Internet is an excellent source for information, you can knew internet search engines, pediatric sites, continuing medical education and evidence based medicine.
All u want to knew about epidemiology, pathology, pathogenesis, clinical picture, investigation, differential diagnosis, different treatment modalities.
This is the magazine of the Ministry of Health & Family Welfare , Government of India . It will be a quarterly magazine dealing with health issues relevant to the public
This document provides an overview of career opportunities in pathology. It discusses what pathology involves, including diagnostic medicine and teaching. It outlines the various career options for pathologists, including community practice, academic practice, and industry roles. It also details the training and fellowship programs, subspecialties, job prospects, salaries, and lifestyle considerations for those in the pathology field.
The document discusses various health issues faced by working women in India based on a 2005 survey of 1000 working women conducted by the DGF. Some key findings from the survey include:
- 90% of working women felt achieving a balance between work and personal life was a major issue.
- 50% felt an imbalance in life reduced their productivity and 45% suffered from stress-related diseases.
- Common health problems among working women included tuberculosis, anemia, obesity, backaches, and cervical spondylosis.
The document then discusses major causes of death among Indian women such as suicide, cancer, tuberculosis, anemia, and pregnancy-related issues. It provides statistics on these health problems and recommends actions like vaccination
This document provides tips from Dr. Sharda Jain on how to be the most productive doctor. Some key tips include protecting morning hours for best work, understanding the importance of prime time, stopping multi-tasking, saying no to unnecessary meetings, meditating, being introspective, and surrounding yourself with positive people. Dr. Jain also shares her secrets to success such as having no expectations, taking charge of your life, not playing blame games, being the change you wish to see, giving back to your country, counting your blessings, and always finding humor through difficult times.
The document discusses the anatomy, risk factors, etiology, clinical presentation, diagnosis, and treatment of gastrointestinal stromal tumors (GIST). GISTs most commonly occur in the stomach and small intestine and symptoms can include abdominal pain or fullness. Treatment involves surgical resection of localized tumors along with targeted therapy using tyrosine kinase inhibitors like imatinib for advanced or recurrent GISTs.
1. Chronic myeloid leukemia (CML) is a cancer of the white blood cells characterized by the Philadelphia chromosome, which results from a reciprocal translocation between chromosomes 9 and 22.
2. CML progresses through chronic, accelerated, and blast crisis phases and presents with splenomegaly, basophilia and elevated white blood cell count.
3. Treatment has advanced significantly with tyrosine kinase inhibitors like imatinib that target the BCR-ABL1 fusion protein resulting from the Philadelphia chromosome. These drugs have improved survival rates and altered the treatment landscape for CML.
Imatinib (Gleevec) is a tyrosine kinase inhibitor developed to treat chronic myelogenous leukemia (CML). [1] It works by binding to the Bcr-Abl protein created by a chromosomal translocation, blocking its ability to phosphorylate proteins and activate cancer-causing pathways. [2-4] Imatinib is well-absorbed orally and highly protein bound. It undergoes hepatic metabolism primarily via CYP3A4 and is eliminated mostly in the feces. The main metabolite is an active N-demethylated derivative. Dose adjustments are generally not needed due to its variable clearance. [5-11]
All u want to knew about epidemiology, pathology, pathogenesis, clinical picture, investigation, differential diagnosis, different treatment modalities.
This is the magazine of the Ministry of Health & Family Welfare , Government of India . It will be a quarterly magazine dealing with health issues relevant to the public
This document provides an overview of career opportunities in pathology. It discusses what pathology involves, including diagnostic medicine and teaching. It outlines the various career options for pathologists, including community practice, academic practice, and industry roles. It also details the training and fellowship programs, subspecialties, job prospects, salaries, and lifestyle considerations for those in the pathology field.
The document discusses various health issues faced by working women in India based on a 2005 survey of 1000 working women conducted by the DGF. Some key findings from the survey include:
- 90% of working women felt achieving a balance between work and personal life was a major issue.
- 50% felt an imbalance in life reduced their productivity and 45% suffered from stress-related diseases.
- Common health problems among working women included tuberculosis, anemia, obesity, backaches, and cervical spondylosis.
The document then discusses major causes of death among Indian women such as suicide, cancer, tuberculosis, anemia, and pregnancy-related issues. It provides statistics on these health problems and recommends actions like vaccination
This document provides tips from Dr. Sharda Jain on how to be the most productive doctor. Some key tips include protecting morning hours for best work, understanding the importance of prime time, stopping multi-tasking, saying no to unnecessary meetings, meditating, being introspective, and surrounding yourself with positive people. Dr. Jain also shares her secrets to success such as having no expectations, taking charge of your life, not playing blame games, being the change you wish to see, giving back to your country, counting your blessings, and always finding humor through difficult times.
The document discusses the anatomy, risk factors, etiology, clinical presentation, diagnosis, and treatment of gastrointestinal stromal tumors (GIST). GISTs most commonly occur in the stomach and small intestine and symptoms can include abdominal pain or fullness. Treatment involves surgical resection of localized tumors along with targeted therapy using tyrosine kinase inhibitors like imatinib for advanced or recurrent GISTs.
1. Chronic myeloid leukemia (CML) is a cancer of the white blood cells characterized by the Philadelphia chromosome, which results from a reciprocal translocation between chromosomes 9 and 22.
2. CML progresses through chronic, accelerated, and blast crisis phases and presents with splenomegaly, basophilia and elevated white blood cell count.
3. Treatment has advanced significantly with tyrosine kinase inhibitors like imatinib that target the BCR-ABL1 fusion protein resulting from the Philadelphia chromosome. These drugs have improved survival rates and altered the treatment landscape for CML.
Imatinib (Gleevec) is a tyrosine kinase inhibitor developed to treat chronic myelogenous leukemia (CML). [1] It works by binding to the Bcr-Abl protein created by a chromosomal translocation, blocking its ability to phosphorylate proteins and activate cancer-causing pathways. [2-4] Imatinib is well-absorbed orally and highly protein bound. It undergoes hepatic metabolism primarily via CYP3A4 and is eliminated mostly in the feces. The main metabolite is an active N-demethylated derivative. Dose adjustments are generally not needed due to its variable clearance. [5-11]
Senior citizen 1, Dr. Sharda jain , Life care centreLifecare Centre
1) The document provides mantras and tips for aging gracefully, including maintaining good health habits like exercise, a healthy diet, stress reduction, and spending time with family and friends.
2) It emphasizes the importance of financial security and independence in retirement by keeping finances and property in one's own name and not relying on children for money.
3) Living with a positive attitude, optimism, and finding purpose through hobbies or spiritual growth are also recommended for enjoying life after retirement.
The document discusses the EGFR pathway in colorectal cancer. It notes that EGFR is overexpressed in 25-82% of colorectal cancers and is involved in cell proliferation pathways. While EGFR overexpression is sometimes associated with worse outcomes, the significance is unclear due to inconsistent measurement methods. Anti-EGFR therapies like cetuximab show promise for colorectal cancer, but EGFR expression levels alone do not predict response to treatment. EGFR gene amplification analysis is also an uncertain prognostic indicator due to varying definitions and guidelines. Overall the role of EGFR in colorectal cancer requires further standardized research.
This document discusses advanced non-small cell lung cancer and targeted therapies. It provides an overview of lung cancer epidemiology and risk factors like smoking. It also reviews molecular targets in NSCLC like EGFR, KRAS, and EML4-ALK and associated targeted therapies. The document outlines NSCLC diagnosis, staging, and management approaches including surgery, chemotherapy, and newer targeted therapies based on molecular profiling.
1) The document discusses response rates and outcomes for patients with chronic myeloid leukemia (CML) treated with various tyrosine kinase inhibitors (TKIs) like imatinib, dasatinib, nilotinib, and bosutinib.
2) It reports that achieving a major cytogenetic response or deeper molecular response (e.g. MMR) at certain timepoints (e.g. 12 months) on imatinib is associated with improved progression-free and overall survival.
3) For patients who become resistant or intolerant to imatinib, the second-generation TKIs dasatinib, nilotinib and bosutinib have response rates ranging from
This document discusses FLT3-ITD mutations in acute myeloid leukemia (AML) and the use of FLT3 tyrosine kinase inhibitors (TKIs) in the setting of allogeneic stem cell transplantation for AML. FLT3-ITD mutations occur in around 25% of AML cases and are associated with an inferior prognosis. TKIs like sorafenib and quizartinib have shown efficacy in relapsed/refractory FLT3-ITD positive AML, particularly after allogeneic stem cell transplantation. Ongoing clinical trials are investigating the use of TKIs as maintenance therapy before and after transplantation to improve outcomes for AML patients with FLT
Gastrointestinal stromal tumor (GIST) dr ridu kumar sharmaRidu Kumar Sharma
GISTs are the most common mesenchymal tumors of the GI tract. They are driven by mutations in c-Kit and PDGFR genes. Surgery is the main treatment for localized disease, while imatinib is effective systemic therapy for advanced or metastatic GISTs. Imatinib targets the c-Kit mutation to inhibit tumor growth with acceptable toxicity. Tumor size and mitotic index are prognostic factors used for risk stratification. Ongoing research is exploring additional targeted therapies to treat GISTs.
- The tumor showed no MYCN amplification or loss of chromosome 1p, which are associated with a poorer prognosis. It had a near triploid number of chromosomes.
- Persisting residual tumors in patients with intermediate-risk neuroblastoma were not associated with progression despite imaging findings, as long as catecholamine levels were not elevated.
- Infants under 18 months with Stage 3 neuroblastoma had a significantly better 5-year event-free and overall survival than patients over 18 months.
CML - DIAGNOSIS,MANAGEMENT AND RECENT ADVANCESRajesh S
The document discusses diagnosis, management, and recent advances in chronic myelogenous leukemia (CML). CML results from a reciprocal translocation between chromosomes 9 and 22, known as the Philadelphia chromosome, which produces the BCR-ABL fusion gene and oncogenic protein. Treatment involves tyrosine kinase inhibitors like imatinib, nilotinib, and dasatinib to inhibit BCR-ABL. Response is monitored through hematologic, cytogenetic, and molecular testing. Resistance can develop through mutations, requiring alternative TKIs or allogeneic stem cell transplant in some cases.
Stress management and relaxation techniques 2013Lifecare Centre
This document summarizes a workshop on stress management and self-love (L.A.R.) therapy conducted by Dr. Sharda Jain, Dr. Jyoti Agarwal, and Dr. Jyoti Bhaskar. It discusses the causes and effects of stress, particularly for women. It then provides tips for managing stress through changing one's thinking, attitude, behavior, and lifestyle, including deep breathing, relaxation, exercise, meditation, and maintaining a positive outlook. Over 200 such workshops have been conducted. Contact information is provided for those interested in the stress management team.
Gastrointestinal stromal tumors (GISTs) arise from interstitial cells of Cajal in the gastrointestinal tract. Pathogenic mutations in KIT or PDGFRA genes drive tumor growth in most GISTs. GISTs most commonly occur in the stomach and small intestine. Microscopically, GISTs demonstrate spindle or epithelioid cell morphologies and strongly express KIT (CD117). Surgical resection is the primary treatment, while the tyrosine kinase inhibitor imatinib is effective for advanced or metastatic disease. Tumor size, mitotic rate, and site determine prognosis, with small intestinal GISTs having the worst outcomes.
Imatinib is the first FDA approved targeted protein kinase inhibitor for chronic myelogenous leukemia and gastrointestinal stromal tumors. It binds to and inactivates the BCR-ABL tyrosine kinase. Dasatinib and nilotinib are also BCR-ABL tyrosine kinase inhibitors approved for CML. Gefitinib, erlotinib and lapatinib inhibit the epidermal growth factor receptor tyrosine kinase and are approved for various cancers. Sunitinib, sorafenib, pazopanib, and vatalanib inhibit vascular endothelial growth factor receptors and are approved for renal cell carcinoma and other cancers. These oral tyrosine kinase inhibitors are important targeted cancer therapies.
This document discusses HIV infection in pregnancy and strategies to reduce mother-to-child transmission of HIV. It covers antepartum, intrapartum, and postpartum care for HIV-infected women including antiretroviral regimens, monitoring, testing protocols, and delivery methods. The goal is to reduce the risk of perinatal HIV transmission to less than 2% through highly effective antiretroviral therapy, elective cesarean section when appropriate, and avoiding breastfeeding.
The document discusses principles of cancer chemotherapy and summarizes various classes of chemotherapeutic agents. It describes how chemotherapy can be used at different stages of treatment and highlights common toxicities. It also reviews mechanisms of action and examples of classical anticancer agents like alkylating agents, antimetabolites, natural products and hormone therapies. Novel targeted agents are discussed such as tyrosine kinase inhibitors, PARP inhibitors, angiogenesis inhibitors, HSP90 inhibitors and others.
This document discusses tyrosine kinase inhibitors (TKIs), a class of targeted cancer drugs. It begins by introducing protein kinases and their role in cell signaling. There are two main categories of protein kinases - those that phosphorylate tyrosine residues and those that phosphorylate serine and threonine residues. Tyrosine kinases function as on/off switches in many cellular functions by adding phosphate groups to tyrosine residues on proteins. The document then discusses the different types of tyrosine kinases and how they can become mutated and cause unregulated cell growth leading to cancer. It describes targeted therapy and TKIs as targeted drugs that block specific molecules needed for tumor growth. The final sections provide examples of approved TKIs
Leukaemia is a progressive neoplastic disease characterized by unregulated proliferation of immature blood cells. The main types are acute and chronic leukaemia. Acute leukaemia has a rapid onset and is more aggressive, while chronic leukaemia has a gradual onset and is less aggressive. Leukaemia is further classified as lymphoid or myeloid depending on the origin of the leukemic stem cell clone. Acute myeloid leukaemia is composed of immature myeloid cells and causes bone marrow failure, while acute lymphoid leukaemia is composed of immature lymphoid cells and most commonly affects children.
This presentation summarizes the state of the art with respect to the management of GIST. It covers the basics of surgical and medical management including the role of neoadjuvant and adjuvant targeted therapy. www.ellenhornmd.com
This document provides an overview of resources for searching for medical and health-related information. It introduces the Queen Mary University library website and search tools, as well as healthcare-specific search engines like Medline Plus and Evidence Search that search across high-quality web resources. It also describes medical databases like PubMed, Web of Science, and Scopus that contain vast collections of published research articles and references. Strategies for broadening and narrowing database searches are also discussed.
This document provides information about researching health topics related to Latinos, including identifying relevant databases such as Medline and CINAHL. It discusses developing search strategies using keywords, Boolean operators, and truncation. The document also emphasizes consulting with librarian Susan Luévano for help with the research process.
This document provides an overview of online resources for telemedicine programs, including Google, PubMed, and other websites. It discusses how to become an effective searcher using Google through techniques like using quotation marks, Boolean operators, and refining searches. It also reviews how to create a MyNCBI account and use advanced features of PubMed like saving searches. The document emphasizes evaluating online resources for authority and accuracy and provides tips for determining the reliability of health-related websites. The overall goal is to teach healthcare professionals how to effectively search for and evaluate online information to support telemedicine programs.
This document provides information on searching for health-related information online. It recommends using specialized search engines that filter results to high-quality sources. It describes several tools for searching medical literature databases, including Medline Plus, Evidence Search, TRIP, PubMed, Web of Science, and Scopus. It also discusses strategies for broadening and narrowing searches, such as using Boolean operators, phrase searching, and subject headings. The goal is to help users efficiently find trustworthy information from curated sources.
This document provides an overview of search tools and databases available through the Queen Mary University library for finding health-related information. It introduces healthcare specific search engines like MedlinePlus, Evidence Search, and TRIP that search across quality internet resources. It also outlines bibliographic databases like PubMed, Web of Science, and Scopus that contain vast collections of published research references that can be filtered and searched using Boolean logic. Key learning points are highlighted on using filters to narrow search results and evaluating the quality and types of sources found through different tools.
Senior citizen 1, Dr. Sharda jain , Life care centreLifecare Centre
1) The document provides mantras and tips for aging gracefully, including maintaining good health habits like exercise, a healthy diet, stress reduction, and spending time with family and friends.
2) It emphasizes the importance of financial security and independence in retirement by keeping finances and property in one's own name and not relying on children for money.
3) Living with a positive attitude, optimism, and finding purpose through hobbies or spiritual growth are also recommended for enjoying life after retirement.
The document discusses the EGFR pathway in colorectal cancer. It notes that EGFR is overexpressed in 25-82% of colorectal cancers and is involved in cell proliferation pathways. While EGFR overexpression is sometimes associated with worse outcomes, the significance is unclear due to inconsistent measurement methods. Anti-EGFR therapies like cetuximab show promise for colorectal cancer, but EGFR expression levels alone do not predict response to treatment. EGFR gene amplification analysis is also an uncertain prognostic indicator due to varying definitions and guidelines. Overall the role of EGFR in colorectal cancer requires further standardized research.
This document discusses advanced non-small cell lung cancer and targeted therapies. It provides an overview of lung cancer epidemiology and risk factors like smoking. It also reviews molecular targets in NSCLC like EGFR, KRAS, and EML4-ALK and associated targeted therapies. The document outlines NSCLC diagnosis, staging, and management approaches including surgery, chemotherapy, and newer targeted therapies based on molecular profiling.
1) The document discusses response rates and outcomes for patients with chronic myeloid leukemia (CML) treated with various tyrosine kinase inhibitors (TKIs) like imatinib, dasatinib, nilotinib, and bosutinib.
2) It reports that achieving a major cytogenetic response or deeper molecular response (e.g. MMR) at certain timepoints (e.g. 12 months) on imatinib is associated with improved progression-free and overall survival.
3) For patients who become resistant or intolerant to imatinib, the second-generation TKIs dasatinib, nilotinib and bosutinib have response rates ranging from
This document discusses FLT3-ITD mutations in acute myeloid leukemia (AML) and the use of FLT3 tyrosine kinase inhibitors (TKIs) in the setting of allogeneic stem cell transplantation for AML. FLT3-ITD mutations occur in around 25% of AML cases and are associated with an inferior prognosis. TKIs like sorafenib and quizartinib have shown efficacy in relapsed/refractory FLT3-ITD positive AML, particularly after allogeneic stem cell transplantation. Ongoing clinical trials are investigating the use of TKIs as maintenance therapy before and after transplantation to improve outcomes for AML patients with FLT
Gastrointestinal stromal tumor (GIST) dr ridu kumar sharmaRidu Kumar Sharma
GISTs are the most common mesenchymal tumors of the GI tract. They are driven by mutations in c-Kit and PDGFR genes. Surgery is the main treatment for localized disease, while imatinib is effective systemic therapy for advanced or metastatic GISTs. Imatinib targets the c-Kit mutation to inhibit tumor growth with acceptable toxicity. Tumor size and mitotic index are prognostic factors used for risk stratification. Ongoing research is exploring additional targeted therapies to treat GISTs.
- The tumor showed no MYCN amplification or loss of chromosome 1p, which are associated with a poorer prognosis. It had a near triploid number of chromosomes.
- Persisting residual tumors in patients with intermediate-risk neuroblastoma were not associated with progression despite imaging findings, as long as catecholamine levels were not elevated.
- Infants under 18 months with Stage 3 neuroblastoma had a significantly better 5-year event-free and overall survival than patients over 18 months.
CML - DIAGNOSIS,MANAGEMENT AND RECENT ADVANCESRajesh S
The document discusses diagnosis, management, and recent advances in chronic myelogenous leukemia (CML). CML results from a reciprocal translocation between chromosomes 9 and 22, known as the Philadelphia chromosome, which produces the BCR-ABL fusion gene and oncogenic protein. Treatment involves tyrosine kinase inhibitors like imatinib, nilotinib, and dasatinib to inhibit BCR-ABL. Response is monitored through hematologic, cytogenetic, and molecular testing. Resistance can develop through mutations, requiring alternative TKIs or allogeneic stem cell transplant in some cases.
Stress management and relaxation techniques 2013Lifecare Centre
This document summarizes a workshop on stress management and self-love (L.A.R.) therapy conducted by Dr. Sharda Jain, Dr. Jyoti Agarwal, and Dr. Jyoti Bhaskar. It discusses the causes and effects of stress, particularly for women. It then provides tips for managing stress through changing one's thinking, attitude, behavior, and lifestyle, including deep breathing, relaxation, exercise, meditation, and maintaining a positive outlook. Over 200 such workshops have been conducted. Contact information is provided for those interested in the stress management team.
Gastrointestinal stromal tumors (GISTs) arise from interstitial cells of Cajal in the gastrointestinal tract. Pathogenic mutations in KIT or PDGFRA genes drive tumor growth in most GISTs. GISTs most commonly occur in the stomach and small intestine. Microscopically, GISTs demonstrate spindle or epithelioid cell morphologies and strongly express KIT (CD117). Surgical resection is the primary treatment, while the tyrosine kinase inhibitor imatinib is effective for advanced or metastatic disease. Tumor size, mitotic rate, and site determine prognosis, with small intestinal GISTs having the worst outcomes.
Imatinib is the first FDA approved targeted protein kinase inhibitor for chronic myelogenous leukemia and gastrointestinal stromal tumors. It binds to and inactivates the BCR-ABL tyrosine kinase. Dasatinib and nilotinib are also BCR-ABL tyrosine kinase inhibitors approved for CML. Gefitinib, erlotinib and lapatinib inhibit the epidermal growth factor receptor tyrosine kinase and are approved for various cancers. Sunitinib, sorafenib, pazopanib, and vatalanib inhibit vascular endothelial growth factor receptors and are approved for renal cell carcinoma and other cancers. These oral tyrosine kinase inhibitors are important targeted cancer therapies.
This document discusses HIV infection in pregnancy and strategies to reduce mother-to-child transmission of HIV. It covers antepartum, intrapartum, and postpartum care for HIV-infected women including antiretroviral regimens, monitoring, testing protocols, and delivery methods. The goal is to reduce the risk of perinatal HIV transmission to less than 2% through highly effective antiretroviral therapy, elective cesarean section when appropriate, and avoiding breastfeeding.
The document discusses principles of cancer chemotherapy and summarizes various classes of chemotherapeutic agents. It describes how chemotherapy can be used at different stages of treatment and highlights common toxicities. It also reviews mechanisms of action and examples of classical anticancer agents like alkylating agents, antimetabolites, natural products and hormone therapies. Novel targeted agents are discussed such as tyrosine kinase inhibitors, PARP inhibitors, angiogenesis inhibitors, HSP90 inhibitors and others.
This document discusses tyrosine kinase inhibitors (TKIs), a class of targeted cancer drugs. It begins by introducing protein kinases and their role in cell signaling. There are two main categories of protein kinases - those that phosphorylate tyrosine residues and those that phosphorylate serine and threonine residues. Tyrosine kinases function as on/off switches in many cellular functions by adding phosphate groups to tyrosine residues on proteins. The document then discusses the different types of tyrosine kinases and how they can become mutated and cause unregulated cell growth leading to cancer. It describes targeted therapy and TKIs as targeted drugs that block specific molecules needed for tumor growth. The final sections provide examples of approved TKIs
Leukaemia is a progressive neoplastic disease characterized by unregulated proliferation of immature blood cells. The main types are acute and chronic leukaemia. Acute leukaemia has a rapid onset and is more aggressive, while chronic leukaemia has a gradual onset and is less aggressive. Leukaemia is further classified as lymphoid or myeloid depending on the origin of the leukemic stem cell clone. Acute myeloid leukaemia is composed of immature myeloid cells and causes bone marrow failure, while acute lymphoid leukaemia is composed of immature lymphoid cells and most commonly affects children.
This presentation summarizes the state of the art with respect to the management of GIST. It covers the basics of surgical and medical management including the role of neoadjuvant and adjuvant targeted therapy. www.ellenhornmd.com
This document provides an overview of resources for searching for medical and health-related information. It introduces the Queen Mary University library website and search tools, as well as healthcare-specific search engines like Medline Plus and Evidence Search that search across high-quality web resources. It also describes medical databases like PubMed, Web of Science, and Scopus that contain vast collections of published research articles and references. Strategies for broadening and narrowing database searches are also discussed.
This document provides information about researching health topics related to Latinos, including identifying relevant databases such as Medline and CINAHL. It discusses developing search strategies using keywords, Boolean operators, and truncation. The document also emphasizes consulting with librarian Susan Luévano for help with the research process.
This document provides an overview of online resources for telemedicine programs, including Google, PubMed, and other websites. It discusses how to become an effective searcher using Google through techniques like using quotation marks, Boolean operators, and refining searches. It also reviews how to create a MyNCBI account and use advanced features of PubMed like saving searches. The document emphasizes evaluating online resources for authority and accuracy and provides tips for determining the reliability of health-related websites. The overall goal is to teach healthcare professionals how to effectively search for and evaluate online information to support telemedicine programs.
This document provides information on searching for health-related information online. It recommends using specialized search engines that filter results to high-quality sources. It describes several tools for searching medical literature databases, including Medline Plus, Evidence Search, TRIP, PubMed, Web of Science, and Scopus. It also discusses strategies for broadening and narrowing searches, such as using Boolean operators, phrase searching, and subject headings. The goal is to help users efficiently find trustworthy information from curated sources.
This document provides an overview of search tools and databases available through the Queen Mary University library for finding health-related information. It introduces healthcare specific search engines like MedlinePlus, Evidence Search, and TRIP that search across quality internet resources. It also outlines bibliographic databases like PubMed, Web of Science, and Scopus that contain vast collections of published research references that can be filtered and searched using Boolean logic. Key learning points are highlighted on using filters to narrow search results and evaluating the quality and types of sources found through different tools.
This document discusses the use of social media in medical education. It begins by defining social media as platforms for connection, conversation and collaboration. It then notes that the majority of medical students and faculty use social media platforms like YouTube, Facebook and Twitter. It provides examples of how different social media platforms can be used in medical education, such as Twitter being used to share resources and announcements, and Facebook being used to connect with medical groups and pages. It also highlights specific uses of social media in specialties like radiology, pediatrics and surgery, such as video sharing sites showing medical procedures and presentation sharing sites to access lectures. The document emphasizes that while social media should be used carefully and not become addictive, it can serve as
Evidence Based Medicine involves integrating the best available research evidence with clinical expertise and patient values. It is a 5-step process: 1) framing a clinical question, 2) finding the best evidence, 3) critically appraising the evidence, 4) integrating the evidence into practice, and 5) evaluating the process. The hierarchy of evidence ranks randomized controlled trials highest, while expert opinion is lowest. Several sources can be used to find evidence, including PubMed, Cochrane Library, UptoDate, and clinical guidelines websites. Skill is required to perform efficient searches and appraise evidence critically.
Searching for information - Global HealthPaulaFunnell
This document provides information on finding quality information for global health topics. It recommends searching specialist search engines that filter for health resources, as well as databases like PubMed, Web of Science, and Scopus. NHS Evidence, Solutions for Public Health, the Department of Health, and WHO websites provide public health information and policy documents. When searching databases, using subject headings, truncation, phrase searching, and combining search terms can help narrow down results.
This document provides information on searching for medical and healthcare information online. It discusses using general search engines to search across many resources but recommends using specialist search engines that search only healthcare sources for more targeted results. It describes several specialist search engines including MedlinePlus, Evidence Search, and TRIP and recommends databases for searching published research articles, highlighting PubMed, Web of Science, Scopus, and The Cochrane Library. It provides tips for effectively searching databases, including using subject headings, truncation, phrase searching, and combining search terms.
Clinical Microbiology - searching for informationPaulaFunnell
This document provides an introduction to searching for medical information through the Queen Mary University library website and various databases and search tools. It outlines key learning objectives around using the library website, searching online for quality health information, and effectively using medical databases and EndNote. Specific databases and search engines introduced include Evidence Search, TRIP, MEDLINE, Web of Science, Scopus, and The Cochrane Library. Search techniques like broadening terms, narrowing searches, phrase searching, and subject headings are also covered.
This document provides an overview of library resources for searching for health information including the library website, search engines, databases, and EndNote. It introduces healthcare specific search engines like MedlinePlus and Evidence Search which search across quality internet resources. Databases discussed include PubMed, Web of Science, and Scopus which contain vast collections of published research references. Strategies are provided for broadening searches using operators like OR and truncation, and narrowing searches using AND and phrase searching. Subject headings like MeSH terms are also covered to define the focus of articles.
This document provides guidance to medical fellows on finding quality online resources. It instructs them to create a MyNCBI account to access PubMed, a biomedical literature database containing over 16 million citations. Fellows are also encouraged to search other sources like Google Scholar, medical libraries, and MedlinePlus for information on assigned medical topics and to evaluate the reliability of websites.
How can doctors more efficiently use the internet and social media to improve patient care and keep current? The videos can be access at www.aboutcancer.com
This document provides an introduction to using library resources at Queen Mary University of London. It outlines learning objectives around searching for information effectively using library tools. It describes the library website and contact information for assistance. It also explains how to access electronic journals, search tools like PubMed and Web of Science, and subject-specific databases. Students are directed to complete activities to practice using the library search tools and databases.
MSc Applied Public Health - Essential Library Skills Jan 2014Adam John Miller
This document provides an overview and guidance on essential library skills for a postgraduate public health course induction at Middlesex University. It outlines resources to be covered, including the library catalogue for finding and borrowing materials, Summon for searching multiple databases, subject guides for relevant resources, and reading lists. It also reviews reliable online sources for public health information, such as the World Health Organization website, Public Health England's data portal, and Google Scholar. Students are guided on navigating these resources and platforms and conducting sample searches. Contact details are provided for librarian support.
This document provides an overview of resources for research on Latin@s and health, including key databases, the research process, and strategies for developing search terms. It recommends consulting with librarian Susan Luévano, who provides guidance on defining research topics, identifying relevant databases, and setting up research consultations. The document also highlights several databases for health-related research, including Medline, CINAHL, Academic Search Complete, and PsychInfo.
This document provides an overview of resources for research on Latin@s and health, including key databases, the research process, and strategies for developing search terms. It discusses consulting with subject librarian Susan Luévano and scheduling a research consultation. Databases highlighted include Medline, CINAHL, Academic Search Complete, and PsychInfo. Boolean operators, truncation, and defining peer-reviewed articles are also summarized.
This document provides tips for evaluating the reliability of medical information found online. It recommends considering the author and affiliation, date of last update, and purpose of a source. Additionally, it lists several reliable sources for medical information, including MedlinePlus, Merck Manual, Harvard Medical School, NHS, Mayo Clinic, and Freebooks4doctors. The document aims to help people find trustworthy health information on the internet.
Community Training in Evidence Based Practice 3-28-13The TMC Library
- The document outlines an agenda for a training on evidence-based practice resources. It will cover the basics of evidence-based practice, searching PubMed and other resources for literature, and obtaining information from local libraries.
- The training will teach the 5 steps of evidence-based practice: assess the question, ask using PICO format, acquire evidence by searching resources, appraise the evidence found, and apply it. Attendees will learn how to search PubMed and other free resources and formulate searches using PICO.
- Attendees will have time to practice searches in PubMed and other discussed resources to find both filtered and unfiltered evidence on a health topic of their choice.
The document provides guidance on conducting research on Latin@s and health, including developing search strategies, selecting relevant databases, evaluating resources, and applying information. It recommends setting up a consultation with the ethnic studies librarian Susan Luévano for additional help with the research process. Key databases highlighted include PubMed, CINAHL, PsycINFO, and Academic Search Complete.
This document provides an overview of evaluating pediatric patients with thrombocytopenia. It defines degrees of thrombocytopenia and associated bleeding risks. The evaluation involves obtaining a detailed history, clinical assessment, and initial laboratory tests including a complete blood count and peripheral blood smear. The history aims to identify potential etiologies such as infections, drugs, recent illness or procedures. The clinical exam evaluates for signs of bleeding and possible underlying conditions. The blood tests can help determine if thrombocytopenia is real or pseudo, and provide clues to possible causes through findings on the peripheral smear. Further testing may then be guided by these initial findings.
Inherited Bone Marrow Failure Syndromes (IBMFS)
- Definition - Why, when and what?
- Clinical, laboratory and genomic approach?
- Key features of the clinical & lab evaluation?
-Malignancy risk, treatment, follow up
Benign hematology lecture includes:
Tips and tricks in cbc reading, approach to anemia, approach to plat count disorders, indications of lymph node biopsy
The document discusses the diagnosis of desmoid fibromatosis (DF). It states that the diagnosis is usually made through a combination of history, physical examination, imaging, and biopsy. On imaging, DF typically appears as a solid mass with variable echogenicity on ultrasound. CT and MRI are more accurate and can show the extent of infiltration. MRI is the best imaging modality, demonstrating low signal on T1-weighted imaging and variable signal on T2-weighted imaging depending on the collagen content. Biopsy is needed to confirm the diagnosis, as imaging features are non-specific. The diagnosis is usually made in young adults presenting with a painless mass or lump. Location depends on the type of DF, which can be
This document discusses several case scenarios related to neuroblastoma. It begins with the case of a 4-month-old girl brought to the pediatrician for projectile vomiting. An abdominal ultrasound reveals an adrenal mass, and further workup is suggested. The second case involves a 3-year-old boy presenting with hip, leg, and back pain who is found to have a large abdominal mass and decreased breath sounds. The third case is a 4-year-old boy with fever, fatigue, and weight loss, who is found to have a large adrenal mass and widespread lymphadenopathy. Molecular studies confirm MYCN-amplified high-risk neuroblastoma. The document then reviews treatment strategies, complications, and
Neuroblastoma is one of the most common solid tumors in early childhood. It accounts for about 8% of all childhood cancers. Current risk classification systems for neuroblastoma utilize age at diagnosis, disease stage, tumor histology, and key tumor genomic features to assign patients to appropriate therapy groups based on risk of disease recurrence. The systems stratify patients into very low, low, intermediate, and high risk groups. Important prognostic factors include age, stage, MYCN status, tumor ploidy, and loss of heterozygosity at chromosomes 1p and 11q.
Answers to the folowing questions:
What does a pediatric hematologist-oncologist do?
What kind of training is necessary?
Is there a future need for specialists in this area?
The document discusses medulloblastoma (MB), the most common malignant brain tumor in children. MB originates in the cerebellum and projects into the fourth ventricle. It is thought to arise from primitive neuroepithelial cells. On imaging, MB typically appears as a large lobulated mass in the posterior fossa that compresses the fourth ventricle and causes hydrocephalus. Molecular analysis has classified MB into four subgroups: SHH, WNT, Group III, and Group IV, which have different characteristics and prognoses. Prognostic factors include age at diagnosis, extent of disease, extent of resection, histology, and biological markers.
More from National Cancer Institute, Cairo University - Children's Cancer Hospital - Egypt 57357 (8)
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
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10. 2. Relevant pediatric websites
A. General pediatric web sites
C. Medical organization
D. Medical Libraries
B. Subspecialty websites
11. • Medscape pediatrics www.medscape.com/pediatrics
• Emedicine pediatrics www.emedicine.com/ped
• Uptodate pediatrics www.pediatriconcall.com
• Pediatric oncall www.uptodate.com
• American Academy of pediatric (APP) www.aap.org
• Journal of pediatrics www.pediatrics.aappublications.org
• Pediatric in Review www.pedsinreview.aappublications.org
• AAP Immunization www.cispimmunize.org
• Pediatric education www.pediatriceducation.org
A. General pediatric web sites
17. • Pediatric society of critical care medicine
www.pedsccm.org
• American society of pediatric nephrology
www.aspneph.com
• American society of pediatric gastroentrology hepatology and nutrition
www.naspghan.org
• American society of allergy asthma and immunology
www.aaaai.org
B. Subspecialty websites
18. • World health organization
www.who.int
• Center for disease control
www.cdc.gov
C. Medical organization
19. • National library of medicine (USA)
www.nlm.nih.gov
• National library of health
www.library.nhs.uk
D. Medical Libraries
20. 3. Continuing Medical Education
A. Medscape pediatrics CME
B. Pediatric in review CME
D. Pedialink CME
C. Pediatric Oncall CME
E. Pediatrics CME
21. 4. Evidence Based Medicine
A. Searching for practice guidelines
B. Searching for systematic reviews
D. Learning Evidence Based Medicine
C. Searching for clinical study