3. Introduction
Figure 1. Physical effect vs. current level
• The current needed to generate
each effect depends on some
conditions such as variability of
let-go current and threshold of
perception, frequency, duration,
body weight, points of entry..
4. Threshold and Let-Go Variability
Figure 2. Distributions of perception thresholds and let-go currents
• Mean “threshold of perception”
1.1mA for men
0.7mA for women
• Minimum threshold of perception
500 µA
80 µA with gel electrodes (reduces skin
impedance)
• Mean “let-go current”
(let-go current = max current where
you can still release your grip)
• 16.5 mA for men
• 10.5 mA for women
5. Frequency
Figure 3. Let-go current vs frequency
Let-go current vs. frequency
• Minimal let-go current occurs at commercial
power-line frequencies of 50-60 Hz
6. Shock (Stimulation) Duration
Figure 4 shows that for short durations
the stimulation current threshold Id is
inversely related to the pulse duration
d by the well-known strenght-duration
equation :
Figure 4. Normalized analytical strength-duration curve for current I, charge Q and energy U.
• Fibrillation current is inversely
proportional to the shock pulse
duration
• longer pulses -> lower current
does damage
7. Shock (Stimulation) Duration
• The longer the duration, the smaller
the current at which ventricular
fibrillation occurs.
• Shock must occur long enough to
coincide with the most vulnerable
period occurring during the T wave.
Figure 5. Fibrillation current vs shock duration. Thresholds for VF in animals for 60 Hz AC current. Duration of
current(0.2 to 5 s) and weight of animal body were varied.
10. Points of Entry
Points of entry
• Skin impedance varies: 15 kΩ to 1 MΩ
(Resistive barrier that limits current flow)
• Tissue (beneath skin) has low impedance
Macroshock
• externally applied current
• spreads through the body so less
concentrated
Microshock
• applied current is concentrated at an
invasive point
• accepted safety limit is only 10 µA
• generally only dangerous if current flows
through the heart
Figure 6. Effect of entry points on current distribution. (a) Macroshock : Externally
applied current spreads throughout the body (b) Microshock : All the current applied
through an intracardiac catheter flows through the heart
In a 70 kg human. For 60 Hz current applied for 1 to 3 s to moistened hand grasping a No. 8 copper wire. The current needed to produce each effect depends on all these conditions as will be explained in this presentation. Safety considerations dictate thinking in terms of minimal rather than average values for each conditions.
Figure 14.2 shows the variability of the threshold of perception and the let-go current for men and women (Dalziel, 1973). On this plot of percentile rank versus rms current in milliamperes, the data are close to the straight lines shown, so a Gaussian distribution may be assumed. For men, the mean value tor the threshold of perception is 1.1 mA; for women, the estimated mean is 0.7 mA. The minimal threshold of perception is 500 uA. When the current was applied to ECG gel electrodes, the threshold of perception averages only 83 uA with a range of 30 to 200 uA (Tan and Johnson, 1990). Recent data for surface electrical stimulation of skeletal muscle showed that sensory threshold was 43%, (p<0.001) lower in women and supramotor threshold was 17% (p< 0.01) less for women (Maffiuletti et al., 2008).
Let-go currents also appear to follow Gaussian distributions, with mean let-go currents of 16 mA for men and 10.55 mA for women. The minimal threshold let-go current is 9.5 mA for men and 6 mA for women. Note that the range of variability for let-go current is much greater than the range for threshold-of-perception current.
Mean “let-go current” let-go current = max current where you can still release your grip • 16.5 mA for men • 10 5 mA for women.
The range of variability for let go current is much greater than the range for threshold of perception current.
For frequencies below 10 Hz, let-go currents rise, probably because the muscles can partially relax during part of each cycle. And at frequencies above several hundred hertz, the let-go currents rise again.
To estimate the ventriculer fibrillstion risk of electromuscular incapacitation devices, it is important to understand the excitation behaviour of myocardial cells. Geddes and Bsker (1989) presented the cell membrane excitation model by a lumped parallel RC circuit that represents the resistance and capacitance of the cell membrane. This model determines the cell excitation thresholds that exceed about 20 mV for varying rectangular pulse durations d by assigning the rheobase currents Ir (for very long pulse durations) and cell membrane time constant T=RC.
A single electric stimulus pulse can induce VF if it is delivered during the vulnerable period of cardiac repolarization that corresponds to the T wave on the ECG. For large-amplitude electric transients less than 100 us in duration applied directly to the heart, the stimulation threshold approaches a constant charge transfer density of 3.55 uC/cm2. For normal hearts, the ratio of the fibrillation stimulation threshold to the single-beat stimulation threshold is 20:1 to 30:1 for electrodes on the heart and 10:1 to 15:1 for chest surface electrodes (Geddes et al., 1986). For 60 Hz current applied to the extremities, the fibrillation threshold increases sharply for shocks that last less than about 1s, as shown in Figure 5. Shocks must last long enough to take place during the vulnerable period that occurs during the T wave in each cardiac cycle (Reilly, 1998). For the 100 microsec pulses of electric fences (TEC, 2006) and Tasers, Figure 4 shows that much higher currents are reguired for excitation.
Table shows that short duration electric pulses, even though applied near the heart do not cause ventriculer fibrillation. In contrast, the continuous current from power lines kills 1000 person per year
These findings deserve more study, bcs they are used to extrapolate fibrillating currents for humans.
When current is applied at two points on the surface of the body, only a small fraction of the total current flows through the heart, as shown in figure 6, these large, externally applied currents are called macroshocks. The magnitude of current needed to fibrillate the heart is far greater when the current is applied on the surface of the body than it would be if the current were applied directly to the heart. The importance of the location of the two macroshock entry points is often overlooked. If the two points are both on the same extremity, the risk of fibrillation is small, even for high currents. For dogs, the current needed for fibrillation is greater for ECG lead I (LA—RA) electrodes than for ECG leads II and III (LL-RA and LL-LA) (Geddes, 1973). The protection afforded by the skin resistance (15 kOhm to 1 MOhm for 1 cm2) is eliminated by many medical procedures that require insertion of conductive devices into natural openings, skin incisions, skin abrasion, or electrode gel.
If the skin resistance is bypassed, less voltage is reguired to produce sufficient current for each physiological effect.
Patients are particularly vulnerable to electric shock when invasive devices are placed in direct contact with cardiac muscle. If a device provides a conductive path to the heart that is insulated except at the heart, then very small currents called microshocks can induce VF. As Figure 6(b) shows, all the current flowing through such a conductive device flows through the heart. The current density at the point of contact can be quite high, and fibrillation in dogs can be induced by total currents as low as 20 microA. (See Roy (1980).|
Application of 60 Hz ac for 5 s test periods to a ventricular pacing catheter during implantable cardioverter—defibrillator implant testing in 40 patients showed intermittent capture with a minimum current of 20 microA, continuous capture with hemodynamic collapse with a minimum current of 32 microA and VF persisting after ac termination with a minimum current of 49 microA (Figure 14.7) (Swerdlow et al., 1999.) The other connection can be at any point on the body. The widely accepted safety limit to prevent microshocks is 10 microA.