandular hairy Traditional uses: Time tested herb and widely used in Ayurveda Used in Indigestion, Bronchitis, Spleen diseases, Elephantiasis, Inflammatory conditions of pelvis in women, Piles, Asthma, Treatment of glandular swelling in the neck Sphaeranthus indicus Fruiting & flowering Inflorescence head Herb in nature Pharmacognostically standardized & Extraction process developed to obtain holistic extract
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9. Safety Check Efficacy Check Quality Check Certificate of Analysis with Specification
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11. Tinefcon inhibits LPS-induced TNF- release in mice ** Bar graph: Mean + SEM; * p<0.0005 Student’s T-test Tinefcon inhibits LPS-induced IL-1 release in mice In vivo activity
12. In vivo activity – Histopathology Protects cartilage degradation in joints
13. Tinefcon reduces the severity of experimental colitis in mice In vivo studies – Ulcerative Colitis model Rectal Bleeding 0.00 0.25 0.50 0.75 1.00 N D Sp Rectal Bleeding Index % Weight Loss -10 -5 0 5 10 15 20 25 30 N D Sp % Weight Loss During Study Disease Activity Index 0 2 4 6 8 10 N D Sp DAI Score Colon Length 0 4 8 12 N D Sp Colon Length (cm) Stool Consistency 0 1 2 3 N D Sp Stool Consistency Index N: Naïve mice D: DSS-fed mice Sp: DSS-fed mice + Tinefcon (400 mg/kg p.o.) * * * *
14. Naïve Well preserved architecture Tinefcon (400 mg/kg p.o.) DSS Complete loss of architecture Protection from mucosal erosions Tinefcon treated mice reduces DSS-induced alterations in mucosal architecture and colonic damage In vivo studies – Ulcerative Colitis model (Histopathology analysis)
15. Tinefcon extract reduces development and progression of atherosclerosis in LDLr-deficient mice Bar graph: Mean + SEM; * p<0.05 vs vehicle, ANOVA Atherosclerotic lesion quantitation In vivo studies – Atherosclerosis model Veh Feno Tinefcon Tinefcon 100 mg/kg 100 mg/kg 300mg/kg -26% -22% -21% * * *
16. **p<0.01 by ANOVA (Dunnett’s Test) Tinefcon Inhibits Atherosclerosis Progression in Hyperlipidemic Hamsters In vivo studies – Atherosclerosis model Vehicle Fenofibrate Tinefcon (100 mpk) (200 mpk) Vehicle Fenofibrate Tinefcon (100 mpk) (200 mpk) Vehicle Fenofibrate Tinefcon Mean 0.5025 0.0834 0.2736 STD 0.2151 0.1131 0.1482 SEM 0.06487 0.03577 0.04686 % Change -84 -45
21. Study Design ENROLMENT (N = 74) WASH OUT 2 wks- TOPICAL Rx WASH OUT 4 wks- PUVA Rx RANDOMIZATION 1:1:1 Tinefcon 2.8 g/day Placebo Tinefcon 1.4 g/day STUDY COMPLETED (N = 48) E M O L L I E N T S
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23. 0 10 20 30 40 50 60 70 Placebo 1.4g 2.8g Treatment % Patients 75% improvement in PASI score Effect of Tinefcon in Psoriasis Patients
24. BASELINE AFTER 12 WEEKS OF TREATMENT Photographic evidence Case 1 Case 2